Muhammad Farooq
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View article: Ex Vivo Protocol for Evaluating Anti-Schizont Activities and Phytochemical Analysis of Zingiber officinale Against Plasmodium falciparum
Ex Vivo Protocol for Evaluating Anti-Schizont Activities and Phytochemical Analysis of Zingiber officinale Against Plasmodium falciparum Open
The emergence of antimalarial drug resistance has spurred interest in the exploration of natural alternative therapeutic agents. This study aimed to optimise the ex vivo protocol for evaluating the anti-schizont activity of Zingiber offici…
View article: Phytochemical Characteristics, in-Vitro and in-Vivo Antioxidant Potentials of Ethyl acetate Fraction from Apple-ring acacia (Faidherbia albida (Delile) A. Chev.) Leaves Extract on Albino Rats
Phytochemical Characteristics, in-Vitro and in-Vivo Antioxidant Potentials of Ethyl acetate Fraction from Apple-ring acacia (Faidherbia albida (Delile) A. Chev.) Leaves Extract on Albino Rats Open
The objective of this paper as to investigate the phytochemical characteristics, in-vitro and in-vivo antioxidant potentials of ethyl acetate fraction from apple-ring acacia (Faidherbia albida (Delile) A. Chev.) Leaves Extract on Albino Ra…
View article: Digit regeneration is expedited in LG/J healer mice compared to SM/J non-healer mice
Digit regeneration is expedited in LG/J healer mice compared to SM/J non-healer mice Open
Limb loss resulting from disease or trauma affects an estimated 185,000 Americans annually, significantly reducing their quality of life. Consequently, successful attempts to regrow missing appendages could substantially improve the progno…
View article: Preparation and Assessment of Surface and Functional Properties of Protein Blends from Moringa oleifera and Monodora myristica Seeds
Preparation and Assessment of Surface and Functional Properties of Protein Blends from Moringa oleifera and Monodora myristica Seeds Open
Protein, an amphoteric macromolecule has proven to play important role in enhancing nutritive standard and product quality. Recently, research attention is been focused on the protein fraction implicit in underexploited biomass to address …
View article: Loss of periostin function impairs ligament fibroblast activity and facilitates <scp>ROS</scp> ‐mediated cellular senescence
Loss of periostin function impairs ligament fibroblast activity and facilitates <span>ROS</span> ‐mediated cellular senescence Open
Anterior cruciate ligament (ACL) injuries pose a significant challenge due to their limited healing potential, often resulting in premature arthritis. The factors and mechanisms contributing to this inadequate healing process remain elusiv…
View article: Application of novel method to withdrawal of thin film flow of a magnetohydrodynamic third grade fluid
Application of novel method to withdrawal of thin film flow of a magnetohydrodynamic third grade fluid Open
In this work, we examine thin film flow of a non-Newtonian third-grade fluid flowing on a vertical moving belt. The modelled differential equation is solved using the Homotopy perturbation method and the Optimal axillary functions method. …
View article: Distinct patterns of cytokines, chemokines, and growth factors in synovial fluid after ACL injury in comparison to osteoarthritis
Distinct patterns of cytokines, chemokines, and growth factors in synovial fluid after ACL injury in comparison to osteoarthritis Open
This study analyzed knee synovial fluid after anterior cruciate ligament (ACL) tear and in osteoarthritis (OA) to test the hypotheses that concentrations of cytokines, chemokines, and growth factors differ (a) by diagnosis and (b) after AC…
View article: Three decades of advancements in osteoarthritis research: insights from transcriptomic, proteomic, and metabolomic studies
Three decades of advancements in osteoarthritis research: insights from transcriptomic, proteomic, and metabolomic studies Open
Leveraging a multi-omics approach that integrates datasets from diverse molecular detection technologies, combined with patients' clinical and sociodemographic features, and molecular and regulatory networks, holds promise for identifying …
View article: DEVELOPMENTAL PARAMETERS OF TRILOCHAVARIANS (LEPIDOPTERA: BOMBYCIDAE); A PEST OF WEEPING FIG, FICUSBENJAMINA IN PAKISTAN
DEVELOPMENTAL PARAMETERS OF TRILOCHAVARIANS (LEPIDOPTERA: BOMBYCIDAE); A PEST OF WEEPING FIG, FICUSBENJAMINA IN PAKISTAN Open
The developmental parameters of Trilochavarianswere studied on weeping fig, Ficusbenjamina at 26°C ± 1.0 temperature and 65±5% relative humidity. The study showed that female laid 160-270 eggs in 2-6 layers on the dorsal side of the leaves…
View article: Innovative Strategies for the Control of Zoonotic Diseases by using Nanotechnology
Innovative Strategies for the Control of Zoonotic Diseases by using Nanotechnology Open
This book chapter focuses on novel innovative strategies for the prevention and treatment of various types of zoonotic diseases like viral, bacterial, fungal, parasitic, mycoplasma, protozoal and chlamydial infections.The treatment and dia…
View article: Glutamine metabolism modulates chondrocyte inflammatory response
Glutamine metabolism modulates chondrocyte inflammatory response Open
Osteoarthritis is the most common joint disease in the world with significant societal consequences but lacks effective disease-modifying interventions. The pathophysiology consists of a prominent inflammatory component that can be targete…
