Kavumpurathu Raman Thankappan
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View article: The association of the age at type 2 diabetes onset with diabetes progression
The association of the age at type 2 diabetes onset with diabetes progression Open
ObjectiveTo examine whether age at type 2 diabetes onset impacts disease progression, assessed by changes in glycaemic control and clinical biomarkers during follow-up.Research Design and MethodsParticipants from the Kerala Diabetes Preven…
View article: The association of the age at type 2 diabetes onset with diabetes progression
The association of the age at type 2 diabetes onset with diabetes progression Open
ObjectiveTo examine whether age at type 2 diabetes onset impacts disease progression, assessed by changes in glycaemic control and clinical biomarkers during follow-up.Research Design and MethodsParticipants from the Kerala Diabetes Preven…
View article: Prevalence and Determinants of Depression Among Older Women in Thiruvananthapuram District, Kerala, India: A Community-Based Cross-Sectional Study
Prevalence and Determinants of Depression Among Older Women in Thiruvananthapuram District, Kerala, India: A Community-Based Cross-Sectional Study Open
Background Depression is common among older women and is shaped by various social, economic, and health-related factors. In Kerala, the rapidly aging population and distinct socio-cultural context may influence the prevalence and risk patt…
View article: Effect of nanoformulated copper/zinc superoxide dismutase on chronic ethanol-induced alterations in liver and adipose tissue
Effect of nanoformulated copper/zinc superoxide dismutase on chronic ethanol-induced alterations in liver and adipose tissue Open
View article: Nanoformulated copper/zinc superoxide dismutase exerts differential effects on glucose vs lipid homeostasis depending on the diet composition possibly via altered AMPK signaling
Nanoformulated copper/zinc superoxide dismutase exerts differential effects on glucose vs lipid homeostasis depending on the diet composition possibly via altered AMPK signaling Open
View article: Benchmarking progress in non-communicable diseases: a global analysis of cause-specific mortality from 2001 to 2019
Benchmarking progress in non-communicable diseases: a global analysis of cause-specific mortality from 2001 to 2019 Open
UK Medical Research Council, UK National Institute for Health and Care Research, and NCD Alliance.
View article: Hypertension Control Rate, Associated Factors, Facilitators, and Barriers in Kerala, India: A Mixed-Methods Study
Hypertension Control Rate, Associated Factors, Facilitators, and Barriers in Kerala, India: A Mixed-Methods Study Open
Introduction Comprehensive studies on the hypertension control rate are limited in India. We assessed the hypertension control rate, associated factors, facilitators, and barriers in Kerala, India. Methods We surveyed 256 hypertensive adul…
View article: Disconnected data: mHealth data systems and challenges for primary health care workers in India
Disconnected data: mHealth data systems and challenges for primary health care workers in India Open
View article: Bending the curve: Modeling the impact of reducing risk factors for noncommunicable diseases to control future health expenditures in Latin America and the Caribbean
Bending the curve: Modeling the impact of reducing risk factors for noncommunicable diseases to control future health expenditures in Latin America and the Caribbean Open
Addressing the World Health Organization’s noncommunicable disease (NCD) “best buys” is key to reducing the disease burden in Latin America and the Caribbean (LAC). Yet, the potential impact of addressing NCD risk factors on current health…
View article: Efficacy, immunogenicity, and safety of a next-generation mRNA-1283 COVID-19 vaccine compared with the mRNA-1273 vaccine (NextCOVE): results from a phase 3, randomised, observer-blind, active-controlled trial
Efficacy, immunogenicity, and safety of a next-generation mRNA-1283 COVID-19 vaccine compared with the mRNA-1273 vaccine (NextCOVE): results from a phase 3, randomised, observer-blind, active-controlled trial Open
