M. Elise Lauterbur
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View article: Genomic and functional adaptations in guanylate-binding protein 5 (GBP5) highlight specificities of bat antiviral innate immunity
Genomic and functional adaptations in guanylate-binding protein 5 (GBP5) highlight specificities of bat antiviral innate immunity Open
Bats are asymptomatic reservoirs of several zoonotic viruses. This may result from long-term coevolution between viruses and bats, that have led to host adaptations contributing to an effective balance between strong antiviral responses wi…
View article: Extensive longevity and DNA virus-driven adaptation in nearctic <i>Myotis</i> bats
Extensive longevity and DNA virus-driven adaptation in nearctic <i>Myotis</i> bats Open
The genus Myotis is one of the largest clades of bats, and exhibits some of the most extreme variation in lifespans among mammals alongside unique adaptations to viral tolerance and immune defense. To study the evolution of longevity-assoc…
View article: Author Response: Expanding the stdpopsim species catalog, and lessons learned for realistic genome simulations
Author Response: Expanding the stdpopsim species catalog, and lessons learned for realistic genome simulations Open
Full text Figures and data Side by side Abstract eLife assessment Introduction Data availability References Peer review Author response Article and author information Metrics Abstract Simulation is a key tool in population genetics for bot…
View article: Expanding the stdpopsim species catalog, and lessons learned for realistic genome simulations
Expanding the stdpopsim species catalog, and lessons learned for realistic genome simulations Open
Simulation is a key tool in population genetics for both methods development and empirical research, but producing simulations that recapitulate the main features of genomic datasets remains a major obstacle. Today, more realistic simulati…
View article: Versatile Detection of Diverse Selective Sweeps with Flex-Sweep
Versatile Detection of Diverse Selective Sweeps with Flex-Sweep Open
Understanding the impacts of selection pressures influencing modern-day genomic diversity is a major goal of evolutionary genomics. In particular, the contribution of selective sweeps to adaptation remains an open question, with persistent…
View article: Author Response: Expanding the stdpopsim species catalog, and lessons learned for realistic genome simulations
Author Response: Expanding the stdpopsim species catalog, and lessons learned for realistic genome simulations Open
Simulation is a key tool in population genetics for both methods development and empirical research, but producing simulations that recapitulate the main features of genomic data sets remains a major obstacle. Today, more realistic simulat…
View article: Expanding the stdpopsim species catalog, and lessons learned for realistic genome simulations
Expanding the stdpopsim species catalog, and lessons learned for realistic genome simulations Open
Simulation is a key tool in population genetics for both methods development and empirical research, but producing simulations that recapitulate the main features of genomic data sets remains a major obstacle. Today, more realistic simulat…
View article: Author Response: Expanding the stdpopsim species catalog, and lessons learned for realistic genome simulations
Author Response: Expanding the stdpopsim species catalog, and lessons learned for realistic genome simulations Open
Simulation is a key tool in population genetics for both methods development and empirical research, but producing simulations that recapitulate the main features of genomic data sets remains a major obstacle. Today, more realistic simulat…
View article: Expanding the stdpopsim species catalog, and lessons learned for realistic genome simulations
Expanding the stdpopsim species catalog, and lessons learned for realistic genome simulations Open
Simulation is a key tool in population genetics for both methods development and empirical research, but producing simulations that recapitulate the main features of genomic data sets remains a major obstacle. Today, more realistic simulat…
View article: Expanding the stdpopsim species catalog, and lessons learned for realistic genome simulations
Expanding the stdpopsim species catalog, and lessons learned for realistic genome simulations Open
Simulation is a key tool in population genetics for both methods development and empirical research, but producing simulations that recapitulate the main features of genomic datasets remains a major obstacle. Today, more realistic simulati…
View article: Adaptive duplication and genetic diversification of protein kinase R contribute to the specificity of bat-virus interactions
Adaptive duplication and genetic diversification of protein kinase R contribute to the specificity of bat-virus interactions Open
Several bat species act as asymptomatic reservoirs for many viruses that are highly pathogenic in other mammals. Here, we have characterized the functional diversification of the protein kinase R (PKR), a major antiviral innate defense sys…
View article: Versatile detection of diverse selective sweeps with Flex-sweep
Versatile detection of diverse selective sweeps with Flex-sweep Open
Understanding the impacts of selection pressures influencing modern-day genomic diversity is a major goal of evolutionary genomics. In particular, the contribution of selective sweeps to adaptation remains an open question, with persistent…
View article: Expanding the stdpopsim species catalog, and lessons learned for realistic genome simulations
Expanding the stdpopsim species catalog, and lessons learned for realistic genome simulations Open
Simulation is a key tool in population genetics for both methods development and empirical research, but producing simulations that recapitulate the main features of genomic data sets remains a major obstacle. Today, more realistic simulat…
View article: Factors influencing terrestriality in primates of the Americas and Madagascar
Factors influencing terrestriality in primates of the Americas and Madagascar Open
Among mammals, the order Primates is exceptional in having a high taxonomic richness in which the taxa are arboreal, semiterrestrial, or terrestrial. Although habitual terrestriality is pervasive among the apes and African and Asian monkey…
View article: Adaptive duplication and functional diversification of Protein kinase R contribute to the uniqueness of bat-virus interactions
Adaptive duplication and functional diversification of Protein kinase R contribute to the uniqueness of bat-virus interactions Open
Several bat species act as asymptomatic reservoirs for many viruses that are instead highly pathogenic in other mammals. Here, we have characterized the functional diversification of the Protein kinase R (PKR), a major antiviral innate def…
View article: Decreased recent adaptation at human mendelian disease genes as a possible consequence of interference between advantageous and deleterious variants
Decreased recent adaptation at human mendelian disease genes as a possible consequence of interference between advantageous and deleterious variants Open
Advances in genome sequencing have improved our understanding of the genetic basis of human diseases, and thousands of human genes have been associated with different diseases. Recent genomic adaptation at disease genes has not been well c…
View article: Author response: Decreased recent adaptation at human mendelian disease genes as a possible consequence of interference between advantageous and deleterious variants
Author response: Decreased recent adaptation at human mendelian disease genes as a possible consequence of interference between advantageous and deleterious variants Open
View article: Fruit odorants mediate co-specialization in a multispecies plant–animal mutualism
Fruit odorants mediate co-specialization in a multispecies plant–animal mutualism Open
Despite the widespread notion that animal-mediated seed dispersal led to the evolution of fruit traits that attract mutualistic frugivores, the dispersal syndrome hypothesis remains controversial, particularly for complex traits such as fr…
View article: An ancient viral epidemic involving host coronavirus interacting genes more than 20,000 years ago in East Asia
An ancient viral epidemic involving host coronavirus interacting genes more than 20,000 years ago in East Asia Open
View article: An ancient viral epidemic involving host coronavirus interacting genes more than 20,000 years ago in East Asia
An ancient viral epidemic involving host coronavirus interacting genes more than 20,000 years ago in East Asia Open
View article: Lowered sensitivity of bitter taste receptors to β-glucosides in bamboo lemurs: an instance of parallel and adaptive functional decline in TAS2R16?
