Melinda T. Coughlan
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View article: <b>miR-214 and its primary transcript Dnm3os</b><b> </b><b>regulate fibrosis and inflammation through RAGE signalling in</b><b> diabetic kidney disease</b>
<b>miR-214 and its primary transcript Dnm3os</b><b> </b><b>regulate fibrosis and inflammation through RAGE signalling in</b><b> diabetic kidney disease</b> Open
Pathological signaling via the receptor for advanced glycation end-products (RAGE) is critical in diabetic kidney disease (DKD) development, while RAGE deletion is reno-protective. Non-coding RNAs (ncRNAs), including microRNAs (miRs), also…
View article: miR-214 and Its Primary Transcript <i>Dnm3os</i> Regulate Fibrosis and Inflammation Through RAGE Signaling in Diabetic Kidney Disease
miR-214 and Its Primary Transcript <i>Dnm3os</i> Regulate Fibrosis and Inflammation Through RAGE Signaling in Diabetic Kidney Disease Open
Pathologic signaling via the receptor for advanced glycation end products (RAGE) is critical to diabetic kidney disease (DKD) development, whereas RAGE deletion is renoprotective. Noncoding RNAs (ncRNAs), including miRNAs, also play key ro…
View article: <b>miR-214 and its primary transcript Dnm3os</b><b> </b><b>regulate fibrosis and inflammation through RAGE signalling in</b><b> diabetic kidney disease</b>
<b>miR-214 and its primary transcript Dnm3os</b><b> </b><b>regulate fibrosis and inflammation through RAGE signalling in</b><b> diabetic kidney disease</b> Open
Pathological signaling via the receptor for advanced glycation end-products (RAGE) is critical in diabetic kidney disease (DKD) development, while RAGE deletion is reno-protective. Non-coding RNAs (ncRNAs), including microRNAs (miRs), also…
View article: Proximal tubular deletion of superoxide dismutase-2 reveals disparate effects on kidney function in diabetes
Proximal tubular deletion of superoxide dismutase-2 reveals disparate effects on kidney function in diabetes Open
There is a large body of evidence implicating mitochondrial reactive oxygen species (ROS) overproduction and oxidative stress in the development of diabetic kidney disease and the deficiency of mitochondrial antioxidant systems in the kidn…
View article: Dietary resistant starch enhances immune health of the kidney in diabetes via promoting microbially-derived metabolites and dampening neutrophil recruitment
Dietary resistant starch enhances immune health of the kidney in diabetes via promoting microbially-derived metabolites and dampening neutrophil recruitment Open
Background Dietary-resistant starch is emerging as a potential therapeutic tool to limit the negative effects of diabetes on the kidneys. However, its metabolic and immunomodulatory effects have not yet been fully elucidated. Methods Six-w…
View article: The AMPK activator ATX-304 alters cellular metabolism to protect against cisplatin-induced acute kidney injury
The AMPK activator ATX-304 alters cellular metabolism to protect against cisplatin-induced acute kidney injury Open
Acute kidney injury (AKI) disrupts energy metabolism. Targeting metabolism through AMP-activated protein kinase (AMPK) may alleviate AKI. ATX-304, a pan-AMPK activator, was evaluated in C57Bl/6 mice and tubular epithelial cell (TEC) cultur…
View article: Glucagon-like peptide-1 receptor signaling modifies the extent of diabetic kidney disease through dampening the receptor for advanced glycation end products–induced inflammation
Glucagon-like peptide-1 receptor signaling modifies the extent of diabetic kidney disease through dampening the receptor for advanced glycation end products–induced inflammation Open
Glucagon like peptide-1 (GLP-1) is a hormone produced and released by cells of the gastrointestinal tract following meal ingestion. GLP-1 receptor agonists (GLP-1RA) exhibit kidney-protective actions through poorly understood mechanisms. H…
View article: Deep multi-omic profiling reveals extensive mitochondrial remodeling driven by glycemia in early diabetic kidney disease
Deep multi-omic profiling reveals extensive mitochondrial remodeling driven by glycemia in early diabetic kidney disease Open
Summary Changes in mitochondrial energy metabolism are thought to be central to the development of diabetic kidney disease (DKD); however, whether this response is explicitly driven by systemic glucose concentrations remains unknown. Here,…
View article: Therapeutic Potential of Targeting Complement C5a Receptors in Diabetic Kidney Disease
Therapeutic Potential of Targeting Complement C5a Receptors in Diabetic Kidney Disease Open
Diabetic kidney disease (DKD) affects 30–40% of patients with diabetes and is currently the leading cause of end-stage renal disease (ESRD). The activation of the complement cascade, a highly conserved element of the innate immune system, …
View article: Resistant starch supplementation alters the gut microbial consortium and attenuates kidney inflammation in an experimental model of autoimmune vasculitis
Resistant starch supplementation alters the gut microbial consortium and attenuates kidney inflammation in an experimental model of autoimmune vasculitis Open
Anti-neutrophil cytoplasmic antibody (ANCA) associated vasculitis (AAV) is a rare autoimmune disease with suboptimal treatment options which contribute to morbidity and mortality. The characteristic pathological feature is severe inflammat…
View article: Resistant Starch as a Dietary Intervention to Limit the Progression of Diabetic Kidney Disease
Resistant Starch as a Dietary Intervention to Limit the Progression of Diabetic Kidney Disease Open
Diabetes is the leading cause of kidney disease, and as the number of individuals with diabetes increases there is a concomitant increase in the prevalence of diabetic kidney disease (DKD). Diabetes contributes to the development of DKD th…
View article: Review of potential biomarkers of inflammation and kidney injury in diabetic kidney disease
Review of potential biomarkers of inflammation and kidney injury in diabetic kidney disease Open
Diabetic kidney disease is expected to increase rapidly over the coming decades with rising prevalence of diabetes worldwide. Current measures of kidney function based on albuminuria and estimated glomerular filtration rate do not accurate…
View article: Microbial influencers: treating diabetes through the gut
Microbial influencers: treating diabetes through the gut Open
A recently published study by Bell et al. shows altered immunotolerance in people with type 1 diabetes by dietary supplementation of modified resistant starch fibre.
