Glenn M. Chertow
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View article: Safety and Efficacy of Vadadustat Versus Darbepoetin Alfa for Chronic Kidney Disease–Related Anemia in Patients Receiving Dialysis by Baseline Erythropoiesis‐Stimulating Agent Dose
Safety and Efficacy of Vadadustat Versus Darbepoetin Alfa for Chronic Kidney Disease–Related Anemia in Patients Receiving Dialysis by Baseline Erythropoiesis‐Stimulating Agent Dose Open
Introduction Erythropoiesis‐stimulating agents (ESAs) and iron supplementation are standard treatments for chronic kidney disease (CKD)–related anemia. Targeting higher hemoglobin values in CKD increases cardiovascular risk. Whether the in…
View article: Risk factors for mortality in patients with kidney failure on hemodialysis identified by proteomic analysis of CRIC and PACE studies
Risk factors for mortality in patients with kidney failure on hemodialysis identified by proteomic analysis of CRIC and PACE studies Open
More than 50% of patients with kidney failure undergoing maintenance hemodialysis die within 5 years, a fate unexplained by traditional risk factors. To identify biological risk factors, we analyze 6287 circulating proteins and mortality i…
View article: Chronic Kidney Disease Progression in Patients with Two APOL1 Variants and Proteinuria from AASK, CRIC, and FSGS-CT
Chronic Kidney Disease Progression in Patients with Two APOL1 Variants and Proteinuria from AASK, CRIC, and FSGS-CT Open
Introduction. APOL1-mediated kidney disease is a genetic condition associated with two variants in the APOL1 gene. These variants significantly increase the risk of developing proteinuric chronic kidney disease (CKD) and are linked to more…
View article: #1770 AMPLITUDE, a Ph2/3 adaptive trial of inaxaplin in APOL1-mediated kidney disease
#1770 AMPLITUDE, a Ph2/3 adaptive trial of inaxaplin in APOL1-mediated kidney disease Open
Background and Aims Two variants in APOL1 drive progressive, proteinuric nephropathies called APOL1-mediated kidney disease (AMKD). Inaxaplin, an oral inhibitor of APOL1, reduced proteinuria by 47.6% in persons with 2 APOL1 variants and fo…
View article: #1502 Utilization of telemedicine for patients receiving in-center hemodialysis in the United States
#1502 Utilization of telemedicine for patients receiving in-center hemodialysis in the United States Open
Background and Aims In March 2020, responding to the COVID-19 pandemic, federal emergency waivers in the United States enabled kidney care providers (nephrologists and advanced practice providers) to substitute face-to-face in-center hemod…
View article: Effects of Dapagliflozin on Progression of CKD According to Different Rates of Pretrial eGFR Loss
Effects of Dapagliflozin on Progression of CKD According to Different Rates of Pretrial eGFR Loss Open
Key Points eGFR slope before a clinical trial may assist in selecting participants at risk of kidney outcomes in whom new therapies are needed. In a post hoc analysis of the Dapagliflozin and Prevention of Adverse Outcomes in Chronic Kidne…
View article: Efficacy and Safety of Baxdrostat in Participants with CKD and Uncontrolled Hypertension
Efficacy and Safety of Baxdrostat in Participants with CKD and Uncontrolled Hypertension Open
Key Points This phase 2 trial assessed baxdrostat, an aldosterone synthase inhibitor, in participants with CKD and uncontrolled hypertension. Baxdrostat showed placebo-corrected reduction in systolic BP of –8.1 (95% confidence interval –13…
View article: A Phase 2 Clinical Trial of Oxylanthanum Carbonate in Patients Receiving Maintenance Hemodialysis with Hyperphosphatemia
A Phase 2 Clinical Trial of Oxylanthanum Carbonate in Patients Receiving Maintenance Hemodialysis with Hyperphosphatemia Open
Key Points Oxylanthanum carbonate (OLC) was well tolerated with fewer than 10% of patients stopping treatment due to side effects. More than 90% of patients with hyperphosphatemia taking OLC achieved effective phosphate control. Two thirds…
View article: Sodium-Glucose Cotransporter 2 Inhibition and Hospitalizations in Patients with CKD
Sodium-Glucose Cotransporter 2 Inhibition and Hospitalizations in Patients with CKD Open
Key Points In this post hoc analysis of Canagliflozin and Renal Events in Diabetes with Established Nephropathy Clinical Evaluation, canagliflozin reduced the risk of first and subsequent all-cause hospitalization by 14%. Sodium-glucose co…
View article: Preoperative Dialysis Dose and Postoperative Outcomes in Patients Receiving Maintenance Hemodialysis
Preoperative Dialysis Dose and Postoperative Outcomes in Patients Receiving Maintenance Hemodialysis Open
Key Points Little is known about preoperative hemodialysis dosing for patients with ESKD. Among patients receiving maintenance hemodialysis, preoperative decreases in Kt/V urea were significantly associated with postoperative mortality. Th…
