M. Fabregate
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View article: Dynamics of urinary chloride and sodium and their link to decongestion in acute heart failure and preserved ejection fraction: NACLOCRo‐HF study
Dynamics of urinary chloride and sodium and their link to decongestion in acute heart failure and preserved ejection fraction: NACLOCRo‐HF study Open
Aims In acute heart failure (AHF), precise assessment of congestion is critical to guide therapy. Urinary sodium (uNa) and urinary chloride (uCl) have emerged as potential biomarkers to monitor decongestion, but their comparative trajector…
View article: New Developments in the Treatment of IgG4-Related Disease: A Comprehensive Clinical Approach
New Developments in the Treatment of IgG4-Related Disease: A Comprehensive Clinical Approach Open
Immunoglobulin G4–related disease (IgG4-RD) is an uncommon fibro-inflammatory process characterized by the infiltration of tissues and organs and a typically dramatic response to glucocorticoids. Its relapsing–remitting course, multisystem…
View article: Prognostic impact of C-reactive protein in elderly patients with acute heart failure and preserved ejection fraction: the modulating role of carbohydrate antigen 125
Prognostic impact of C-reactive protein in elderly patients with acute heart failure and preserved ejection fraction: the modulating role of carbohydrate antigen 125 Open
Aims The systemic inflammation in heart failure (HF) is a common process, even more evident in acute scenario. Elevated C-reactive protein (CRP) is typically linked to increased morbidity and mortality in both acute and chronic heart failu…
View article: Pulsatile Arterial Haemodynamic Effect on Renal Outcomes in Patients with Acute Heart Failure
Pulsatile Arterial Haemodynamic Effect on Renal Outcomes in Patients with Acute Heart Failure Open
Introduction: Haemodynamic changes in acute heart failure (AHF) are closely linked to renal function alterations. Pulse pressure (PP) may offer insights beyond mean arterial pressure in identifying patients with vulnerable renal function d…
View article: Genotype–Phenotype Relationship in Hereditary Hemorrhagic Telangiectasia: Quality of Life and Cardiovascular Risk Evaluation
Genotype–Phenotype Relationship in Hereditary Hemorrhagic Telangiectasia: Quality of Life and Cardiovascular Risk Evaluation Open
Hereditary hemorrhagic telangiectasia (HHT) is an autosomal dominant vascular disorder caused by pathogenic variants in ENG (HHT1) and ACVRL1 (HHT2), with distinct phenotypic expressions. Background/Objectives: This study investigates the …
View article: Advances in Gene Therapy for Rare Diseases: Targeting Functional Haploinsufficiency Through AAV and mRNA Approaches
Advances in Gene Therapy for Rare Diseases: Targeting Functional Haploinsufficiency Through AAV and mRNA Approaches Open
Most rare diseases (RDs) encompass a diverse group of inherited disorders that affect millions of people worldwide. A significant proportion of these diseases are driven by functional haploinsufficiency, which is caused by pathogenic genet…
View article: Effect of Encapsulated Purple Garlic Oil on Microvascular Function and the Components of Metabolic Syndrome: A Randomized Placebo-Controlled Study—The ENDOTALLIUM Study
Effect of Encapsulated Purple Garlic Oil on Microvascular Function and the Components of Metabolic Syndrome: A Randomized Placebo-Controlled Study—The ENDOTALLIUM Study Open
Endothelial dysfunction (ED) is associated with progressive changes contributing to clinical complications related to macro- and microvascular diseases. Garlic (Allium sativum L.) and its organosulfur components have been related to benefi…
View article: Loop diuretic down‐titration at discharge in patients hospitalized for acute heart failure
Loop diuretic down‐titration at discharge in patients hospitalized for acute heart failure Open
Aims The current literature provides limited guidance on the best diuretic strategy post‐hospitalization for acute heart failure (AHF). It is postulated that the efficacy and safety of the outpatient diuretic regimen may be significantly i…
View article: Trajectory of urine albumin-creatinine ratio in patients with acute heart failure (TACRAHF study)
Trajectory of urine albumin-creatinine ratio in patients with acute heart failure (TACRAHF study) Open
Introduction: Albuminuria is prevalent in patients with chronic heart failure and is a risk factor for disease progression. However, its clinical meaning in acute heart failure remains elusive. This study analyzed the trajectory of urine a…
View article: Prognostic significance of plasma chloride in elderly patients hospitalized for acute heart failure
Prognostic significance of plasma chloride in elderly patients hospitalized for acute heart failure Open
Aims Previous studies demonstrated the relationship between hypochloraemia and poor prognosis in patients hospitalized for acute heart failure (AHF). However, the usefulness of chloride in clinical practice remains uncertain, notably in ve…
