Alfred M. Handler
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View article: Abiotic conditions can modify the penetrance of transgene-based lethality systems for insect population control
Abiotic conditions can modify the penetrance of transgene-based lethality systems for insect population control Open
Modern genetic biocontrol techniques for insect pest management, when compared to chemical insecticide spraying, offer high species specificity and reduced environmental impact, and some of these methods require the environmental release o…
View article: Gut commensal bacteria-derived methionine is required for host reproduction by modulating RNA m6A methylation of the insulin receptor
Gut commensal bacteria-derived methionine is required for host reproduction by modulating RNA m6A methylation of the insulin receptor Open
Gut commensal bacteria promote host reproduction by modulating metabolism and nutrition, but the molecular mechanisms by which microbes regulate reproduction remain unclear. Here, we show that gut commensal bacteria promote host reproducti…
View article: CRISPR/Cas9-mediated mutagenesis of the <i>white-eye</i> gene in the tephritid pest <i>Bactrocera zonata</i>
CRISPR/Cas9-mediated mutagenesis of the <i>white-eye</i> gene in the tephritid pest <i>Bactrocera zonata</i> Open
Bactrocera zonata is a highly invasive agricultural pest that causes extensive damage to fruit crops. The Sterile Insect Technique (SIT), a species-specific and environmentally friendly pest control method, depends on the availability of G…
View article: Abiotic environments can modify the penetrance of a transgene-based lethality system for genetic biocontrol of insect populations
Abiotic environments can modify the penetrance of a transgene-based lethality system for genetic biocontrol of insect populations Open
Genetic biocontrol approaches to insect pest management offer high species specificity and reduce insecticidal chemical pollution, but these approaches require the release of genetically modified organisms that must perform across a variet…
View article: Gut Commensal Bacteria-Derived Methionine is Required for Host Reproduction by Modulating RNA m6A Methylation of the Insulin Receptor
Gut Commensal Bacteria-Derived Methionine is Required for Host Reproduction by Modulating RNA m6A Methylation of the Insulin Receptor Open
Gut commensal bacteria promote host reproduction by modulating metabolism and nutrition, yet the molecular mechanisms by which microbes modulate reproduction remain unclear. Here, we show that gut commensal bacteria promote host reproducti…
View article: Mitochondrial superoxide dismutase overexpression and low oxygen conditioning hormesis improve the performance of irradiated sterile males
Mitochondrial superoxide dismutase overexpression and low oxygen conditioning hormesis improve the performance of irradiated sterile males Open
The Sterile Insect Technique (SIT) is a successful autocidal control method that uses ionizing radiation to sterilize insects. However, irradiation in normal atmospheric conditions can be damaging for males, because irradiation generates s…
View article: Combining Enzymatic Antioxidant Overexpression and Short-term Low Oxygen Conditioning Hormesis to Improve Performance of Gamma-irradiated Anastrepha Suspensa Males
Combining Enzymatic Antioxidant Overexpression and Short-term Low Oxygen Conditioning Hormesis to Improve Performance of Gamma-irradiated Anastrepha Suspensa Males Open
The Sterile Insect Technique (SIT) is a successful autocidal control method that uses ionizing radiation to sterilize insects. Unfortunately, irradiation in normal atmospheric conditions can be damaging for males, because it generates subs…
View article: The hAT-family transposable element, hopper, from Bactrocera dorsalis is a functional vector for insect germline transformation
The hAT-family transposable element, hopper, from Bactrocera dorsalis is a functional vector for insect germline transformation Open
Background The hopper hAT -family transposable element isolated from the Oriental fruit fly, Bactrocera dorsalis , is distantly related to both the Drosophila hobo element and the Activator element from maize. The original 3120 bp hopper B…
View article: Genetic breakdown of a Tet-off conditional lethality system for insect population control
Genetic breakdown of a Tet-off conditional lethality system for insect population control Open
Genetically modified conditional lethal strains have been created to improve the control of insect pest populations damaging to human health and agriculture. However, understanding the potential for the genetic breakdown of lethality syste…
View article: Transcriptome Analysis of the Oriental Fruit Fly Bactrocera dorsalis Early Embryos
Transcriptome Analysis of the Oriental Fruit Fly Bactrocera dorsalis Early Embryos Open
The oriental fruit fly, Bactrocera dorsalis (Hendel), is one of the most devastating and highly invasive agricultural pests world-wide, resulting in severe economic loss. Thus, it is of great interest to understand the transcriptional chan…
View article: miRNA-1-3p is an early embryonic male sex-determining factor in the Oriental fruit fly Bactrocera dorsalis
miRNA-1-3p is an early embryonic male sex-determining factor in the Oriental fruit fly Bactrocera dorsalis Open
Regulation of male sexual differentiation by a Y chromosome-linked male determining factor (M-factor) is one of a diverse array of sex determination mechanisms found in insects. By deep sequencing of small RNAs from Bactrocera dorsalis ear…
View article: Additional file 1. of Gene content evolution in the arthropods
Additional file 1. of Gene content evolution in the arthropods Open
Supplementary Tables S1 – S29.
