Eugene Dempsey
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View article: Cerebral oximetry monitoring versus usual care for extremely preterm infants: a detailed statistical analysis plan for the 2-year follow-up of the participants of the SafeBoosC-III randomised clinical trial
Cerebral oximetry monitoring versus usual care for extremely preterm infants: a detailed statistical analysis plan for the 2-year follow-up of the participants of the SafeBoosC-III randomised clinical trial Open
ClinicalTrials.gov NCT05134116. Registered on November 24, 2021.
View article: Treatment guided by cerebral oximetry in mechanically ventilated newborns: a statistical analysis plan for step one of the SafeBoosC-IIIv randomised clinical trial
Treatment guided by cerebral oximetry in mechanically ventilated newborns: a statistical analysis plan for step one of the SafeBoosC-IIIv randomised clinical trial Open
ClinicalTrials.gov NCT05907317. First submitted on 8 June 2023, https://clinicaltrials.gov/study/NCT05907317.
View article: Infant gut microbiome reprogramming following introduction of solid foods (weaning)
Infant gut microbiome reprogramming following introduction of solid foods (weaning) Open
The infant gut microbiome undergoes a crucial transformation when solid foods enter the diet during weaning. This introduction normally happens at about six months post-birth and leads to major shifts in the gut microbiome. Many of the cha…
View article: Assessment of Diastolic Function during the transitional period and infancy using Serial Echocardiography in a tertiary neonatal unit (DiFuSE): a longitudinal prospective observational study protocol
Assessment of Diastolic Function during the transitional period and infancy using Serial Echocardiography in a tertiary neonatal unit (DiFuSE): a longitudinal prospective observational study protocol Open
Introduction There are structural and functional modifications that occur to the neonatal heart immediately after birth. While a number of studies recently have assessed cardiac function in the newborn, there is a dearth of data on diastol…
View article: Late-onset sepsis treatment in very preterm infants alters longitudinal microbiome trajectory with lower abundance of <i>Bifidobacterium</i> despite probiotic supplementation
Late-onset sepsis treatment in very preterm infants alters longitudinal microbiome trajectory with lower abundance of <i>Bifidobacterium</i> despite probiotic supplementation Open
Estimation of absolute abundance reveals fluctuations and blooms in key genera within the gut microbiome of very preterm infants that may not be recognized using relative abundance alone. Very preterm neonates with sepsis have a significan…
View article: Perinatal factors influencing the earliest establishment of the infant microbiome
Perinatal factors influencing the earliest establishment of the infant microbiome Open
Background: While extensive research exists on the human microbiome, a number of outstanding questions remain regarding the infant microbiome in the initial stages of life. This study aimed to determine the timing of very early microbial c…
View article: Assessment of absolute abundance in mother-infant gut microbiome using marine-sourced bacterial DNA spike-in and comparison with conventional quantification methods
Assessment of absolute abundance in mother-infant gut microbiome using marine-sourced bacterial DNA spike-in and comparison with conventional quantification methods Open
Aim: To evaluate the effectiveness of marine-sourced bacterial DNA spike-in quantification for determining absolute microbial abundance in the gut microbiome of mother-infant pairs and to compare this method with conventional quantificatio…
View article: Respiratory Function Monitoring and Visual Attention in Resuscitating Term Infants: A Manikin‐Based Randomised Crossover Trial
Respiratory Function Monitoring and Visual Attention in Resuscitating Term Infants: A Manikin‐Based Randomised Crossover Trial Open
Aim Determine the effect of Respiratory Function Monitor (RFM) use on the time taken to provide 30 s of effective positive pressure ventilation (PPV) in a simulated newborn‐term resuscitation. Methods Randomised crossover trial conducted a…
View article: Influence of feeding habit and duration on infant gut microbiome – a 6 month pilot study
Influence of feeding habit and duration on infant gut microbiome – a 6 month pilot study Open
While the importance of breastfeeding on the developing infant gut microbiota has been established, few studies have compared the effect of breastfeeding duration on infant gut microbiota development. In this pilot study, we included 23 in…
View article: The effect of maternal position on cerebral oxygenation in premature infants during Kangaroo care: a randomised controlled trial
The effect of maternal position on cerebral oxygenation in premature infants during Kangaroo care: a randomised controlled trial Open
Objective To assess whether there was an optimal maternal position (30° versus 60° incline) for kangaroo mother care. Design Single centre cross-over randomised controlled trial. Mothers were randomly assigned to start at either a 30° or 6…
View article: Addressing the Humans in the Delivery Room—Optimising Neonatal Monitoring and Decision-Making in Transition
Addressing the Humans in the Delivery Room—Optimising Neonatal Monitoring and Decision-Making in Transition Open
During the first minutes of life, complex dynamic processes occur, facilitating a normal transition to ex utero life. In healthy term infants, these processes typically occur with minimal intervention required but are often more challengin…
View article: Outcomes of extremely preterm infants who participated in a randomised trial of dopamine for treatment of hypotension (the HIP trial) at 2 years corrected age
Outcomes of extremely preterm infants who participated in a randomised trial of dopamine for treatment of hypotension (the HIP trial) at 2 years corrected age Open
Objective To determine survival and neurodevelopmental outcomes in the Hypotension in Preterm (HIP) trial. Design Prospective follow-up of infants enrolled in randomised controlled trial. Participants 58 infants born before 28 weeks of ges…
