Haitham M. Ahmed
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View article: The development of Liver Research Cymru, a new partnership to increase hepatology research activity in Wales
The development of Liver Research Cymru, a new partnership to increase hepatology research activity in Wales Open
Background The incidence and severity of liver disease in the United Kingdom have increased over the last 20 years. Many patients present with advanced disease with limited treatment options and subsequently high morbidity and mortality. T…
View article: Expression of Long Non-Coding RNA-NEAT-1 in Papillary Thyroid Carcinoma in Relation to Immunohistochemical expression of CD8 and PD-L1 as Indicators of Tumor Immune Microenvironment
Expression of Long Non-Coding RNA-NEAT-1 in Papillary Thyroid Carcinoma in Relation to Immunohistochemical expression of CD8 and PD-L1 as Indicators of Tumor Immune Microenvironment Open
LncRNA-NEAT1 and PD-L1 expression levels are associated with more aggressive PTC. In contrast, high CD8 expression is associated with favorable parameters. These findings suggest the possible diagnostic and prognostic role of these biomark…
View article: The development of Liver Research Cymru, a new partnership to increase hepatology research activity in Wales
The development of Liver Research Cymru, a new partnership to increase hepatology research activity in Wales Open
Background The incidence and severity of liver disease in the United Kingdom have increased over the last 20 years. Many patients present with advanced disease with limited treatment options and subsequently high morbidity and mortality. T…
View article: Relationship between Periodontal Pathogens and Fundamental Ailment of Systematic Diseases
Relationship between Periodontal Pathogens and Fundamental Ailment of Systematic Diseases Open
A developing collection of writing proposes that there is a connection among periodontitis and foundational illnesses. These illnesses incorporate cardiovascular sickness, gastrointestinal and colorectal malignant growth, diabetes and insu…
View article: Relationship between Periodontal Pathogens and Fundamental Ailment of Systematic Diseases
Relationship between Periodontal Pathogens and Fundamental Ailment of Systematic Diseases Open
A developing collection of writing proposes that there is a connection among periodontitis and foundational illnesses. These illnesses incorporate cardiovascular sickness, gastrointestinal and colorectal malignant growth, diabetes and insu…
View article: Statin intolerance and new lipid-lowering treatments
Statin intolerance and new lipid-lowering treatments Open
C oronary artery disease continues to be the leading cause of death in developed countries, and rates are rapidly rising in the developing world. 1 With the current obesity epidemic and growth of metabolic syndrome, its prevalence is likel…
View article: Functional capacity and quality of life in the postural tachycardia syndrome: A retrospective cross-sectional study
Functional capacity and quality of life in the postural tachycardia syndrome: A retrospective cross-sectional study Open
In this large cohort, patients with POTS were predominantly female (91%) and relatively young. The novel findings are that younger patients with POTS were more likely to have lower-than-average functional capacity for their age and sex com…
View article: In Reply: Familial hypercholesterolemia: Clarifications
In Reply: Familial hypercholesterolemia: Clarifications Open
Familial hypercholesterolemia: Clarifi cationsTo the Editor: The article by Shah and colleagues 1 is an excellent review of familial hypercholesterolemia (FH) and highlights an underdiagnosed condition on which clinicians can make a signif…
View article: Familial hypercholesterolemia: Detect, treat, and ask about family
Familial hypercholesterolemia: Detect, treat, and ask about family Open
Familial hypercholesterolemia is an autosomal dominant disorder that affects the metabolism of low-density lipo-protein cholesterol (LDL-C) through mutations in the gene for LDL receptor (LDLR), and less commonly in those for apolipoprotei…
View article: Association of Maternal Lactation With Diabetes and Hypertension
Association of Maternal Lactation With Diabetes and Hypertension Open
This study suggests that education about the benefits of breastfeeding for prevention of diabetes and hypertension in women is a low-risk intervention that can be easily included in daily practice and may have a positive impact on cardiova…
View article: The clinical aspect of overweight on rheumatoid arthritis and disease activity
The clinical aspect of overweight on rheumatoid arthritis and disease activity Open
