Alain Dagher
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View article: Global network and local vulnerabilities underlie brain atrophy across Parkinson’s disease stages
Global network and local vulnerabilities underlie brain atrophy across Parkinson’s disease stages Open
Parkinson’s disease (PD) is associated with extensive structural brain changes. Recent work has proposed that the spatial pattern of disease pathology is shaped by both network spread and local vulnerability. However, only few studies asse…
View article: Parkinson Disease <i>SNCA</i> Risk Variants Are Associated With Higher Asymmetric Putamen Dopaminergic Dysfunction
Parkinson Disease <i>SNCA</i> Risk Variants Are Associated With Higher Asymmetric Putamen Dopaminergic Dysfunction Open
Our findings suggest that a more lateralized putaminal dopaminergic degeneration in early PD may represent a viable endophenotype in carriers of SNCA risk variants, emphasizing the relevant role of neuroimaging in PD subtyping and b…
View article: Adopting open-science infrastructure in the ENIGMA-Parkinson’s Disease consortium: A case study
Adopting open-science infrastructure in the ENIGMA-Parkinson’s Disease consortium: A case study Open
The adoption of open science principles for data has been instrumental in enabling the creation and reuse of large datasets and efficient collaboration, but requires a dedicated open data sharing infrastructure. Although clinical neuroscie…
View article: Joint multi-omics profiling of brain and body health in aging
Joint multi-omics profiling of brain and body health in aging Open
The human brain and peripheral systems undergo coordinated changes throughout the lifespan, yet studies of aging have traditionally examined these systems as separate entities. Here we ask how brain health relates to peripheral biomarkers …
View article: Adopting open-science infrastructure in the ENIGMA-Parkinson’s Disease consortium: A case study
Adopting open-science infrastructure in the ENIGMA-Parkinson’s Disease consortium: A case study Open
The adoption of open science principles for data has been instrumental in enabling the creation and reuse of large datasets and efficient collaboration, but requires a dedicated open data sharing infrastructure. Although clinical neuroscie…
View article: The effects of 12 weeks of Cardiovascular Exercise on Sleep Architecture and Corticospinal Excitability in Parkinson’s Disease: a mechanistic insight
The effects of 12 weeks of Cardiovascular Exercise on Sleep Architecture and Corticospinal Excitability in Parkinson’s Disease: a mechanistic insight Open
Regular exercise is a safe adjunct to standard pharmacological treatment and may improve common sleep architecture alterations observed in Parkinson’s disease (PD). However, research in this area is limited, and it is unclear which potenti…
View article: Network spreading and local biological vulnerability in amyotrophic lateral sclerosis
Network spreading and local biological vulnerability in amyotrophic lateral sclerosis Open
Amyotrophic Lateral Sclerosis (ALS) is a progressive neurodegenerative disease that predominantly targets the motor system. Spread of pathology is thought to be driven by both local vulnerability and network architecture. Namely, molecular…
View article: Mapping cerebral blood perfusion and its links to multi-scale brain organization across the human lifespan
Mapping cerebral blood perfusion and its links to multi-scale brain organization across the human lifespan Open
Blood perfusion delivers oxygen and nutrients to all cells, making it a fundamental feature of brain organization. How cerebral blood perfusion maps onto micro-, meso- and macro-scale brain structure and function is therefore a key questio…
View article: Obesity-related brain atrophy is independent of Alzheimer's disease protein pathways
Obesity-related brain atrophy is independent of Alzheimer's disease protein pathways Open
Background Obesity increases the risk for Alzheimer's disease (AD) and other dementias. Obesity causes structural brain injury, and it has been suggested that this may contribute to the development of AD pathology. Neurodegeneration in AD …
View article: In vivo and in silico alpha-synuclein propagation dynamics: The role of genotype, epicentre, and connectivity
In vivo and in silico alpha-synuclein propagation dynamics: The role of genotype, epicentre, and connectivity Open
Synucleinopathies, like Parkinson’s disease (PD) are characterized by progressive accumulation and spread of misfolded alpha-synuclein (aSyn) throughout the brain. To improve understanding of disease mechanisms we studied the generalizabil…
View article: Neurocognition in youth with versus without prediabetes
Neurocognition in youth with versus without prediabetes Open
