Malihe Moghadam
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View article: How Do Small Adjustments in Apical Surface Area Impact Tissue-Wide Homeostasis?
How Do Small Adjustments in Apical Surface Area Impact Tissue-Wide Homeostasis? Open
Epithelial tissues, the primary origin of most cancers, undergo complex changes in organization and size. Understanding epithelial mechanisms is crucial for elucidating how their disruption leads to cancer, despite the stochastic nature of…
View article: Common Dietary Patterns Among Female Employees Participating in the Persian Cohort Study (Mashhad) and Their Relationship With Metabolic Syndrome
Common Dietary Patterns Among Female Employees Participating in the Persian Cohort Study (Mashhad) and Their Relationship With Metabolic Syndrome Open
Background The protective effect of a healthy diet against chronic diseases has been confirmed in several primary studies. This study identifies the dominant food patterns using factor analysis and determining its relationship with metabol…
View article: The Hydrogel Based Allergen-Coated Gold Nanoparticles for Topical Administration: A Possible Epicutaneous Immunotherapy in Pollen-Sensitized Mice?
The Hydrogel Based Allergen-Coated Gold Nanoparticles for Topical Administration: A Possible Epicutaneous Immunotherapy in Pollen-Sensitized Mice? Open
The rapid uptake of antigens by antigen-presenting cells (APCs) and their migration to draining lymph nodes in the initial hours after antigen administration in epicutaneous allergen specific immunotherapy (EPIT) prompted us to investigate…
View article: Evaluation of <i>Kynu</i>, <i>Defb2</i>, <i>Camp</i>, and <i>Penk</i> Expression Levels as Psoriasis Marker in the Imiquimod‐Induced Psoriasis Model
Evaluation of <i>Kynu</i>, <i>Defb2</i>, <i>Camp</i>, and <i>Penk</i> Expression Levels as Psoriasis Marker in the Imiquimod‐Induced Psoriasis Model Open
Background . Psoriasis is a noncontagious auto‐inflammatory chronic skin disease. So far, some of the inflammatory genes were upregulated in mouse model of psoriasis. This study examined changes in skin mRNA expression of L‐kynureninase ( …
View article: An epicutaneous therapeutic pollen-allergen extract delivery system in an allergic rhinitis mouse model: based on allergen loading on DC-specific aptamers conjugated nanogolds
An epicutaneous therapeutic pollen-allergen extract delivery system in an allergic rhinitis mouse model: based on allergen loading on DC-specific aptamers conjugated nanogolds Open
Loading total protein extract on the GNPs and the Apt-modified GNPs could be an effective approach to improve EPIT efficacy in a pollen-induced allergic mouse model.
View article: An epicutaneous therapeutic pollen-allergen extract delivery system in the allergic rhinitis mouse model: based on allergen loading on DC-specific aptamers conjugated nanogolds
An epicutaneous therapeutic pollen-allergen extract delivery system in the allergic rhinitis mouse model: based on allergen loading on DC-specific aptamers conjugated nanogolds Open
Background : We investigated whether gold nanoparticles (GNPs) and dendritic cells (DC)-specific aptamer-modified GNPs (Apts-GNP) could be effective for epicutaneous immunotherapy (EPIT) in the case of pollen allergen extracts containing a…
View article: Influence of biologic and conventional disease-modifying antirheumatic drugs on COVID-19 incidence among rheumatic patients during the first and second wave of the pandemic in Iran
Influence of biologic and conventional disease-modifying antirheumatic drugs on COVID-19 incidence among rheumatic patients during the first and second wave of the pandemic in Iran Open
Introduction During the SARS-CoV-2 virus pandemic, immunosuppressive agents in treating chronic disease have become a concern, and rheumatic patients are not an exception. The controversies about the deteriorating effects of such medicatio…
View article: Optimization of cloning conditions: An experience from recombinant mice Interferon gamma
Optimization of cloning conditions: An experience from recombinant mice Interferon gamma Open
View article: Cloning, Expression, and Purification of Recombinant Mouse Interferon-γ
Cloning, Expression, and Purification of Recombinant Mouse Interferon-γ Open
Background: Interferon-gamma [IFN-γ) is the most important cytokine in the immune system. This protein has been expressed in bacterial cells. However, bacterial cloning is not an easy task. We aimed to clone, express, and purify recombinan…
View article: Level of professional ethics of medical students in externships and internships in Mashhad University of Medical Sciences in 2018
Level of professional ethics of medical students in externships and internships in Mashhad University of Medical Sciences in 2018 Open
Introduction: Due to the fact that medical errors leading to mortality have been associated with low levels of professional ethics in physicians, this study was performed with aim to determine and compare the level of professional ethics o…
View article: Assessment of Knowledge and Consumption Level of Probiotics Dairy Products among the Students and Staff of Mashhad University of Medical Sciences
Assessment of Knowledge and Consumption Level of Probiotics Dairy Products among the Students and Staff of Mashhad University of Medical Sciences Open
Introduction: An increasing interest concerning probiotics has emerged among the public, researchers, governmental organizations (such as the WHO/FAO), and medicinal and food companies. Little is known abo…
View article: Introducing a Stabilizer Formulation for Allergenic Mold Extracts
Introducing a Stabilizer Formulation for Allergenic Mold Extracts Open
The present study reveals a novel formulation that is an efficient stabilizer of allergenic mold extract activity and has practical applications in mold skin prick tests, ELISAs, immunotherapies, and RAST.
