Minoru Hasegawa
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View article: An open-label randomized parallel-group phase I study of the oral Bruton tyrosine kinase inhibitor tirabrutinib in systemic sclerosis
An open-label randomized parallel-group phase I study of the oral Bruton tyrosine kinase inhibitor tirabrutinib in systemic sclerosis Open
Background Systemic sclerosis (SSc) is an autoimmune connective tissue disease with a high risk of organ damage and mortality. Objectives To investigate whether tirabrutinib, an inhibitor of Bruton tyrosine kinase, is useful for treating S…
View article: Post-herpetic Abdominal Pseudohernia With Underrecognized Characteristics of Male Predominance and Co-occurring Fatal Visceral Herniation: A Case Report and a Literature Review
Post-herpetic Abdominal Pseudohernia With Underrecognized Characteristics of Male Predominance and Co-occurring Fatal Visceral Herniation: A Case Report and a Literature Review Open
Post-herpetic abdominal pseudohernia (PHAP) is a rare complication associated with herpes zoster (HZ), characterized by transient paresis of the myotome ipsilateral to the affected segmental nerves. Clinically, it manifests as asymptomatic…
View article: Wound, Pressure Ulcer, and Burn Guidelines (2023)–2: Guidelines for the Diagnosis and Treatment of Pressure Ulcers, Third Edition
Wound, Pressure Ulcer, and Burn Guidelines (2023)–2: Guidelines for the Diagnosis and Treatment of Pressure Ulcers, Third Edition Open
Guidelines for the diagnosis and treatment of pressure ulcers, third edition, is a fully revised guidelines drafted by the Japanese Dermatological Association Wound/Pressure Ulcer/Burn Guidelines Drafting Committee. They were developed in …
View article: Wound, Pressure Ulcer and Burn Guidelines (2023)―5: Guidelines for the Management of Lower Leg Ulcers/Varicose Veins, Third Edition Wound/Pressure Ulcer/Burn Guidelines Drafting Committee (Lower Leg Ulcers/Varicose Veins Group)
Wound, Pressure Ulcer and Burn Guidelines (2023)―5: Guidelines for the Management of Lower Leg Ulcers/Varicose Veins, Third Edition Wound/Pressure Ulcer/Burn Guidelines Drafting Committee (Lower Leg Ulcers/Varicose Veins Group) Open
Guidelines for the management of lower leg ulcers/varicose veins, third edition is a fully revised guideline drafted by the Japanese Dermatological Association Wound/Pressure Ulcer/Burn Guidelines Drafting Committee. They were developed in…
View article: Wound, pressure ulcer, and burn guidelines (2023)―4: Guidelines for the management of connective tissue disease/vasculitis‐associated skin ulcers, third edition
Wound, pressure ulcer, and burn guidelines (2023)―4: Guidelines for the management of connective tissue disease/vasculitis‐associated skin ulcers, third edition Open
View article: Wound, pressure ulcer, and burn guidelines – 3: Guidelines for the diagnosis and treatment of diabetic ulcers and gangrene, second edition
Wound, pressure ulcer, and burn guidelines – 3: Guidelines for the diagnosis and treatment of diabetic ulcers and gangrene, second edition Open
The Japanese Dermatological Association aimed to prepare a second edition of guidelines for the management of diabetic ulcer/gangrene with emphasis on the diagnosis and treatment of skin symptoms. This new edition serves as a tool to impro…
View article: Plasma Cell Balanitis Unresponsive to Topical Corticosteroids: Combined Efficacy of Tacrolimus and Emerging Evidence for Underrecognized Intrinsic Resistance to Corticosteroids
Plasma Cell Balanitis Unresponsive to Topical Corticosteroids: Combined Efficacy of Tacrolimus and Emerging Evidence for Underrecognized Intrinsic Resistance to Corticosteroids Open
View article: A case of segmental acquired reactive perforating collagenosis: case report and literature review of the unique presentation
A case of segmental acquired reactive perforating collagenosis: case report and literature review of the unique presentation Open
View article: Predictors of clinical features in early‐onset severe systemic sclerosis: An analysis from a multicenter prospective observational Japanese cohort
Predictors of clinical features in early‐onset severe systemic sclerosis: An analysis from a multicenter prospective observational Japanese cohort Open
As the clinical course of systemic sclerosis (SSc) varies widely, prognostic indicators have been sought to predict the outcomes of individual patients. Racial differences in SSc render it necessary to validate prognostic indicators in dif…
