M. Graciela Pucciarelli
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View article: Rli51 Attenuates Transcription of the Listeria Pathogenicity Island 1 Gene mpl and Functions as a Trans-Acting sRNA in Intracellular Bacteria
Rli51 Attenuates Transcription of the Listeria Pathogenicity Island 1 Gene mpl and Functions as a Trans-Acting sRNA in Intracellular Bacteria Open
Listeria pathogenicity island 1 (LIPI-1) is a genetic region containing a cluster of genes essential for virulence of the bacterial pathogen Listeria monocytogenes. Main virulence factors in LIPI-1 include long 5′ untranslated regions (5′U…
View article: Experimental evidence of <scp>d</scp> ‐glutamate racemase activity in the uncultivated bacterium <i>Candidatus Saccharimonas aalborgensis</i>
Experimental evidence of <span>d</span> ‐glutamate racemase activity in the uncultivated bacterium <i>Candidatus Saccharimonas aalborgensis</i> Open
The Candidate Phyla Radiation (CPR) encompasses widespread uncultivated bacteria with reduced genomes and limited metabolic capacities. Most CPR bacteria lack the minimal set of enzymes required for peptidoglycan (PG) synthesis, leaving it…
View article: Acid stress signals are integrated into the σB-dependent general stress response pathway via the stressosome in the food-borne pathogen Listeria monocytogenes
Acid stress signals are integrated into the σB-dependent general stress response pathway via the stressosome in the food-borne pathogen Listeria monocytogenes Open
The general stress response (GSR) in Listeria monocytogenes plays a critical role in the survival of this pathogen in the host gastrointestinal tract. The GSR is regulated by the alternative sigma factor B (σ B ), whose role in protection …
View article: Peptidoglycan editing in non-proliferating intracellular Salmonella as source of interference with immune signaling
Peptidoglycan editing in non-proliferating intracellular Salmonella as source of interference with immune signaling Open
Salmonella enterica causes intracellular infections that can be limited to the intestine or spread to deeper tissues. In most cases, intracellular bacteria show moderate growth. How these bacteria face host defenses that recognize peptidog…
View article: Acid stress signals are integrated into the σ<sup>B</sup>-dependent general stress response pathway via the stressosome in the food-borne pathogen <i>Listeria monocytogenes</i>
Acid stress signals are integrated into the σ<sup>B</sup>-dependent general stress response pathway via the stressosome in the food-borne pathogen <i>Listeria monocytogenes</i> Open
The general stress response (GSR) in Listeria monocytogenes plays a critical role in the survival of this pathogen in the host gastrointestinal tract. The GSR is regulated by the alternative sigma factor B (σ B ), whose role in protection …
View article: Pathogenicity and virulence of<i>Listeria monocytogenes</i>: A trip from environmental to medical microbiology
Pathogenicity and virulence of<i>Listeria monocytogenes</i>: A trip from environmental to medical microbiology Open
Listeria monocytogenes is a saprophytic gram-positive bacterium, and an opportunistic foodborne pathogen that can produce listeriosis in humans and animals. It has evolved an exceptional ability to adapt to stress conditions encountered in…
View article: Balance between bacterial extracellular matrix production and intramacrophage proliferation by a <i>Salmonella</i>‐specific SPI‐2‐encoded transcription factor
Balance between bacterial extracellular matrix production and intramacrophage proliferation by a <i>Salmonella</i>‐specific SPI‐2‐encoded transcription factor Open
Biosynthesis and secretion of a complex extracellular matrix (EM) is a hallmark of Salmonella biofilm formation, impacting on its relationship with both the environment and the host. Cellulose is a major component of Salmonella EM. It is c…
View article: Activation of the Listeria monocytogenes Stressosome in the Intracellular Eukaryotic Environment
Activation of the Listeria monocytogenes Stressosome in the Intracellular Eukaryotic Environment Open
The response to stress mediated by the alternative sigma factor SigB has been extensively characterized in Bacillus subtilis and Listeria monocytogenes . These bacteria sense stress using a supramacromolecular complex, the stressosome, whi…
View article: Balance between extracellular matrix production and macrophage survival by a<i>Salmonella</i>-specific SPI-2 encoded transcription factor
Balance between extracellular matrix production and macrophage survival by a<i>Salmonella</i>-specific SPI-2 encoded transcription factor Open