View article: Determination of Optimum Excipients for Platanus orientalis Pollen Extract by Accelerating Chemical Stability Test and Their Synergistic Effect.
Determination of Optimum Excipients for Platanus orientalis Pollen Extract by Accelerating Chemical Stability Test and Their Synergistic Effect. Open
The P. orientalis extract stability was increased by a mixture of lysine (20 mM), trehalose (20 mM), and D-mannitol.
View article: The Influence of Gamma Radiation Processing on the Allergenicity of Main Pistachio Allergens.
The Influence of Gamma Radiation Processing on the Allergenicity of Main Pistachio Allergens. Open
Gamma irradiation appears to be an effective method in reducing the allergenicity of pistachios. Thus, this form of processing has the potential to prevent adverse allergic reactions to the major pistachio allergens in sensitized subjects.…
View article: Relationship between the findings of vaginal sonography and pathology of endometrial curettage in women with abnormal uterine bleeding at perimenopause
Relationship between the findings of vaginal sonography and pathology of endometrial curettage in women with abnormal uterine bleeding at perimenopause Open
Introduction: Abnormal uterine bleeding (AUB) is one common problem in perimenopausal women that should be carefully evaluated. Evaluation in terms of endometrial cancer and premalignant lesions is very important. This study was performed …
View article: Oral Presentation Versus Role Playing in Medical Education: A Quasi-Experimental Study
Oral Presentation Versus Role Playing in Medical Education: A Quasi-Experimental Study Open
Background It is claimed that role-playing is a teaching strategy that has several advantages for both the teacher and student. This study aimed to compare two educational methods (oral presentation, a traditional method that is known to b…
View article: Interaction Between Air Pollutants and Pollen Grains: The Role on the Rising Trend in Allergy.
Interaction Between Air Pollutants and Pollen Grains: The Role on the Rising Trend in Allergy. Open
This interaction can occur through several mechanisms; chemical pollutants might facilitate pollen allergen release, act as adjuvants to stimulate IgE-mediated responses, modify allergenic potential, and enhance the expression of some alle…
View article: Association between smoking and non-alcoholic fatty liver disease: A systematic review and meta-analysis
Association between smoking and non-alcoholic fatty liver disease: A systematic review and meta-analysis Open
Background/aims: Non-alcoholic fatty liver disease is one of the most common chronic liver diseases. Some risk factors are known to influence the development of non-alcoholic fatty liver disease, but the effect of tobacco smoking on the pr…
View article: Metabolic effects of fasting in adolescents with diabetes type 1
Metabolic effects of fasting in adolescents with diabetes type 1 Open
Type I diabetes mellitus is a common chronic disease in adolescents. According to statistics, 12,243 diabetic Muslims fast in thirteen Islamic countries, 43% of whom have type I diabetes. This longitudinal study was conducted on volunteer …
View article: Lung-derived innate cytokines: new epigenetic targets of allergen-specific sublingual immunotherapy.
Lung-derived innate cytokines: new epigenetic targets of allergen-specific sublingual immunotherapy. Open
In our study, sublingual immunotherapy with recombinant allergen effectively attenuated allergic immune responses, at least partly, by induction of distinct histone modifications at specific loci. Additionally, the lung-derived pro-allergi…
View article: Refolding process of cysteine-rich proteins:Chitinase as a model
Refolding process of cysteine-rich proteins:Chitinase as a model Open
BACKGROUND: Recombinant proteins overexpressed in E. coli are usually deposited in inclusion bodies. Cysteines in the protein contribute to this process. Inter- and intra- molecular disulfide bonds in chitinase, a cysteine-rich protein, ca…