David Liu
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View article: Understanding the Canadian Interventional Radiology Landscape Through the Canadian Association of Interventional Radiology Database: A Descriptive Study
Understanding the Canadian Interventional Radiology Landscape Through the Canadian Association of Interventional Radiology Database: A Descriptive Study Open
Background: Physicians in Canada are disproportionately concentrated in urban centers, with rural regions facing significant gaps in specialist care. The geo-spatial characteristics of Interventional Radiology (IR) in Canada have not been …
View article: A scalable proteogenomic framework for dissecting phospho-signaling pathways in primary immune cells
A scalable proteogenomic framework for dissecting phospho-signaling pathways in primary immune cells Open
Signaling networks modulated by post-translational modifications orchestrate cellular responses to external cues. Traditional approaches to study these pathways lack the throughput to systematically capture the causal architecture of these…
View article: Reduced Long-Term Survival After Postoperative Complications in Major Gastrointestinal Surgery
Reduced Long-Term Survival After Postoperative Complications in Major Gastrointestinal Surgery Open
Postoperative complications significantly reduce long-term survival following major gastrointestinal surgery. Both their severity and frequency are critical determinants of poorer outcomes, emphasizing the need for effective prevention str…
View article: Loss of the tumor suppressor PTEN activates cell-intrinsic interferon signaling to drive immune resistance
Loss of the tumor suppressor PTEN activates cell-intrinsic interferon signaling to drive immune resistance Open
Loss of the tumor suppressor PTEN is strongly associated with a lack of response to immune checkpoint blockade therapies in cancer patients, but the underlying mechanisms are not fully understood. We have developed a transformation model w…
View article: Vitamin D-loaded lipid nanoparticles: antioxidant properties, preparation, optimization, and in vitro characterization
Vitamin D-loaded lipid nanoparticles: antioxidant properties, preparation, optimization, and in vitro characterization Open
Vitamin D 3 -loaded lipid nanoparticles (Vit D 3 -LNP), integrated into an azulene cream, were developed to enhance the topical delivery and stability of Vitamin D 3 . The LNP was formulated using a lipid mixture and hot homogenization-ult…
View article: The Case for Training Large Models in Low Precision
The Case for Training Large Models in Low Precision Open
View article: AI for Computational Biology: Highlights from the first BioAI Hackathon at University of Warsaw
AI for Computational Biology: Highlights from the first BioAI Hackathon at University of Warsaw Open
The BioAI Hackathon at the Centre of New Technologies at the University of Warsaw convened 43 international researchers to collaboratively explore artificial intelligence (AI) approaches for solving complex challenges in computational biol…
View article: Role of immune checkpoint inhibitor combinations in resectable and unresectable, embolization-eligible hepatocellular carcinoma
Role of immune checkpoint inhibitor combinations in resectable and unresectable, embolization-eligible hepatocellular carcinoma Open
Immune checkpoint inhibitor (ICI) combination regimens have recently become the new standard of care for advanced hepatocellular carcinoma (HCC). Large, phase III registrational trials of ICI-containing regimens in resectable and embolizat…
View article: Fu's Subcutaneous Needling for Pain: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Fu's Subcutaneous Needling for Pain: A Systematic Review and Meta-Analysis of Randomized Controlled Trials Open
View article: Vitamin D-Loaded Lipid Nanoparticles for Potential Treatment of Vitiligo: Preparation, Optimization, and In Vitro Characterization
Vitamin D-Loaded Lipid Nanoparticles for Potential Treatment of Vitiligo: Preparation, Optimization, and In Vitro Characterization Open
Vitamin D3-loaded lipid nanoparticles (Vit D3-LNP), integrated into an azulene cream, were developed to enhance the topical delivery and stability of Vitamin D3. The LNP was formulated using a lipid mixture…
View article: An international multi-center application of self-radiopaque markers guiding physician-modified fenestration (S-fenestration) in endovascular repair of aortic arch pathologies
An international multi-center application of self-radiopaque markers guiding physician-modified fenestration (S-fenestration) in endovascular repair of aortic arch pathologies Open
Backgrounds and objects: Thoracic endovascular aortic repair (TEVAR) has currently become the “first-line choice” for the repair of various descending aorta pathologies. However, for aortic arch pathologies, physician-modified fenestration…
View article: Tip palpation of the intraduodenal biliary segment for needle-knife fistulotomy
Tip palpation of the intraduodenal biliary segment for needle-knife fistulotomy Open
Previous palpation for the bile duct may aid endoscopists with NKF. This may lead to wider adoption of NKF. Further prospective research is needed.