View article: Glutamine metabolism modulates chondrocyte inflammatory response
Glutamine metabolism modulates chondrocyte inflammatory response Open
Osteoarthritis is the most common joint disease in the world with significant societal consequences, but lacks effective disease modifying interventions. The pathophysiology consists of a prominent inflammatory component that can be target…
View article: Amelioration of Posttraumatic Osteoarthritis in Mice Using Intraarticular Silencing of Periostin via Nanoparticle‐Based Small Interfering RNA
Amelioration of Posttraumatic Osteoarthritis in Mice Using Intraarticular Silencing of Periostin via Nanoparticle‐Based Small Interfering RNA Open
Objective Recent evidence delineates an emerging role of periostin in osteoarthritis (OA), since its expression after knee injury is detrimental to the articular cartilage. We undertook this study to examine whether intraarticular (IA) kno…
View article: Peeping into the Emerging Threat of Novel Influenza D Virus: A Review
Peeping into the Emerging Threat of Novel Influenza D Virus: A Review Open
In 2011, a new virus was isolated from swine with influenza-like symptoms in Oklahoma, USA. Later in 2013, it was also evidenced in cattle, considered as its natural reservoir, elsewhere in the USA. This new virus has certain resemblance w…
View article: Additional file 1 of Periostin loss-of-function protects mice from post-traumatic and age-related osteoarthritis
Additional file 1 of Periostin loss-of-function protects mice from post-traumatic and age-related osteoarthritis Open
Additional file 1. Gene transcripts
View article: Association of Dietary Intake with Nutritional Status of School-Going Children (5-10 years) in District Charsadda
Association of Dietary Intake with Nutritional Status of School-Going Children (5-10 years) in District Charsadda Open
S chool-going age is the active growing stage of individual's life span ( UNICEF, 2003).This stage of life is vital for physical growth and mental development.Balanced diet, both in terms of dietary diversity, amount and all essential nutr…
View article: KIF26B Silencing Prevents Osseous Transdifferentiation of Progenitor/Stem Cells and Attenuates Ectopic Calcification in a Murine Model
KIF26B Silencing Prevents Osseous Transdifferentiation of Progenitor/Stem Cells and Attenuates Ectopic Calcification in a Murine Model Open
Ectopic calcification is an osteogenic process that leads to the formation of inappropriate bone within intra-articular soft tissues, often in response to injury or surgery. The molecular mechanisms governing this phenotype have yet to be …
View article: Gene Expression in Meniscal Tears at the Time of Arthroscopic Partial Meniscectomy Predicts the Progression of Osteoarthritis Within 6 Years of Surgery
Gene Expression in Meniscal Tears at the Time of Arthroscopic Partial Meniscectomy Predicts the Progression of Osteoarthritis Within 6 Years of Surgery Open
Background: While knees with meniscal tears are associated with a heightened risk of developing osteoarthritis (OA), it is difficult to predict which patients are at the greatest risk for OA. Gene signatures in menisci that are resected du…
View article: Distinct Pattern of Inflammation of Articular Cartilage and the Synovium in Early and Late Hip Femoroacetabular Impingement
Distinct Pattern of Inflammation of Articular Cartilage and the Synovium in Early and Late Hip Femoroacetabular Impingement Open
Background: The molecular mechanism of how femoroacetabular impingement (FAI) morphology leads to hip osteoarthritis (OA) is yet to be determined. The expression and location of inflammation-related molecules during early- and late-stage F…
View article: Micro-Clotting of Platelet-Rich Plasma Upon Loading in Hydrogel Microspheres Leads to Prolonged Protein Release and Slower Microsphere Degradation
Micro-Clotting of Platelet-Rich Plasma Upon Loading in Hydrogel Microspheres Leads to Prolonged Protein Release and Slower Microsphere Degradation Open
Platelet-rich plasma (PRP) is an autologous blood product that contains a variety of growth factors (GFs) that are released upon platelet activation. Despite some therapeutic potential of PRP in vitro, in vivo data are not convincing. Bolu…
View article: LDHA-mediated ROS generation in chondrocytes is a potential therapeutic target for osteoarthritis
LDHA-mediated ROS generation in chondrocytes is a potential therapeutic target for osteoarthritis Open
The contribution of inflammation to the chronic joint disease osteoarthritis (OA) is unclear, and this lack of clarity is detrimental to efforts to identify therapeutic targets. Here we show that chondrocytes under inflammatory conditions …
View article: Intraarticular Inflammation and Catabolic Markers in Femoroacetabular Impingement during Progression of Disease -comparison between early and late stage disease-
Intraarticular Inflammation and Catabolic Markers in Femoroacetabular Impingement during Progression of Disease -comparison between early and late stage disease- Open
Objectives: Femoroacetabular impingement (FAI) has been proposed as an etiologic factor in up to 50% of osteoarthritis hips (OA). Inflammation is thought to be one of the main initiators of hip OA, yet little is known about the location an…