Cellulose is a major component of the Salmonella biofilm extracellular matrix and it is considered an antivirulence factor because it interferes with Salmonella survival inside macrophages and virulence in mice. Its synthesis is stimulated…
View article: A Novel Salmonella Periplasmic Protein Controlling Cell Wall Homeostasis and Virulence
A Novel Salmonella Periplasmic Protein Controlling Cell Wall Homeostasis and Virulence Open
Horizontal gene transfer has shaped the evolution of Salmonella enterica as pathogen. Some functions acquired by this mechanism include enzymes involved in peptidoglycan (PG) synthesis and remodeling. Here, we report a novel serovar Typhim…
View article: Structure-based analyses of<i>Salmonella</i>RcsB variants unravel new features of the Rcs regulon
Structure-based analyses of<i>Salmonella</i>RcsB variants unravel new features of the Rcs regulon Open
RcsB is a transcriptional regulator that controls expression of numerous genes in enteric bacteria. RcsB accomplishes this role alone or in combination with auxiliary transcriptional factors independently or dependently of phosphorylation.…
View article: Impact of osmotic stress on the phosphorylation and subcellular location of Listeria monocytogenes stressosome proteins
Impact of osmotic stress on the phosphorylation and subcellular location of Listeria monocytogenes stressosome proteins Open
Listeria monocytogenes responds to environmental stress using a supra-macromolecular complex, the stressosome, to activate the stress sigma factor SigB. The stressosome structure, inferred from in vitro -assembled complexes, consists of th…
View article: Two distinct penicillin binding proteins promote cell division in different Salmonella lifestyles
Two distinct penicillin binding proteins promote cell division in different Salmonella lifestyles Open
The bacterial cell wall preserves cell integrity in response to external insults and the internal turgor pressure. The major component of the cell wall is the peptidoglycan (PG); a giant macromolecule formed by glycan chains cross-linked b…
View article: A Specialized Peptidoglycan Synthase Promotes <i>Salmonella</i> Cell Division inside Host Cells
A Specialized Peptidoglycan Synthase Promotes <i>Salmonella</i> Cell Division inside Host Cells Open
Bacterial cell division has been studied extensively under laboratory conditions. Despite being a key event in the bacterial cell cycle, cell division has not been explored in vivo in bacterial pathogens interacting with their hosts. We di…
View article: A Disulfide Bond in the Membrane Protein IgaA Is Essential for Repression of the RcsCDB System
A Disulfide Bond in the Membrane Protein IgaA Is Essential for Repression of the RcsCDB System Open
IgaA is an integral inner membrane protein that was discovered as repressor of
\nthe RcsCDB phosphorelay system in the intracellular pathogen Salmonella enterica
\nserovar Typhimurium. The RcsCDB system, conserved in many members of the fa…
View article: Within-Host Envelope Remodelling and its Impact in Bacterial Pathogen Recognition
Within-Host Envelope Remodelling and its Impact in Bacterial Pathogen Recognition Open
Following colonization of host tissues, bacterial pathogens encounter new niches in which they must gain access to nutrients and cope with stresses and defence signals generated by the host. For some pathogens, the adaptation to a new 'wit…
View article: <i>Salmonella</i> Intracellular Lifestyles and Their Impact on Host-to-Host Transmission
<i>Salmonella</i> Intracellular Lifestyles and Their Impact on Host-to-Host Transmission Open
More than a century ago, infections by Salmonella were already associated with foodborne enteric diseases with high morbidity in humans and cattle. Intestinal inflammation and diarrhea are hallmarks of infections caused by nontyphoidal Sal…
View article: RNA-Seq unveils new attributes of the heterogeneous <i>Salmonella</i>-host cell communication
RNA-Seq unveils new attributes of the heterogeneous <i>Salmonella</i>-host cell communication Open
High-throughput RNA sequencing (RNA-Seq) has uncovered hundreds of small RNAs and complex modes of RNA regulation in every bacterium analyzed to date. This complexity agrees with the adaptability of most bacteria to varied environments inc…
View article: <i>Listeria monocytogenes</i>encodes a functional ESX-1 secretion system whose expression is detrimental to<i>in vivo</i>infection
<i>Listeria monocytogenes</i>encodes a functional ESX-1 secretion system whose expression is detrimental to<i>in vivo</i>infection Open
Bacterial pathogenicity deeply depends on the ability to secrete virulence factors that bind specific targets on host cells and manipulate host responses. The Gram-positive bacterium Listeria monocytogenes is a human foodborne pathogen tha…