Marie Anne Gebara
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View article: Cognitive changes in older adults receiving pharmacotherapy for treatment-resistant depression: a secondary analysis of the OPTIMUM randomised controlled trial
Cognitive changes in older adults receiving pharmacotherapy for treatment-resistant depression: a secondary analysis of the OPTIMUM randomised controlled trial Open
The US National Institute of Mental Health and the Patient-Centered Outcomes Research Institute.
View article: Poor Sleep is Common in Treatment-Resistant Late-life Depression and Associated With Poorer Antidepressant Response: Findings From the OPTIMUM Clinical Trial
Poor Sleep is Common in Treatment-Resistant Late-life Depression and Associated With Poorer Antidepressant Response: Findings From the OPTIMUM Clinical Trial Open
Insufficient sleep is common in TRLLD and it is associated with poorer treatment response to antidepressants.
View article: GRIEF SYMPTOM PROFILES OF OLDER SPOUSES BEREAVED BY COVID-19
GRIEF SYMPTOM PROFILES OF OLDER SPOUSES BEREAVED BY COVID-19 Open
Many older adults lost their spouse or life partner to COVID-19. Despite the anticipated rise in the prevalence of prolonged grief disorder, the association between COVID-19 bereavement and symptoms of complicated (or pathological) grief i…
View article: Comparing Treatment Approaches for Older Adults with Treatment-Resistant Depression -- The OPTIMUM Study
Comparing Treatment Approaches for Older Adults with Treatment-Resistant Depression -- The OPTIMUM Study Open
How can people use the results?Older patients and their doctors can use these results when considering ways to treat treatment-resistant depression.To learn more about this project, visit www.pcori.org/Lenze481.PCORI identified treatment-r…
View article: Antidepressant Augmentation versus Switch in Treatment-Resistant Geriatric Depression
Antidepressant Augmentation versus Switch in Treatment-Resistant Geriatric Depression Open
In older adults with treatment-resistant depression, augmentation of existing antidepressants with aripiprazole improved well-being significantly more over 10 weeks than a switch to bupropion and was associated with a numerically higher in…
View article: Psychosocial interventions to improve adherence in depressed and anxious older adults prescribed antidepressant pharmacotherapy: a scoping review
Psychosocial interventions to improve adherence in depressed and anxious older adults prescribed antidepressant pharmacotherapy: a scoping review Open
Medication nonadherence in depressed and anxious older adults is prevalent and associated with non-response to antidepressant pharmacotherapy. Evidence-based options to improve medication adherence are limited in this population. To review…
View article: Geriatric considerations for collaborative care for depression in rural populations
Geriatric considerations for collaborative care for depression in rural populations Open
This editorial comments on the article by Renn et al in this issue.
View article: Sleep disturbances are among the risk factors associated with cognitive impairment
Sleep disturbances are among the risk factors associated with cognitive impairment Open
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View article: Illness Narratives and Preferences for Treatment among Older Veterans Living with Treatment-Resistant Depression and Insomnia
Illness Narratives and Preferences for Treatment among Older Veterans Living with Treatment-Resistant Depression and Insomnia Open
Background Despite the prevalence of comorbid late-life treatment-resistant depression (LLTRD) and insomnia in older adults, there is a gap in the literature describing patient factors, such as patients’ beliefs about their illnesses and p…
View article: Bypassing the Blues: Insomnia in the Depressed Post-Cabg Population
Bypassing the Blues: Insomnia in the Depressed Post-Cabg Population Open
Background Recovery from coronary artery bypass graft (CABG) surgery often is complicated by depression and insomnia, resulting in poorer health-related quality of life and clinical outcomes. We explored the relationships among depression,…
View article: Specific depressive symptoms predict remission to aripiprazole augmentation in late‐life treatment resistant depression
Specific depressive symptoms predict remission to aripiprazole augmentation in late‐life treatment resistant depression Open
Objective To identify which specific depressive symptoms predict remission to aripiprazole augmentation in late‐life treatment resistant depression. Methods This is a secondary analysis of data from a late‐life treatment resistant depressi…
View article: Subjective-Objective Sleep Discrepancy in Older Adults With MCI and Subsyndromal Depression
Subjective-Objective Sleep Discrepancy in Older Adults With MCI and Subsyndromal Depression Open
Background/Objectives: We investigated the prevalence and correlates of discrepancies between self-reported sleep quality (Pittsburgh Sleep Quality Index) and objective sleep efficiency (actigraphy) in older adults with mild cognitive impa…
View article: Self-reported obstructive sleep apnea is associated with nonresponse to antidepressant pharmacotherapy in late-life depression
Self-reported obstructive sleep apnea is associated with nonresponse to antidepressant pharmacotherapy in late-life depression Open
OSA may impair response to antidepressant pharmacotherapy in depressed older adults. Future studies of antidepressant response rates among depressed older adults with OSA should both prospectively diagnose OSA and monitor adherence to trea…