Explanipedia

Infective endocarditis meets native vertebral osteomyelitis: a mortality perspective Open

Fabio Borgonovo, Francesco Petri, Takahiro Matsuo, Rita Igwilo-Alaneme, Seyed Mohammad Amin Alavi , et al. · 2025

Background: Native vertebral osteomyelitis and infective endocarditis (NVO + IE) are increasingly recognized as overlapping entities, sharing common risk factors (e.g., advanced age, immunosuppression) and similar pathogen profiles, most c…

Study protocol for developing the evaluation instrument of guideline adherence to GRADE approach (GRADE-Check) Open

Yinghui Jin, Siyu Yan, Xiaomei Yao, Philipp Dahm, Pablo Alonso‐Coello , et al. · 2025

Introduction Many clinical practice guidelines (CPGs) claim to use Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach, but its implementation varies. This suggests that CPG developers, methodologists and use…

Association of incident dialysis modality with patient survival: a systematic review and meta-analysis Open

Luca Nardelli, Matteo Passerini, Dalia Zubidat, Anna Sikharulidze, Elisa Cicero , et al. · 2025

Background Although the choice of dialysis technique is based on several factors, patient survival is undoubtedly one of the most relevant. In a context where randomization to either peritoneal dialysis (PD) or hemodialysis (HD) proved to …

Gene expression profiling of KLF4 and KLF5 in visceral adipose tissue of obese women: insights into adipogenic and metabolic regulation Open

Dalya Jamal Muhi, M. Hassan Murad, Ghodratollah Panahi, Hossein Zabihi Mahmoudabadi, Solaleh Emamgholipour , et al. · 2025

SUN-519 The Utilization of Hybrid Closed Loop System in Management of Type I Diabetes in Pregnant Women: A Systematic Review and Meta-Analysis Open

Alaa Al Nofal, Khalid Benkhadra, Marie-Joy Nduwimana, Al-Kordi Mohammad, Alzhraa Salah Abbas , et al. · 2025

Disclosure: A. Al Nofal: None. K. Benkhadra: None. M. Nduwimana: None. A. Mohammad: None. A. Abbas: None. Z. Wang: None. M. Murad: None. Background: Hybrid closed-loop (HCL) systems for automated insulin delivery are increasingly used in d…

Barriers and limitations for undergoing mammography screenings among Kuwaiti women (aged 40–69) attending primary health care centers Open

Omar Alfailakawi, Hussain Alostath, Asmaa Aldubian, A.I. Al-Saleh, Ghadeer Alsughayer , et al. · 2025

Evaluating the properties of the fragility index of meta-analyses Open

Aiwen Xing, Xing Xing, M. Hassan Murad, Lifeng Lin · 2025

Background The fragility index (FI) has become an increasingly popular supplementary measure for evaluating the robustness of a study’s conclusions. While initially developed for individual clinical trials, the FI has been extended to meta…

Leveraging AI for Meta‐Analysis: Evaluating LLMs in Detecting Publication Bias for Next‐Generation Evidence Synthesis Open

Xing Xing, Lifeng Lin, M. Hassan Murad, Jiayi Tong · 2025

Introduction Publication bias (PB) threatens the validity of meta‐analyses by distorting effect size estimates, potentially leading to misleading conclusions. With advanced pattern recognition and multimodal capabilities, large language mo…

Lifecycles of Cochrane Systematic Reviews (2003–2024): A Bibliographic Study Open

Shiyin Li, Chong Wu, Zichen Zhang, Mengli Xiao, M. Hassan Murad , et al. · 2025

Background and Objectives The relevance of Cochrane systematic reviews depends on timely completion and updates. This study aimed to empirically assess the lifecycles of Cochrane reviews published from 2003 to 2024, including transitions f…

A Systematic Review Supporting the Endocrine Society Clinical Practice Guideline on Management of Primary Aldosteronism Open

Magdoleen H. Farah, Moustafa Hegazi, Mohammed Firwana, Mohamed Abusalih, Samer Saadi , et al. · 2025

Context Primary aldosteronism (PA) is a leading endocrine cause of secondary hypertension. Objective To support the development of the Endocrine Society Clinical Practice Guideline on managing PA. Data Source MEDLINE, Embase, Scopus, and o…

