Explanipedia

Diagnostic Performance of Magnifying Endoscopy With Crystal Violet Staining for Superficial Non‐ampullary Duodenal Epithelial Tumors: A Single‐center Prospective Study Open

Tomo Kumei, Yosuke Toya, Shun Yamada, Makoto Eizuka, Shunichi Yanai , et al. · 2025

Objectives We previously reported a potential diagnostic algorithm for superficial non‐ampullary duodenal epithelial tumors (SNADETs) using white‐light magnifying endoscopy with crystal violet staining (ME‐CV). This study aimed to determin…

Efficacy and Safety of Three Janus Kinase Inhibitors in Ulcerative Colitis Patients over and under 65 Years of Age: A Real-World Comparative Analysis Open

Shintaro Akiyama, Hiromichi Shimizu, Akiko Tamura, Kaoru Yokoyama, Toshiyuki Sakurai , et al. · 2025

Introduction: It remains unclear whether Janus kinase (JAK) inhibitors differ in efficacy and safety between elderly and non-elderly patients with ulcerative colitis. Methods: We retrospectively compared outcomes between patients who start…

A case of jejunal cancer arising from ectopic pancreas Open

Makoto Eizuka, Yosuke Toya, Ryo Sugimoto, Masahiko Komai, Ako Yamada , et al. · 2025

A 74-year-old man presented with intestinal obstruction. CT (computed tomography) revealed a 25-mm mass in the proximal jejunum. Double-balloon endoscopy (DBE) identified a smooth, asymmetrically localized mass with oozing and luminal sten…

A case of undifferentiated pleomorphic rectal sarcoma occurring after radiation exposure Open

Makoto Eizuka, Yosuke Toya, Shun Yamada, Tomofumi Oizumi, Shunichi Yanai , et al. · 2024

A 72 year-old man was referred to our hospital for a detailed examination of a recurrent rectal polyp. He had past histories of surgery and radiation therapy for prostate cancer at the age of 66 and endoscopic excision of a rectal polyp at…

Appropriate leucine-rich α-2 glycoprotein cut-off value for Japanese patients with ulcerative colitis Open

Masanao Yamazato, Shunichi Yanai, Tomofumi Oizumi, Makoto Eizuka, Shun Yamada , et al. · 2023

BACKGROUND It has been suggested that serum leucine-rich α-2 glycoprotein (LRG) could be a novel monitoring biomarker for the assessment of disease activity in inflammatory bowel disease. In particular, the relationship between LRG levels …

Is bowel preparation necessary for early colonoscopy in patients with suspected colonic diverticular bleeding?: A multicenter retrospective study with propensity score matching analysis Open

Takahiro Gonai, Yosuke Toya, Norihiko Kudara, Keinosuke Abe, Sera Sawaguchi , et al. · 2023

Objectives There are few reports on bowel preparation for early colonoscopy in patients with suspected colonic diverticular bleeding (CDB). We aim to clarify in a retrospective, multicenter study. Methods In a multicenter retrospective coh…

A case of a stuck mesh in the rectum after pelvic surgery Open

Makoto Eizuka, Yosuke Toya, Risaburo Akasaka, Shun Yamada, Tomofumi Oizumi , et al. · 2023

A 67‐year‐old woman was referred to our hospital for further evaluation of a positive fecal occult blood test. Colonoscopy revealed an elevated rectal lesion (10 mm in size) with a central depression. A rod‐like object was noted in the cen…

Attenuated Familial Adenomatous Polyposis Open

Makoto Eizuka, Yosuke Toya, Takashi Kosaka, Tomofumi Oizumi, Toshifumi Morishita , et al. · 2023

A 36-year-old man was diagnosed with multiple gastric polyps by esophagogastroduodenoscopy. Subsequent colonoscopy identified two tubular adenomas, and computed tomography revealed subcutaneous tumors. Based on these findings, we suspected…

A Case of Serotonergic Gastric Neuroendocrine Tumor with Fibrous Stroma an Unusual EUS Finding Open

Noriyuki Arakawa, Atsushi Irisawa, Kazuyuki Ishida, Yoshiko Yamaguchi, Akane Yamabe , et al. · 2022

Our patient was a man in his eighties who was referred to our department after a screening endoscopy indicated some abnormalities.Upper gastrointestinal endoscopy identified a 6-mm submucosal tumor in the posterior wall of the lesser curva…

Genome-Wide Analysis of microRNA and mRNA Expression in Colorectal Intramucosal Neoplasia and Colorectal Cancer With a Microsatellite-Stable Phenotype Based on Adenoma-Carcinoma Sequences Open

Tamotsu Sugai, Mitsumasa Osakabe, Takeshi Niinuma, Ryo Sugimoto, Makoto Eizuka , et al. · 2022

