Michal Heger
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View article: Nucleolar protein DCAF13 promotes non–small cell lung cancer cell proliferation via facilitating rDNA transcription and ribosome biogenesis
Nucleolar protein DCAF13 promotes non–small cell lung cancer cell proliferation via facilitating rDNA transcription and ribosome biogenesis Open
The nucleolus is an important nonmembranous organelle within the nucleus and is responsible for ribosome biogenesis. This process is frequently upregulated in tumors to support elevated protein synthesis and sustain tumor growth. The trans…
View article: Biomimetic Tumour Model Systems for Pancreatic Ductal Adenocarcinoma in Relation to Photodynamic Therapy
Biomimetic Tumour Model Systems for Pancreatic Ductal Adenocarcinoma in Relation to Photodynamic Therapy Open
Pancreatic ductal adenocarcinoma (PDAC) is the most common type of pancreatic cancer and is associated with poor prognosis. Despite years of research and improvements in chemotherapy regimens, the 5-year survival rate of PDAC remains disma…
View article: Participation of lipids in the tumor response to photodynamic therapy and its exploitation for therapeutic gain
Participation of lipids in the tumor response to photodynamic therapy and its exploitation for therapeutic gain Open
Hydroperoxides of unsaturated membrane lipids (LOOHs) are the most abundant non-radical intermediates generated by photodynamic therapy (PDT) of soft tissues such as tumors and have far longer average lifetimes than singlet oxygen or oxyge…
View article: Intra-Operative Tumour Detection and Staging in Pancreatic Cancer Surgery: An Integrative Review of Current Standards and Future Directions
Intra-Operative Tumour Detection and Staging in Pancreatic Cancer Surgery: An Integrative Review of Current Standards and Future Directions Open
Background: Surgical resection for pancreatic ductal adenocarcinoma (PDAC) entails the excision of the primary tumour and regional lymphadenectomy. This traditional strategy is challenged by the high rate of early recurrence, suggesting in…
View article: DCAF13 promotes ovarian cancer progression by activating FRAS1-mediated FAK signaling pathway
DCAF13 promotes ovarian cancer progression by activating FRAS1-mediated FAK signaling pathway Open
Cullin-RING ubiquitin ligase 4 (CRL4) is closely correlated with the incidence and progression of ovarian cancer. DDB1- and CUL4-associated factor 13 (DCAF13), a substrate-recognition protein in the CRL4 E3 ubiquitin ligase complex, is inv…
View article: Downregulation of PIF1 induce DNA damage and inhibit ovarian cancer cell proliferation via RAD51
Downregulation of PIF1 induce DNA damage and inhibit ovarian cancer cell proliferation via RAD51 Open
Background PIF1 helicase (5ʹ→3ʹ DNA helicase) is a member of helicase superfamily 1. It has unwinding activity and plays a crucial role in maintaining genome stability and coordinating DNA damage repair processes. Overexpression of PIF1 is…
View article: Comparative analysis of whole cell-derived vesicular delivery systems for photodynamic therapy of extrahepatic cholangiocarcinoma
Comparative analysis of whole cell-derived vesicular delivery systems for photodynamic therapy of extrahepatic cholangiocarcinoma Open
This first-in-its-class proof-of-concept study explored the use of bionanovesicles for the delivery of photosensitizer into cultured cholangiocarcinoma cells and subsequent treatment by photodynamic therapy (PDT). Two types of bionanovesic…
View article: Enhanced phototoxicity and specificity of AlPCS4 when loaded in liposomes conjugated with a MET-targeting nanobody
Enhanced phototoxicity and specificity of AlPCS4 when loaded in liposomes conjugated with a MET-targeting nanobody Open
Photodynamic therapy (PDT) improves the survival of cholangiocarcinoma patients. Here, to improve the pharmacokinetics and efficacy of PDT, AlPCS4 was encapsulated into liposomes conjugated with a nanobody. AlPCS4 was loaded in liposomes c…
View article: Nanobody-mediated targeting of zinc phthalocyanine with polymer micelles as nanocarriers
Nanobody-mediated targeting of zinc phthalocyanine with polymer micelles as nanocarriers Open
Photodynamic therapy (PDT) is a suitable alternative to currently employed cancer treatments. However, the hydrophobicity of most photosensitizers (e.g., zinc phthalocyanine (ZnPC)) leads to their aggregation in blood. Moreover, non-specif…
View article: Prognostic and predictive value of human equilibrative nucleoside transporter 1 (hENT1) in extrahepatic cholangiocarcinoma: a translational study
Prognostic and predictive value of human equilibrative nucleoside transporter 1 (hENT1) in extrahepatic cholangiocarcinoma: a translational study Open
Introduction: Effective (neo) adjuvant chemotherapy for cholangiocarcinoma is lacking due to chemoresistance and the absence of predictive biomarkers. Human equilibrative nucleoside transporter 1 (hENT1) has been described as a potential p…
View article: S1PR1 regulates ovarian cancer cell senescence through the PDK1-LATS1/2-YAP pathway
S1PR1 regulates ovarian cancer cell senescence through the PDK1-LATS1/2-YAP pathway Open
Cell senescence deters the activation of various oncogenes. Induction of senescence is therefore a potentially effective strategy to interfere with vital processes in tumor cells. Sphingosine-1-phosphate receptor 1 (S1PR1) has been implica…
