Eyad Gadour
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View article: Pediatric liver transplant for maple syrup urine disease a single center experience
Pediatric liver transplant for maple syrup urine disease a single center experience Open
Introduction Maple syrup urine disease (MSUD) is an autosomal recessive inborn error of branched-chain amino acid metabolism caused by an inherited deficiency of branched-chain alpha-ketoacid dehydrogenase (BCKDH) activity that degrades is…
View article: Multiparametric Quantitative Ultrasound for Hepatic Steatosis: Comparison with CAP and Robustness Across Breathing States
Multiparametric Quantitative Ultrasound for Hepatic Steatosis: Comparison with CAP and Robustness Across Breathing States Open
Background: Practical, quantitative ultrasound-based tools for measuring hepatic steatosis are needed in everyday MASLD care. We evaluated a new multiparametric quantitative ultrasound (QUS) platform that integrates ultrasound-guided fat f…
View article: Assessing Quality of Life in Hepatitis C Patients: Improvements Following Direct-Acting Antiviral Therapy—A Single-Center Romanian Study
Assessing Quality of Life in Hepatitis C Patients: Improvements Following Direct-Acting Antiviral Therapy—A Single-Center Romanian Study Open
Background/Objectives: The Hepatitis C Virus (HCV) affects both physical health and overall well-being. The advent of direct-acting antivirals (DAAs) has greatly improved treatment outcomes. This study aimed to evaluate changes in quality …
View article: Efficacy and Safety of Non-Surgical Treatments for Pancreatic Neuroendocrine Tumors: A Systematic Review and Meta-Analysis
Efficacy and Safety of Non-Surgical Treatments for Pancreatic Neuroendocrine Tumors: A Systematic Review and Meta-Analysis Open
Background: Pancreatic neuroendocrine tumor (pNET) is a rare and complex disease that requires careful management and treatment. Currently, a range of treatments, including surgery, somatostatin analogs (SSA), peptide receptor radionuclide…
View article: Assessment of Intra-Individual Variability and Reproducibility in Pancreatic EUS-Guided Elastography
Assessment of Intra-Individual Variability and Reproducibility in Pancreatic EUS-Guided Elastography Open
Background: Shear-wave elastography (SWE) performed during endoscopic ultrasound (EUS) is a promising tool for quantifying pancreatic stiffness, but its intra-session reproducibility remains incompletely defined. Methods: In this prospecti…
View article: Gender disparities in hepatitis C treatment: A call for tailored approaches
Gender disparities in hepatitis C treatment: A call for tailored approaches Open
Considering the recent study by Dobrowolska et al , which investigated sex-related differences in treatment outcomes for chronic hepatitis C infection, this letter endorses the findings that highlight significant disparities between male a…
View article: Enhancing adenoma detection rates: The case for upgrading to advanced colonoscopy technology
Enhancing adenoma detection rates: The case for upgrading to advanced colonoscopy technology Open
A recent study by Nishizawa et al presented significant findings regarding the advantages of next-generation colonoscopes, specifically the CF-XZ1200 and CF-EZ1500 models, in enhancing the adenoma and sessile serrated lesion detection rate…
View article: Calcineurin inhibitor exposure and de novo malignancy risk in liver transplant recipients: a narrative review of dose-dependent effects, risk factors and minimisation strategies
Calcineurin inhibitor exposure and de novo malignancy risk in liver transplant recipients: a narrative review of dose-dependent effects, risk factors and minimisation strategies Open
This review examined the association between calcineurin inhibitor (CNI) exposure and de novo malignancy risk in liver transplant recipients. A comprehensive electronic search was conducted in PubMed, Medline and Cochrane Library until Apr…
View article: Efficacy and Safety of 1 L PEG-ASC Preparation for Colonoscopy in Patients with Inflammatory Bowel Diseases: A Multicenter Observational Study
Efficacy and Safety of 1 L PEG-ASC Preparation for Colonoscopy in Patients with Inflammatory Bowel Diseases: A Multicenter Observational Study Open
Background/Objectives: The effectiveness of 1 L PEG-ASC preparation in inflammatory bowel disease (IBD) patients is still unclear. The aim of this study was to determine the efficacy and safety of 1 L PEG-ASC in a series of IBD patients. M…
View article: Evolving role of endoscopic ultrasound in biliary stricture management: A meta-analysis and systematic review