Background Although MicroRNAs (miRNAs) play important roles in various biological processes, the biological functions of miRNAs are achieved through mRNAs. The aim of this study is to identify dysregulated miRNA/mRNA expression patterns in…

Genome-wide analysis of mRNA expression identified the involvement of trefoil factor 1 in the development of sessile serrated lesions Open

Tamotsu Sugai, Mitsumasa Osakabe, Makoto Eizuka, Yoshihito Tanaka, Shun Yamada , et al. · 2022

Precursor lesions that progress into colorectal cancer (CRC) could be largely classified into sessile serrated lesions (SSLs), traditional serrated adenoma (TSA), and tubular adenoma (TA). We aimed to determine whether high expression of t…

Comprehensive Analysis of microRNA Expression During the Progression of Colorectal Tumors Open

Tamotsu Sugai, Ryo Sugimoto, Makoto Eizuka, Mitsumasa Osakabe, Shun Yamada , et al. · 2022

We showed that several miRs were dysregulated during progression from adenoma to intramucosal cancer. Specific miRs may have key roles in progression from intramucosal tumor to invasive CRC.

Successful endoscopic sclerotherapy with bile duct stenting for a vascular malformation neighboring the duodenal papilla in blue rubber bleb nevus syndrome Open

Shingo Unoura, Yosuke Toya, Satoshi Kasugai, Tomo Kumei, Masanao Yamazato , et al. · 2022

A 14‐year‐old girl, who had been diagnosed with blue rubber bleb nevus syndrome, was referred to our hospital because of iron deficiency anemia. Esophagogastroduodenoscopy revealed a dark and red‐colored vascular malformation occurring jus…

Endoscopic Removal of a Denture Lining Material Stuck in the Duodenum Open

Makoto Eizuka, Yosuke Toya, Manami Miura, Hiroshi Takahashi, Takayuki Matsumoto · 2022

A 52-year-old woman visited our hospital with a complaint of upper abdominal pain. Abdominal computed tomography did not show any lesion responsible for the pain. However, esophagogastroduodenoscopy identified a pale, pink-colored, U-shape…

Cribriform-type adenocarcinoma of the colorectum: comprehensive molecular analyses of a distinctive histologic subtype of colorectal cancer Open

Shun Yamada, Mitsumasa Osakabe, Makoto Eizuka, Mai Hashimoto, Noriyuki Uesugi , et al. · 2022

Colorectal adenocarcinoma (CRA) is characterized by marked heterogeneity and may be composed of an admixture of various histologic patterns, including well-formed gland and cribriform types. Although tumors displaying a prominent or predom…

Hemorrhagic Colitis Caused by Everolimus in a Patient with Nonfunctional Pancreatic Neuroendocrine Neoplasms: A Case Report Open

Noriyuki Arakawa, Atsushi Irisawa, Kazuyuki Ishida, Takuya Tsunoda, Yoshiko Yamaguchi , et al. · 2022

A 60-year-old woman was diagnosed with nonfunctional pancreatic neuroendocrine neoplasm with multiple liver metastases and was administered everolimus. Due to persistent epigastric pain and diarrhea, a colonoscopy was performed on the 14th…

Risk factors for short-term re-bleeding in patients with colonic diverticular bleeding: a multicenter retrospective study Open

Takahiro Gonai, Yosuke Toya, Norihiko Kudara, Keinosuke Abe, Sera Sawaguchi , et al. · 2022

Use of ATs was an independent risk factor for short-term re-bleeding within a month in patients with CDB. This was especially the case for the use of multiple ATs and continuation of ATs. However, discontinuation of ATs may increase the th…

Clinical Differences in c-Myc Expression in Early-Stage Gastric Neoplasia: A Retrospective Study Based on the WHO Classification Open

Noriyuki Arakawa, Atsushi Irisawa, Kazuyuki Ishida, Takuya Tsunoda, Yoshiko Yamaguchi , et al. · 2022

c-Myc is an oncogene that is dysregulated in various cancers. Early gastric neoplasia with c-Myc expression has been reported as a more malignant lesion. This study clarifies the differences in c-Myc expression in early gastric neoplasia b…

Role of barium enema examination for the diagnosis of submucosal invasion depth in T1 colorectal cancers Open

Keisuke Kawasaki, Takehiro Torisu, Takahisa Nagahata, Motohiro Esaki, Koichi Kurahara , et al. · 2021

Prognostic nutritional index is an independent prognostic factor for older patients aged ≥ 85 years treated by gastric endoscopic submucosal dissection Open

Yosuke Toya, Masaki Endo, Risaburo Akasaka, Toshifumi Morishita, Shunichi Yanai , et al. · 2021

