Marcus Dörr
YOU?
Author Swipe
View article: Sex-specific associations of anthropometric markers with prediabetes in the general population
Sex-specific associations of anthropometric markers with prediabetes in the general population Open
View article: CONVENTIONAL VERSUS HYPOFRACTIONATED POSTMASTECTOMY PROTON RADIOTHERAPY: PATIENT REPORTED OUTCOMES FROM A RANDOMIZED PHASE 2 TRIAL
CONVENTIONAL VERSUS HYPOFRACTIONATED POSTMASTECTOMY PROTON RADIOTHERAPY: PATIENT REPORTED OUTCOMES FROM A RANDOMIZED PHASE 2 TRIAL Open
View article: Associations of lipoprotein subclasses with all-cause and cardiovascular mortality: results of two independent cohorts with a 20 year follow-up
Associations of lipoprotein subclasses with all-cause and cardiovascular mortality: results of two independent cohorts with a 20 year follow-up Open
View article: Plasma Ceramide C24:0/C16:0 Relates to Outcomes in Patients With Heart Failure With Preserved Ejection Fraction
Plasma Ceramide C24:0/C16:0 Relates to Outcomes in Patients With Heart Failure With Preserved Ejection Fraction Open
View article: COVID-19 vaccination lowers SARS-CoV-2 infection risk independent of diabetes, cancer and smoking in SHIP-COVID cohort, Northern Germany
COVID-19 vaccination lowers SARS-CoV-2 infection risk independent of diabetes, cancer and smoking in SHIP-COVID cohort, Northern Germany Open
View article: DNA methylation of genes involved in lipid metabolism drives adiponectin levels and metabolic disease
DNA methylation of genes involved in lipid metabolism drives adiponectin levels and metabolic disease Open
Aims/hypothesis Despite playing critical roles in the pathophysiology of type 2 diabetes and other metabolic disorders, the molecular mechanisms underlying circulating adipokine levels remain poorly understood. By identifying genomic regio…
View article: Trans-eQTL mapping prioritises USP18 as a negative regulator of interferon response at a lupus risk locus
Trans-eQTL mapping prioritises USP18 as a negative regulator of interferon response at a lupus risk locus Open
Although genome-wide association studies have provided valuable insights into the genetic basis of complex traits and diseases, translating these findings to causal genes and their downstream mechanisms remains challenging. We performed tr…
View article: Does explainable AI-ECG heart age differentiate pathological from physiological LV remodeling? A multi-cohort analysis including young elite athletes
Does explainable AI-ECG heart age differentiate pathological from physiological LV remodeling? A multi-cohort analysis including young elite athletes Open
Aim Artificial intelligence applied to electrocardiography (AI-ECG) can derive a heart age or ECG-age , potentially reflecting waveform patterns that indicate cumulative myocardial stress. The heart age gap (HA-gap, Δ age ) is defined as t…
View article: Using Two-Sample Mendelian Randomization to Identify Potential Drug Targets: The Case of Desmoplakin
Using Two-Sample Mendelian Randomization to Identify Potential Drug Targets: The Case of Desmoplakin Open
BACKGROUND Two-sample Mendelian randomization (2SMR) is a powerful tool for causal hypothesis testing. However, the simplicity of the statistical techniques combined with lack of causal inference reasoning has prompted an explosion of 2SMR…
View article: Symmetric dimethylarginine as a biomarker of renal impairment after a decade of follow-up
Symmetric dimethylarginine as a biomarker of renal impairment after a decade of follow-up Open
View article: Pharmacokinetics and safety of single and repeat doses of ceftibuten in healthy participants: a phase 1 dose escalation study
Pharmacokinetics and safety of single and repeat doses of ceftibuten in healthy participants: a phase 1 dose escalation study Open
Ledaborbactam etzadroxil, the prodrug of the active β-lactamase inhibitor ledaborbactam, is being developed in combination with ceftibuten to treat serious infections caused by drug-resistant Enterobacterales. This study evaluated the safe…
View article: Safety and pharmacokinetics of single and multiple doses of ledaborbactam etzadroxil with or without ceftibuten in healthy volunteers
Safety and pharmacokinetics of single and multiple doses of ledaborbactam etzadroxil with or without ceftibuten in healthy volunteers Open
Ledaborbactam etzadroxil (LED-E), a novel oral prodrug that converts to the active β-lactamase inhibitor (BLI) ledaborbactam (LED), is being developed in combination with ceftibuten (CTB) to address a need for oral treatments against drug-…
View article: PPG-based smartphone application vs usual care for atrial fibrillation screening: A European multicenter randomized trial
PPG-based smartphone application vs usual care for atrial fibrillation screening: A European multicenter randomized trial Open
In this multicenter trial, application usage in combination with early intervention did not significantly increase overall AF detection rates. However, asymptomatic AF detection was numerically higher in the intervention group, aligning wi…
View article: Genomic and molecular evidence that the LncRNA DSP-AS1 modulates desmoplakin expression
Genomic and molecular evidence that the LncRNA DSP-AS1 modulates desmoplakin expression Open
View article: Periodontitis and its association with left ventricular geometry and function
Periodontitis and its association with left ventricular geometry and function Open
Objectives The aim of this study was to investigate the cross-sectional association between periodontal status and cardiac structural and functional status, with a focus on left ventricular (LV) geometry and function. The primary research …
View article: Physiological serum uric acid concentrations correlate with arterial stiffness in a sex-dependent manner
Physiological serum uric acid concentrations correlate with arterial stiffness in a sex-dependent manner Open
View article: Diagnostic and prognostic value of ECG-predicted hypertension-mediated left ventricular hypertrophy using machine learning
Diagnostic and prognostic value of ECG-predicted hypertension-mediated left ventricular hypertrophy using machine learning Open