Evolving role of endoscopic ultrasound in biliary stricture management: A meta-analysis and systematic review Open
BACKGROUND Endoscopic ultrasound (EUS) has evolved from a diagnostic tool to a management technique for various gastroenterological conditions, including biliary strictures. AIM To summarize the current evidence on EUS’s role in diagnosing…
View article: Diagnostic yield of video capsule endoscopy <i>vs</i> simple balloon enteroscopy in small intestinal disorders: A systematic review
Diagnostic yield of video capsule endoscopy <i>vs</i> simple balloon enteroscopy in small intestinal disorders: A systematic review Open
BACKGROUND Small-bowel disorders, including obscure gastrointestinal bleeding (OGIB), Crohn's disease, and tumors, require accurate diagnostic approaches for effective treatment. Video capsule endoscopy (VCE) and simple balloon enteroscopy…
View article: Gut-Microbiome Signatures Predicting Response to Neoadjuvant Chemoradiotherapy in Locally Advanced Rectal Cancer: A Systematic Review
Gut-Microbiome Signatures Predicting Response to Neoadjuvant Chemoradiotherapy in Locally Advanced Rectal Cancer: A Systematic Review Open
Background and Objectives: Rectal cancer management increasingly relies on watch-and-wait strategies after neoadjuvant chemoradiotherapy (nCRT). Accurate, non-invasive prediction of pathological complete response (pCR) remains elusive. Eme…
View article: Effects of the COVID-19 Pandemic and Post-Pandemic Changes on the Diagnosis, Treatment, and Mortality of Hepatocellular Carcinoma in a Tertiary Center in Western Romania
Effects of the COVID-19 Pandemic and Post-Pandemic Changes on the Diagnosis, Treatment, and Mortality of Hepatocellular Carcinoma in a Tertiary Center in Western Romania Open
Background/Objectives: Access to healthcare services was significantly restricted during the COVID-19 pandemic, leading to changes in the management of hepatocellular carcinoma (HCC). However, limited research has examined how these change…
View article: Efficacy and Safety of Novel Oral Anti-Cholestatic Agents for Primary Biliary Cholangitis: Meta-Analyses and Systematic Review
Efficacy and Safety of Novel Oral Anti-Cholestatic Agents for Primary Biliary Cholangitis: Meta-Analyses and Systematic Review Open
Background: Primary biliary cholangitis (PBC) is a chronic autoimmune liver disease characterized by progressive bile duct damage and cholestasis. While ursodeoxycholic acid (UDCA) is the first-line therapy, approximately 40% of patients h…
View article: Illuminating the black box: Machine learning enhances preoperative prediction in intrahepatic cholangiocarcinoma
Illuminating the black box: Machine learning enhances preoperative prediction in intrahepatic cholangiocarcinoma Open
The study by Huang et al , published in the World Journal of Gastroenterology , advances intrahepatic cholangiocarcinoma (ICC) management by developing a machine-learning model to predict textbook outcomes (TO) based on preoperative factor…
View article: Advancements in the diagnosis of biliopancreatic diseases: A comparative review and study on future insights
Advancements in the diagnosis of biliopancreatic diseases: A comparative review and study on future insights Open
Owing to the complex and often asymptomatic presentations, the diagnosis of biliopancreatic diseases, including pancreatic and biliary malignancies, remains challenging. Recent technological advancements have remarkably improved the diagno…
View article: Delayed Diagnosis and Evolving Trends in Gastric Cancer During and After COVID-19: A Comparative Study of Staging, Helicobacter pylori Infection and Bleeding Risk in Western Romania
Delayed Diagnosis and Evolving Trends in Gastric Cancer During and After COVID-19: A Comparative Study of Staging, Helicobacter pylori Infection and Bleeding Risk in Western Romania Open
Background and Objectives: Gastric cancer (GC) remains a leading cause of cancer mortality worldwide, and the COVID-19 pandemic posed new barriers in diagnosis and management. This study aimed to assess whether pandemic-related healthcare …
View article: Hepaticojejunostomy and long-term interventional treatment for recurrent biliary stricture after proximal bile duct injury: A case report
Hepaticojejunostomy and long-term interventional treatment for recurrent biliary stricture after proximal bile duct injury: A case report Open
BACKGROUND Proximal bile duct injury (BDI), which often occurs after laparoscopic cholecystectomy (LC), can lead to complex biliary stricture and recurrent cholangitis. This case report presented a 39-year-old woman who experienced proxima…