View article: Inhibition of Calcium Release-Activated Calcium (CRAC) channels to Treat Acute Kidney Injury: Design and Rationale of the KOURAGE study
Inhibition of Calcium Release-Activated Calcium (CRAC) channels to Treat Acute Kidney Injury: Design and Rationale of the KOURAGE study Open
Introduction: Patients with severe acute kidney injury (AKI) with associated acute hypoxemic respiratory failure (AHRF) experience poorer outcomes, including higher rates of in-hospital mortality, relative to patients with less severe AKI,…
View article: Cost-effectiveness of transplanting older candidates with acceptable quality deceased donor kidneys
Cost-effectiveness of transplanting older candidates with acceptable quality deceased donor kidneys Open
Importance Many acceptable quality deceased donor kidneys go unused every year. Older transplant candidates are more vulnerable to rapid health decline. Objective To assess the cost-effectiveness of increasing the rate of kidney transplant…
View article: Safety and Efficacy of Vadadustat for the Treatment of CKD-Related Anemia within and outside the United States
Safety and Efficacy of Vadadustat for the Treatment of CKD-Related Anemia within and outside the United States Open
Key Points Among patients with dialysis-dependent CKD, safety and efficacy of vadadustat and darbepoetin alfa in the United States and outside the United States were similar. Among US patients with non–dialysis-dependent CKD, safety outcom…
View article: Calcimimetic Prescriptions in Fee-for-Service Medicare Beneficiaries Undergoing Dialysis
Calcimimetic Prescriptions in Fee-for-Service Medicare Beneficiaries Undergoing Dialysis Open
Importance Calcimimetics are a mainstay of treatment for secondary hyperparathyroidism (sHPT), a ubiquitous condition in end-stage kidney disease (ESKD) associated with fractures, cardiovascular events, and mortality. In 2018, Medicare imp…
View article: Balancing Efficiency and Equity in Population-Wide CKD Screening
Balancing Efficiency and Equity in Population-Wide CKD Screening Open
Importance In the era of sodium-glucose cotransporter 2 (SGLT2) inhibitors, population-wide screening for chronic kidney disease (CKD) may provide good value, yet implications across racial and ethnic groups are unknown. Objective To evalu…
View article: Kidney Transplant Wait Times Under Waiting List Expansion Scenarios
Kidney Transplant Wait Times Under Waiting List Expansion Scenarios Open
Importance Kidney transplantation offers survival benefits and superior quality of life compared with maintenance dialysis for patients with end-stage kidney disease (ESKD), but it is limited to approximately 25 000 patients annually in th…
View article: Association of Diabetes with Heart Rate Variability during Hemodialysis
Association of Diabetes with Heart Rate Variability during Hemodialysis Open
Key Points Patients with diabetes on hemodialysis had 18% lower SD of the normal-to-normal R-R interval, a proxy for lower heart rate variability. The association of diabetes with intradialytic hypotension was not mediated by SD of the nor…
View article: Hemodynamics are associated with subsequent lumen remodeling and clinical maturation of hemodialysis arteriovenous fistula
Hemodynamics are associated with subsequent lumen remodeling and clinical maturation of hemodialysis arteriovenous fistula Open
The pathogenesis of arteriovenous fistula (AVF) maturation failure is unclear. We evaluated the associations of wall shear stress (WSS) with subsequent AVF remodeling and clinical maturation using regression models in this prospective coho…
View article: Combination Oxylanthanum Carbonate and Tenapanor Lowers Urinary Phosphate Excretion in Rats
Combination Oxylanthanum Carbonate and Tenapanor Lowers Urinary Phosphate Excretion in Rats Open
Key Points Combination therapy with oxylanthanum carbonate+tenapanor led to greater reductions in urinary phosphate excretion than either drug alone. We demonstrated dose-dependent and sizable reductions in urinary phosphate excretion in r…
View article: Estimating the Benefit of Transplant Over Dialysis in Candidates Over 55 Years
Estimating the Benefit of Transplant Over Dialysis in Candidates Over 55 Years Open
Key Points Older kidney transplant candidates experience a gain in life years from transplantation. More updated models using a contemporary cohort are needed to guide current clinical practice for older adults. The magnitude of gain in li…
View article: Hyperkalemia and the Risks of Adverse Cardiovascular Outcomes in Patients With Chronic Kidney Disease
Hyperkalemia and the Risks of Adverse Cardiovascular Outcomes in Patients With Chronic Kidney Disease Open
Background This real‐world evidence study compared risks of cardiovascular events in hospital settings among patients with chronic kidney disease (CKD) with and without hyperkalemia. Methods and Results Adults with CKD stages 3b/4 with and…