Winfried V. Kern
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View article: Lidiando con iguanas en el paisaje del sur de Florida
Lidiando con iguanas en el paisaje del sur de Florida Open
Debido a la prominencia de Florida en el comercio de mascotas exóticas, las iguanas importadas como mascotas se han escapado o han sido liberadas, y ahora están establecidas en el sur de Florida. Esto ha creado problemas únicos para los pr…
View article: Frequent high-level rifaximin resistance in <i>Escherichia coli</i> associated with long-term treatment of patients with liver cirrhosis: a prospective, controlled study
Frequent high-level rifaximin resistance in <i>Escherichia coli</i> associated with long-term treatment of patients with liver cirrhosis: a prospective, controlled study Open
We conducted a prospective, controlled study to assess the prevalence of high-level rifaximin resistance in intestinal Escherichia coli (E. coli ) among patients with liver cirrhosis (LC). Rectal swabs were collected from consenting adult …
View article: Impact of enhanced infection control and antimicrobial stewardship on infections by Clostridioides difficile, vancomycin-resistant enterococci, and third-generation cephalosporin-resistant Enterobacterales: a stepped-wedge cluster intervention study
Impact of enhanced infection control and antimicrobial stewardship on infections by Clostridioides difficile, vancomycin-resistant enterococci, and third-generation cephalosporin-resistant Enterobacterales: a stepped-wedge cluster intervention study Open
Combined with IPC enhanced short-term AMS measures led to a significant reduction in the incidence of CDI, whereas the incidence of BSI by VRE and 3GCREB remained unchanged in sites with well-established baseline IPC and AMS programmes and…
View article: Association between fluoroquinolones and retinal detachment: insights from a large German health claims-based cohort study
Association between fluoroquinolones and retinal detachment: insights from a large German health claims-based cohort study Open
View article: Symptom burden and post-COVID-19 syndrome 24 months following SARS-CoV-2 infection: Longitudinal population-based study
Symptom burden and post-COVID-19 syndrome 24 months following SARS-CoV-2 infection: Longitudinal population-based study Open
We found a remaining high symptom prevalence two years after SARS-CoV-2 infection, but symptoms present nine months after the index infection often resolved, which was associated with increasing hrQoL. Remarkably, a considerable portion of…
View article: Fluoroquinolones and the risk of aortic aneurysm or dissection: A population‐based propensity score‐matched German cohort study
Fluoroquinolones and the risk of aortic aneurysm or dissection: A population‐based propensity score‐matched German cohort study Open
Objective To investigate the risk of aortic aneurysm or dissection associated with fluoroquinolone (FQ) prescription compared to macrolides in German routine health care data in order to replicate the recent study ( Pharmacotherapy 2023;43…
View article: Limitations of estimating antibiotic resistance using German hospital consumption data - a comprehensive computational analysis
Limitations of estimating antibiotic resistance using German hospital consumption data - a comprehensive computational analysis Open
For almost a century, antibiotics have played an important role in the treatment of infectious diseases. However, the efficacy of these very drugs is now threatened by the development of resistances, which pose major challenges to medical …
View article: Cardiac structure and function 1.5 years after COVID-19: results from the EPILOC study
Cardiac structure and function 1.5 years after COVID-19: results from the EPILOC study Open
Purpose Impaired left and right ventricular (LV/RV) function during acute SARS-CoV-2 infection has been predominantly reported in hospitalized patients, but long-term cardiac sequelae in large, well-characterized cohorts remain inconclusiv…
View article: High risk for life-threatening adverse events of fluoroquinolones in young adults: a large German population-based cohort study
High risk for life-threatening adverse events of fluoroquinolones in young adults: a large German population-based cohort study Open
View article: Persistent symptoms and clinical findings in adults with post-acute sequelae of COVID-19/post-COVID-19 syndrome in the second year after acute infection: A population-based, nested case-control study
Persistent symptoms and clinical findings in adults with post-acute sequelae of COVID-19/post-COVID-19 syndrome in the second year after acute infection: A population-based, nested case-control study Open
Background Self-reported health problems following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection are common and often include relatively non-specific complaints such as fatigue, exertional dyspnoea, concentration o…