Background Clinical outcomes and prognostic factors for survival after endoscopic submucosal dissection (ESD) in older patients aged ≥ 85 years with early gastric cancer (EGC) are not well defined. The aim of this study was to investigate …

The mucin phenotype does not affect the endoscopic resection outcome of non-ampullary duodenal epithelial tumors Open

Yosuke Toya, Masaki Endo, Shun Yamada, Tomofumi Oizumi, Toshifumi Morishita , et al. · 2021

Background and study aims Some studies have reported an association between clinicopathological features and mucin phenotypes of non-ampullary duodenal epithelial tumors (NADETs). However, the association between clinical outcomes of endos…

A genome‐wide analysis of the molecular alterations occurring in the adenomatous and carcinomatous components of the same tumor based on the adenoma–carcinoma sequence Open

Tamotsu Sugai, Mitsumasa Osakabe, Wataru Habano, Yoshihito Tanaka, Makoto Eizuka , et al. · 2021

Identification of molecular alterations occurring in the adenomatous and carcinomatous components within the same tumor would greatly enhance understanding of the neoplastic progression of colorectal cancer. We examined somatic copy number…

Microenvironmental markers are correlated with lymph node metastasis in invasive submucosal colorectal cancer Open

Tamotsu Sugai, Noriyuki Yamada, Mitsumasa Osakabe, Mai Hashimoto, Noriyuki Uesugi , et al. · 2021

Aims Recent studies have shown that the microenvironment can include cancer cells and cancer‐associated fibroblasts (CAFs), and that both play important roles in the progression and metastasis of CRC. Here, we aimed to analyse the expressi…

Evaluation of the Long-term Administration of Rifaximin for More than Three Years in the Treatment of Repeated and Recurrent Overt Hepatic Encephalopathy Open

Yudai Fujiwara, Kazuyuki Suzuki, Kenji Yusa, Makoto Eizuka, Manami Miura , et al. · 2021

The patient was a 65-year-old man with alcoholic liver cirrhosis who had been admitted to hospital 5 times for repeated and recurrent overt hepatic encephalopathy (HE) despite numerous therapies, including disaccharide, branched-chain amin…

A genome‐wide study of the relationship between chromosomal abnormalities and gene expression in colorectal tumors Open

Tamotsu Sugai, Mitsumasa Osakabe, Ryo Sugimoto, Makoto Eizuka, Yoshihito Tanaka , et al. · 2020

The role of somatic copy number alterations (SCNAs) that occur in colorectal tumors is poorly understood. SCNAs are correlated with corresponding gene expression changes that may contribute to neoplastic progression. Thus, we examined SCNA…

Analysis of clinicopathological and molecular features of crawling-type gastric adenocarcinoma Open

Yasuko Fujita, Noriyuki Uesugi, Ryo Sugimoto, Makoto Eizuka, Yosuke Toya , et al. · 2020

Background Crawling-type adenocarcinoma (CRA) is an important gastric cancer (GC) subtype that exhibits a specific histological pattern and has characteristic clinicopathological findings. Despite its characteristic histology, little is kn…

Analysis of clinicopathological and molecular features of crawling-type gastric adenocarcinoma Open

Yasuko Fujita, Noriyuki Uesugi, Ryo Sugimoto, Makoto Eizuka, Yosuke Toya , et al. · 2020

Background: Crawling-type adenocarcinoma (CRA) is an important gastric cancer (GC) subtype that exhibits a specific histological pattern and has characteristic clinicopathological findings. Despite its characteristic histology, little is k…

Analysis of clinicopathological and molecular features of crawling-type gastric adenocarcinoma Open

Yasuko Fujita, Noriyuki Uesugi, Ryo Sugimoto, Makoto Eizuka, Yosuke Toya , et al. · 2020

Background: Crawling-type adenocarcinoma (CRA) is an important gastric cancer (GC) subtype that exhibits a specific histological pattern and has characteristic clinicopathological findings. Despite its characteristic histology, little is k…

Analysis of clinicopathological and molecular features of crawling-type gastric adenocarcinoma Open

Yasuko Fujita, Noriyuki Uesugi, Ryo Sugimoto, Makoto Eizuka, Yosuke Toya , et al. · 2020

Background: Crawling-type adenocarcinoma (CRA) is an important gastric cancer (GC) subtype that exhibits a specific histological pattern and has characteristic clinicopathological findings. Despite its characteristic histology, little is k…

Dysregulation of microRNA expression during the progression of colorectal tumors Open

Makoto Eizuka, Mitsumasa Osakabe, Ayaka Sato, Yasuko Fujita, Yoshihito Tanaka , et al. · 2020

MicroRNAs (miRNAs) are potential biomarkers of neoplastic lesions, but additional information on dysregulated miRNA expression during progression of the adenoma–adenocarcinoma sequence may be helpful to identify the role of miRNAs in this …

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