Explanipedia

MZB1 is a GRP94 cochaperone that enables proper immunoglobulin heavy chain biosynthesis upon ER stress Open

Marc Rosenbaum, Virginia Andreani, Tanya Kapoor, Simone Herp, Henrik Flach , et al. · 2014

MZB1 (pERp1) is a B-cell-specific and endoplasmic reticulum (ER)-localized protein implicated in antibody secretion and integrin-mediated cell adhesion. Here, we examine the role of MZB1 in vivo by conditional gene inactivation in the mous…

Activation of the TCR Complex by Peptide-MHC and Superantigens Open

Christine Louis-Dit-Sully, Britta Blumenthal, Marlena Duchniewicz, Katharina Beck-García, Gina J. Fiala , et al. · 2013

Mzb1 Protein Regulates Calcium Homeostasis, Antibody Secretion, and Integrin Activation in Innate-like B Cells Open

Henrik Flach, Marc Rosenbaum, Marlena Duchniewicz, Sola Kim, Shenyuan L. Zhang , et al. · 2010

Retrotransposition and mutation events yield Rap1 GTPases with differential signalling capacity Open

Tomasz Żemojtel, Marlena Duchniewicz, Zhongchun Zhang, Taisa Paluch, Hannes Luz , et al. · 2010

PBX1 is dispensable for neural commitment of RA-treated murine ES cells Open

Anne S. Jürgens, Mateusz Kolanczyk, Dietrich C. C. Moebest, Tomasz Żemojtel, Urs Lichtenauer , et al. · 2009

Experimentation with PBX1 knockout mice has shown that PBX1 is necessary for early embryogenesis. Despite broad insight into PBX1 function, little is known about the underlying target gene regulation. Utilizing the Cre-loxP system, we targ…

Determination of Ras-GTP and Ras-GDP in patients with acute myelogenous leukemia (AML), myeloproliferative syndrome (MPS), juvenile myelomonocytic leukemia (JMML), acute lymphocytic leukemia (ALL), and malignant lymphoma: assessment of mutational and indirect activation Open

D. Raepple, F. von Lintig, Tomasz Żemojtel, Marlena Duchniewicz, Andreas Jung , et al. · 2008

The 21-kD protein Ras of the low-molecular-weight GTP-binding (LMWG) family plays an important role in transduction of extracellular signals. Ras functions as a 'molecular switch' in transduction of signals from the membrane receptors of m…

Corrigendum to “Mammalian mitochondrial nitric oxide synthase: Characterization of a novel candidate” [FEBS Lett. 580 (2006) 455–462] Open

Tomasz Żemojtel, Mateusz Kolanczyk, Nadine Kossler, Sigmar Stricker, Rudi Lurz , et al. · 2007

Since the time of our report on the mitochondrial localization of mouse ortholog of AtNOS1, mAtNOS1 [1], the following data has been acquired. Importantly, both ours and Dr. Durner's labs have failed to detect any NO-synthase activity in p…

Pre-B-Cell Transcription Factor 1 and Steroidogenic Factor 1 Synergistically Regulate Adrenocortical Growth and Steroidogenesis Open

Urs Lichtenauer, Marlena Duchniewicz, Mateusz Kolanczyk, Andreas Hoeflich, Stefanie Hahner , et al. · 2006

A variety of transcription factors including Wilms tumor gene (Wt-1), steroidogenic factor 1 (Sf-1), dosage-sensitive sex reversal, adrenal hypoplasia congenita on the X-chromosome, Gene 1 (Dax-1), and pre-B-cell transcription factor 1 (Pb…

Rap1A-Deficient T and B Cells Show Impaired Integrin-Mediated Cell Adhesion Open

Marlena Duchniewicz, Tomasz Żemojtel, Mateusz Kolanczyk, Steffen Großmann, Jürgen Scheele , et al. · 2005

Studies in tissue culture cells have demonstrated a role for the Ras-like GTPase Rap1 in the regulation of integrin-mediated cell-matrix and cadherin-mediated cell-cell contacts. To analyze the function of Rap1 in vivo, we have disrupted t…

Dual Role of the Mitochondrial Chaperone Mdj1p in Inheritance of Mitochondrial DNA in Yeast Open

Marlena Duchniewicz, Aleksandra Germaniuk, Benedikt Westermann, Walter Neupert, Elisabeth Schwarz , et al. · 1999

Mdj1p, a homolog of the bacterial DnaJ chaperone protein, plays an essential role in the biogenesis of functional mitochondria in the yeast Saccharomyces cerevisiae. We analyzed the role of Mdj1p in the inheritance of mitochondrial DNA (mt…

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