View article: Gram-negative bloodstream infections in six German university hospitals, 2016–2020: clinical and microbiological features
Gram-negative bloodstream infections in six German university hospitals, 2016–2020: clinical and microbiological features Open
Purpose To analyze the longitudinal epidemiology and antimicrobial resistance (AMR) patterns of Gram-negative bloodstream infections (BSI) in Germany. Methods Post-hoc analysis of prospectively documented BSI due to Escherichia coli , Kleb…
View article: Impact of the COVID-19 Pandemic on Inpatient Antibiotic and Antifungal Drug Prescribing Volumes in Germany
Impact of the COVID-19 Pandemic on Inpatient Antibiotic and Antifungal Drug Prescribing Volumes in Germany Open
Background: Previous studies found that the coronavirus disease 2019 (COVID-19) pandemic had a variable impact on the consumption of antimicrobial drugs in human medicine, with trends in several European countries differing between communi…
View article: Impact of the COVID-19 Pandemic on Inpatient Antibiotic and Antifungal Drug Prescribing Volumes in Germany
Impact of the COVID-19 Pandemic on Inpatient Antibiotic and Antifungal Drug Prescribing Volumes in Germany Open
Background: Previous studies have found variable impact of the coronavirus disease 2019 (COVID-19) pandem-ic on the consumption of antimicrobial drugs in human medicine, with trends in several European countries differing between community…
View article: Informing pandemic management in Germany with trustworthy living evidence syntheses and guideline development: lessons learned from the COVID-19 evidence ecosystem
Informing pandemic management in Germany with trustworthy living evidence syntheses and guideline development: lessons learned from the COVID-19 evidence ecosystem Open
CEOsys provided a proof-of-concept for a functioning evidence ecosystem at the national level. Lessons learned include that similar networks should, among others, involve methodological and clinical key stakeholders early on, aim for (inte…
View article: Persistent symptoms and clinical findings in adults with post-acute sequelae of COVID-19/post-COVID-19 syndrome in the second year after acute infection: population-based, nested case-control study
Persistent symptoms and clinical findings in adults with post-acute sequelae of COVID-19/post-COVID-19 syndrome in the second year after acute infection: population-based, nested case-control study Open
Objective To assess risk factors for persistence vs improvement and to describe clinical characteristics and diagnostic evaluation of subjects with post-acute sequelae of COVID-19/post-COVID-19 syndrome (PCS) persisting for more than one y…
View article: Limitations of estimating antibiotic resistance using German hospital consumption data - A comprehensive computational analysis
Limitations of estimating antibiotic resistance using German hospital consumption data - A comprehensive computational analysis Open
For almost a century, antibiotics have played an important role in the treatment of infectious diseases. However, the efficacy of these very drugs is now threatened by the development of resistances, which pose major challenges to medical …
View article: Epidemiological trends and susceptibility patterns of bloodstream infections caused by Enterococcus spp. in six German university hospitals: a prospectively evaluated multicentre cohort study from 2016 to 2020 of the R-Net study group
Epidemiological trends and susceptibility patterns of bloodstream infections caused by Enterococcus spp. in six German university hospitals: a prospectively evaluated multicentre cohort study from 2016 to 2020 of the R-Net study group Open
Purpose To analyse recent epidemiological trends of bloodstream infections (BSI) caused by Enterococcus spp. In adult patients admitted to tertiary care centres in Germany. Methods Epidemiological data from the multicentre R-NET study was …
View article: Health care utilisation of asylum seekers and refugees in the South-West of Germany
Health care utilisation of asylum seekers and refugees in the South-West of Germany Open
Background Limited evidence on utilisation of health care by recently arrived asylum seekers and refugees in high-income countries is available. This study aims to describe the implementation of an integrated care facility (ICF) in an init…
View article: Pseudomonas aeruginosa Bloodstream Infections Presenting with Septic Shock in Neutropenic Cancer Patients: Impact of Empirical Antibiotic Therapy
Pseudomonas aeruginosa Bloodstream Infections Presenting with Septic Shock in Neutropenic Cancer Patients: Impact of Empirical Antibiotic Therapy Open
This large, multicenter, retrospective cohort study including onco-hematological neutropenic patients with Pseudomonas aeruginosa bloodstream infection (PABSI) found that among 1213 episodes, 411 (33%) presented with septic shock. The pres…