View article: Observational study protocol: the faecal microbiome in the acute stage of new-onset paediatric type 1 diabetes in an Irish cohort
Observational study protocol: the faecal microbiome in the acute stage of new-onset paediatric type 1 diabetes in an Irish cohort Open
Introduction Type 1 diabetes (T1D) is an autoimmune-mediated disorder caused by the destruction of pancreatic beta cells. Although there is an underlying genetic predisposition to developing T1D, the trigger is multifactorial and likely in…
View article: Cerebral oximetry monitoring versus usual care for extremely preterm infants: a detailed statistical analysis plan for the 2-year follow-up of the SafeBoosC-III randomised clinical trial
Cerebral oximetry monitoring versus usual care for extremely preterm infants: a detailed statistical analysis plan for the 2-year follow-up of the SafeBoosC-III randomised clinical trial Open
Background The SafeBoosC-III trial investigated treatment guided by cerebral oximetry monitoring for the first 72 hours after birth in extremely preterm infants and showed no effects on mortality or severe brain injury at 36 weeks’ postmen…
View article: The Effect of Maternal Position on Cerebral Oxygenation in Premature Infants During Kangaroo Care: a Randomised Controlled Trial
The Effect of Maternal Position on Cerebral Oxygenation in Premature Infants During Kangaroo Care: a Randomised Controlled Trial Open
Objective: To assess whether there was an optimal maternal position (30° versus 60° incline) for kangaroo mother care. Design: Single centre cross-over randomised controlled trial. Mothers were randomly assigned to either a 30° or 60° angl…
View article: Machine learning models of cerebral oxygenation (rcSO<sub>2</sub>) for brain injury detection in neonates with hypoxic‐ischaemic encephalopathy
Machine learning models of cerebral oxygenation (rcSO<sub>2</sub>) for brain injury detection in neonates with hypoxic‐ischaemic encephalopathy Open
The present study was designed to test the potential utility of regional cerebral oxygen saturation (rcSO 2 ) in detecting term infants with brain injury. The study also examined whether quantitative rcSO 2 features are associated with gra…
View article: Correction: A recommendation for the use of electrical biosensing technology in neonatology
Correction: A recommendation for the use of electrical biosensing technology in neonatology Open
Correction to: Pediatric Researchhttps://doi.org/10.1038/s41390-024-03369-z, published online 08 July 2024 In the original version of the article, the author’s name Christoph E. Schwarz was incorrectly given as ‘Christop E. Schwarz’. The a…
View article: Somatic cell count as an indicator of subclinical mastitis and increased inflammatory response in asymptomatic lactating women
Somatic cell count as an indicator of subclinical mastitis and increased inflammatory response in asymptomatic lactating women Open
Subclinical mastitis is an asymptomatic inflammatory condition that can be difficult to define and diagnose. In the dairy industry, subclinical mastitis is diagnosed by milk somatic cell counts (SCCs) of ≥250,000 cells mL −1 . In this pilo…
View article: Proceedings of the 15 <sup>th</sup> International Newborn Brain Conference: Other forms of brain monitoring, such as NIRS, fMRI, biochemical, etc.
Proceedings of the 15 <sup>th</sup> International Newborn Brain Conference: Other forms of brain monitoring, such as NIRS, fMRI, biochemical, etc. Open
BACKGROUND AND OBJECTIVE: Preterm neonates with intraventricular hemorrhage (IVH) are at risk for posthemorrhagic ventricular dilatation (PHVD).In recent years targeted proteomics has developed into a powerful protein quantifi cation tool …
View article: Proceedings of the 15 <sup>th</sup> International Newborn Brain Conference: Neonatal Neurocritical Care, seizures, and continuous aEEG and /or EEG monitoring
Proceedings of the 15 <sup>th</sup> International Newborn Brain Conference: Neonatal Neurocritical Care, seizures, and continuous aEEG and /or EEG monitoring Open
Preterm children are at risk for language development delays. Early shared reading has been demonstrated to enhance language development and functional brain connectivity in full-term
\nchildren. Therefore, recent research examines the pot…
View article: Delaying cord clamping for more than 1 minute after vaginal deliveries appeared to result in smoother cardiocirculatory transition
Delaying cord clamping for more than 1 minute after vaginal deliveries appeared to result in smoother cardiocirculatory transition Open
None.
View article: Reference Ranges for Arterial Oxygen Saturation, Heart Rate, and Cerebral Oxygen Saturation during Immediate Postnatal Transition in Neonates Born Extremely or Very Preterm
Reference Ranges for Arterial Oxygen Saturation, Heart Rate, and Cerebral Oxygen Saturation during Immediate Postnatal Transition in Neonates Born Extremely or Very Preterm Open
This study provides new centile charts for SpO2, HR, and crSO2 for neonates born extremely or very preterm with favorable outcome. Implementing these centiles in guiding interventions during the stabilization process after birth might help…
View article: Neonatal blood pressure by birth weight, gestational age, and postnatal age: a systematic review
Neonatal blood pressure by birth weight, gestational age, and postnatal age: a systematic review Open
Background Blood pressure is a vital hemodynamic marker during the neonatal period. However, normative values are often derived from small observational studies. Understanding the normative range would help to identify ideal thresholds for…
View article: Does the use of higher versus lower oxygen concentration improve neurodevelopmental outcomes at 18–24 months in very low birthweight infants?
Does the use of higher versus lower oxygen concentration improve neurodevelopmental outcomes at 18–24 months in very low birthweight infants? Open
Background Immediately after birth, the oxygen saturation is between 30 and 50%, which then increases to 85–95% within the first 10 min. Over the last 10 years, recommendations regarding the ideal level of the initial fraction of inspired …