Objective: Four hypertension-mediated left ventricular hypertrophy (LVH) phenotypes have been reported using cardiac magnetic resonance (CMR): normal LV, LV remodelling, eccentric and concentric LVH, with varying prognostic implications. T…
View article: Risk tools for predicting long-term sequelae based on symptom profiles after known and undetected SARS-CoV-2 infections in the population
Risk tools for predicting long-term sequelae based on symptom profiles after known and undetected SARS-CoV-2 infections in the population Open
View article: Associations of lower values of peak oxygen uptake and handgrip strength with a smaller liver volume
Associations of lower values of peak oxygen uptake and handgrip strength with a smaller liver volume Open
Background and aims: The associations between physical fitness markers and liver volume in the general population are unclear. We investigated the associations of peak oxygen uptake (VO2peak)and handgrip strength with liver volume in a gen…
View article: Low-density lipoprotein cholesterol, lipoprotein(a) and high-sensitivity C-reactive protein are independent predictors of cardiovascular events
Low-density lipoprotein cholesterol, lipoprotein(a) and high-sensitivity C-reactive protein are independent predictors of cardiovascular events Open
Background and Aims Associations of hyperlipidaemia and inflammation with the risk for incident major adverse cardiovascular events (MACEs) were analysed in individuals with and without cholesterol-lowering medication therapy. Methods Data…
View article: Sex specific association of body composition with sphingosine-1-phosphate levels-results from the study of health in pomerania (SHIP) analysis
Sex specific association of body composition with sphingosine-1-phosphate levels-results from the study of health in pomerania (SHIP) analysis Open
Background/Introduction Sphingosine-1-Phosphate (S1P), is a highly bioactive lipid mediator that+ plays an important role in many physiological and pathophysiological processes and is associated with various cardiovascular and metabolic di…
View article: Time to change the electrocardiography (ECG) indices of left ventricular hypertrophy: the Bialystok PLUS and SHIP-TREND population-based studies
Time to change the electrocardiography (ECG) indices of left ventricular hypertrophy: the Bialystok PLUS and SHIP-TREND population-based studies Open
Background Left ventricular hypertrophy (LVH) represents a significant risk factor for cardiovascular disease (CVD). Electrocardiography (ECG) is a commonly used diagnostic tool for LVH, however, its accuracy and sensitivity are limited. P…
View article: Individual dopaminergic neurons induce unique, yet overlapping combinations of behavioural modulations including safety learning, memory retrieval and acute locomotion
Individual dopaminergic neurons induce unique, yet overlapping combinations of behavioural modulations including safety learning, memory retrieval and acute locomotion Open
Two evolutionary highly conserved functions of dopamine are to carry “teaching” signals during associative learning and to control movement. In mammals and humans these functions are generally thought to be produced by different population…
View article: Individual dopaminergic neurons induce unique, yet overlapping combinations of behavioural modulations including safety learning, memory retrieval and acute locomotion
Individual dopaminergic neurons induce unique, yet overlapping combinations of behavioural modulations including safety learning, memory retrieval and acute locomotion Open
Two evolutionary highly conserved functions of dopamine are to carry “teaching” signals during associative learning and to control movement. In mammals and humans these functions are generally thought to be produced by different population…
View article: Cardiovascular magnetic resonance reference ranges for cardiac function and structure and recommendations for grading severity: the Healthy Hearts Consortium
Cardiovascular magnetic resonance reference ranges for cardiac function and structure and recommendations for grading severity: the Healthy Hearts Consortium Open
Introduction Cardiovascular magnetic resonance (CMR) imaging offers precise quantification of cardiac structure and function. However, its clinical utility is often limited by the absence of robust, standardized reference ranges and severi…
View article: Genomic and molecular evidence that the lncRNA<i>DSP-AS1</i>modulates Desmoplakin expression
Genomic and molecular evidence that the lncRNA<i>DSP-AS1</i>modulates Desmoplakin expression Open
Cardiac desmosomes are specialized cell junctions responsible for cardiomyocytes mechanical coupling. Mutation in desmosomal genes cause autosomal dominant and recessive familial arrhythmogenic cardiomyopathy. Motivated by evidence that Me…
View article: Clinical and Imaging Markers of Cardiac Function and Brain Health
Clinical and Imaging Markers of Cardiac Function and Brain Health Open
In this large study among community-dwelling adults, subclinical cardiac dysfunction was associated with brain imaging markers of neurodegeneration. These findings encourage longitudinal investigations on the effect of maintaining cardiac …
View article: Movement behaviors and cardiorespiratory fitness – a cross-sectional compositional data analysis among German adults
Movement behaviors and cardiorespiratory fitness – a cross-sectional compositional data analysis among German adults Open
View article: The relationship between age related changes in strength and fitness with body size, shape and composition
The relationship between age related changes in strength and fitness with body size, shape and composition Open
View article: Exploring the ‘fit for work’ principle: The association between occupational physical activity, cardio-respiratory fitness, and mortality – a meta-analysis of male worker data
Exploring the ‘fit for work’ principle: The association between occupational physical activity, cardio-respiratory fitness, and mortality – a meta-analysis of male worker data Open
OBJECTIVES: This individual participant data meta-analysis investigates the association between occupational physical activity (OPA) and both cardiovascular mortality and all-cause mortality across different cardio-respiratory fitness (CRF…