View article: Anti-CX3CL1 (fractalkine) monoclonal antibody attenuates lung and skin fibrosis in sclerodermatous graft-versus-host disease mouse model
Anti-CX3CL1 (fractalkine) monoclonal antibody attenuates lung and skin fibrosis in sclerodermatous graft-versus-host disease mouse model Open
View article: A Case of Refractory Pemphigus Herpetiformis with Positive Anti-Desmoglein 1 Antibody: Case Report and Literature Review to Revisit the Disease Characteristics of 167 Cases
A Case of Refractory Pemphigus Herpetiformis with Positive Anti-Desmoglein 1 Antibody: Case Report and Literature Review to Revisit the Disease Characteristics of 167 Cases Open
View article: Obituary: Thomas Fletcher Tedder, PhD (1956–2024)
Obituary: Thomas Fletcher Tedder, PhD (1956–2024) Open
View article: A case of refractory peripheral neuropathy associated with eosinophilic granulomatosis with polyangiitis with successful tapering of systemic corticosteroid and reduced dosing frequency of high-dose intravenous immunoglobulin after combined use of mepolizumab
A case of refractory peripheral neuropathy associated with eosinophilic granulomatosis with polyangiitis with successful tapering of systemic corticosteroid and reduced dosing frequency of high-dose intravenous immunoglobulin after combined use of mepolizumab Open
LETTER TO THE EDITOR J. Cutan. Immunol. Allergy, 19 April 2024 https://doi.org/10.3389/jcia.2024.12776
View article: International exchange on the clinical practice and research of rheumatic skin diseases: A report of the 5th International Conference of Cutaneous Lupus Erythematosus
International exchange on the clinical practice and research of rheumatic skin diseases: A report of the 5th International Conference of Cutaneous Lupus Erythematosus Open
The 5th International Conference of Cutaneous Lupus Erythematosus was held in Tokyo, Japan on May 9 and 10, 2023. The latest topics on the pathogenesis, diagnosis, assessment, and treatment of cutaneous lupus erythematosus, dermatomyositis…
View article: GWAS for systemic sclerosis identifies six novel susceptibility loci including one in the Fcγ receptor region
GWAS for systemic sclerosis identifies six novel susceptibility loci including one in the Fcγ receptor region Open
View article: Perspective to precision medicine in scleroderma
Perspective to precision medicine in scleroderma Open
Systemic sclerosis (SSc) is a rare and heterogeneous disease with no relevant environmental trigger or significant responsible gene. It has been and will continue to be difficult to identify large enough patients to conduct classic populat…
View article: 巨匠と手術画
巨匠と手術画 Open
View article: An Aggressive Case Of Infundibulocystic Squamous Cell Carcinoma On The Upper Lip: A Hybrid Pathology Of Well-Differentiated And Infiltrative Variants
An Aggressive Case Of Infundibulocystic Squamous Cell Carcinoma On The Upper Lip: A Hybrid Pathology Of Well-Differentiated And Infiltrative Variants Open
Citation: Hasegawa T, Iino S, Sekine S, et al. An Aggressive Case Of Infundibulocystic Squamous Cell Carcinoma On The Upper Lip: A Hybrid Pathology Of Well-Differentiated And Infiltrative Variants. Dermatol Pract Concept. 2023;13(4):e20232…
View article: Two cases of acute‐onset cystoid macular edema and serous retinal detachment associated with combined use of encorafenib and binimetinib for advanced melanoma: A possible confounding risk for drug intolerance
Two cases of acute‐onset cystoid macular edema and serous retinal detachment associated with combined use of encorafenib and binimetinib for advanced melanoma: A possible confounding risk for drug intolerance Open
While combined use of BRAF/MEK inhibitors has elicited dramatic clinical efficacy in incurable melanoma, drug‐associated retinopathy has become an emerging adverse event. We present two Japanese men with advanced melanoma who developed vis…
View article: A case of methotrexate‐related lymphoproliferative disorder resolved with discontinuation of the drug: A literature review for clinical characteristics in 105 Japanese cases
A case of methotrexate‐related lymphoproliferative disorder resolved with discontinuation of the drug: A literature review for clinical characteristics in 105 Japanese cases Open
We report a case of rheumatoid arthritis who developed cutaneous diffuse large B-cell lymphoma during methotrexate (MTX) monotherapy with prompt resolution after discontinuation of the drug. Our literature review of over 100 reported Japan…
View article: A cysteine proteinase inhibitor ALLN alleviates bleomycin-induced skin and lung fibrosis
A cysteine proteinase inhibitor ALLN alleviates bleomycin-induced skin and lung fibrosis Open