View article: Overexpression of an antioxidant enzyme improves male mating performance after stress in a lek-mating fruit fly
Overexpression of an antioxidant enzyme improves male mating performance after stress in a lek-mating fruit fly Open
In many species, courtship displays are reliable signals of male quality, and current hypotheses suggest that these displays allow females to choose males with high cellular function. Environmental stressors generate excess reactive oxygen…
View article: Gene Content Evolution in the Arthropods
Gene Content Evolution in the Arthropods Open
Background Arthropods comprise the largest and most diverse phylum on Earth and play vital roles in nearly every ecosystem. Their diversity stems in part from variations on a conserved body plan, resulting from and recorded in adaptive cha…
View article: The genomic basis of arthropod diversity
The genomic basis of arthropod diversity Open
Arthropods comprise the largest and most diverse phylum on Earth and play vital roles in nearly every ecosystem. Their diversity stems in part from variations on a conserved body plan, resulting from and recorded in adaptive changes in the…
View article: Recommendations for Laboratory Containment and Management of Gene Drive Systems in Arthropods
Recommendations for Laboratory Containment and Management of Gene Drive Systems in Arthropods Open
Versatile molecular tools for creating driving transgenes and other invasive genetic factors present regulatory, ethical, and environmental challenges that should be addressed to ensure their safe use. In this article, we discuss driving t…
View article: The whole genome sequence of the Mediterranean fruit fly, Ceratitis capitata (Wiedemann), reveals insights into the biology and adaptive evolution of a highly invasive pest species
The whole genome sequence of the Mediterranean fruit fly, Ceratitis capitata (Wiedemann), reveals insights into the biology and adaptive evolution of a highly invasive pest species Open
The medfly genome sequence provides critical insights into the biology of one of the most serious and widespread agricultural pests. This knowledge should significantly advance the means of controlling the size and invasive potential of me…
View article: Additional file 2: of The whole genome sequence of the Mediterranean fruit fly, Ceratitis capitata (Wiedemann), reveals insights into the biology and adaptive evolution of a highly invasive pest species
Additional file 2: of The whole genome sequence of the Mediterranean fruit fly, Ceratitis capitata (Wiedemann), reveals insights into the biology and adaptive evolution of a highly invasive pest species Open
Supplementary Tables S1–S26. Table S1 C. capitata genome and RNA-seq source material and sequencing runs. Table S2 Pluralibacter gergoviae genome metrics. Table S3 P. gergoviae genes associated with general functional categories. Table S4 …
View article: Germline transformation of the olive fruit fly, Bactrocera oleae(Rossi) (Diptera: Tephritidae), with a piggyBac transposon vector
Germline transformation of the olive fruit fly, Bactrocera oleae(Rossi) (Diptera: Tephritidae), with a piggyBac transposon vector Open
The olive fruit fly, Bactrocera oleae, is a highly significant pest in olive growing countries, and controlling it may be enhanced by using genetically modified strains, especially for sterile insect technique programs. To improve and expa…