Morten Gram Pedersen
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View article: Near-Hamiltonian dynamics and energy-like quantities of next-generation neural mass models
Near-Hamiltonian dynamics and energy-like quantities of next-generation neural mass models Open
Neural mass models describe the mean-field dynamics of populations of neurons. In this work we illustrate how fundamental ideas of physics, such as energy and conserved quantities, can be explored for such models. We show that time-rescali…
View article: On the role of L-type Ca<sup>2+</sup> and BK channels in a biophysical model of cartwheel interneurons
On the role of L-type Ca<sup>2+</sup> and BK channels in a biophysical model of cartwheel interneurons Open
Cartwheel interneurons (CWCs) in the auditory system exhibit a range of activity patterns relevant to auditory function and pathologies. Although experiments have shown how these patterns can vary across individual neurons and can change u…
View article: Single‐Cell Membrane Potential Stimulation and Recording by an Electrolyte‐Gated Organic Field‐Effect Transistor
Single‐Cell Membrane Potential Stimulation and Recording by an Electrolyte‐Gated Organic Field‐Effect Transistor Open
The reliable stimulation and recording of electrical activity in single cells by means of organic bio‐electronics will be an important milestone in developing new low‐cost and highly biocompatible medical devices. This paper demonstrates e…
View article: Modelling and analysis of cAMP-induced mixed-mode oscillations in cortical neurons: Critical roles of HCN and M-type potassium channels
Modelling and analysis of cAMP-induced mixed-mode oscillations in cortical neurons: Critical roles of HCN and M-type potassium channels Open
Cyclic AMP controls neuronal ion channel activity. For example hyperpolarization-activated cyclic nucleotide–gated (HCN) and M-type K + channels are activated by cAMP. These effects have been suggested to be involved in astrocyte control o…
View article: Geometric slow–fast analysis of a hybrid pituitary cell model with stochastic ion channel dynamics
Geometric slow–fast analysis of a hybrid pituitary cell model with stochastic ion channel dynamics Open
To obtain explicit understanding of the behavior of dynamical systems, geometrical methods and slow–fast analysis have proved to be highly useful. Such methods are standard for smooth dynamical systems and increasingly used for continuous,…
View article: Geometric slow-fast analysis of a hybrid pituitary cell model with stochastic ion channel dynamics
Geometric slow-fast analysis of a hybrid pituitary cell model with stochastic ion channel dynamics Open
To obtain explicit understanding of the behavior of dynamical systems, geometrical methods and slow-fast analysis have proved to be highly useful. Such methods are standard for smooth dynamical systems, and increasingly used for continuous…
View article: Modeling Doxorubicin Pharmacokinetics in Multiple Myeloma Suggests Mechanism of Drug Resistance
Modeling Doxorubicin Pharmacokinetics in Multiple Myeloma Suggests Mechanism of Drug Resistance Open
The proposed PK model, once integrated with DOXO pharmacodynamics, has the potential of allowing the study and the optimization of DOXO treatment strategies in MM.
View article: Modelling and analysis of cAMP-induced mixed-mode oscillations in cortical neurons: Critical roles of HCN and M-type potassium channels
Modelling and analysis of cAMP-induced mixed-mode oscillations in cortical neurons: Critical roles of HCN and M-type potassium channels Open
Cyclic AMP controls neuronal ion channel activity. For example hyperpolarizationactivated cyclic nucleotide–gated (HCN) and M-type K + channels are activated by cAMP. These effects have been suggested to be involved in astrocyte control of…
View article: Mixed-mode oscillations in coupled FitzHugh-Nagumo oscillators: blowup analysis of cusped singularities
Mixed-mode oscillations in coupled FitzHugh-Nagumo oscillators: blowup analysis of cusped singularities Open
In this paper, we use geometric singular perturbation theory and blowup, as our main technical tool, to study the mixed-mode oscillations (MMOs) that occur in two coupled FitzHugh-Nagumo units with symmetric and repulsive coupling. In part…
View article: Amplitude-modulated spiking as a novel route to bursting: Coupling-induced mixed-mode oscillations by symmetry breaking
Amplitude-modulated spiking as a novel route to bursting: Coupling-induced mixed-mode oscillations by symmetry breaking Open
Mixed-mode oscillations consisting of alternating small- and large-amplitude oscillations are increasingly well understood and are often caused by folded singularities, canard orbits, or singular Hopf bifurcations. We show that coupling be…
