M. Daniele Fallin
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View article: The association of prenatal ambient air pollution with placental epigenetic gestational age at birth
The association of prenatal ambient air pollution with placental epigenetic gestational age at birth Open
Background: Prenatal air pollutants have been associated with adverse birth outcomes, and DNA methylation (DNAm) changes in placenta may contribute to these associations. DNAm-based epigenetic gestational age (GA) estimators are emerging b…
View article: Changes in Autism Traits from Early Childhood to Adolescence in the Study to Explore Early Development
Changes in Autism Traits from Early Childhood to Adolescence in the Study to Explore Early Development Open
Purpose: The objectives of this study were to investigate associations between co-occurring developmental, psychiatric, behavioral, and medical symptoms and conditions and autism spectrum disorder (ASD) traits, as well as predictors of cha…
View article: Commonly used genomic arrays may lose information due to imperfect coverage of discovered variants for autism spectrum disorder
Commonly used genomic arrays may lose information due to imperfect coverage of discovered variants for autism spectrum disorder Open
Background Common genetic variation has been shown to account for a large proportion of ASD heritability. Polygenic scores generated for autism spectrum disorder (ASD-PGS) using the most recent discovery data, however, explain less varianc…
View article: Multicohort Epigenome-Wide Association Study of All-Cause Cardiovascular Disease and Cancer Incidence
Multicohort Epigenome-Wide Association Study of All-Cause Cardiovascular Disease and Cancer Incidence Open
These results point to molecular pathways and potential treatments for precision prevention of CVD and cancer. Screening based on common epigenetic signatures of incident CVD and cancer may help identify patients with newly diagnosed CVD a…
View article: Exposure to heavy metals in utero and autism spectrum disorder at age 3: a meta-analysis of two longitudinal cohorts of siblings of children with autism
Exposure to heavy metals in utero and autism spectrum disorder at age 3: a meta-analysis of two longitudinal cohorts of siblings of children with autism Open
Background Autism spectrum disorder (ASD) is a prevalent and heterogeneous neurodevelopmental disorder. Risk is attributed to genetic and prenatal environmental factors, though the environmental agents are incompletely characterized. Metho…
View article: Food, nutrition, and autism: from soil to fork
Food, nutrition, and autism: from soil to fork Open
Food and nutrition-related factors have the potential to impact development of autism spectrum disorder (ASD) and quality of life for people with ASD, but gaps in evidence exist. On 10 November 2022, Tufts University's Friedman School of N…
View article: Arsenic Exposure and Epigenetic Aging: The Association with Cardiovascular Disease and All-Cause Mortality in the Strong Heart Study
Arsenic Exposure and Epigenetic Aging: The Association with Cardiovascular Disease and All-Cause Mortality in the Strong Heart Study Open
Arsenic exposure was associated with older GrimAge and faster DunedinPACE measures of biological age. Furthermore, accelerated biological aging measured from DNA methylation accounted for a relevant fraction of As-associated risk for CVD, …
View article: Exposure to heavy metals<i>in utero</i>and autism spectrum disorder at age 3: A meta-analysis of two longitudinal cohorts of siblings of children with autism
Exposure to heavy metals<i>in utero</i>and autism spectrum disorder at age 3: A meta-analysis of two longitudinal cohorts of siblings of children with autism Open
Background Autism spectrum disorder (ASD) is a prevalent and heterogeneous neurodevelopmental disorder. Risk is attributed to genetic and prenatal environmental factors, though the environmental agents are incompletely characterized. Metho…
View article: A Mixture of Urinary Phthalate Metabolite Concentrations During Pregnancy and Offspring Social Responsiveness Scale Scores
A Mixture of Urinary Phthalate Metabolite Concentrations During Pregnancy and Offspring Social Responsiveness Scale Scores Open
Background: Phthalates are a group of chemicals with ubiquitous exposure worldwide. Exposures to phthalates during pregnancy may play a role in autism spectrum disorder (ASD) etiology by disrupting hormone levels or directly impacting feta…