View article: A calpain inhibitor ALLN alleviates bleomycin-induced skin and lung fibrosis
A calpain inhibitor ALLN alleviates bleomycin-induced skin and lung fibrosis Open
Background Systemic sclerosis (SSc) is a connective tissue disease that is characterized by fibrosis in the skin and internal organs, such as the lungs. Activated differentiation of progenitor cells, which are mainly resident fibroblasts, …
View article: GWAS for Systemic Sclerosis Identified six novel susceptibility loci including penetrating Fcγ-Receptor Region
GWAS for Systemic Sclerosis Identified six novel susceptibility loci including penetrating Fcγ-Receptor Region Open
We conducted a Japanese GWAS for systemic sclerosis (SSc) comprising 1,428 cases and 112,599 controls, the largest Asian GWAS for SSc ever, and identified three novel signals. The lead SNP in FCGR/FCRL region had a strong effect size (OR 2…
View article: Lichen Sclerosus: A Current Landscape of Autoimmune and Genetic Interplay
Lichen Sclerosus: A Current Landscape of Autoimmune and Genetic Interplay Open
Lichen sclerosus (LS) is an acquired chronic inflammatory dermatosis predominantly affecting the anogenital area with recalcitrant itching and soreness. Progressive or persistent LS may cause urinary and sexual disturbances and an increase…
View article: 154 Ultrasound Visualizes Peripheral Vascular Dysfunction in Finger Pulp Blood Flow in Patients with Systemic Sclerosis
154 Ultrasound Visualizes Peripheral Vascular Dysfunction in Finger Pulp Blood Flow in Patients with Systemic Sclerosis Open
View article: Retrospective evaluation of the utility of two-step surgery for facial basal cell carcinoma and squamous cell carcinoma
Retrospective evaluation of the utility of two-step surgery for facial basal cell carcinoma and squamous cell carcinoma Open
In older patients with facial basal cell carcinoma (BCC) or squamous cell carcinoma (SCC), surgery should be aimed to reduce treatment-related sequelae and burden with achieving local tumor care. Therefore, we adopted a two-step surgery (T…
View article: Erythema annulare centrifugum in the setting of <scp>COVID</scp>‐19 infection: A case report and literature review
Erythema annulare centrifugum in the setting of <span>COVID</span>‐19 infection: A case report and literature review Open
Erythema annulare centrifugum (EAC) is a figurate papulo-erythema following a self-limiting course, caused by a variety of underlying factors. Skin manifestations associated with COVID-19 infection considerably vary,1 and sometimes exhibit…
View article: A case of refractory hypertrophic lupus erythematosus on the face whose irreversible skin fibrosis was treated by local full‐thickness skin graft under disease control with a combined use of topical and systemic immunosuppressants, and hydroxychloroquine
A case of refractory hypertrophic lupus erythematosus on the face whose irreversible skin fibrosis was treated by local full‐thickness skin graft under disease control with a combined use of topical and systemic immunosuppressants, and hydroxychloroquine Open
Hypertrophic lupus erythematosus (HLE) remains pose a treatment challenge, and often displays disfiguring scar with cosmetic and/or functional impairment. We report a male case of refractory hypertrophic lupus erythematosus on the face, wh…
View article: A case of widespread unilateral subcutaneous sarcoidosis with ocular and pulmonary involvements with seropositivity for anti‐double<scp>strand‐DNA</scp>antibody and rheumatoid factor: A revisit of gap between humoral autoimmune abnormalities and clinical findings
A case of widespread unilateral subcutaneous sarcoidosis with ocular and pulmonary involvements with seropositivity for anti‐double<span>strand‐DNA</span>antibody and rheumatoid factor: A revisit of gap between humoral autoimmune abnormalities and clinical findings Open
We present a middle‐aged female Japanese case of subcutaneous sarcoidosis on the unilateral limb with pulmonary and eye involvements, who was seropositive for anti‐double strand DNA antibody and rheumatoid factor. The oculocutaneous and pu…
View article: The compound LG283 inhibits bleomycin-induced skin fibrosis via antagonizing TGF-β signaling
The compound LG283 inhibits bleomycin-induced skin fibrosis via antagonizing TGF-β signaling Open
Background Systemic sclerosis (SSc) is a collagen disease that exhibits intractable fibrosis and vascular injury of the skin and internal organs. Transforming growth factor-β (TGF-β)/Smad signaling plays a central role in extracellular mat…