Mehdi Hedayati
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Exploring the genetic basis of essential hypertension: association with AGT gene variants in an Iranian population Open
This study provides evidence for the involvement of AGT gene variants and haplotypes in the pathogenesis of EH in the Iranian population. These findings highlight the importance of considering genetic factors in the development and managem…
View article: Breast Milk and Brain: The Influence of Iodine and Neurotrophic and Growth Factors on Children’s Neurodevelopment-A Secondary Analysis
Breast Milk and Brain: The Influence of Iodine and Neurotrophic and Growth Factors on Children’s Neurodevelopment-A Secondary Analysis Open
Objective: This study targeted to investigate the potential role of breast milk iodine concentration (BMIC), insulin-like growth factor-1 (IGF-I), and brain-derived neurotrophic factor (BDNF) during the early stage of lactation in child ne…
View article: Development of a sensitive, reliable, and cost-effective sandwich ELISA for quantitative measurement of human hemoglobin A2 in beta-thalassemia diagnosis
Development of a sensitive, reliable, and cost-effective sandwich ELISA for quantitative measurement of human hemoglobin A2 in beta-thalassemia diagnosis Open
Introduction: Accurate quantification of hemoglobin A2 (HbA2) is essential for the diagnosis and monitoring of beta-thalassemia and related hemoglobinopathies. Existing methods, such as HPLC and capillary electrophoresis (CE), are effectiv…
View article: Metabolomics-Based Diagnosis of Medullary Thyroid Cancer: A Plasma 1H NMR Approach
Metabolomics-Based Diagnosis of Medullary Thyroid Cancer: A Plasma 1H NMR Approach Open
Background: Medullary thyroid cancer (MTC) is a rare neuroendocrine malignancy, accounting for 5-10% of all thyroid cancer cases. The precise molecular processes driving MTC remain largely elusive. We aimed to conduct a pilot study analyzi…
View article: The effect of iodine supplementation on oocyte apoptosis and proliferation in women with diminished ovarian reserve: a pilot study
The effect of iodine supplementation on oocyte apoptosis and proliferation in women with diminished ovarian reserve: a pilot study Open
Iodine, an essential trace element, may play a role in reproductive health through its extrathyroidal actions. This study aimed to investigate the effects of iodine supplementation on oocyte apoptosis and proliferation in women with dimini…
View article: Plasma Fatty Acid Profiles Modulate <scp>PPARγ</scp> Expression in Adipose Tissue: A Lipidomic Insight Into Obesity‐Related Metabolic Dysregulation
Plasma Fatty Acid Profiles Modulate <span>PPARγ</span> Expression in Adipose Tissue: A Lipidomic Insight Into Obesity‐Related Metabolic Dysregulation Open
Aim This study aimed to investigate the relationship between plasma fatty acids (FAs), FA‐derived factors and PPARγ expression in visceral and subcutaneous adipose tissues (VAT and SAT) of obese and nonobese adults. Methods This cross‐sect…
View article: Effect of dried Ziziphus Jujube Consumption on Plasma Insulin, Blood Pressure, Oxidative Stress, and Advanced Glycation End Products in Diabetic Patients with Excess Weight: A Randomized Controlled Trial
Effect of dried Ziziphus Jujube Consumption on Plasma Insulin, Blood Pressure, Oxidative Stress, and Advanced Glycation End Products in Diabetic Patients with Excess Weight: A Randomized Controlled Trial Open
Background: Poor glycemic control and oxidative stress can accelerate the development of type 2 diabetes (T2D) complications. Recently, the potential benefits of herbs in managing T2D have received more attention. Therefore, we examined th…
View article: Endocrine polyautoimmunity: Mechanistic insights and the future of AI-driven diagnostics
Endocrine polyautoimmunity: Mechanistic insights and the future of AI-driven diagnostics Open
The most prevalent form of polyautoimmunity is autoimmune thyroid diseases (AITD), which frequently coexist with other autoimmune disorders and often act as a central conductor in the symphony of autoimmunity. Due to overlapping clinical m…
Investigation of the causal relationship of saturated fat acids on heart stroke: evidence from two-sample Mendelian randomization Open
Our MR study did not yield convincing evidence supporting the association of SFAs with HF risk. Future studies should focus on alternative approaches to investigate this association.