View article: Remote Delivery of Allied and Behavioral Healthcare During COVID-19 for Children With Developmental Disabilities
Remote Delivery of Allied and Behavioral Healthcare During COVID-19 for Children With Developmental Disabilities Open
Our study demonstrates the caregiver-reported impacts of COVID-19 on remote delivery of allied and behavioral healthcare services for children with ASD and other DD. Considerations for caregiver support and remote delivery of services are …
View article: The association of prenatal ambient air pollution with placenta epigenetic age at birth
The association of prenatal ambient air pollution with placenta epigenetic age at birth Open
BACKGROUND AND AIM: Prenatal exposures to air pollutants (AP) are well-established risk factors for preterm birth, yet evidence on implicated tissues and underlying biological mechanisms remain inconclusive. DNA methylation (DNAm) is invol…
View article: Analysis of DNA methylation at birth and in childhood reveals changes associated with season of birth and latitude
Analysis of DNA methylation at birth and in childhood reveals changes associated with season of birth and latitude Open
View article: Accelerated epigenetic age at birth and child emotional and behavioural development in early childhood: a meta-analysis of four prospective cohort studies in ECHO
Accelerated epigenetic age at birth and child emotional and behavioural development in early childhood: a meta-analysis of four prospective cohort studies in ECHO Open
Background: ‘Epigenetic clocks’ have been developed to accurately predict chronologic gestational age and have been associated with child health outcomes in prior work. Methods: We meta-analysed results from four prospective …
View article: Genetic liability for gastrointestinal inflammation disorders and association with gastrointestinal symptoms in children with and without autism
Genetic liability for gastrointestinal inflammation disorders and association with gastrointestinal symptoms in children with and without autism Open
Children with autism spectrum disorder (ASD) have a greater prevalence of gastrointestinal (GI) symptoms than children without ASD. We tested whether polygenic scores for each of three GI disorders (ulcerative colitis, inflammatory bowel d…
View article: Associations of Sex, Race, and Apolipoprotein E Alleles With Multiple Domains of Cognition Among Older Adults
Associations of Sex, Race, and Apolipoprotein E Alleles With Multiple Domains of Cognition Among Older Adults Open
Importance Sex differences are established in associations between apolipoprotein E ( APOE ) ε4 and cognitive impairment in Alzheimer disease (AD). However, it is unclear whether sex-specific cognitive consequences of APOE are consistent a…
View article: Smoking, blood DNA methylation sites and lung cancer risk
Smoking, blood DNA methylation sites and lung cancer risk Open
View article: Accelerated epigenetic age at birth and child emotional and behavioral development in early childhood: a meta-analysis of four prospective cohort studies in ECHO
Accelerated epigenetic age at birth and child emotional and behavioral development in early childhood: a meta-analysis of four prospective cohort studies in ECHO Open
Background: “Epigenetic clocks” have been developed to accurately predict chronologic gestational age and have been associated with child health outcomes in prior work. Methods: We meta-analyzed results from four prospective U.S cohorts in…
View article: Additional file 1 of Analysis of DNA methylation at birth and in childhood reveals changes associated with season of birth and latitude
Additional file 1 of Analysis of DNA methylation at birth and in childhood reveals changes associated with season of birth and latitude Open
Additional file 1. Table S1: “Summary of the studies in the meta-analysis for the association between Season of Birth and DNA methylation at birth and in children (age: 1 to 11 years)”. Baseline summary of participants from each of the ind…
View article: Additional file 5 of Analysis of DNA methylation at birth and in childhood reveals changes associated with season of birth and latitude
Additional file 5 of Analysis of DNA methylation at birth and in childhood reveals changes associated with season of birth and latitude Open
Additional file 5. Table S4: “Direction of differential methylation of CpGs in DMRs of the at-birth and childhood analyses (preliminary analysis”).