View article: Epidemiological trends and susceptibility patterns of bloodstream infections caused by Enterococcus spp. in six German university hospitals – a prospectively evaluated multicentre cohort study from 2016-2020 of the R-Net study group
Epidemiological trends and susceptibility patterns of bloodstream infections caused by Enterococcus spp. in six German university hospitals – a prospectively evaluated multicentre cohort study from 2016-2020 of the R-Net study group Open
Objectives To analyse recent epidemiological trends of bloodstream infections (BSI) caused by Enterococcus spp. In adult patients admitted to tertiary care centres in Germany. Methods Epidemiological data from the multicentre R-NET study w…
View article: Comparative reassessment of AcrB efflux inhibitors reveals differential impact of specific pump mutations on the activity of potent compounds
Comparative reassessment of AcrB efflux inhibitors reveals differential impact of specific pump mutations on the activity of potent compounds Open
Multidrug resistance poses global challenges, particularly with regard to Gram-negative bacterial infections. In view of the lack of new antibiotics, drug enhancers, such as efflux pump inhibitors (EPIs), have increasingly come into focus.…
View article: Post-COVID syndrome and work ability 9-12 months after a SARS-CoV-2 infection among over 9000 employees from the general population
Post-COVID syndrome and work ability 9-12 months after a SARS-CoV-2 infection among over 9000 employees from the general population Open
Our findings revealed risk factors of mWAI
View article: Association of known SARS-CoV-2 serostatus and adherence to personal protection measures and the impact of personal protective measures on seropositivity in a population-based cross-sectional study (MuSPAD) in Germany
Association of known SARS-CoV-2 serostatus and adherence to personal protection measures and the impact of personal protective measures on seropositivity in a population-based cross-sectional study (MuSPAD) in Germany Open
View article: Antibiotic use in pediatric acute care hospitals: an analysis of antibiotic consumption data from Germany, 2013–2020
Antibiotic use in pediatric acute care hospitals: an analysis of antibiotic consumption data from Germany, 2013–2020 Open
View article: Imported Toxigenic <i>Corynebacterium Diphtheriae</i> in Refugees with Polymicrobial Skin Infections, Germany, 2022
Imported Toxigenic <i>Corynebacterium Diphtheriae</i> in Refugees with Polymicrobial Skin Infections, Germany, 2022 Open
During August-December 2022, toxigenic Corynebacterium diphtheriae was isolated from 25 refugees with skin infections and 2 refugees with asymptomatic throat colonization at a refugee reception center in Germany. None had systemic toxin-me…
View article: Early oral switch in low-risk <i>Staphylococcus aureus</i> bloodstream infection
Early oral switch in low-risk <i>Staphylococcus aureus</i> bloodstream infection Open
Background Staphylococcus aureus bloodstream infection (SAB) is treated with at least 14 days of intravenously administered antimicrobials. We assessed the efficacy and safety of an early oral switch therapy in patients at low risk for SAB…
View article: Pre‐existing sleep problems as a predictor of post‐acute sequelae of <scp>COVID</scp>‐19
Pre‐existing sleep problems as a predictor of post‐acute sequelae of <span>COVID</span>‐19 Open
Summary Several months after COVID‐19 many individuals still report persisting symptoms, the so‐called ‘post‐COVID‐19 syndrome’. An immunological dysfunction is one of the main pathophysiological hypotheses. As sleep is central to the func…
View article: Tick-borne encephalitis virus IgG antibody surveillance: vaccination- and infection-induced seroprevalences, south-western Germany, 2021
Tick-borne encephalitis virus IgG antibody surveillance: vaccination- and infection-induced seroprevalences, south-western Germany, 2021 Open
Background The exact epidemiology of tick-borne encephalitis virus (TBEV) infections is unknown because many TBEV infections have an influenza-like or asymptomatic course. Surveillance data are based on patients with any (predominantly neu…
View article: Resolving colistin resistance and heteroresistance in Enterobacter species
Resolving colistin resistance and heteroresistance in Enterobacter species Open
View article: Anti-SARS-CoV-2 antibody-containing plasma improves outcome in patients with hematologic or solid cancer and severe COVID-19: a randomized clinical trial
Anti-SARS-CoV-2 antibody-containing plasma improves outcome in patients with hematologic or solid cancer and severe COVID-19: a randomized clinical trial Open
Patients with cancer are at high risk of severe coronavirus disease 2019 (COVID-19), with high morbidity and mortality. Furthermore, impaired humoral response renders severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines le…