View article: The Impact of Nanobody Density on the Targeting Efficiency of PEGylated Liposomes
The Impact of Nanobody Density on the Targeting Efficiency of PEGylated Liposomes Open
Nanoparticles (NPs) are commonly modified with tumor-targeting moieties that recognize proteins overexpressed on the extracellular membrane to increase their specific interaction with target cells. Nanobodies (Nbs), the variable domain of …
View article: Utility of Intravenous Curcumin Nanodelivery Systems for Improving <i>In Vivo</i> Pharmacokinetics and Anticancer Pharmacodynamics
Utility of Intravenous Curcumin Nanodelivery Systems for Improving <i>In Vivo</i> Pharmacokinetics and Anticancer Pharmacodynamics Open
Curcumin nanoformulations for intravenous injection have been developed to offset poor absorption, biotransformation, degradation, and excessive clearance associated with parenteral delivery. This review investigates (1) whether intravenou…
View article: A tumor microenvironment-responsive micelle co-delivered radiosensitizer Dbait and doxorubicin for the collaborative chemo-radiotherapy of glioblastoma
A tumor microenvironment-responsive micelle co-delivered radiosensitizer Dbait and doxorubicin for the collaborative chemo-radiotherapy of glioblastoma Open
Glioblastoma is rather recalcitrant to existing therapies and effective interventions are needed. Here we report a novel microenvironment-responsive micellar system (ch-K5(s-s)R8-An) for the co-delivery of the radiosensitizer Dbait and the…
View article: Experimental Conditions That Influence the Utility of 2′7′-Dichlorodihydrofluorescein Diacetate (DCFH2-DA) as a Fluorogenic Biosensor for Mitochondrial Redox Status
Experimental Conditions That Influence the Utility of 2′7′-Dichlorodihydrofluorescein Diacetate (DCFH2-DA) as a Fluorogenic Biosensor for Mitochondrial Redox Status Open
Oxidative stress has been causally linked to various diseases. Electron transport chain (ETC) inhibitors such as rotenone and antimycin A are frequently used in model systems to study oxidative stress. Oxidative stress that is provoked by …
View article: CpG-binding protein CFP1 promotes ovarian cancer cell proliferation by regulating BST2 transcription
CpG-binding protein CFP1 promotes ovarian cancer cell proliferation by regulating BST2 transcription Open
Epigenetic alterations have been functionally linked to ovarian cancer development and occurrence. The CXXC zinc finger protein 1 (CFP1) is an epigenetic regulator involved in DNA methylation and histone modification in mammalian cells. Ho…
View article: DCAF13 promotes breast cancer cell proliferation by ubiquitin inhibiting <i>PERP</i> expression
DCAF13 promotes breast cancer cell proliferation by ubiquitin inhibiting <i>PERP</i> expression Open
Evolutionarily conserved DDB1‐and CUL4‐associated factor 13 (DCAF13) is a recently discovered substrate receptor for the cullin RING‐finger ubiquitin ligase 4 (CRL4) E3 ubiquitin ligase that regulates cell cycle progression. DCAF13 is over…
View article: Tumor grade and symptoms at presentation are survival risk factors in Chinese patients with primary retroperitoneal sarcoma
Tumor grade and symptoms at presentation are survival risk factors in Chinese patients with primary retroperitoneal sarcoma Open
The present study identifies the risk factors of survival in RPS and suggests symptoms at presentation should be considered in the preoperative consultation and added in prognostic grouping.
View article: No difference in treatment outcome between patients with nodal versus extranodal diffuse large B-cell lymphoma
No difference in treatment outcome between patients with nodal versus extranodal diffuse large B-cell lymphoma Open
DLBCL is an aggressive type of non-Hodgkin's lymphoma, however; patients respond well to standard systemic chemotherapy. Extranodal type of DLBCL patients tend to have more residual disease after first-line systemic chemotherapy, but physi…
View article: The Role of Farnesoid X Receptor in Accelerated Liver Regeneration in Rats Subjected to ALPPS
The Role of Farnesoid X Receptor in Accelerated Liver Regeneration in Rats Subjected to ALPPS Open
Background: the role of bile acid (BA)-induced farnesoid X receptor (Fxr) signaling in liver regeneration following associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) was investigated in a rat model. Method…
View article: Analysis and Optimization of Conditions for the Use of 2′,7′-Dichlorofluorescein Diacetate in Cultured Hepatocytes
Analysis and Optimization of Conditions for the Use of 2′,7′-Dichlorofluorescein Diacetate in Cultured Hepatocytes Open
Numerous liver pathologies encompass oxidative stress as molecular basis of disease. The use of 2′,7′-dichlorodihydrofluorescein-diacetate (DCFH2-DA) as fluorogenic redox probe is problematic in liver cell lines because of membrane transpo…
View article: Unaltered Liver Regeneration in Post-Cholestatic Rats Treated with the FXR Agonist Obeticholic Acid
Unaltered Liver Regeneration in Post-Cholestatic Rats Treated with the FXR Agonist Obeticholic Acid Open
In a previous study, obeticholic acid (OCA) increased liver growth before partial hepatectomy (PHx) in rats through the bile acid receptor farnesoid X-receptor (FXR). In that model, OCA was administered during obstructive cholestasis. Howe…