View article: Additional file 6 of Analysis of DNA methylation at birth and in childhood reveals changes associated with season of birth and latitude
Additional file 6 of Analysis of DNA methylation at birth and in childhood reveals changes associated with season of birth and latitude Open
Additional file 6. Table S5: “Genes mapped to DMP/DMR identified in at-birth samples of babies born in the latitude ≥ 50°N and some examples of their associations with biological functions”. Provides examples of known functional associatio…
View article: Additional file 8 of Analysis of DNA methylation at birth and in childhood reveals changes associated with season of birth and latitude
Additional file 8 of Analysis of DNA methylation at birth and in childhood reveals changes associated with season of birth and latitude Open
Additional file 8. Table S8: “Genes mapped to DMR identified in the childhood samples of children born in the latitude ≥ 50°N and some examples of their associations with biological functions”. Provides examples of known functional associa…
View article: Accelerated epigenetic age at birth and child emotional and behavioural development in early childhood: a meta-analysis of four prospective cohort studies in ECHO
Accelerated epigenetic age at birth and child emotional and behavioural development in early childhood: a meta-analysis of four prospective cohort studies in ECHO Open
Background: ‘Epigenetic clocks’ have been developed to accurately predict chronologic gestational age and have been associated with child health outcomes in prior work. Methods: We meta-analysed results from four prospective U.S cohorts in…
View article: Association of prenatal exposure to opioids, cannabis, and polysubstance use with cord blood DNA methylation patterns in a multiancestry cohort
Association of prenatal exposure to opioids, cannabis, and polysubstance use with cord blood DNA methylation patterns in a multiancestry cohort Open
Background: Blood DNA methylation patterns are highly predictive of prenatal exposure to smoking and differential methylation has been associated with maternal alcohol use. We extended this to determine whether DNA methylation patterns in …
View article: Associations between accelerated parental biologic age, autism spectrum disorder, social traits, and developmental and cognitive outcomes in their children
Associations between accelerated parental biologic age, autism spectrum disorder, social traits, and developmental and cognitive outcomes in their children Open
Parental age is a known risk factor for autism spectrum disorder (ASD), however, studies to identify the biologic changes underpinning this association are limited. In recent years, “epigenetic clock” algorithms have been developed to esti…
View article: Effects of Prenatal Phthalate Exposure on Early Childhood Expressive Language Development Trajectories
Effects of Prenatal Phthalate Exposure on Early Childhood Expressive Language Development Trajectories Open
BACKGROUND AND AIM: Phthalates are common endocrine disruptors that can impair neurodevelopment. We investigated potential links between prenatal exposure to phthalates and child language development trajectories given prior inconsistent e…
View article: Study of Parental Occupational Exposures to Solvents and Risk of Autism Spectrum Disorder in Offspring
Study of Parental Occupational Exposures to Solvents and Risk of Autism Spectrum Disorder in Offspring Open
BACKGROUND AND AIM: Solvents can accumulate in fat and later metabolize during pregnancy. Additionally, these toxicants could lead to germline mutations. We investigated associations between multiple parental occupational solvent exposures…
View article: Prenatal exposure to POPs mixtures and DNA methylation alterations in multiple tissues at birth
Prenatal exposure to POPs mixtures and DNA methylation alterations in multiple tissues at birth Open
Background/Aim: Prenatal exposure to persistent organic pollutants (POPs) has been linked to adverse health conditions in the offspring. However, little is known about the underlying mechanisms. Growing literature suggests epigenetics may …
View article: Prenatal Exposure to Ambient Air Pollution and Epigenetic Aging at Birth in Newborns
Prenatal Exposure to Ambient Air Pollution and Epigenetic Aging at Birth in Newborns Open
In utero air pollution exposure has been associated with adverse birth outcomes, yet effects of air pollutants on regulatory mechanisms in fetal growth and critical windows of vulnerability during pregnancy are not well understood. There i…
View article: Placental morphology in association with autism-related traits in the EARLI study
Placental morphology in association with autism-related traits in the EARLI study Open
View article: Arsenic Exposure, Blood DNA Methylation, and Cardiovascular Disease
Arsenic Exposure, Blood DNA Methylation, and Cardiovascular Disease Open
Background: Epigenetic dysregulation has been proposed as a key mechanism for arsenic-related cardiovascular disease (CVD). We evaluated differentially methylated positions (DMPs) as potential mediators on the association between arsenic a…