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View article: #684 Prognostic value of changes in the serum indoxyl sulfate concentration in septic-shock-associated AKI: the Tox-AKI cohort study
#684 Prognostic value of changes in the serum indoxyl sulfate concentration in septic-shock-associated AKI: the Tox-AKI cohort study Open
Background and Aims Indoxyl sulfate (IxS) is a gut-derived toxin that accumulates with kidney function loss and presents endothelial toxicity. Elevated serum concentrations of IxS are associated with adverse outcomes in chronic kidney dise…
View article: Effect of a virtual reality program on patient comfort in the surgical intensive care unit of a French university hospital: study protocol for a monocentric, prospective, superiority, randomised controlled trial–ZION study
Effect of a virtual reality program on patient comfort in the surgical intensive care unit of a French university hospital: study protocol for a monocentric, prospective, superiority, randomised controlled trial–ZION study Open
Introduction Admission to a surgical intensive care unit (ICU) following major surgery is associated with a number of discomforts, not only related to the disease itself but also to the care provided or the ICU environment itself (lights, …
View article: Alcohol induces sorafenib resistance in hepatocellular carcinoma: A Translational Study
Alcohol induces sorafenib resistance in hepatocellular carcinoma: A Translational Study Open
Background: Alcohol is a major cause of hepatocellular carcinoma (HCC), accounting for 30% of cases worldwide. Sorafenib, a tyrosine kinase inhibitor (TKI), was the standard first-line treatment for advanced HCC until 2021, but sorafenib r…
View article: Value of intravenous cholangiography with indocyanine green during laparoscopic cholecystectomy for grade I or II acute lithiasic cholecystitis: Results of a prospective, open, randomized, monocentric study (VIFCAL trial)
Value of intravenous cholangiography with indocyanine green during laparoscopic cholecystectomy for grade I or II acute lithiasic cholecystitis: Results of a prospective, open, randomized, monocentric study (VIFCAL trial) Open
International audience
View article: Effect of the MyDéfi Smartphone Application on Binge Drinking Among University Students: Protocol of a Double‐Blind Multicenter Prospective National Randomized Controlled Trial Using Phosphatidylethanol as a Biomarker—The SMARTBINGE Trial
Effect of the MyDéfi Smartphone Application on Binge Drinking Among University Students: Protocol of a Double‐Blind Multicenter Prospective National Randomized Controlled Trial Using Phosphatidylethanol as a Biomarker—The SMARTBINGE Trial Open
Objective The purpose of this paper is to describe a study protocol of a clinical trial exploring the effectiveness of the new mobile application MyDéfi proposing personalized feedback, on both alcohol consumption and quality of life, as w…
View article: Study protocol: diagnosis of atrial fibrillation in postoperative thoracic surgery using a smartwatch, an open-label randomised controlled study (THOFAWATCH trial)
Study protocol: diagnosis of atrial fibrillation in postoperative thoracic surgery using a smartwatch, an open-label randomised controlled study (THOFAWATCH trial) Open
Introduction Postoperative atrial fibrillation (POAF) affects approximately 20% of patients undergoing thoracic surgery and is associated with severe complications such as stroke, myocardial infarction, heart failure, and increased mortali…
View article: Is a bridge (rod) necessary for loop ileostomy? A phase II randomized control trial
Is a bridge (rod) necessary for loop ileostomy? A phase II randomized control trial Open
NCT02756273 (May 10, 2016).
View article: Cytokine Hemoadsorption versus Standard Care in Cardiac Surgery Using the Oxiris Membrane: The OXICARD Single-center Randomized Trial
Cytokine Hemoadsorption versus Standard Care in Cardiac Surgery Using the Oxiris Membrane: The OXICARD Single-center Randomized Trial Open
Background: Cardiac surgery can lead to dysregulation with a proinflammatory state, resulting in adverse outcomes. Hemadsorption using the AN-69 membrane (Oxiris membrane, Baxter, USA) has the properties to chelate inflammatory cytokines. …
View article: The Effect of Vasopressin on 90‐Day Mortality in Patients With Cardiogenic Shock: A Retrospective Cohort Study Using Propensity Score‐Weighted Analysis
The Effect of Vasopressin on 90‐Day Mortality in Patients With Cardiogenic Shock: A Retrospective Cohort Study Using Propensity Score‐Weighted Analysis Open
Background: Cardiogenic shock (CS) may lead to a refractory vasoplegic state that requires vasopressin on top of norepinephrine. Vasopressin has been available in France since January 2022. However, data assessing the clinical impact of va…
View article: Prognostic Implications of Right Ventricular Dysfunction in Severe Degenerative Mitral Regurgitation
Prognostic Implications of Right Ventricular Dysfunction in Severe Degenerative Mitral Regurgitation Open
Background The prevalence and impact of right ventricular dysfunction (RVD) in degenerative mitral regurgitation (DMR) is unknown. We aimed to determine whether RVD assessed by echocardiography in routine clinical practice is independently…
View article: Association between acute exacerbation of chronic obstructive pulmonary disease and short-term exposure to ambient air pollutants in France
Association between acute exacerbation of chronic obstructive pulmonary disease and short-term exposure to ambient air pollutants in France Open
NCT03079661.
