Jesús M. de la Fuente
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View article: Functionalization of magnetotactic bacteria with gold Nanoprisms. A Route to novel photothermal agents
Functionalization of magnetotactic bacteria with gold Nanoprisms. A Route to novel photothermal agents Open
View article: Cr<sup>3+</sup>‐Doped γ‐ and β‐Gallium Oxide Nanoprobes for Bioimaging: Synthesis, Persistent Luminescence, and Biocompatibility
Cr<sup>3+</sup>‐Doped γ‐ and β‐Gallium Oxide Nanoprobes for Bioimaging: Synthesis, Persistent Luminescence, and Biocompatibility Open
Persistent luminescent (PersL) nanophosphors that emit in the near infrared (NIR) region are promising nanoprobes for in vivo bioimaging. Although Cr 3+ ‐doped zinc gallate nanoparticles (NPs) have been widely studied as in vivo bioimaging…
View article: Heat up, silence on: IDO1 gene silencing in THP-1-derived dendritic cells triggered by magnetic hyperthermia
Heat up, silence on: IDO1 gene silencing in THP-1-derived dendritic cells triggered by magnetic hyperthermia Open
View article: Magnetic hyperthermia drastically enhances killing of Mycobacterium tuberculosis by bacteriocin AS-48 grafted on biomimetic nanoparticles
Magnetic hyperthermia drastically enhances killing of Mycobacterium tuberculosis by bacteriocin AS-48 grafted on biomimetic nanoparticles Open
View article: Modified Bis-pyrimidine Clamps for Triplex Formation and Their Use in SARS-CoV-2 Detection
Modified Bis-pyrimidine Clamps for Triplex Formation and Their Use in SARS-CoV-2 Detection Open
The formation of nucleic acid triple helices ("triplexes") is an area of great interest due to their potential role in the natural and artificial regulation of gene expression or for use in analytical, diagnostic, or synthetic methods. Dur…
View article: Förster Resonance Energy Transfer (FRET) Demonstrates In Vitro Chitosan-Coated Nanocapsules Suitability for Intranasal Brain Delivery
Förster Resonance Energy Transfer (FRET) Demonstrates In Vitro Chitosan-Coated Nanocapsules Suitability for Intranasal Brain Delivery Open
Intranasal drug delivery to the brain offers a promising strategy to overcome biological barriers. Chitosan-coated nanoemulsion-based nanocapsules demonstrate significant potential due to their mucoadhesive properties, ability to permeate …
View article: Dynamic regulation of Rgs16 and its correlation with Neuregulin1 expression in acute and chronic nerve injury
Dynamic regulation of Rgs16 and its correlation with Neuregulin1 expression in acute and chronic nerve injury Open
Introduction: Regulators of G Protein Signaling (RGS) form a gene family that modulates G protein-coupled receptor signaling by enhancing the GTPase activity of the Gα-GTP complex, effectively inhibiting G protein-dependent signal transduc…
View article: Nanoparticle-assisted targeting of heart lesions with cardiac myofibroblasts: Combined gene and cell therapy
Nanoparticle-assisted targeting of heart lesions with cardiac myofibroblasts: Combined gene and cell therapy Open
Rationale: The cardiac scar is an area rich in collagen. It is populated by myofibroblasts and lacks Connexin 43 expressing cardiomyocytes. Myocardial infarctions have so far proven little amenable to gene- and cell-based therapeuti…
View article: Correction: Membrane-localized magnetic hyperthermia promotes intracellular delivery of cell-impermeant probes
Correction: Membrane-localized magnetic hyperthermia promotes intracellular delivery of cell-impermeant probes Open
Correction for ‘Membrane-localized magnetic hyperthermia promotes intracellular delivery of cell-impermeant probes’ by Javier Idiago-López et al. , Nanoscale , 2024, 16 , 15176–15195, https://doi.org/10.1039/D4NR01955E.
View article: Opportunities for nanomaterials in enzyme therapy
Opportunities for nanomaterials in enzyme therapy Open
View article: Biophysical evaluation of antiparallel triplexes for biosensing and biomedical applications
Biophysical evaluation of antiparallel triplexes for biosensing and biomedical applications Open
Polypyrimidine sequences can be targeted by antiparallel clamps forming triplex structures either for biosensing or therapeutic purposes. Despite its successful implementation, their biophysical properties remain to be elusive. In this wor…
View article: Surface Functionalization of Nanoparticles with Polyethylene Glycol: Effects on Protein Adsorption and Cellular Uptake
Surface Functionalization of Nanoparticles with Polyethylene Glycol: Effects on Protein Adsorption and Cellular Uptake Open
Here we have investigated the effect of enshrouding polymer-coated nanoparticles (NPs) with polyethylene glycol (PEG) on the adsorption of proteins and uptake by cultured cells. PEG was covalently linked to the polymer surface to the maxim…
View article: Membrane-localized magnetic hyperthermia promotes intracellular delivery of cell-impermeant probes
Membrane-localized magnetic hyperthermia promotes intracellular delivery of cell-impermeant probes Open
In this work, we report the disruptive use of membrane-localized magnetic hyperthermia to promote the internalization of cell-impermeant probes (fluorescent molecules and small interfering RNA), without affecting cell viability.
View article: Harnessing the power of thermosensitive liposomes with gold nanoprisms and silica for controlled drug delivery in combined chemotherapy and phototherapy
Harnessing the power of thermosensitive liposomes with gold nanoprisms and silica for controlled drug delivery in combined chemotherapy and phototherapy Open
Strategies used to obtain multifunctional nanoformulations for controlled drug delivery in combined chemotherapy and phototherapy.
