María Jesús Álvarez-Cubero
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View article: Custom Gene Panel Analysis Identifies Novel Polymorphisms Associated with Clopidogrel Response in Patients Undergoing Percutaneous Coronary Intervention with Stent
Custom Gene Panel Analysis Identifies Novel Polymorphisms Associated with Clopidogrel Response in Patients Undergoing Percutaneous Coronary Intervention with Stent Open
Clopidogrel is widely used as an antiplatelet therapy for acute coronary syndrome (ACS) patients undergoing percutaneous coronary intervention (PCI). Genetic factors influence variability in clopidogrel response, with non-functional CYP2C1…
View article: The effects of a supervised exercise training program during pregnancy on placental cytokines, and the potential role of fetal sex and maternal weight status
The effects of a supervised exercise training program during pregnancy on placental cytokines, and the potential role of fetal sex and maternal weight status Open
Maternal exercise during pregnancy is related to increased placental levels of G-CSF and lower EGF and IL-1ra levels. Some exercise-induced effects are observed exclusively in female placentas, including increased G-CSF and lower TNF-α and…
View article: GSTM5 as a Potential Biomarker for Treatment Resistance in Prostate Cancer
GSTM5 as a Potential Biomarker for Treatment Resistance in Prostate Cancer Open
Background/Objectives: Androgen deprivation therapy (ADT) is widely used to manage prostate cancer (PC), but the emergence of treatment resistance remains a major clinical challenge. Although the GST family has been implicated in drug resi…
View article: Integration of T cell repertoire, CyTOF, genotyping and symptomatology data reveals subphenotypic variability in COVID-19 patients
Integration of T cell repertoire, CyTOF, genotyping and symptomatology data reveals subphenotypic variability in COVID-19 patients Open
COVID-19 manifests a broad spectrum of clinical outcomes, from asymptomatic cases to severe disease. While several biomarkers have been proposed, comprehensive immunological analyses integrating mass cytometry (CyTOF) and T-cell receptor s…
View article: Influence of Genetic Polymorphisms on Cognitive Function According to Dietary Exposure to Bisphenols in a Sample of Spanish Schoolchildren
Influence of Genetic Polymorphisms on Cognitive Function According to Dietary Exposure to Bisphenols in a Sample of Spanish Schoolchildren Open
Background: Neurodevelopmental disorders (NDDs) like intellectual disability (ID) are highly heritable, but the environment plays an important role. For example, endocrine disrupting chemicals (EDCs), including bisphenol A (BPA) and its an…
View article: Multi‐omic study to unmask genes involved in prostate cancer development in a multi‐case family
Multi‐omic study to unmask genes involved in prostate cancer development in a multi‐case family Open
Dear Editor, Hereditary prostate cancer (PC) comprises 5%-10% of all PC cases. The increased risk of PC in men with a family history of the disease is well known and is commonly caused by germline mutations, leading to clinical guidelines …
View article: Explainable artificial intelligence to predict and identify prostate cancer tissue by gene expression
Explainable artificial intelligence to predict and identify prostate cancer tissue by gene expression Open
This model has shown good performance in 4 independent external cohorts of different ancestries and the explanations provided are consistent with each other and with the literature, opening a horizon for its application in clinical practic…
View article: Relevance of TMPRSS2, CD163/CD206, and CD33 in clinical severity stratification of COVID-19
Relevance of TMPRSS2, CD163/CD206, and CD33 in clinical severity stratification of COVID-19 Open
Background Approximately 13.8% and 6.1% of coronavirus disease 2019 (COVID-19) patients require hospitalization and sometimes intensive care unit (ICU) admission, respectively. There is no biomarker to predict which of these patients will …
View article: Type 2 Diabetes-Related Variants Influence the Risk of Developing Prostate Cancer: A Population-Based Case-Control Study and Meta-Analysis
Type 2 Diabetes-Related Variants Influence the Risk of Developing Prostate Cancer: A Population-Based Case-Control Study and Meta-Analysis Open
In this study, we have evaluated whether 57 genome-wide association studies (GWAS)-identified common variants for type 2 diabetes (T2D) influence the risk of developing prostate cancer (PCa) in a population of 304 Caucasian PCa patients an…
View article: OBEMIRISK‐Knowledge platform for assessing the risk of bisphenols on gut microbiota and its role in obesogenic phenotype: looking for biomarkers
OBEMIRISK‐Knowledge platform for assessing the risk of bisphenols on gut microbiota and its role in obesogenic phenotype: looking for biomarkers Open
International audience
View article: Determination of Exosome Mitochondrial DNA as a Biomarker of Renal Cancer Aggressiveness
Determination of Exosome Mitochondrial DNA as a Biomarker of Renal Cancer Aggressiveness Open
Here, the role of non-invasive biomarkers in liquid biopsy was evaluated, mainly in exosomes and mitochondrial DNA (mtDNA) as promising, novel, and stable biomarkers for renal cell carcinoma (RCC). A total of 140 fractions (named from B to…