Preexisting Diabetes and Pregnancy: An Endocrine Society and European Society of Endocrinology Joint Clinical Practice Guideline Open

Jennifer Wyckoff, A. Lapolla, Bernadette Asias-Dinh, Linda A. Barbour, Florence M. Brown , et al. · 2025

Background Preexisting diabetes (PDM) increases the risk of maternal and perinatal mortality and morbidity. Reduction of maternal hyperglycemia prior to and during pregnancy can reduce these risks. Despite compelling evidence that preconce…

A Systematic Review Supporting the Clinical Practice Guidelines on the Management of Preexisting Diabetes and Pregnancy Open

Alaa Al Nofal, Khalid Benkhadra, Alzhraa Salah Abbas, Marie-Joy Nduwimana, Mohammad Al-Kordi , et al. · 2025

Context Women with preexisting diabetes mellitus (PDM) are at increased risk of pregnancy-related complications. Objective To summarize the available supporting evidence for the Endocrine Society guidelines about management of PDM in pregn…

Association of Incident Dialysis Modality With Patient Survival: A Systematic Review and Meta-analysis Open

Luca Nardelli, Matteo Passerini, Dalia Zubidat, Anna Sikharulidze, Elisa Cicero , et al. · 2025

Background Although the choice of dialysis technique is based on several factors, patient survival is undoubtedly one of the most relevant. In a context where randomization to either peritoneal dialysis (PD) or hemodialysis (HD) proved to …

Dehydroepiandrosterone Sulfate in Diagnosing Mild Autonomous Cortisol Secretion and Adrenal Insufficiency Open

Jasmine Saini, Bahaa Salama, Kai Yu, Shireen R Chacko, Ashley J Han , et al. · 2025

Context Data on diagnostic accuracy of dehydroepiandrosterone sulfate (DHEA-S) for mild autonomous cortisol secretion (MACS) and adrenal insufficiency (AI) are discrepant. Objective We conducted a systematic review and meta-analysis of pub…

Occupational heat-related illness risk screening protocols for aviation: a systematic review Open

Wiaam Elkhatib, Mohammad Al-Kordi, Darshankumar Manubhai Raval, Sandipan Ganguly, E. Finnegan , et al. · 2025

Objectives Aircrew are subject to thermal stress and heat-related illness (HRI). Published screening methods and safety thresholds remain limited. The objective of this review was to evaluate the available evidence, approaches and guidelin…

Comparing FIB-4, VCTE, pSWE, 2D-SWE, and MRE Thresholds and Diagnostic Accuracies for Detecting Hepatic Fibrosis in Patients with MASLD: A Systematic Review and Meta-Analysis Open

Mitchell P. Wilson, Ranjit Singh, Shyam B. Mehta, M. Hassan Murad, Christopher Fung , et al. · 2025

Objectives: To compare thresholds and accuracies of FIB-4, vibration-controlled transient elastography (VCTE), point shear wave elastography (pSWE), 2D shear wave elastography (2D-SWE), and MR elastography (MRE) for detecting hepatic fibro…

Financial Toxicity of Partial Versus Whole Breast Irradiation: A Systematic Review Open

Taema Brinjikji, Kimberly S. Corbin, Zhen Wang, M. Hassan Murad, Dean A. Shumway · 2025

Core GRADE 7: principles for moving from evidence to recommendations and decisions Open

Gordon Guyatt, Per Olav Vandvik, Alfonso Iorio, Arnav Agarwal, Liang Yao , et al. · 2025

This seventh article in a seven part series presents the Core GRADE (Grading of Recommendations Assessment, Development and Evaluation) approach for moving from evidence to recommendations or policy decisions. Core GRADE users make strong …

Core GRADE 6: presenting the evidence in summary of findings tables Open

Gordon Guyatt, Liang Yao, M. Hassan Murad, Monica Hultcrantz, Thomas Agoritsas , et al. · 2025

This sixth article in a seven part series presents the Core GRADE (Grading of Recommendations Assessment, Development and Evaluation) approach to summary of findings tables. These tables provide essential information about the effects of i…

Core GRADE 5: rating certainty of evidence—assessing indirectness Open

Gordon Guyatt, Alfonso Iorio, Hans de Beer, Andrew Owen, Thomas Agoritsas , et al. · 2025

