Marta Giralt
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View article: Chaperone-mediated autophagy controls brown adipose tissue thermogenic activity
Chaperone-mediated autophagy controls brown adipose tissue thermogenic activity Open
Brown adipose tissue (BAT) protects against obesity, diabetes, and cardiovascular disease. During BAT activation, macroautophagy is inhibited, while chaperone-mediated autophagy (CMA) is induced, promoting thermogenic gene expression, adip…
View article: Adipose Tissue, at the Core of the Action of Incretin and Glucagon-Based Anti-Obesity Drugs
Adipose Tissue, at the Core of the Action of Incretin and Glucagon-Based Anti-Obesity Drugs Open
View article: Lipodystrophy in HIV: Evolving Challenges and Unresolved Questions
Lipodystrophy in HIV: Evolving Challenges and Unresolved Questions Open
The advent of effective antiretroviral therapy in the mid-1990s, which successfully prevented the progression to AIDS in people living with HIV (PLWH), was associated with the appearance of the so-called HIV-associated lipodystrophy. This …
View article: Acyl CoA-binding protein in brown adipose tissue acts as a negative regulator of adaptive thermogenesis
Acyl CoA-binding protein in brown adipose tissue acts as a negative regulator of adaptive thermogenesis Open
View article: OR30-01 Brown Adipose Tissue as an Endocrine Organ: Multiple-omics Analysis Identifies ACBP as a Novel Brown Adipokine Secreted in Response to Brown Fat Inactivation
OR30-01 Brown Adipose Tissue as an Endocrine Organ: Multiple-omics Analysis Identifies ACBP as a Novel Brown Adipokine Secreted in Response to Brown Fat Inactivation Open
A. Blasco-Roset: None. T.P. Quesada-López: None. F.J. Godoy-Nieto: None. C. Garcia-Beltran: None. M. Peyrou: None. C. Rupérez: None. A. Mestres-Arenas: None. J. Villarroya: None. M. Giralt: None. L. Ibáñez: None. A. Planavila: None. F. Vil…
View article: Metabolic, Mitochondrial, and Inflammatory Effects of Efavirenz, Emtricitabine, and Tenofovir Disoproxil Fumarate in Asymptomatic Antiretroviral-Naïve People with HIV
Metabolic, Mitochondrial, and Inflammatory Effects of Efavirenz, Emtricitabine, and Tenofovir Disoproxil Fumarate in Asymptomatic Antiretroviral-Naïve People with HIV Open
This study aimed to comprehensively assess the metabolic, mitochondrial, and inflammatory effects of first-line efavirenz, emtricitabine, and tenofovir disoproxil fumarate (EFV/FTC/TDF) single-tablet regimen (STR) relative to untreated asy…
View article: Ante un doble desafío: obesidad y cambio climático
Ante un doble desafío: obesidad y cambio climático Open
View article: The splicing factor SF3B1 is involved in brown adipocyte thermogenic activation
The splicing factor SF3B1 is involved in brown adipocyte thermogenic activation Open
The ability of alternative splicing mechanisms to control gene expression is increasingly being recognized as relevant for adipose tissue function. The expression of SF3B1, a key component of the SF3B complex directly involved in spliceoso…
View article: Divergent effects of the antiretroviral drugs, dolutegravir, tenofovir alafenamide, and tenofovir disoproxil fumarate, on human adipocyte function
Divergent effects of the antiretroviral drugs, dolutegravir, tenofovir alafenamide, and tenofovir disoproxil fumarate, on human adipocyte function Open
Combined antiretroviral therapy (cART) has been associated with increased body weight accompanied by metabolic alterations in people living with human immunodeficiency virus (PLWH). To gain insight into the combined effects of cART compone…
View article: Parkin depletion prevents the age-related alterations in the FGF21 system and the decline in white adipose tissue thermogenic function in mice
Parkin depletion prevents the age-related alterations in the FGF21 system and the decline in white adipose tissue thermogenic function in mice Open
Parkin is an ubiquitin‐E3 ligase that is involved in cellular mitophagy and was recently shown to contribute to controlling adipose tissue thermogenic plasticity. We found that Parkin expression is induced in brown (BAT) and white (WAT) ad…
View article: Adipose tissue plasticity in pheochromocytoma patients suggests a role of the splicing machinery in human adipose browning
Adipose tissue plasticity in pheochromocytoma patients suggests a role of the splicing machinery in human adipose browning Open
View article: Impact of maternal perinatal depression on the early neurodevelopment of the offspring
Impact of maternal perinatal depression on the early neurodevelopment of the offspring Open
View article: Adipose tissue plasticity in pheochromocytoma patients reveals a key role of the splicing machinery in human adipose browning
Adipose tissue plasticity in pheochromocytoma patients reveals a key role of the splicing machinery in human adipose browning Open
RNA-sequencing counts data from omental adipose tissue from control individuals (C1-3) and patients with pheochromocytoma (P1-4) for whole genes (genes-counts.tsv) and individual isoforms (isoform-counts.tsv). Additional details regarding …
View article: Adipose tissue plasticity in pheochromocytoma patients reveals a key role of the splicing machinery in human adipose browning
Adipose tissue plasticity in pheochromocytoma patients reveals a key role of the splicing machinery in human adipose browning Open
RNA-sequencing counts data from omental adipose tissue from control individuals (C1-3) and patients with pheochromocytoma (P1-4) for whole genes (genes-counts.tsv) and individual isoforms (isoform-counts.tsv). Additional details regarding …
View article: Differential effects of dolutegravir, bictegravir and raltegravir in adipokines and inflammation markers on human adipocytes
Differential effects of dolutegravir, bictegravir and raltegravir in adipokines and inflammation markers on human adipocytes Open
The INsTIs studied do not have a significant effect on human adipose cell differentiation but exert distinct effects on gene expression and secretion of adipokines and cytokines. These findings will help understand and manage the effects o…
