Linda Harkness
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View article: Neoplastic Transformation of Human Mesenchymal Stromal Cells Mediated via LIN28B
Neoplastic Transformation of Human Mesenchymal Stromal Cells Mediated via LIN28B Open
Bone marrow stromal (Mesenchymal) stem cells (MSCs) are multipotent bone cells capable of differentiating into mesoderm-type cells, such as osteoblasts and adipocytes. Existing evidence suggests that transformation of MSCs gives rise to sa…
View article: Media composition modulates human embryonic stem cell morphology and may influence preferential lineage differentiation potential
Media composition modulates human embryonic stem cell morphology and may influence preferential lineage differentiation potential Open
Undifferentiated human embryonic stem cells have a distinct morphology (hESC). Changes in cell morphology during culture can be indicative of differentiation. hESC, maintained in diverse medias, demonstrated alterations in morphological pa…
View article: Canine CD117-Specific Antibodies with Diverse Binding Properties Isolated from a Phage Display Library Using Cell-Based Biopanning
Canine CD117-Specific Antibodies with Diverse Binding Properties Isolated from a Phage Display Library Using Cell-Based Biopanning Open
CD117 (c-Kit) is a tyrosine kinase receptor that is overexpressed in multiple dog tumors. There is 100% homology between the juxtamembrane domain of human and canine CD117, and many cancer-causing mutations occur in this region in both spe…
View article: TAFA2 Induces Skeletal (Stromal) Stem Cell Migration Through Activation of Rac1-p38 Signaling
TAFA2 Induces Skeletal (Stromal) Stem Cell Migration Through Activation of Rac1-p38 Signaling Open
Understanding the mechanisms regulating recruitment of human skeletal (stromal or mesenchymal) stem cells (hMSC) to sites of tissue injury is a prerequisite for their successful use in cell replacement therapy. Chemokine-like protein TAFA2…
View article: Induction of quiescence (G0) in bone marrow stromal stem cells enhances their stem cell characteristics
Induction of quiescence (G0) in bone marrow stromal stem cells enhances their stem cell characteristics Open
Several studies have suggested that bone marrow stromal steam cells (BMSC) exist in a quiescent state (G0) within the in vivo niche; however, an explicit analysis of the biology of G0 state-BMSC has not been reported. We hypothesized that …
View article: Molecular Phenotyping of Telomerized Human Bone Marrow Skeletal Stem Cells Reveals a Genetic Program of Enhanced Proliferation and Maintenance of Differentiation Responses
Molecular Phenotyping of Telomerized Human Bone Marrow Skeletal Stem Cells Reveals a Genetic Program of Enhanced Proliferation and Maintenance of Differentiation Responses Open
Long‐term in vitro expansion of bone marrow stromal (skeletal) stem cells (also known as human mesenchymal stem cells [hMSC]) is associated with replicative senescence and impaired functions. We have previously reported that telomerization…
View article: Bioactive nano‐fibrous scaffold for vascularized craniofacial bone regeneration
Bioactive nano‐fibrous scaffold for vascularized craniofacial bone regeneration Open
There has been a growing demand for bone grafts for correction of bone defects in complicated fractures or tumours in the craniofacial region. Soft flexible membrane like material that could be inserted into defect by less invasive approac…
View article: Transcription factor ZNF25 is associated with osteoblast differentiation of human skeletal stem cells
Transcription factor ZNF25 is associated with osteoblast differentiation of human skeletal stem cells Open
This study shows that the uncharacterized transcription factor, ZNF25, is associated with differentiation of hMSC to osteoblasts.
View article: CD146/MCAM defines functionality of human bone marrow stromal stem cell populations
CD146/MCAM defines functionality of human bone marrow stromal stem cell populations Open
Background Identification of surface markers for prospective isolation of functionally homogenous populations of human skeletal (stromal, mesenchymal) stem cells (hMSCs) is highly relevant for cell therapy protocols. Thus, we examined the …