View article: Nanoparticle Assisted Targeting of Heart Lesions with Cardiac Myofibroblasts: Combined Gene and Cell Therapy
Nanoparticle Assisted Targeting of Heart Lesions with Cardiac Myofibroblasts: Combined Gene and Cell Therapy Open
View article: A Simple and Versatile Strategy for Oriented Immobilization of His-Tagged Proteins on Magnetic Nanoparticles
A Simple and Versatile Strategy for Oriented Immobilization of His-Tagged Proteins on Magnetic Nanoparticles Open
Oriented and covalent immobilization of proteins on magnetic nanoparticles (MNPs) is particularly challenging as it requires both the functionality of the protein and the colloidal stability of the MNPs to be preserved. Here, we describe a…
View article: NASAL DELIVERY OF GLUCOCORTICOIDS ENCAPSULATED IN CHITOSAN NANOPARTICLES FOR THE TREATMENT OF BRAIN PATHOLOGY IN THE ACID SPHINGOMYELINASE DEFICIENCY.
NASAL DELIVERY OF GLUCOCORTICOIDS ENCAPSULATED IN CHITOSAN NANOPARTICLES FOR THE TREATMENT OF BRAIN PATHOLOGY IN THE ACID SPHINGOMYELINASE DEFICIENCY. Open
View article: Fast and controlled Ring-Opening Polymerization of N-carboxyanhydrides via a cooperative bifunctional amino acid
Fast and controlled Ring-Opening Polymerization of N-carboxyanhydrides via a cooperative bifunctional amino acid Open
The Ring-Opening Polymerization (ROP) of amino acid N-Carboxyanhydrides (NCAs) offers a straightforward method for preparing polypeptide-like polymers that display characteristics of their natural counterparts, e.g. secondary structure, an…
View article: Divalent transition metal coatings for an effective protein-nanoparticle conjugation
Divalent transition metal coatings for an effective protein-nanoparticle conjugation Open
View article: Remote Activation of Enzyme Nanohybrids for Cancer Prodrug Therapy Controlled by Magnetic Heating
Remote Activation of Enzyme Nanohybrids for Cancer Prodrug Therapy Controlled by Magnetic Heating Open
Herein, we have developed nanohybrids (nHs) to remotely activate a therapeutic enzyme for its use in Directed Enzyme Prodrug Therapy (DEPT). The coencapsulation of magnetic nanoparticles (MNPs) with horseradish peroxidase (HRP) using biomi…
View article: Artificial intelligence in theranostics of gastric cancer, a review
Artificial intelligence in theranostics of gastric cancer, a review Open
Gastric cancer (GC) is one of the commonest cancers with high morbidity and mortality in the world. How to realize precise diagnosis and therapy of GC owns great clinical requirement. In recent years, artificial intelligence (AI) has been …
View article: Química bioortogonal: cuando los organismos vivos se convierten en matraces de reacción
Química bioortogonal: cuando los organismos vivos se convierten en matraces de reacción Open
En este artículo se introducen los conceptos de química “click” y química bioortogonal, que han recibido el Premio Nobel de Química 2022 por sus numerosas ventajas (sencillez, robustez, rendimientos prácticamente cuantitativos, etc.). Se d…
View article: Divalent Transition Metal Coatings for an Effective Protein-Nanoparticle Conjugation
Divalent Transition Metal Coatings for an Effective Protein-Nanoparticle Conjugation Open
View article: Europium doped-double sodium bismuth molybdate nanoparticles as contrast agents for luminescence bioimaging and X-ray computed tomography
Europium doped-double sodium bismuth molybdate nanoparticles as contrast agents for luminescence bioimaging and X-ray computed tomography Open
We have synthesized Eu-doped NaBi(MoO 4 ) 2 nanoparticles functionalized with PAA whose properties make them excellent multimodal contrast agents for X-ray computed tomography and luminescent bioimaging, as illustrated using a C. Elegans a…
View article: Subcellular localization and therapeutic efficacy of polymeric micellar nanoparticles encapsulating bedaquiline for tuberculosis treatment in zebrafish
Subcellular localization and therapeutic efficacy of polymeric micellar nanoparticles encapsulating bedaquiline for tuberculosis treatment in zebrafish Open
Polymeric nanoparticles containing Bedaquiline reduce bacterial burden and improve survival in Mycobacterium marinum infected zebrafish. The nanoparticles accumulate in tuberculosis granulomas and in endothelial cells ending up in late end…
View article: Tailoring the plasmonic properties of gold-liposome nanohybrids as a potential powerful tool for light-mediated therapies
Tailoring the plasmonic properties of gold-liposome nanohybrids as a potential powerful tool for light-mediated therapies Open
View article: Stiffness-dependent active wetting enables optimal collective cell durotaxis
Stiffness-dependent active wetting enables optimal collective cell durotaxis Open
View article: Detection of SARS-CoV-2 Virus by Triplex Enhanced Nucleic Acid Detection Assay (TENADA)
Detection of SARS-CoV-2 Virus by Triplex Enhanced Nucleic Acid Detection Assay (TENADA) Open
SARS-CoV-2, a positive-strand RNA virus has caused devastating effects. The standard method for COVID diagnosis is based on polymerase chain reaction (PCR). The method needs expensive reagents and equipment and well-trained personnel and t…
View article: Photonic and magnetic materials for on-demand local drug delivery
Photonic and magnetic materials for on-demand local drug delivery Open
View article: Stiffness-dependent active wetting enables optimal collective cell durotaxis
Stiffness-dependent active wetting enables optimal collective cell durotaxis Open
The directed migration of cellular clusters enables morphogenesis, wound healing, and collective cancer invasion. Gradients of substrate stiffness are known to direct the migration of cellular clusters in a process called collective durota…