Aims/Hypothesis Type 2 diabetes has a well-established link to cognitive impairment in older adults; however, studies often do not control for adiposity and co-morbid conditions which might mediate this cognitive impairment. To overcome th…
View article: Non-invasive brain stimulation to enhance sleep quality and architecture in Parkinson's disease: A systematic review and Bayesian network meta-analysis
Non-invasive brain stimulation to enhance sleep quality and architecture in Parkinson's disease: A systematic review and Bayesian network meta-analysis Open
Individuals with Parkinson's disease (PD) suffer from sleep disorders and maladaptive alterations in sleep architecture. These disorders, which increase in frequency and severity as the disease progresses, are multifactorial and clinically…
View article: Genomic structural equation modeling of impulsivity and risk-taking traits reveals three latent factors distinctly associated with brain structure and development
Genomic structural equation modeling of impulsivity and risk-taking traits reveals three latent factors distinctly associated with brain structure and development Open
Background Impulsivity is a multifaceted transdiagnostic trait that emerges in childhood. Research has identified genetic loci and brain systems associated with different facets of impulsivity and risk-taking. However, how these genetic un…
View article: Distinct brain atrophy progression subtypes underlie phenoconversion in isolated REM sleep behaviour disorder
Distinct brain atrophy progression subtypes underlie phenoconversion in isolated REM sleep behaviour disorder Open
This study was supported by grants to S.R. from Alzheimer Society Canada (0000000082) and by Parkinson Canada (PPG-2023-0000000122). The work performed in Montreal was supported by the Canadian Institutes of Health Research (CIHR), the Fon…
View article: Convergent large-scale network and local vulnerabilities underlie brain atrophy across Parkinson’s disease stages: a worldwide ENIGMA study
Convergent large-scale network and local vulnerabilities underlie brain atrophy across Parkinson’s disease stages: a worldwide ENIGMA study Open
Parkinson’s disease (PD) is associated with extensive structural brain changes. Recent work has proposed that the spatial pattern of disease pathology is shaped by both network spread and local vulnerability. However, only few studies asse…
View article: Unity and diversity of NEO-PI personality profiles of 162 phenotypes
Unity and diversity of NEO-PI personality profiles of 162 phenotypes Open
For over 30 years, detailed personality-phenotype association profiles based on the NEO Personality Inventory (NEO PI) have been published, yet the phenotype profiles have been rarely linked across studies as has been done in brain imaging…
View article: The Effects of Multimodal Exercise on Sleep Quality and Architecture, Motor Function, Cognition, Fatigue, and Systemic Inflammation in Corticobasal Syndrome: A Case Report.
The Effects of Multimodal Exercise on Sleep Quality and Architecture, Motor Function, Cognition, Fatigue, and Systemic Inflammation in Corticobasal Syndrome: A Case Report. Open
Importance. Corticobasal syndrome (CBS) is a rare tauopathy, with a complex pathophysiology that usually includes neuroinflammation. Parkinsonism, cognitive impairments, and sleep disturbances are common in CBS, although alterations in sle…
View article: Brain network dynamics determine tau presence while regional vulnerability governs tau load in Alzheimer’s disease
Brain network dynamics determine tau presence while regional vulnerability governs tau load in Alzheimer’s disease Open
In Alzheimer’s disease (AD), tau pathology accumulates gradually throughout the brain, with clinical decline reflecting tau progression. A comprehensive understanding of, first, whether tau propagation is predominantly governed by connecto…
View article: Ultra-processed food consumption affects structural integrity of feeding-related brain regions independent of and via adiposity
Ultra-processed food consumption affects structural integrity of feeding-related brain regions independent of and via adiposity Open
Consumption of ultra-processed foods (UPFs) increases overall caloric intake and is associated with obesity, cardiovascular disease, and brain pathology. There is scant evidence as to why UPF consumption leads to increased caloric intake a…
View article: Novel silica-based polymer hemostatic matrix improves vessel patency rates in a coagulopathic porcine model with penetrating arterial injury
Novel silica-based polymer hemostatic matrix improves vessel patency rates in a coagulopathic porcine model with penetrating arterial injury Open
BACKGROUND Traumatic hemorrhage is the leading cause of preventable battlefield death and hemostatic agents can improve survival. We compared a novel, amorphous, silica dioxide–based fiber (SBF) hemostatic matrix to the criterion standard …