View article: Reduced Growth, Altered Gut Microbiome and Metabolite Profile, and Increased Chronic Kidney Disease Risk in Young Pigs Consuming a Diet Containing Highly Resistant Protein
Reduced Growth, Altered Gut Microbiome and Metabolite Profile, and Increased Chronic Kidney Disease Risk in Young Pigs Consuming a Diet Containing Highly Resistant Protein Open
High-heat processed foods contain proteins that are partially resistant to enzymatic digestion and pass through to the colon. The fermentation of resistant proteins by gut microbes produces products that may contribute to chronic disease r…
View article: Independent of Renox, NOX5 Promotes Renal Inflammation and Fibrosis in Diabetes by Activating ROS-sensitive Pathways
Independent of Renox, NOX5 Promotes Renal Inflammation and Fibrosis in Diabetes by Activating ROS-sensitive Pathways Open
Excessive production of renal reactive oxygen species (ROS) play a major role in diabetic kidney disease (DKD). Here, we provide key novel findings demonstrating the predominant pathological role of the prooxidant enzyme NADPH oxidase-NOX5…
View article: Independent of Renox, NOX5 Promotes Renal Inflammation and Fibrosis in Diabetes by Activating ROS-sensitive Pathways
Independent of Renox, NOX5 Promotes Renal Inflammation and Fibrosis in Diabetes by Activating ROS-sensitive Pathways Open
Excessive production of renal reactive oxygen species (ROS) play a major role in diabetic kidney disease (DKD). Here, we provide key novel findings demonstrating the predominant pathological role of the prooxidant enzyme NADPH oxidase-NOX5…
View article: Independent of Renox, NOX5 Promotes Renal Inflammation and Fibrosis in Diabetes by Activating ROS-Sensitive Pathways
Independent of Renox, NOX5 Promotes Renal Inflammation and Fibrosis in Diabetes by Activating ROS-Sensitive Pathways Open
Excessive production of renal reactive oxygen species (ROS) plays a major role in diabetic kidney disease (DKD). Here, we provide key findings demonstrating the predominant pathological role of the pro-oxidant enzyme NADPH oxidase 5 (NOX5)…
View article: The Role of AGE-RAGE Signalling as a Modulator of Gut Permeability in Diabetes
The Role of AGE-RAGE Signalling as a Modulator of Gut Permeability in Diabetes Open
There is increasing evidence for the role of intestinal permeability as a contributing factor in the pathogenesis of diabetes; however, the molecular mechanisms are poorly understood. Advanced glycation endproducts, of both exogenous and e…
View article: The Complement Pathway: New Insights into Immunometabolic Signaling in Diabetic Kidney Disease
The Complement Pathway: New Insights into Immunometabolic Signaling in Diabetic Kidney Disease Open
Significance: The metabolic disorder, diabetes mellitus, results in microvascular complications, including diabetic kidney disease (DKD), which is partly believe to involve disrupted energy generation in the kidney, leading to injury that …
View article: Characterisation of the Myocardial Mitochondria Structural and Functional Phenotype in a Murine Model of Diabetic Cardiomyopathy
Characterisation of the Myocardial Mitochondria Structural and Functional Phenotype in a Murine Model of Diabetic Cardiomyopathy Open
People affected by diabetes are at an increased risk of developing heart failure than their non-diabetic counterparts, attributed in part to a distinct cardiac pathology termed diabetic cardiomyopathy. Mitochondrial dysfunction and excess …
View article: Novel Therapies for Kidney Disease in People With Diabetes
Novel Therapies for Kidney Disease in People With Diabetes Open
Context The increasing burden of diabetic kidney disease (DKD) has led to the discovery of novel therapies. Objective This review aims to summarize the results of recent clinical trials that test the efficacy of potential therapies for DKD…
View article: The AGE receptor, OST48 drives podocyte foot process effacement and basement membrane expansion (alters structural composition)
The AGE receptor, OST48 drives podocyte foot process effacement and basement membrane expansion (alters structural composition) Open
Aims The accumulation of advanced glycation end products is implicated in the development and progression of diabetic kidney disease. No study has examined whether stimulating advanced glycation clearance via receptor manipulation is reno‐…
View article: SOD2 in Skeletal Muscle: New Insights from an Inducible Deletion Model
SOD2 in Skeletal Muscle: New Insights from an Inducible Deletion Model Open
Metabolic conditions such as obesity, insulin resistance and glucose intolerance are frequently associated with impairments in skeletal muscle function and metabolism. This is often linked to dysregulation of homeostatic pathways including…