Edwin Lee
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View article: An ecological momentary assessment of the dynamic relationship between microaggression, idea of reference and affects in patients with first-episode psychosis
An ecological momentary assessment of the dynamic relationship between microaggression, idea of reference and affects in patients with first-episode psychosis Open
These results suggested that negative affects and the presence of IoR may influence their perception of microaggressive experiences. The study allows a better understanding of the role of different factors in the processing of microaggress…
View article: Mediators of psychotic-like experiences in community youths after trauma: positive sense of agency and post-traumatic stress symptoms
Mediators of psychotic-like experiences in community youths after trauma: positive sense of agency and post-traumatic stress symptoms Open
Background Trauma exposure has been associated with the development of psychotic disorders in adolescence and young adulthood. Trauma can compromise the sense of agency, a predictor of psychosis. Symptoms of post-traumatic stress disorder …
View article: Impact of financial deprivation in first-episode psychosis: a prospective 4-year follow-up study
Impact of financial deprivation in first-episode psychosis: a prospective 4-year follow-up study Open
Purpose Socioeconomic disadvantage can exacerbate psychosis outcomes, yet the long-term impact of financial deprivation remains underexplored. This study examined how financial deprivation at first-episode psychosis affects clinical, funct…
View article: Machine Learning with Multitype Protected Attributes: Intersectional Fairness through Regularisation
Machine Learning with Multitype Protected Attributes: Intersectional Fairness through Regularisation Open
Ensuring equitable treatment (fairness) across protected attributes (such as gender or ethnicity) is a critical issue in machine learning. Most existing literature focuses on binary classification, but achieving fairness in regression task…
View article: Eye Movement Abnormalities During the Gaze Perception Task in Individuals With Clinical High Risk for Psychosis: A Discriminant Analysis With Hidden Markov Models
Eye Movement Abnormalities During the Gaze Perception Task in Individuals With Clinical High Risk for Psychosis: A Discriminant Analysis With Hidden Markov Models Open
Objectives Social cognitive impairments were well-documented in schizophrenia and individuals with clinical high risk for psychosis (CHR). While eye movement abnormalities during gaze perception in schizophrenia have been suggested, such u…
View article: Population-based study of long-term mortality risk associated with clozapine use among patients with schizophrenia
Population-based study of long-term mortality risk associated with clozapine use among patients with schizophrenia Open
Background Patients with schizophrenia have a significantly elevated risk of mortality. Clozapine is effective for treatment-resistant schizophrenia, but its use is limited by side-effects. Understanding its association with mortality risk…
View article: Can <i>headwind</i> , an online clinician-led mental health advisory platform, improve the engagement of distressed young people in community services? A multicohort analysis
Can <i>headwind</i> , an online clinician-led mental health advisory platform, improve the engagement of distressed young people in community services? A multicohort analysis Open
Objective The study evaluated the effectiveness of headwind service, an online, clinician-led mental health advisory platform, in engaging individuals with moderate to severe psychological distress. It also compared distress reduction achi…
View article: Validation of the Chinese version of the Connor-Davidson Resilience Scale-10 among young people in Hong Kong
Validation of the Chinese version of the Connor-Davidson Resilience Scale-10 among young people in Hong Kong Open
The Chinese version of the CD-RISC-10 is reliable and valid for resilience assessment among adolescents and young adults in Hong Kong. However, it has limited capacity to predict future psychiatric diagnoses. These findings highlight the i…
View article: Breakfast skipping and depressive symptoms in an epidemiological youth sample in Hong Kong: the mediating role of reduced attentional control
Breakfast skipping and depressive symptoms in an epidemiological youth sample in Hong Kong: the mediating role of reduced attentional control Open
Introduction Breakfast skipping is common among young people, although previous work has suggested its negative influences on cognitive and executive functions and mental health outcomes. Whether reduced impulse control, particularly in th…
View article: Analytical and numerical evaluation of the relationship between elongation calibration function and cyber standard tensile tests for ductile materials
Analytical and numerical evaluation of the relationship between elongation calibration function and cyber standard tensile tests for ductile materials Open
Cylindrical tensile testing is critically reviewed focusing on the gage length per diameter (GLPD) and its effect on the elongation. Flow behaviors and patterns of representative cold forging materials of SCM435, SWCH45F, S25C, SWCH10A, SU…
View article: Temporal trends of the utilization patterns of sedative-hypnotic medications in children, adolescents and young adults: a 21-year population-based study with joinpoint regression analysis
Temporal trends of the utilization patterns of sedative-hypnotic medications in children, adolescents and young adults: a 21-year population-based study with joinpoint regression analysis Open
This first Asian population-based study indicates a significant rising trend of BZRA prescriptions, especially among adolescents and young adults. Judicious prescribing-practices and further investigation clarifying factors contributing to…
View article: Three-year outcome comparison between extended early intervention and standard psychiatric care for adults with first-episode psychosis in Hong Kong
Three-year outcome comparison between extended early intervention and standard psychiatric care for adults with first-episode psychosis in Hong Kong Open
Background Early intervention (EI) for first-episode psychosis (FEP) mainly focuses on adolescents and young adults. Previous evaluation demonstrated superiority of 2-year EI program (EASY) over standard care in outcome improvement in youn…