View article: Usefulness of urinary potassium to creatinine ratio to predict diuretic response in patients with acute heart failure and preserved ejection fraction
Usefulness of urinary potassium to creatinine ratio to predict diuretic response in patients with acute heart failure and preserved ejection fraction Open
Background Patients with acute heart failure (AHF) require intensification in the diuretic strategy. However, the optimal diuretic strategy remains unclear. In this work, we aimed to evaluate the role of urinary potassium to creatinine rat…
View article: Oral Sodium Chloride in the Prevention of Contrast-Associated Acute Kidney Injury in Elderly Outpatients: The PNIC-Na Randomized Non-Inferiority Trial
Oral Sodium Chloride in the Prevention of Contrast-Associated Acute Kidney Injury in Elderly Outpatients: The PNIC-Na Randomized Non-Inferiority Trial Open
Objective: We aimed to test the non-inferiority of oral versus intravenous hydration in the incidence of contrast-associated acute kidney injury (CA-AKI) in elderly outpatients undergoing a contrast-enhanced computed tomography (CE-CT) sca…
View article: Efficacy and Safety of Anakinra Plus Standard of Care for Patients With Severe COVID-19
Efficacy and Safety of Anakinra Plus Standard of Care for Patients With Severe COVID-19 Open
Importance COVID-19 pneumonia is often associated with hyperinflammation. The efficacy and safety of anakinra in treating patients with severe COVID-19 pneumonia and hyperinflammation are still unclear. Objective To assess the efficacy and…
View article: Meta-DiSc 2.0: a web application for meta-analysis of diagnostic test accuracy data
Meta-DiSc 2.0: a web application for meta-analysis of diagnostic test accuracy data Open
Background Diagnostic evidence of the accuracy of a test for identifying a target condition of interest can be estimated using systematic approaches following standardized methodologies. Statistical methods for the meta-analysis of diagnos…
View article: Hereditary Hemorrhagic Telangiectasia: Genetics, Pathophysiology, Diagnosis, and Management
Hereditary Hemorrhagic Telangiectasia: Genetics, Pathophysiology, Diagnosis, and Management Open
Hereditary hemorrhagic telangiectasia is an inherited disease related to an alteration in angiogenesis, manifesting as cutaneous telangiectasias and epistaxis. As complications, it presents vascular malformations in organs such as the lung…
View article: Comparison of chlorthalidone and spironolactone as additional diuretic therapy in patients with acute heart failure and preserved ejection fraction
Comparison of chlorthalidone and spironolactone as additional diuretic therapy in patients with acute heart failure and preserved ejection fraction Open
Aims Patients with acute heart failure (AHF) require intensification in the diuretic strategy. However, the optimal diuretic strategy remains unclear. In this work, we aimed to evaluate the effect of chlorthalidone compared with spironolac…
View article: In-hospital mortality among immunosuppressed patients with COVID-19: Analysis from a national cohort in Spain
In-hospital mortality among immunosuppressed patients with COVID-19: Analysis from a national cohort in Spain Open
Background Whether immunosuppressed (IS) patients have a worse prognosis of COVID-19 compared to non-IS patients is not known. The aim of this study was to evaluate the clinical characteristics and outcome of IS patients hospitalized with …
View article: Predicting critical illness on initial diagnosis of COVID-19 based on easily obtained clinical variables: development and validation of the PRIORITY model
Predicting critical illness on initial diagnosis of COVID-19 based on easily obtained clinical variables: development and validation of the PRIORITY model Open
The PRIORITY model, based on easily obtained clinical information, had good discrimination and generalizability for identifying COVID-19 patients at risk of critical outcomes.
View article: Predicting critical illness on initial diagnosis of COVID-19 based on easily-obtained clinical variables: Development and validation of the PRIORITY model
Predicting critical illness on initial diagnosis of COVID-19 based on easily-obtained clinical variables: Development and validation of the PRIORITY model Open
Objectives Currently available COVID-19 prognostic models have focused on laboratory and radiological data obtained following admission. However, these tests are not available on initial assessment or in resource-limited settings. We aim t…
View article: An Unusual Amyloid Goiter in a 48-Year-Old Woman with Rheumatoid Arthritis, Secondary Amyloidosis and Renal Failure
An Unusual Amyloid Goiter in a 48-Year-Old Woman with Rheumatoid Arthritis, Secondary Amyloidosis and Renal Failure Open
Amyloid goiter (AG) is characterized by the presence of deposits of amyloid protein in the thyroid tissue in sufficient amounts to produce enlargement of the gland, accompanied by fat deposition or thyrolipomatosis. It can be seen in long-…