Objective: To investigate the influence of obesity on disease activity in rheumatoid arthritis patients and to determine a probable connection with the acute phase response. Materials and methods: The recruited patients satisfied the crite…
View article: Visit-to-Visit Blood Pressure Variability, Coronary Atheroma Progression, and Clinical Outcomes
Visit-to-Visit Blood Pressure Variability, Coronary Atheroma Progression, and Clinical Outcomes Open
Greater BPV, particularly systolic BPV, is significantly associated with coronary atheroma progression and adverse clinical outcomes. These data suggest maintaining stable blood pressure levels may be important to further improve outcomes …
View article: Hypertension guidelines: Treat patients, not numbers
Hypertension guidelines: Treat patients, not numbers Open
The updated 2017 American College of Cardiology and American Heart Association (ACC/AHA) guidelines for managing hypertension advocate tighter blood pressure control than previous guidelines. This review summarizes the evidence behind the …
View article: Association Between Obesity and Cardiovascular Outcomes
Association Between Obesity and Cardiovascular Outcomes Open
The present meta-analysis suggests that obesity is associated with type 2 diabetes and coronary artery disease. Although this analysis of mendelian randomization studies does not prove causality, it is supportive of a causal association. H…
View article: Predictors of cardiorespiratory fitness improvement in phase II cardiac rehabilitation
Predictors of cardiorespiratory fitness improvement in phase II cardiac rehabilitation Open
Background Cardiac rehabilitation (CR) improves cardiorespiratory fitness (CRF) and has been shown to reduce cardiovascular events and death. However, data about predictors of fitness improvement during CR are limited and conflicting. The …
View article: Six-Year Changes in Physical Activity and the Risk of Incident Heart Failure
Six-Year Changes in Physical Activity and the Risk of Incident Heart Failure Open
Background: Higher physical activity (PA) is associated with lower heart failure (HF) risk; however, the effect of changes in PA on HF risk is unknown. Methods: We evaluated 11 351 ARIC study (Atherosclerosis Risk in Communities) participa…
View article: Cardioprotective anti-hyperglycaemic medications: a review of clinical trials
Cardioprotective anti-hyperglycaemic medications: a review of clinical trials Open
Despite extensive clinical efforts to achieve stricter glycaemic control over the past few decades, cardiovascular (CV) disease remains the leading cause of death among diabetic patients. Recently, sodium-glucose cotransporter-2 (SGLT-2) i…
View article: Feasibility of a Facebook Intervention for Exercise Motivation and Cardiac Rehabilitation Adherence: Study Protocol
Feasibility of a Facebook Intervention for Exercise Motivation and Cardiac Rehabilitation Adherence: Study Protocol Open
ClinicalTrials.gov NCT02971813; https://clinicaltrials.gov/ct2/show/NCT02971813 (Archived by WebCite at http://www.webcitation.org/6sRsz8Zpa).
View article: Primary Low Level of High-Density Lipoprotein Cholesterol and Risks of Coronary Heart Disease, Cardiovascular Disease, and Death: Results From the Multi-Ethnic Study of Atherosclerosis
Primary Low Level of High-Density Lipoprotein Cholesterol and Risks of Coronary Heart Disease, Cardiovascular Disease, and Death: Results From the Multi-Ethnic Study of Atherosclerosis Open
Prior studies observing associations between low levels of high-density lipoprotein (HDL) cholesterol and cardiovascular disease (CVD) have often been conducted among persons with metabolic or other lipid abnormalities. In this study, we i…
View article: Sex and Race-Ethnicity Secular Trends in Mean and Elevated Red Blood Cell Distribution Width Among Adults in the United States, 1999-2012
Sex and Race-Ethnicity Secular Trends in Mean and Elevated Red Blood Cell Distribution Width Among Adults in the United States, 1999-2012 Open
Objective: Red blood cell distribution width (RDW) has been shown to associate with increased risk of cardiovascular and non-cardiovascular death. To our knowledge, no study has examined secular trends in RDW over the last decade.Design: S…
View article: US Hypertension Management Guidelines: A Review of the Recent Past and Recommendations for the Future
US Hypertension Management Guidelines: A Review of the Recent Past and Recommendations for the Future Open
Target organ damage defined as albumin:creatinine ratio >200 mg/g
View article: <i>Propionibacterium acnes</i>: A Treatable Cause of Constrictive Pericarditis
<i>Propionibacterium acnes</i>: A Treatable Cause of Constrictive Pericarditis Open
In this case report we share a case of infective Pericarditis caused by Propionibacterium acnes ( P. acnes ) in an immune-competent, nonsurgical patient. This case and review will illustrate the importance of considering P. acnes as a caus…