View article: Prevalence and Factors Associated With Eating Disorder Risk Among College Students in Kerala, India: A Cross-Sectional Study
Prevalence and Factors Associated With Eating Disorder Risk Among College Students in Kerala, India: A Cross-Sectional Study Open
Introduction Unhealthy diets are a major contributor to the global burden of disease, with eating disorders (EDs) being among the most prevalent psychological disorders affecting youth worldwide. Despite their increasing recognition, there…
View article: Supplementary Figure S5 from Mucin 5AC Promotes Breast Cancer Brain Metastasis through cMET/CD44v6
Supplementary Figure S5 from Mucin 5AC Promotes Breast Cancer Brain Metastasis through cMET/CD44v6 Open
Supplementary Figure 5. MUC5AC silencing inhibits cMET and CD44v6 expression and Astrocytes induce MUC5AC expression in breast cancer cells. A-B. Western blots showing knockdown of MUC5AC in MDA-231BR HER2 (A) and MUC5AC knockout in HCC195…
View article: Supplementary Figure S6 from Mucin 5AC Promotes Breast Cancer Brain Metastasis through cMET/CD44v6
Supplementary Figure S6 from Mucin 5AC Promotes Breast Cancer Brain Metastasis through cMET/CD44v6 Open
Supplementary Figure 6. PLB1001 inhibit cMET and CD44v6 expression. A. Representative IHC images showing MUC5AC expression in G5-3 PDXs B. Representative fluorescence microscopy images showing GFP+ in G5-3 PDXs C. Representative IHC images…
View article: Supplementary Figure S4 from Mucin 5AC Promotes Breast Cancer Brain Metastasis through cMET/CD44v6
Supplementary Figure S4 from Mucin 5AC Promotes Breast Cancer Brain Metastasis through cMET/CD44v6 Open
Supplementary Figure 4. MUC5AC silencing inhibits brain metastasis. A. Fluorescence microscopy images showing Cytokeratin 8/18 and MUC5AC in the brain tissue sections of the mice intracardially injected with shSCR and shMUC5AC KD MDA-231BR…
View article: Data from Mucin 5AC Promotes Breast Cancer Brain Metastasis through cMET/CD44v6
Data from Mucin 5AC Promotes Breast Cancer Brain Metastasis through cMET/CD44v6 Open
Purpose:Breast cancer brain metastasis remains a significant clinical problem. Mucins have been implicated in metastasis; however, whether they are also involved in breast cancer brain metastasis remains unknown. We queried databases of pa…
View article: Supplementary Figure S1 from Mucin 5AC Promotes Breast Cancer Brain Metastasis through cMET/CD44v6
Supplementary Figure S1 from Mucin 5AC Promotes Breast Cancer Brain Metastasis through cMET/CD44v6 Open
Supplementary Figure 1. Expression of MUC5AC is high in breast cancer brain metastasis. A. Heatmap showing the expression of upregulated genes in BC BrM cells as compared to primary BC cells (MDA-231BR vs MDA-231P). B. Comparison of MUC5AC…
View article: Supplementary Figure S2 from Mucin 5AC Promotes Breast Cancer Brain Metastasis through cMET/CD44v6
Supplementary Figure S2 from Mucin 5AC Promotes Breast Cancer Brain Metastasis through cMET/CD44v6 Open
Supplementary Figure 2. MUC5AC IHC staining using Aperio Digital Imaging revealed MUC5AC strong to medium scores in BrM patient samples. Tumor areas were defined by annotations (green color) and necrotic areas or areas not corresponding to…
View article: Supplementary Figure S3 from Mucin 5AC Promotes Breast Cancer Brain Metastasis through cMET/CD44v6
Supplementary Figure S3 from Mucin 5AC Promotes Breast Cancer Brain Metastasis through cMET/CD44v6 Open
Supplementary Figure 3. MUC5AC promotes brain metastasis. A. Western blot for HER2 expression in MDA-231BR HER2 cells. B. Western blot showing knockout of MUC5AC in the HCC1954BR cells. C-F. Wound healing assay and quantification showing r…
View article: Attainment of Global Diabetes Targets in 2021: A Pooled Analysis of Individual-Level Data from National Surveys in 100 Low-, Middle-, and High-Income Countries
Attainment of Global Diabetes Targets in 2021: A Pooled Analysis of Individual-Level Data from National Surveys in 100 Low-, Middle-, and High-Income Countries Open
View article: Tracheostomy in Pediatric Otolaryngology: A Clinical Audit of 30 Consecutive Cases