View article: Successful Percutaneous Extraction of a WATCHMAN FLX Device From the Left Ventricular Outflow Tract
Successful Percutaneous Extraction of a WATCHMAN FLX Device From the Left Ventricular Outflow Tract Open
LAAO device embolization is a rare, yet serious, complication. Retrieval from the LVOT is typically performed with cardiac surgery to avoid damage to the mitral valve. This case demonstrates that percutaneous Watchman device retrieval from…
View article: Variceal Hemorrhage as Complication of Vascular Access for Total Parenteral Nutrition
Variceal Hemorrhage as Complication of Vascular Access for Total Parenteral Nutrition Open
Downhill varices, a rare manifestation of venous hypertension, arise from superior vena cava (SVC) obstruction. We present a unique case of downhill varices secondary to SVC syndrome in a 69-year-old man on chronic total parenteral nutriti…
View article: Intraoperative right ventricular end-systolic pressure–volume loop analysis in patients undergoing cardiac surgery: A proof-of-concept methodology
Intraoperative right ventricular end-systolic pressure–volume loop analysis in patients undergoing cardiac surgery: A proof-of-concept methodology Open
It is clinically feasible to derive RV PV loops from routine hemodynamic and echocardiographic data. With further validation and technological support, this can be a potential real-time intraoperative RV function monitoring tool.
View article: Functional preoperative assessment of coronal knee laxity better predicts postoperative patient outcomes than intraoperative surgeon‐defined laxity in total knee arthroplasty
Functional preoperative assessment of coronal knee laxity better predicts postoperative patient outcomes than intraoperative surgeon‐defined laxity in total knee arthroplasty Open
Purpose Intraoperative laxity assessments in total knee arthroplasty (TKA) are subjective, with few studies comparing against standardised preoperative and postoperative assessments. This study compares coronal knee laxity in TKA patients …
View article: Advancements in needle visualization enhancement and localization methods in ultrasound: a literature review
Advancements in needle visualization enhancement and localization methods in ultrasound: a literature review Open
Ultrasound guidance plays a central role in numerous minimally invasive procedures involving percutaneous needle insertion, ensuring safe and accurate needle placement. However, it encounters two primary challenges: (1) aligning the needle…
View article: Imageable Radioembolization Microspheres for Treatment of Unresectable Hepatocellular Carcinoma: Interim Results from a First-in-Human Trial
Imageable Radioembolization Microspheres for Treatment of Unresectable Hepatocellular Carcinoma: Interim Results from a First-in-Human Trial Open
Radioembolization using imageable microspheres was safe and effective in 6 subjects with unresectable HCC at 6-month interim analysis. Microsphere distribution by radiopacity on CT correlated with radioactivity distribution by SPECT, provi…
View article: Low-dose clonidine infusion to improve sleep in postoperative patients in the high dependency unit: a randomised placebo controlled trial
Low-dose clonidine infusion to improve sleep in postoperative patients in the high dependency unit: a randomised placebo controlled trial Open
Purpose Dexmedetomidine increases sleep and reduces delirium in postoperative patients, but it is expensive and requires a monitored environment. Clonidine, another a2-agonist, is cheaper and is used safely for other purposes in…
View article: The effect of an intraoperative patient-specific, surgery-specific haemodynamic algorithm in improving textbook outcomes for hepatobiliary–pancreatic surgery: a multicentre retrospective study
The effect of an intraoperative patient-specific, surgery-specific haemodynamic algorithm in improving textbook outcomes for hepatobiliary–pancreatic surgery: a multicentre retrospective study Open
Background The concept of a “textbook outcome” is emerging as a metric for ideal surgical outcomes. We aimed to evaluate the impact of an advanced haemodynamic monitoring (AHDM) algorithm on achieving a textbook outcome in patients undergo…