View article: Transjugular intrahepatic portosystemic shunt and non-selective beta-blockers act as friends or foe in decompensated cirrhosis: A comparative review
Transjugular intrahepatic portosystemic shunt and non-selective beta-blockers act as friends or foe in decompensated cirrhosis: A comparative review Open
The management of portal hypertension and its complications, such as variceal bleeding, in patients with cirrhosis often involves the use of nonselective beta-blockers (NSBBs) and a transjugular intrahepatic portosystemic shunt (TIPS). Bot…
View article: Comprehensive analysis of endoscopic ultrasound (EUS) in mediastinal lesions: patient characteristics, diagnostic outcomes, safety, and efficacy: a multi-country study
Comprehensive analysis of endoscopic ultrasound (EUS) in mediastinal lesions: patient characteristics, diagnostic outcomes, safety, and efficacy: a multi-country study Open
Background Mediastinal lesions are tumors that develop mainly from structures commonly located in the three compartments of the mediastinum and the paravertebral areas. The diagnosis of these lesions is primarily based on imaging studies s…
View article: Endoscopic ultrasound-guided radiofrequency ablation (EUS-RFA) and endoscopic ultrasound-guided ethanol ablation (EUS-EA) of pancreatic neuroendocrine tumors and adenocarcinoma: a prospective multicenter study
Endoscopic ultrasound-guided radiofrequency ablation (EUS-RFA) and endoscopic ultrasound-guided ethanol ablation (EUS-EA) of pancreatic neuroendocrine tumors and adenocarcinoma: a prospective multicenter study Open
EUS-RFA and EUS-EA can potentially treat lesions and control symptoms. EUS-RFA is a more promising and safer technique for managing functioning insulinomas. However, it cannot downstage pancreatic ductal adenocarcinoma patients. EUS-EA see…
View article: Lesson learnt from 60 years of liver transplantation: Advancements, challenges, and future directions
Lesson learnt from 60 years of liver transplantation: Advancements, challenges, and future directions Open
Over the past six decades, liver transplantation (LT) has evolved from an experimental procedure into a standardized and life-saving intervention, reshaping the landscape of organ transplantation. Driven by pioneering breakthroughs, techno…
View article: Gastric fundoplication with endoscopic technique: A novel approach for gastroesophageal reflux disease treatment
Gastric fundoplication with endoscopic technique: A novel approach for gastroesophageal reflux disease treatment Open
BACKGROUND Gastric fundoplication with endoscopic technique (GFET) is an innovative approach to managing gastroesophageal reflux disease (GERD). This minimally invasive procedure utilizes the GEN-2 Apollo endosuture device and Olympus H2T1…
View article: Mucosal immunity in upper and lower respiratory tract to MERS-CoV
Mucosal immunity in upper and lower respiratory tract to MERS-CoV Open
Introduction Middle East respiratory syndrome coronavirus (MERS-CoV) has emerged as a deadly pathogen with a mortality rate of up to 36.2%. MERS-CoV can cause severe respiratory tract disease and multiorgan failure. Therefore, therapeutic …
View article: Linear endoscopic ultrasound: Current uses and future perspectives in mediastinal examination
Linear endoscopic ultrasound: Current uses and future perspectives in mediastinal examination Open
This editorial elaborates on the current and future applications of linear endoscopic ultrasound (EUS), a substantial diagnostic and therapeutic modality for various anatomical regions. The scope of endosonographic assessment is broad and,…
View article: Outcomes in COVID-19 Patients with Acute Cholangitis: A Single-Center Retrospective Analysis
Outcomes in COVID-19 Patients with Acute Cholangitis: A Single-Center Retrospective Analysis Open
Background and Objectives: This study aimed to assess the impact of coronavirus disease 2019 (COVID-19) on patients with acute cholangitis (AC) by comparing outcomes, complications, and hospital stays in a tertiary Gastroenterology departm…
View article: Prospective Assessment of Serum Lipid Alterations in Chronic Hepatitis C Patients Treated with Direct Acting Antivirals: Insights Six Months Post Sustained Virological Response
Prospective Assessment of Serum Lipid Alterations in Chronic Hepatitis C Patients Treated with Direct Acting Antivirals: Insights Six Months Post Sustained Virological Response Open
Background and Objectives: Chronic hepatitis C virus (HCV) infection is intricately linked with dysregulation of lipid metabolism. In particular, cholesterol plays a crucial role in HCV replication. Direct-acting antiviral agents (DAAs) th…