James M. Ford
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View article: PARP inhibitor and PRMT5 inhibitor synergy is independent of BRCA1/2 and MTAP status in breast cancer cells
PARP inhibitor and PRMT5 inhibitor synergy is independent of BRCA1/2 and MTAP status in breast cancer cells Open
PARP inhibitors have been approved for treating a subset of breast cancer patients harboring BRCA1/2 mutations. However, TNBC patients with wildtype BRCA1/2 have limited targeted therapeutic options. Dysregulation of protein arginine methy…
View article: Figure S3 from A Four Amino Acid Intracellular Motif of VISTA Blocks Growth Receptor Signaling in Cancer Cells to Induce Tumor Suppression
Figure S3 from A Four Amino Acid Intracellular Motif of VISTA Blocks Growth Receptor Signaling in Cancer Cells to Induce Tumor Suppression Open
Figure S3
View article: Figure S6 from A Four Amino Acid Intracellular Motif of VISTA Blocks Growth Receptor Signaling in Cancer Cells to Induce Tumor Suppression
Figure S6 from A Four Amino Acid Intracellular Motif of VISTA Blocks Growth Receptor Signaling in Cancer Cells to Induce Tumor Suppression Open
Figure S6
View article: Data from A Four Amino Acid Intracellular Motif of VISTA Blocks Growth Receptor Signaling in Cancer Cells to Induce Tumor Suppression
Data from A Four Amino Acid Intracellular Motif of VISTA Blocks Growth Receptor Signaling in Cancer Cells to Induce Tumor Suppression Open
V-domain immunoglobulin suppressor of T-cell activation (VISTA, VSIR) is a key immune checkpoint receptor under investigation as a target for cancer immunotherapy. However, a better understanding of the signaling mechanisms of VISTA is nee…
View article: Figure S4 from A Four Amino Acid Intracellular Motif of VISTA Blocks Growth Receptor Signaling in Cancer Cells to Induce Tumor Suppression
Figure S4 from A Four Amino Acid Intracellular Motif of VISTA Blocks Growth Receptor Signaling in Cancer Cells to Induce Tumor Suppression Open
Figure S4
View article: Figure S5 from A Four Amino Acid Intracellular Motif of VISTA Blocks Growth Receptor Signaling in Cancer Cells to Induce Tumor Suppression
Figure S5 from A Four Amino Acid Intracellular Motif of VISTA Blocks Growth Receptor Signaling in Cancer Cells to Induce Tumor Suppression Open
Figure S5
View article: Figure S2 from A Four Amino Acid Intracellular Motif of VISTA Blocks Growth Receptor Signaling in Cancer Cells to Induce Tumor Suppression
Figure S2 from A Four Amino Acid Intracellular Motif of VISTA Blocks Growth Receptor Signaling in Cancer Cells to Induce Tumor Suppression Open
Figure S2
View article: Figure S1 from A Four Amino Acid Intracellular Motif of VISTA Blocks Growth Receptor Signaling in Cancer Cells to Induce Tumor Suppression
Figure S1 from A Four Amino Acid Intracellular Motif of VISTA Blocks Growth Receptor Signaling in Cancer Cells to Induce Tumor Suppression Open
Figure S1
View article: Polyclonal origins of human premalignant colorectal lesions
Polyclonal origins of human premalignant colorectal lesions Open
Cancer is generally thought to be caused by expansion of a single mutant cell 1 . However, analyses of early colorectal cancer lesions suggest that tumors may instead originate from multiple, genetically distinct cell populations 2,3 . Det…
View article: PARP inhibitor and PRMT5 inhibitor synergy is independent of BRCA1/2 and MTAP status in breast cancer cells
PARP inhibitor and PRMT5 inhibitor synergy is independent of BRCA1/2 and MTAP status in breast cancer cells Open
Purpose : PARP inhibitors have been approved for treating a subset of breast cancer patients harboring BRCA1/2 mutations. However, TNBC patients with wildtype BRCA1/2 have limited targeted therapeutic options. Dysregulation of protein argi…
View article: A Four Amino Acid Intracellular Motif of VISTA Blocks Growth Receptor Signaling in Cancer Cells to Induce Tumor Suppression
A Four Amino Acid Intracellular Motif of VISTA Blocks Growth Receptor Signaling in Cancer Cells to Induce Tumor Suppression Open
V-domain immunoglobulin suppressor of T-cell activation (VISTA, VSIR) is a key immune checkpoint receptor under investigation as a target for cancer immunotherapy. However, a better understanding of the signaling mechanisms of VISTA is nee…
View article: A triple-punch approach: methionine restriction enhances combination inhibitors in brain metastatic triple-negative breast cancer
A triple-punch approach: methionine restriction enhances combination inhibitors in brain metastatic triple-negative breast cancer Open
Triple-negative breast cancer (TNBC), the most aggressive subtype of breast cancer, presents a clinical challenge in developing effective treatment options. In this issue of the JCI, Zeng et al. demonstrate a provocative and promising ther…
View article: A 20-feature radiomic signature of triple-negative breast cancer identifies patients at high risk of death
A 20-feature radiomic signature of triple-negative breast cancer identifies patients at high risk of death Open
A substantial proportion of patients with non-metastatic triple-negative breast cancer (TNBC) experience disease progression and death despite treatment. However, no tool currently exists to discriminate those at higher risk of death. To i…