This fifth article in a seven part series presents the Core GRADE (Grading of Recommendations Assessment, Development and Evaluation) approach to systematic reviews, clinical practice guidelines, and health technology assessments and addre…

Core GRADE 4: rating certainty of evidence—risk of bias, publication bias, and reasons for rating up certainty Open

Gordon Guyatt, Ying Wang, Prashanti Eachempati, Alfonso Iorio, M. Hassan Murad , et al. · 2025

This fourth article in a seven part series presents the Core GRADE (Grading of Recommendations Assessment, Development and Evaluation) approach to addressing risk of bias, publication bias, and rating up certainty. In Core GRADE, randomise…

Core GRADE 3: rating certainty of evidence—assessing inconsistency Open

Gordon Guyatt, Stefan Schandelmaier, Romina Brignardello‐Petersen, Hans de Beer, Manya Prasad , et al. · 2025

This third article in a seven part series presents the Core GRADE (Grading of Recommendations Assessment, Development and Evaluation) approach to deciding whether to rate down certainty of evidence due to inconsistency—that is, unexplained…

B-44 | Mitral Gradient Post Transcatheter Edge-to-Edge Repair Impact on Outcomes: A systematic review and meta-analysis Open

Mohamad S. Alabdaljabar, Alyaman Almiro, Jibran Khan, Dana Gerberi, M. Hassan Murad , et al. · 2025

Core GRADE 2: choosing the target of certainty rating and assessing imprecision Open

Gordon Guyatt, Linan Zeng, Romina Brignardello‐Petersen, Manya Prasad, Hans de Beer , et al. · 2025

This second article in a seven part series presents the Core GRADE (Grading of Recommendations Assessment, Development and Evaluation) approach to deciding on the target of the certainty rating, and decisions about rating down certainty of…

Core GRADE 1: overview of the Core GRADE approach Open

Gordon Guyatt, Thomas Agoritsas, Romina Brignardello‐Petersen, Reem A. Mustafa, Jamie Rylance , et al. · 2025

This first article in a seven part series presents an overview of the essential elements of the GRADE (Grading of Recommendations Assessment, Development and Evaluation) approach that has proved extremely useful in systematic reviews, heal…

Systemic treatment options for metastatic castration resistant prostate cancer: A living systematic review Open

Syed Arsalan Ahmed Naqvi, Muhammad Umair Anjum, Arifa Bibi, Muhammad Ali Khan, Kaneez Zahra Rubab Khakwani , et al. · 2025

Background Optimal treatment selection for metastatic castration resistant prostate cancer (mCRPC) remains challenging due to evolving standards of care in castration sensitive setting. Purpose To synthesize and appraise evidence on system…

Lack of reproducibility of trial sequential analyses: a meta-epidemiological study Open

Xing Xing, Yining Wang, Yipeng Wang, M. Hassan Murad, Lifeng Lin · 2025

Rating certainty when the target threshold is the null and the point estimate is close to the null Open

Linan Zeng, Monica Hultcrantz, David Tovey, Nancy Santesso, Philipp Dahm , et al. · 2025

When one initially targets the null effect and the point estimate falls close to the null, two challenges exist in rating certainty of evidence. First, when the point estimate is near the null and the data, therefore, suggests little or no…

Certainty of evidence assessment in high‐impact medical journals: A meta‐epidemiological survey Open

Madelin R. Siedler, Neha Tangri, Leena AlShenaiber, Tejanth Pasumarthi, Faisal S. Ali , et al. · 2025

Introduction While certainty of evidence assessment is key to a rigorous and transparent systematic review, it is unknown how – and how frequently – it is assessed in systematic reviews. The objective of this study was to examine the preva…

Propensity Score Analysis of the Utility of Supervised Perioperative Abdominal Wall Exercises for the Prevention of Parastomal Hernia Open

Victoria Alejandra López-Callejón, Amparo Yuste-Sanchez, M. Hassan Murad, Rut Navarro-Martínez, Leticia Pérez‐Santiago , et al. · 2025

Retrospective studies have suggested that performing perioperative abdominal wall exercises may decrease the incidence of parastomal hernias. Objectives: This study seeks to assess the usefulness of supervised preoperative and postoperativ…

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