View article: Downregulation of hepatic lipopolysaccharide binding protein improves lipogenesis-induced liver lipid accumulation
Downregulation of hepatic lipopolysaccharide binding protein improves lipogenesis-induced liver lipid accumulation Open
Circulating lipopolysaccharide-binding protein (LBP) is increased in individuals with liver steatosis. We aimed to evaluate the possible impact of liver LBP downregulation using lipid nanoparticle-containing chemically modified LBP small i…
View article: Sexual Dimorphism in Brown Adipose Tissue Activation and White Adipose Tissue Browning
Sexual Dimorphism in Brown Adipose Tissue Activation and White Adipose Tissue Browning Open
The present narrative review gathers the studies reported so far, addressing sex differences in the effects of cold exposure, feeding pattern and age on brown adipose tissue (BAT) thermogenesis and white adipose tissue (WAT) browning. In r…
View article: Downregulation of peripheral lipopolysaccharide binding protein impacts on perigonadal adipose tissue only in female mice
Downregulation of peripheral lipopolysaccharide binding protein impacts on perigonadal adipose tissue only in female mice Open
View article: Adipose tissue aging partially accounts for fat alterations in HIV lipodystrophy
Adipose tissue aging partially accounts for fat alterations in HIV lipodystrophy Open
Lipodystrophy is a major disturbance in people living with HIV-1 (PLWH). Several systemic alterations in PLWH are reminiscent of those that occur in ageing. It is unknown whether the lipodystrophy in PLWH is the consequence of accelerated …
View article: Increased Circulating Levels of Growth Differentiation Factor 15 in Association with Metabolic Disorders in People Living with HIV Receiving Combined Antiretroviral Therapy
Increased Circulating Levels of Growth Differentiation Factor 15 in Association with Metabolic Disorders in People Living with HIV Receiving Combined Antiretroviral Therapy Open
Objective: People living with HIV (PLWH) have an increased cardiovascular risk (CVR) owing to dyslipidemia, insulin resistance, metabolic syndrome, and HIV/combination antiretroviral therapy (cART)-associated lipodystrophy (HALS). Atherosc…
View article: Specific adipose tissue Lbp gene knockdown prevents diet-induced body weight gain, impacting fat accretion-related gene and protein expression
Specific adipose tissue Lbp gene knockdown prevents diet-induced body weight gain, impacting fat accretion-related gene and protein expression Open
View article: A Differential Pattern of Batokine Expression in Perivascular Adipose Tissue Depots From Mice
A Differential Pattern of Batokine Expression in Perivascular Adipose Tissue Depots From Mice Open
Depending on its anatomical placement, perivascular adipose tissue (PVAT) has been found to possess features more (e.g., aortic thoracic) or less (e.g., aortic abdominal) similar to brown/beige adipose tissue in mice, whereas PVAT surround…
View article: A virtual exchange between university students of Tourism and Business: connecting languages and cultures through a sustainable tourism project [TAPP-Virtual exchange]
A virtual exchange between university students of Tourism and Business: connecting languages and cultures through a sustainable tourism project [TAPP-Virtual exchange] Open
This paper examines a Virtual Exchange (VE) amongst 42 participants which took place with University of Limerick business students and Universidad of León tourism students. The primary aims of the VE were the development of disciplinary, l…
View article: FGF21 serum levels are related to insulin resistance, metabolic changes and obesity in Mexican people living with HIV (PLWH)
FGF21 serum levels are related to insulin resistance, metabolic changes and obesity in Mexican people living with HIV (PLWH) Open
Background Antiretroviral therapy has significantly improved prognosis in treatment against HIV infection, however, prolonged exposure is associated to cardiovascular diseases, lipodystrophy, type 2 diabetes, insulin resistance, metabolic …
View article: FGF15/19 is required for adipose tissue plasticity in response to thermogenic adaptations
FGF15/19 is required for adipose tissue plasticity in response to thermogenic adaptations Open
Enterokine FGF15/19 is a key factor required for adipose tissue plasticity in response to thermogenic adaptations.
View article: The kallikrein–kinin pathway as a mechanism for auto-control of brown adipose tissue activity
The kallikrein–kinin pathway as a mechanism for auto-control of brown adipose tissue activity Open
View article: Potential role of the melanocortin signaling system interference in the excess weight gain associated to some antiretroviral drugs in people living with HIV
Potential role of the melanocortin signaling system interference in the excess weight gain associated to some antiretroviral drugs in people living with HIV Open
View article: New insights into the secretory functions of brown adipose tissue
New insights into the secretory functions of brown adipose tissue Open
In recent years, an important secretory role of brown adipose tissue (BAT) has emerged, which is consistent, to some extent, with the earlier recognition of the important secretory role of white fat. The so-called brown adipokines or ‘bato…
View article: GPR120 controls neonatal brown adipose tissue thermogenic induction
GPR120 controls neonatal brown adipose tissue thermogenic induction Open
Adaptive induction of thermogenesis in brown adipose tissue (BAT) is essential for the survival of mammals after birth. We show here that G protein-coupled receptor protein 120 (GPR120) expression is dramatically induced after birth in mou…
View article: Parkin controls brown adipose tissue plasticity in response to adaptive thermogenesis
Parkin controls brown adipose tissue plasticity in response to adaptive thermogenesis Open