Tracheostomy in Pediatric Otolaryngology: A Clinical Audit of 30 Consecutive Cases Open
Introduction: Pediatric tracheostomy is a vital airway intervention performed for conditions such as airway obstruction, neuromuscular weakness, or prolonged ventilation. The procedure poses unique challenges due to pediatric anatomical di…
View article: Varied Clinical Features and Outcomes of Autoimmune Encephalitis: A Retrospective Case Series
Varied Clinical Features and Outcomes of Autoimmune Encephalitis: A Retrospective Case Series Open
Patients with AE need to be diagnosed early because prompt immunosuppressive therapy effectively reduces morbidity and mortality. A detailed history, clinical examinations, and relevant investigations are required. Mild and atypical forms …
View article: A Cross-Sectional Study of the Prevalence and Determinants of Formula-Feeding Practices by Mothers in a Sub-district of Kerala, India
A Cross-Sectional Study of the Prevalence and Determinants of Formula-Feeding Practices by Mothers in a Sub-district of Kerala, India Open
View article: Prevalence and Determinants of Postnatal Depression in Ernakulam District, India: A Cross-Sectional Study
Prevalence and Determinants of Postnatal Depression in Ernakulam District, India: A Cross-Sectional Study Open
View article: Comparative Efficacy of Antipsychotic Medication for Stereotypic Behavior in Autism Spectrum Disorder: A Systematic Review and Meta-analysis
Comparative Efficacy of Antipsychotic Medication for Stereotypic Behavior in Autism Spectrum Disorder: A Systematic Review and Meta-analysis Open
Background: Stereotypic movements in autism form core symptoms under the rubric of repetitive and restricted patterns of behavior. Aim: The systematic review was aimed to find which antipsychotic has better efficacy in treating stereotypic…
View article: Caregiver burden and quality of life in palliative care: cross-sectional study
Caregiver burden and quality of life in palliative care: cross-sectional study Open
Background Literature on caregiver burden is limited in India and Kerala. We examined the prevalence and factors associated with caregiver burden and its impact on their quality of life. Methods We conducted a cross-sectional study among 1…
View article: Worldwide trends in diabetes prevalence and treatment from 1990 to 2022: a pooled analysis of 1108 population-representative studies with 141 million participants
Worldwide trends in diabetes prevalence and treatment from 1990 to 2022: a pooled analysis of 1108 population-representative studies with 141 million participants Open
View article: Menstrual Hygiene Management and Reproductive Morbidity among Women Tea Plantation Workers in Wayanad District, Kerala, India
Menstrual Hygiene Management and Reproductive Morbidity among Women Tea Plantation Workers in Wayanad District, Kerala, India Open
A BSTRACT Background: There is a lack of studies focusing on menstrual hygiene management in the workplace, particularly in the informal sector where such facilities are insufficient or even absent. This study investigated menstrual hygien…
View article: High Prevalence of Work-Related Musculoskeletal Disorders Among Dentists: A Cross-Sectional Study From Kerala, India
High Prevalence of Work-Related Musculoskeletal Disorders Among Dentists: A Cross-Sectional Study From Kerala, India Open
Despite the high prevalence of MSD among dentists, more than three-fourths reported good or excellent work ability. Implementing mandatory ergonomic assessments and interventions in dental workplaces may help reduce MSD among dentists.
View article: Adjusting for quality of care in primary health care utilization and benefits in Bihar, India: A benefit incidence analysis
Adjusting for quality of care in primary health care utilization and benefits in Bihar, India: A benefit incidence analysis Open
View article: A rigorous multi-laboratory study of known PDAC biomarkers identifies increased sensitivity and specificity over CA19-9 alone
A rigorous multi-laboratory study of known PDAC biomarkers identifies increased sensitivity and specificity over CA19-9 alone Open