View article: Calcium Signaling in the Photodamaged Skin: In Vivo Experiments and Mathematical Modeling
Calcium Signaling in the Photodamaged Skin: In Vivo Experiments and Mathematical Modeling Open
The epidermis forms an essential barrier against a variety of insults. The overall goal of this study was to shed light not only on the effects of accidental epidermal injury, but also on the mechanisms that support laser skin resurfacing …
View article: Geometric Analysis of Mixed-mode Oscillations in a Model of Electrical Activity in Human Beta-cells
Geometric Analysis of Mixed-mode Oscillations in a Model of Electrical Activity in Human Beta-cells Open
Human pancreatic beta-cells may exhibit complex mixed-mode oscillatory electrical activity, which underlies insulin secretion. A recent biophysical model of human beta-cell electrophysiology can simulate such bursting behavior, but a mathe…
View article: Data-driven estimation of change points reveals correlation between face mask use and accelerated curtailing of the COVID-19 epidemic in Italy
Data-driven estimation of change points reveals correlation between face mask use and accelerated curtailing of the COVID-19 epidemic in Italy Open
Italy was the first Western country to be seriously affected by COVID-19, and the first to implement drastic measures, which have successfully curtailed the epidemic. To understand which containment measures altered disease dynamics, we es…
View article: A simple method to quantify country-specific effects of COVID-19 containment measures
A simple method to quantify country-specific effects of COVID-19 containment measures Open
Most of the world is currently fighting to limit the impact of the COVID-19 pandemic. Italy, the Western country with most COVID-19 related deaths, was the first to implement drastic containment measures in early March, 2020. Since then mo…
View article: Confronting COVID-19: Surging critical care capacity in Italy
Confronting COVID-19: Surging critical care capacity in Italy Open
Summary The current spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Europe threats Italian’s capacity and that of other national health systems to effectively respond to the needs of patients who require intensive…
View article: From Local to Global Modeling for Characterizing Calcium Dynamics and Their Effects on Electrical Activity and Exocytosis in Excitable Cells
From Local to Global Modeling for Characterizing Calcium Dynamics and Their Effects on Electrical Activity and Exocytosis in Excitable Cells Open
Electrical activity in neurons and other excitable cells is a result of complex interactions between the system of ion channels, involving both global coupling (e.g., via voltage or bulk cytosolic Ca2+ concentration) of the channels, and l…
View article: Calcium signaling and secretory granule pool dynamics underlie biphasic insulin secretion and its amplification by glucose: experiments and modeling
Calcium signaling and secretory granule pool dynamics underlie biphasic insulin secretion and its amplification by glucose: experiments and modeling Open
Glucose-stimulated insulin secretion from pancreatic β-cells is controlled by a triggering pathway that culminates in calcium influx and regulated exocytosis of secretory granules, and by a less understood amplifying pathway that augments …
View article: Explicit Theoretical Analysis of How the Rate of Exocytosis Depends on Local Control by Ca<sup>2+</sup> Channels
Explicit Theoretical Analysis of How the Rate of Exocytosis Depends on Local Control by Ca<sup>2+</sup> Channels Open
Hormones and neurotransmitters are released from cells by calcium-regulated exocytosis, and local coupling between Ca 2+ channels (CaVs) and secretory granules is a key factor determining the exocytosis rate. Here, we devise a methodology …
View article: Ca2+ channel clustering with insulin-containing granules is disturbed in type 2 diabetes
Ca2+ channel clustering with insulin-containing granules is disturbed in type 2 diabetes Open
Loss of first-phase insulin secretion is an early sign of developing type 2 diabetes (T2D). Ca2+ entry through voltage-gated L-type Ca2+ channels triggers exocytosis of insulin-containing granules in pancreatic β cells and is required for …
View article: CFTR is involved in the regulation of glucagon secretion in human and rodent alpha cells
CFTR is involved in the regulation of glucagon secretion in human and rodent alpha cells Open
Glucagon is the main counterregulatory hormone in the body. Still, the mechanism involved in the regulation of glucagon secretion from pancreatic alpha cells remains elusive. Dysregulated glucagon secretion is common in patients with Cysti…