View article: Mapping energy metabolism systems in the human brain
Mapping energy metabolism systems in the human brain Open
Energy metabolism involves a network of biochemical reactions that generate ATP, utilizing substrates such as glucose and oxygen supplied via cerebral blood flow. Energy substrates are metabolized in multiple interrelated pathways that are…
View article: Carriers of<i>LRRK2</i>pathogenic variants show a milder, anatomically distinct brain signature of Parkinson’s disease
Carriers of<i>LRRK2</i>pathogenic variants show a milder, anatomically distinct brain signature of Parkinson’s disease Open
LRRK2 gene variants are a major genetic risk factor for both familial and sporadic Parkinson’s disease (PD), opening an unattended window on the disease’s mechanisms and potential therapies. Investigating the influence of pathogenic varian…
View article: Cell type transcriptomics reveal shared genetic mechanisms in Alzheimer’s and Parkinson’s disease
Cell type transcriptomics reveal shared genetic mechanisms in Alzheimer’s and Parkinson’s disease Open
Historically, Alzheimer’s disease (AD) and Parkinson’s disease (PD) have been investigated as two distinct disorders of the brain. However, a few similarities in neuropathology and clinical symptoms have been documented over the years. Tra…
View article: Selective Effects of Substantia Nigra and Locus Coeruleus Degeneration on Cognition in Parkinson's Disease
Selective Effects of Substantia Nigra and Locus Coeruleus Degeneration on Cognition in Parkinson's Disease Open
Background The substantia nigra (SN) and locus coeruleus (LC) are among the first brain regions to degenerate in Parkinson's disease (PD). This has important implications for early cognitive deficits because these nuclei are sources of asc…
View article: Cerebral blood perfusion across biological systems and the human lifespan
Cerebral blood perfusion across biological systems and the human lifespan Open
Blood perfusion delivers oxygen and nutrients to all cells, making it a fundamental feature of brain organization. How cerebral blood perfusion maps onto micro-, meso- and macro-scale brain structure and function is therefore a key questio…
View article: BRAIN RESPONSES TO ALCOHOL CUES IN YOUTH AT RISK FOR SUBSTANCE USE DISORDERS (SUDS): A FUNCTIONAL MAGNETIC RESONANCE IMAGING STUDY
BRAIN RESPONSES TO ALCOHOL CUES IN YOUTH AT RISK FOR SUBSTANCE USE DISORDERS (SUDS): A FUNCTIONAL MAGNETIC RESONANCE IMAGING STUDY Open
Background Adolescent alcohol use is the norm, but only some develop a substance use disorder (SUD). The most common vulnerability traits are characterized by diverse externalizing (EXT) behaviors (e.g., poor impulse-control and emotion re…
View article: Cardiac Kaposi Sarcoma Complicated by Kaposi Sarcoma Inflammatory Cytokine Syndrome: A Case Report
Cardiac Kaposi Sarcoma Complicated by Kaposi Sarcoma Inflammatory Cytokine Syndrome: A Case Report Open
Kaposi sarcoma (KS), caused by human herpesvirus-8 (HHV-8), is among the most common malignancies in people living with HIV. Kaposi sarcoma is an angiogenic endothelial cell neoplasm and an acquired immunodeficiency syndrome (AIDS)-definin…
View article: <i>LRRK2</i> -associated parkinsonism with and without <i>in vivo</i> evidence of alpha-synuclein aggregates: longitudinal clinical and biomarker characterization
<i>LRRK2</i> -associated parkinsonism with and without <i>in vivo</i> evidence of alpha-synuclein aggregates: longitudinal clinical and biomarker characterization Open
Among LRRK2-associated parkinsonism cases with nigral degeneration, over two-thirds demonstrate evidence of pathologic alpha-synuclein, but many do not. Understanding the clinical phenotype and underlying biology in such individuals is cri…
View article: Uncovering atrophy progression pattern and mechanisms in individuals at risk of Alzheimer's disease
Uncovering atrophy progression pattern and mechanisms in individuals at risk of Alzheimer's disease Open
Alzheimer's disease is associated with pre-symptomatic changes in brain morphometry and accumulation of abnormal tau and amyloid-beta pathology. Studying the development of brain changes prior to symptoms onset may lead to early diagnostic…
View article: Right posterior theta reflects human parahippocampal phase resetting by salient cues during goal-directed navigation
Right posterior theta reflects human parahippocampal phase resetting by salient cues during goal-directed navigation Open
Animal and computational work indicate that phase resetting of theta oscillations (4–12 Hz) in the parahippocampal gyrus (PHG) by salient events (e.g., reward, landmarks) facilitates the encoding of goal-oriented information during navigat…