Lowered sensitivity of bitter taste receptors to β-glucosides in bamboo lemurs: an instance of parallel and adaptive functional decline in TAS2R16? Open
Bitter taste facilitates the detection of potentially harmful substances and is perceived via bitter taste receptors (TAS2Rs) expressed on the tongue and oral cavity in vertebrates. In primates, TAS2R16 specifically recognizes β-glucosides…
View article: Decreased adaptation at human disease genes as a possible consequence of interference between advantageous and deleterious variants
Decreased adaptation at human disease genes as a possible consequence of interference between advantageous and deleterious variants Open
Advances in genome sequencing have dramatically improved our understanding of the genetic basis of human diseases, and thousands of human genes have been associated with different diseases. Despite our expanding knowledge of gene-disease a…
View article: Santana et al_ESM, data & code from Fruit odorants mediate co-specialization in a multispecies plant–animal mutualism
Santana et al_ESM, data & code from Fruit odorants mediate co-specialization in a multispecies plant–animal mutualism Open
Methods details, supplementary figures and tables, data files and R code used in analyses
View article: An ancient viral epidemic involving host coronavirus interacting genes more than 20,000 years ago in East Asia
An ancient viral epidemic involving host coronavirus interacting genes more than 20,000 years ago in East Asia Open
Summary The current SARS-CoV-2 pandemic has emphasized the vulnerability of human populations to novel viral pressures, despite the vast array of epidemiological and biomedical tools now available. Notably, modern human genomes contain evo…
View article: Species tree disequilibrium positively misleads models of gene family evolution
Species tree disequilibrium positively misleads models of gene family evolution Open
Gene duplication is a key source of evolutionary innovation, and multigene families evolve in a birth-death process, continuously duplicating and pseudogenizing through time. To empirically test hypotheses about adaptive expansion and cont…
View article: A Fruitful Endeavor: Scent Cues and Echolocation Behavior Used by <i>Carollia castanea</i> to Find Fruit
A Fruitful Endeavor: Scent Cues and Echolocation Behavior Used by <i>Carollia castanea</i> to Find Fruit Open
Synopsis Frugivores have evolved sensory and behavioral adaptations that allow them to find ripe fruit effectively, but the relative importance of different senses in varying foraging scenarios is still poorly understood. Within Neotropica…
View article: Coalescent models at small effective population sizes and population declines are positively misleading
Coalescent models at small effective population sizes and population declines are positively misleading Open
Population genetics employs two major models for conceptualizing genetic relationships among individuals – outcome-driven (coalescent) and process-driven (forward). These models are complementary, but the basic Kingman coalescent and its e…
View article: orthoCapture: Facilitating Gene Capture Probe Design for Non-Model Species
orthoCapture: Facilitating Gene Capture Probe Design for Non-Model Species Open
In non-model species, targeted gene capture (selective enrichment of specific genomic regions of interest) applications in molecular ecology have been limited by the practicalities of capture design. Currently, the minimal requirement for …
View article: A fruitful endeavor: scent cues and echolocation behavior used by <i>Carollia castanea</i> to find fruit
A fruitful endeavor: scent cues and echolocation behavior used by <i>Carollia castanea</i> to find fruit Open
Frugivores have evolved sensory and behavioral adaptations that allow them to find ripe fruit effectively, but the relative importance of different senses in varying foraging scenarios is poorly known. Within Neotropical ecosystems, short-…
View article: Testing Convergent Evolution in Auditory Processing Genes between Echolocating Mammals and the Aye-Aye, a Percussive-Foraging Primate
Testing Convergent Evolution in Auditory Processing Genes between Echolocating Mammals and the Aye-Aye, a Percussive-Foraging Primate Open
Several taxonomically distinct mammalian groups-certain microbats and cetaceans (e.g., dolphins)-share both morphological adaptations related to echolocation behavior and strong signatures of convergent evolution at the amino acid level ac…