View article: Interplay between genetics and lifestyle on pain susceptibility in women with fibromyalgia: the al-Ándalus project
Interplay between genetics and lifestyle on pain susceptibility in women with fibromyalgia: the al-Ándalus project Open
Objectives It is widely acknowledged that the experience of pain is promoted by both genetic susceptibility and environmental factors such as engaging in physical activity (PA), and that pain-related cognitions are also important. Thus, th…
View article: Determination of Exosome Mitochondrial DNA as a Biomarker of Renal Cancer Aggressiveness
Determination of Exosome Mitochondrial DNA as a Biomarker of Renal Cancer Aggressiveness Open
Background: Components of liquid biopsy are promising non-invasive biomarkers for monitoring the renal cell carcinoma (RCC) status. Present study tries to evaluate the role of exosomes and mitochondrial DNA (mtDNA) as promise, novel and st…
View article: Identification of MicroRNAs as Viable Aggressiveness Biomarkers for Prostate Cancer
Identification of MicroRNAs as Viable Aggressiveness Biomarkers for Prostate Cancer Open
MiRNAs play a relevant role in PC (prostate cancer) by the regulation in the expression of several pathways’ AR (androgen receptor), cellular cycle, apoptosis, MET (mesenchymal epithelium transition), or metastasis. Here, we report the rol…
View article: Fatigue in Women with Fibromyalgia: A Gene-Physical Activity Interaction Study
Fatigue in Women with Fibromyalgia: A Gene-Physical Activity Interaction Study Open
Fatigue is a cardinal symptom in fibromyalgia. Fatigue is assumed to be the result of genetic susceptibility and environmental factors. We aimed at examining the role of genetic susceptibility for fatigue in southern Spanish women with fib…
View article: OMICs Role in Hereditarian Prostate Cancer
OMICs Role in Hereditarian Prostate Cancer Open
Prostate cancer (PC) is one of the most prevalent tumours in the world, however, the hereditary (Hereditary PC; HPC) form is a rare pathology, that does not exceed 6%. Despite its very low incidence, a family history of PC in a first-degre…
View article: Study of Some Candidate Genes for Treatment in Prostate Cancer
Study of Some Candidate Genes for Treatment in Prostate Cancer Open
The androgenic signalling pathway is essential for carcinogenesis and tumour development in prostate cancer (PC). The importance of that pathway makes it the main target of treatments against PC, among which androgen deprivation therapy (A…
View article: Determination of Expression Signature and Proportion of mtDNA in Plasma Fractions in Patients with Renal Cell Carcinoma
Determination of Expression Signature and Proportion of mtDNA in Plasma Fractions in Patients with Renal Cell Carcinoma Open
Renal Cell Carcinoma (RCC) is the third most common urologic malignancy, remaining one of the most lethal urological malignancies, preferably in developed countries. The incidence and mortality rates differ significantly according to sex, …
View article: Influence of Oxidative Stress-Related Genes on Susceptibility to Fibromyalgia
Influence of Oxidative Stress-Related Genes on Susceptibility to Fibromyalgia Open
Background Fibromyalgia (FM) is a complex syndrome to diagnose and treat because of its unknown etiology. However, previous studies reported that patients with FM experience oxidative stress. Objectives In this study, we investigated singl…
View article: Post-Surgery Circulating Tumor Cells and AXL Overexpression as New Poor Prognostic Biomarkers in Resected Lung Adenocarcinoma
Post-Surgery Circulating Tumor Cells and AXL Overexpression as New Poor Prognostic Biomarkers in Resected Lung Adenocarcinoma Open
Background: The prognosis of early stage non-small cell lung cancer (NSCLC) is quite disappointing and the benefits of adjuvant therapy are relatively small. Thus, there is an urgent need to identify novel prognostic and predictive biomark…
View article: Impact of oxidative stress SNPs and dietary antioxidant quality score on prostate cancer
Impact of oxidative stress SNPs and dietary antioxidant quality score on prostate cancer Open
Purpose: To analyse the relation between antioxidant genotypes and Dietary Antioxidant Quality score (DAQs) effect on prostate cancer (PCa) risk and aggressiveness in a Spanish population. Methods: Men (N = 155 patients and 152 controls) w…
View article: Bisphenol A Analogues in Food and Their Hormonal and Obesogenic Effects: A Review
Bisphenol A Analogues in Food and Their Hormonal and Obesogenic Effects: A Review Open
Bisphenol A (BPA) is the most well-known compound from the bisphenol family. As BPA has recently come under pressure, it is being replaced by compounds very similar in structure, but data on the occurrence of these BPA analogues in food an…
View article: Methodology for Y Chromosome Capture: A complete genome sequence of Y chromosome using flow cytometry, laser microdissection and magnetic streptavidin-beads
Methodology for Y Chromosome Capture: A complete genome sequence of Y chromosome using flow cytometry, laser microdissection and magnetic streptavidin-beads Open
This study is a comparison of the efficiency of three technologies used for Y chromosome capture and the next-generation sequencing (NGS) technologies applied for determining its whole sequence. Our main findings disclose that streptavidin…