View article: New developments in epigenetic and genetic biomarkers for differentiated thyroid cancer (DTC): Moving toward accurate diagnosis and treatment by 2025
New developments in epigenetic and genetic biomarkers for differentiated thyroid cancer (DTC): Moving toward accurate diagnosis and treatment by 2025 Open
Differentiated thyroid carcinoma (DTC), such as papillary and follicular carcinoma of the thyroid, has rising global incidence. While most present with extremely favorable prognosis, some poor prognostic subgroups develop recurrence and be…
The association of PTEN/PI3K/Akt pathway gene expression with insulin indices in adipose tissues of non-diabetic female adults: a cross-sectional study Open
Insulin resistance (IR) is a complex metabolic condition that serves as a common thread connecting type 2 diabetes (T2DM), metabolic syndrome (MetS), cardiovascular disease (CVD), and even certain cancer outcomes. Understanding and address…
View article: Effect of High-Intensity Interval Training on Mitigating High-Fat Diet-Induced Damage in Rat Testicular Tissue
Effect of High-Intensity Interval Training on Mitigating High-Fat Diet-Induced Damage in Rat Testicular Tissue Open
A high-fat diet (HFD) is a risk factor for infertility, and regular exercise has been considered as a nonpharmacological intervention in the treatment of infertility. This study examined how high-intensity interval training (HIIT) affects …
View article: Uncovering the Hidden Connections Between PCOS and Alzheimer’s Disease: A Two-Sample Mendelian Randomization Perspective
Uncovering the Hidden Connections Between PCOS and Alzheimer’s Disease: A Two-Sample Mendelian Randomization Perspective Open
Background: Polycystic ovary syndrome (PCOS) and Alzheimer’s disease (AD) are two prevalent and complex conditions characterized by overlapping features such as metabolic dysfunction, hormonal imbalance, and chronic inflammation. These com…
View article: Treatment of hypothyroidism with levothyroxine plus slow-release liothyronine; A Study Protocol for a Randomized Controlled Double-Blinded Clinical Trial
Treatment of hypothyroidism with levothyroxine plus slow-release liothyronine; A Study Protocol for a Randomized Controlled Double-Blinded Clinical Trial Open
Background There are emerging controversies regarding the priority of T4 + T3 combination therapy over standard care with LT4 monotherapy in the management of hypothyroid subjects. Combination therapy with a slow-release form of liothyroni…
View article: Polydeoxyribonucleotide in Skincare and Cosmetics: Mechanisms, Therapeutic Applications, and Advancements Beyond Wound Healing and Anti-aging
Polydeoxyribonucleotide in Skincare and Cosmetics: Mechanisms, Therapeutic Applications, and Advancements Beyond Wound Healing and Anti-aging Open
Context: Polydeoxyribonucleotide (PDRN), a nucleic acid extract derived from trout sperm, has gained attention for its regenerative properties in dermatology and aesthetics. This review evaluates the therapeutic potential of PDRN in variou…
View article: The Effect of Endurance Training and Dill Seed Extract on Insulin Sensitivity and Nicotinamide N-methyltransferase Levels in the Liver and Adipose Tissue of Obese Rats
The Effect of Endurance Training and Dill Seed Extract on Insulin Sensitivity and Nicotinamide N-methyltransferase Levels in the Liver and Adipose Tissue of Obese Rats Open
Background: Evidence suggests that exercise training and dill extract can influence obesity and related metabolic conditions, such as type 2 diabetes. Objectives: This study aimed to investigate the effects of endurance training (ET) and d…
View article: Association of Adiponectin Gene Polymorphisms rs17300539, rs266729 and rs1501299 with Adiponectin Levels, Insulin Resistance and Non-Alcoholic Fatty Liver Disease, in an Iranian Population
Association of Adiponectin Gene Polymorphisms rs17300539, rs266729 and rs1501299 with Adiponectin Levels, Insulin Resistance and Non-Alcoholic Fatty Liver Disease, in an Iranian Population Open
Background & Objectives: In this study, we investigated the relationship between polymorphisms in the adiponectin gene and biochemical parameters—specifically adiponectin levels, insulin resistance, and the presence of non-alcoholic fatty …
View article: Royal Jelly Effect on Chronic Unpredictable Stress‐Induced Pancreatic Oxidative and Endoplasmic Reticulum Stress and Insulin Secretion Impairment in Adult Male Rats
Royal Jelly Effect on Chronic Unpredictable Stress‐Induced Pancreatic Oxidative and Endoplasmic Reticulum Stress and Insulin Secretion Impairment in Adult Male Rats Open
Background: Royal jelly (RJ), secreted by nurse honeybees, possesses antioxidant properties. Studies have demonstrated that chronic stress can impair glucose metabolism, a process intricately linked to oxidative stress and endoplasmic reti…
View article: A novel approach to regulate glucose uptake in an anaplastic thyroid cancer cell line
A novel approach to regulate glucose uptake in an anaplastic thyroid cancer cell line Open
Aims and background Curcumin’s function in affecting cancer metabolic reprogramming remains poorly understood. Herein, we aimed to elucidate a novel link between curcumin and the glucose uptake metabolism and the status of glucose transpor…
View article: Thyroid Function in the Time of COVID-19: A Systematic Review of Disease Progression and Vaccination Effect
Thyroid Function in the Time of COVID-19: A Systematic Review of Disease Progression and Vaccination Effect Open
Objectives: This systematic review sought to address three key questions: (1) what differences in abnormal thyroid function test results are observed between COVID-19 patients and healthy individuals? (2) How does the severity of COVID-19 …