View article: Epigenomic insights into extreme longevity in the world’s oldest terrestrial animal, Jonathan
Epigenomic insights into extreme longevity in the world’s oldest terrestrial animal, Jonathan Open
Giant tortoises exhibit exceptional longevity, often exceeding the human lifespan. To understand the genomic and epigenomic basis of their longevity, awe analyzed the DNA sequence and methylome of Jonathan, an Aldabra giant tortoise (Aldab…
View article: MDM2 inhibition is associated with the emergence of TP53-altered clonal hematopoiesis
MDM2 inhibition is associated with the emergence of TP53-altered clonal hematopoiesis Open
Murine double minute 2 (MDM2) inhibitors have shown promising activity in TP53-wild type tumors and are under active investigation across a spectrum of malignancies. Herein, we report a 51-year-old female with MDM2-amplified, TP53-wild typ…
View article: Breast Cancer MRI Screening of Patients After Multiplex Gene Panel Testing
Breast Cancer MRI Screening of Patients After Multiplex Gene Panel Testing Open
Importance Enhanced breast cancer screening with magnetic resonance imaging (MRI) is recommended to women with elevated risk of breast cancer, yet uptake of screening remains unclear after genetic testing. Objective To evaluate uptake of M…
View article: VISTA-induced tumor suppression by a four amino acid intracellular motif
VISTA-induced tumor suppression by a four amino acid intracellular motif Open
Summary VISTA is a key immune checkpoint receptor under investigation for cancer immunotherapy; however, its signaling mechanisms remain unclear. Here we identify a conserved four amino acid (NPGF) intracellular motif in VISTA that suppres…
View article: An eMERGEing definition of patient engagement in genetic counseling
An eMERGEing definition of patient engagement in genetic counseling Open
The concept of patient engagement has been widely studied for decades in the fields of medicine, nursing, psychology, social science, public health, and policy, and increased levels of patient engagement have been shown to improve health o…
View article: Single-cell spatial mapping reveals alteration of tissue microenvironment during early colorectal cancer
Single-cell spatial mapping reveals alteration of tissue microenvironment during early colorectal cancer Open
Summary Familial adenomatous polyposis (FAP) is a rare, hereditary syndrome that raises the risk of developing colorectal cancer (CRC). This disease model is well suited for studying the early stages of malignant transformation. Our spatia…
View article: Multiomic analysis of familial adenomatous polyposis reveals molecular pathways associated with early tumorigenesis
Multiomic analysis of familial adenomatous polyposis reveals molecular pathways associated with early tumorigenesis Open
Familial adenomatous polyposis (FAP) is a genetic disease causing hundreds of premalignant polyps in affected persons and is an ideal model to study transitions of early precancer states to colorectal cancer (CRC). We performed deep multio…
View article: Global loss of promoter–enhancer connectivity and rebalancing of gene expression during early colorectal cancer carcinogenesis
Global loss of promoter–enhancer connectivity and rebalancing of gene expression during early colorectal cancer carcinogenesis Open
Although three-dimensional (3D) genome architecture is crucial for gene regulation, its role in disease remains elusive. We traced the evolution and malignant transformation of colorectal cancer (CRC) by generating high-resolution chromati…
View article: Charting the Future: Using Chart Question-Answering for Scalable Evaluation of LLM-Driven Data Visualizations
Charting the Future: Using Chart Question-Answering for Scalable Evaluation of LLM-Driven Data Visualizations Open
We propose a novel framework that leverages Visual Question Answering (VQA) models to automate the evaluation of LLM-generated data visualizations. Traditional evaluation methods often rely on human judgment, which is costly and unscalable…
View article: Development and Validation of a Deep Learning Model for Prediction of Adult Physiological Deterioration
Development and Validation of a Deep Learning Model for Prediction of Adult Physiological Deterioration Open
BACKGROUND: Prediction-based strategies for physiologic deterioration offer the potential for earlier clinical interventions that improve patient outcomes. Current strategies are limited because they operate on inconsistent definitions of …
View article: Germline <i>CDH1</i> Variants and Lifetime Cancer Risk
Germline <i>CDH1</i> Variants and Lifetime Cancer Risk Open
Importance Approximately 1% to 3% of gastric cancers and 5% of lobular breast cancers are hereditary. Loss of function CDH1 gene variants are the most common gene variants associated with hereditary diffuse gastric cancer and lobular breas…
View article: Repurposing mebendazole against triple-negative breast cancer leptomeningeal disease
Repurposing mebendazole against triple-negative breast cancer leptomeningeal disease Open
Purpose Triple-negative breast cancer (TNBC) is an aggressive subtype that often metastasizes to the brain. Leptomeningeal disease (LMD), a devastating brain metastasis common in TNBC, has limited treatment options. We sought to test wheth…