View article: Association Between Serum Phosphate Levels and Progression of Aortic Stenosis
Association Between Serum Phosphate Levels and Progression of Aortic Stenosis Open
International audience
View article: Quality of Life in Patients with Obesity: The Role of Multidisciplinary Rehabilitation Medicine
Quality of Life in Patients with Obesity: The Role of Multidisciplinary Rehabilitation Medicine Open
Background: Little is known about the role of rehabilitation medicine in obesity. Objective: to examine the benefits of a multidisciplinary rehabilitation program on the quality of life in patients with severe obesity. Methodology: We incl…
View article: The predictive performance of the ANCA renal risk score in patients over 65 years of age with renal ANCA-associated vasculitis
The predictive performance of the ANCA renal risk score in patients over 65 years of age with renal ANCA-associated vasculitis Open
Background The anti-neutrophil cytoplasmic antibody (ANCA) renal risk score (ARRS) for predicting renal survival in ANCA-associated vasculitis (AAV) had not previously been validated in adults over 65 years of age and presenting impairment…
View article: Transmural healing is not associated with less disability than complete endoscopic mucosal healing: a prospective study in a patient with Crohn's disease
Transmural healing is not associated with less disability than complete endoscopic mucosal healing: a prospective study in a patient with Crohn's disease Open
Introduction: Crohn's disease (CD) is associated with disability by affecting physical and emotional well-being, and by altering social interactions. The impact of transmural healing on disability is currently unknown. Methods We conducted…
View article: The combination of kidney function variables with cell cycle arrest biomarkers identifies distinct subphenotypes of sepsis-associated acute kidney injury: a <i>post-hoc</i> analysis (the PHENAKI study)
The combination of kidney function variables with cell cycle arrest biomarkers identifies distinct subphenotypes of sepsis-associated acute kidney injury: a <i>post-hoc</i> analysis (the PHENAKI study) Open
The severity and course of sepsis-associated acute kidney injury (SA-AKI) are correlated with the mortality rate. Early detection of SA-AKI subphenotypes might facilitate the rapid provision of individualized care. In this post-hoc analysi…
View article: P408 Complete endoscopic healing, the future therapeutic target in Crohn's disease? Results of a prospective multicenter study
P408 Complete endoscopic healing, the future therapeutic target in Crohn's disease? Results of a prospective multicenter study Open
Background The STRIDE II guidelines recognize endoscopic healing (EH), defined by an SES-CD score ≤2 or a CDEIS score <3, as one of the main therapeutic targets in Crohn's disease (CD). Nevertheless, complete endoscopic healing could re…
View article: Carbon monoxide rebreathing method is a reliable test to evaluate the red cell mass in polycythaemia
Carbon monoxide rebreathing method is a reliable test to evaluate the red cell mass in polycythaemia Open
International audience
View article: Mitral annular plane systolic excursion for assessing left ventricular systolic dysfunction in patients with septic shock
Mitral annular plane systolic excursion for assessing left ventricular systolic dysfunction in patients with septic shock Open
Septal MAPSE is easily measured at the bedside and might help clinicians to detect left ventricular systolic dysfunction early-especially when myocardial strain measurements are not feasible.
View article: Is there concordance between the Cellvizio system and pathology in determining microscopic inflammation at the ileal resection margins in Crohn's ileal disease? The CELLVICROHN study
Is there concordance between the Cellvizio system and pathology in determining microscopic inflammation at the ileal resection margins in Crohn's ileal disease? The CELLVICROHN study Open
International audience
View article: A new statistical model for binge drinking pattern classification in college-student populations
A new statistical model for binge drinking pattern classification in college-student populations Open
Background Binge drinking (BD) among students is a frequent alcohol consumption pattern that produces adverse consequences. A widely discussed difficulty in the scientific community is defining and characterizing BD patterns. This study ai…
View article: Annexin-V positive extracellular vesicles level is increased in severe COVID-19 disease
Annexin-V positive extracellular vesicles level is increased in severe COVID-19 disease Open
Objectives To evaluate extracellular vesicles levels in a cohort of SARS-CoV-2’s patients hospitalized in an intensive care unit with and without COVID-19 associated thromboembolic events. Methods In this study, we aim to assess endothelia…
View article: Chronic kidney disease is a key risk factor for aortic stenosis progression
Chronic kidney disease is a key risk factor for aortic stenosis progression Open
Background Rapid progression of aortic stenosis (AS) has been observed in patients undergoing dialysis, but existing cross-sectional evidence is contradictory in non-dialysis-dependent chronic kidney disease (CKD). The present study sought…
View article: The combination of kidney function variables with cell cycle arrest biomarkers identifies distinct subphenotypes of sepsis-associated acute kidney injury: a post-hoc analysis (the PHENAKI study)
The combination of kidney function variables with cell cycle arrest biomarkers identifies distinct subphenotypes of sepsis-associated acute kidney injury: a post-hoc analysis (the PHENAKI study) Open
Background: The severity and course of sepsis-associated acute kidney injury (SA-AKI) are correlated with the mortality rate. Early detection of SA-AKI subphenotypes might facilitate the rapid provision of individualized care. Patients and…
View article: P338 Transmural healing is not associated with less disability than complete endoscopic mucosal healing: a prospective study in a patient with Crohn's disease
P338 Transmural healing is not associated with less disability than complete endoscopic mucosal healing: a prospective study in a patient with Crohn's disease Open
Background Crohn's disease (CD) is associated with disability by affecting physical and emotional well-being, and by altering social interactions. In the era of treat to target, endoscopic remission has become the therapeutic target to pre…
View article: Gangrenous acute calculous cholecystitis is not classical acute calculous cholecystitis: A propensity score weighted study of postoperative outcomes
Gangrenous acute calculous cholecystitis is not classical acute calculous cholecystitis: A propensity score weighted study of postoperative outcomes Open
Gangrenous acute calculous cholecystitis (GACC) is acute calculous cholecystitis (ACC) with gallbladder wall necrosis. This study compared specific postoperative course between grade II non-gangrenous acute calculous cholecystitis (NGACC) …