View article: Determinants of enduring major depressive episodes in the youth population of Hong Kong: The roles of comorbid psychopathology and stressful life events
Determinants of enduring major depressive episodes in the youth population of Hong Kong: The roles of comorbid psychopathology and stressful life events Open
Background Major depressive episodes (MDEs) are highly recurrent in clinical samples. However, the course of MDEs and predictors of their endurance are unclear in the general youth population. Methods We investigated prospective factors as…
View article: Effects of mindfulness-based intervention in preventing relapse in patients with remitted psychosis: a randomized controlled trial
Effects of mindfulness-based intervention in preventing relapse in patients with remitted psychosis: a randomized controlled trial Open
Stress is a key factor in psychotic relapse, and mindfulness offers stress resilience and well-being benefits. This study examined the effects of mindfulness-based intervention for psychosis (MBI-p) in preventing relapse at 1 year among pa…
View article: Association Between Oral Fluoroquinolones and Neuropsychiatric Events: Self‐Controlled Case Series With Active Comparator Design
Association Between Oral Fluoroquinolones and Neuropsychiatric Events: Self‐Controlled Case Series With Active Comparator Design Open
Purpose The evidence of the neuropsychiatric effects associated with fluoroquinolones is mainly supported by case reports. Population‐based evidence remains largely limited. We aimed to investigate the association between the use of fluoro…
View article: Moderating effects of age on associations between exercise self-efficacy and physical activity in women with psychosis in Hong Kong
Moderating effects of age on associations between exercise self-efficacy and physical activity in women with psychosis in Hong Kong Open
Among women with psychosis, ESE domains of 'must exercise alone', 'inconvenience to exercise', and 'resistance from others' as well as overall ESE were significantly associated with moderate-intensity PA in older age group only. Age-specif…
View article: Factor analysis of the Chinese version of the Autism Spectrum Quotient 10 and its association with schizotypal traits in adolescents and young adults in Hong Kong
Factor analysis of the Chinese version of the Autism Spectrum Quotient 10 and its association with schizotypal traits in adolescents and young adults in Hong Kong Open
In Chinese adolescents and young adults, autistic traits, especially task switching and attention deficits (compared with theory of mind) are more closely correlated with schizotypal personality traits. Disentangling the overlapping and di…
View article: Personalized Food Elimination Diet: A Clinical Trial based on Food sensitivity assessment
Personalized Food Elimination Diet: A Clinical Trial based on Food sensitivity assessment Open
Food sensitivity, a common but overlooked condition, has been associated with a variety of gastrointestinal symptoms. Typically, patients suffering from food sensitivity are placed on elimination diets, although the success of this approac…
View article: Effects of long-term antipsychotic medication on brain instability in first-episode schizophrenia patients: a resting-state fMRI study
Effects of long-term antipsychotic medication on brain instability in first-episode schizophrenia patients: a resting-state fMRI study Open
Early initiation of antipsychotic treatment plays a crucial role in the management of first-episode schizophrenia (FES) patients, significantly improving their prognosis. However, limited attention has been given to the long-term effects o…
View article: Assessing the generalisability of the psychosis metabolic risk calculator (PsyMetRiC) for young people with first-episode psychosis with validation in a Hong Kong Chinese Han population: a 4-year follow-up study
Assessing the generalisability of the psychosis metabolic risk calculator (PsyMetRiC) for young people with first-episode psychosis with validation in a Hong Kong Chinese Han population: a 4-year follow-up study Open
This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.
View article: Daratumumab, cyclophosphamide, bortezomib, and dexamethasone for transplant-ineligible myeloma: AMaRC 03-16
Daratumumab, cyclophosphamide, bortezomib, and dexamethasone for transplant-ineligible myeloma: AMaRC 03-16 Open
In newly diagnosed transplant-ineligible patients with myeloma, daratumumab has improved outcomes when added to the standard-of-care regimens. In a randomized trial, we tested whether similar improvements would be observed when daratumumab…
View article: Age‐related differences in the impact of resilience on mental health outcomes during the COVID‐19 pandemic in Hong Kong
Age‐related differences in the impact of resilience on mental health outcomes during the COVID‐19 pandemic in Hong Kong Open
Objective This study investigated changes in mental health in Hong Kong over two years and examined the role of resilience and age in mitigating the negative effects of public health emergencies, particularly the COVID‐19 pandemic. Methods…
View article: Exploring the effects of Dasatinib, Quercetin, and Fisetin on DNA methylation clocks: a longitudinal study on senolytic interventions
Exploring the effects of Dasatinib, Quercetin, and Fisetin on DNA methylation clocks: a longitudinal study on senolytic interventions Open
Senolytics, small molecules targeting cellular senescence, have emerged as potential therapeutics to enhance health span. However, their impact on epigenetic age remains unstudied. This study aimed to assess the effects of Dasatinib and Qu…
View article: Development of an individualized risk calculator of treatment resistance in patients with first-episode psychosis (TRipCal) using automated machine learning: a 12-year follow-up study with clozapine prescription as a proxy indicator
Development of an individualized risk calculator of treatment resistance in patients with first-episode psychosis (TRipCal) using automated machine learning: a 12-year follow-up study with clozapine prescription as a proxy indicator Open
About 15–40% of patients with schizophrenia are treatment resistance (TR) and require clozapine. Identifying individuals who have higher risk of development of TR early in the course of illness is important to provide personalized interven…