View article: Combination and Optimal Sequencing of Systemic and Locoregional Therapies in Hepatocellular Carcinoma: Proceedings from the Society of Interventional Radiology Foundation Research Consensus Panel
Combination and Optimal Sequencing of Systemic and Locoregional Therapies in Hepatocellular Carcinoma: Proceedings from the Society of Interventional Radiology Foundation Research Consensus Panel Open
View article: Contralateral Hypertrophy Post Yttrium-90 Transarterial Radioembolization in Patients With Hepatocellular Carcinoma and Portal Vein Tumor Thrombus
Contralateral Hypertrophy Post Yttrium-90 Transarterial Radioembolization in Patients With Hepatocellular Carcinoma and Portal Vein Tumor Thrombus Open
Objectives Contralateral hypertrophy of non-irradiated liver following Yttrium-90 (90Y) transarterial radioembolization (TARE) is increasingly recognized as an option to facilitate curative surgical resection in patients that wo…
View article: Functional References for Tibial Axial Rotation in Total Knee Arthroplasty
Functional References for Tibial Axial Rotation in Total Knee Arthroplasty Open
Excessive post-operative tibiofemoral rotational mismatch can result in inferior patient outcomes. This highlights the importance considering the femoral axial alignment during tibial axial alignment. This study investigates different tibi…
View article: Abstract No. 150 ▪ FEATURED ABSTRACT Multimodal Imageable Eye90 microspheres Radioembolization for Hepatocellular Carcinoma: 6-Month Interim Safety and Efficacy and 3-Month Liver Volume Results from a First-in-Human Trial
Abstract No. 150 ▪ FEATURED ABSTRACT Multimodal Imageable Eye90 microspheres Radioembolization for Hepatocellular Carcinoma: 6-Month Interim Safety and Efficacy and 3-Month Liver Volume Results from a First-in-Human Trial Open
View article: Risk Factors for Rescue Opioid Prescription After Cubital Tunnel Surgery
Risk Factors for Rescue Opioid Prescription After Cubital Tunnel Surgery Open
Background: Concerns regarding the ongoing opioid epidemic have led to heightened scrutiny of postoperative opioid prescribing patterns for common orthopedic surgical procedures. This study investigated patient- and procedure-specific risk…
View article: Pan-Canadian consensus recommendations for GIST management in high- and low-throughput centres across Canada
Pan-Canadian consensus recommendations for GIST management in high- and low-throughput centres across Canada Open
Gastrointestinal stromal tumours (GISTs) are mesenchymal tumours that originate from the interstitial cells of Cajal. GISTs are mainly driven by gain-of-function mutations in receptor tyrosine kinase or platelet-derived growth factor recep…
View article: Optimizing Retention Strategies for Opioid Use Disorder Pharmacotherapy: The Retention Phase of the Ctn-0100 Trial (RDD)
Optimizing Retention Strategies for Opioid Use Disorder Pharmacotherapy: The Retention Phase of the Ctn-0100 Trial (RDD) Open
View article: Realistic material property prediction using domain adaptation based machine learning
Realistic material property prediction using domain adaptation based machine learning Open
Scientists aim to predict properties for a known subset of related out-of-distribution materials rather than universally distributed samples. Introducing target material information enhances machine learning models.
View article: Treatment Journey of Patients with Hepatocellular Carcinoma Using Real-World Data in British Columbia, Canada
Treatment Journey of Patients with Hepatocellular Carcinoma Using Real-World Data in British Columbia, Canada Open
The research emphasizes the complexities of managing HCC and underscores the need for personalized treatment strategies to enhance patient outcomes. These findings contribute valuable insights into HCC management and provide a foundation f…
View article: Correction: Precision dosimetry in yttrium-90 radioembolization through CT imaging of radiopaque microspheres in a rabbit liver model
Correction: Precision dosimetry in yttrium-90 radioembolization through CT imaging of radiopaque microspheres in a rabbit liver model Open