Joseph M. Herman
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View article: Adjuvant Radiation for Resected Pancreatic Cancer: Historical Review and Current State
Adjuvant Radiation for Resected Pancreatic Cancer: Historical Review and Current State Open
Pancreatic cancer is the third leading cause of cancer-related deaths, projected to become the second leading cause by 2040. Curative intent resection remains the only non-palliative treatment strategy; however, the 5-year overall survival…
View article: Risk Reduction of Intrahepatic Abscess After Locoregional Therapy for Liver Cancer in Patients with Prior Hepatobiliary Intervention
Risk Reduction of Intrahepatic Abscess After Locoregional Therapy for Liver Cancer in Patients with Prior Hepatobiliary Intervention Open
Intrahepatic abscess is an exceedingly rare complication of locoregional therapy for patients with liver cancer. However, in patients who underwent prior hepatobiliary intervention, the incidence of liver abscess increases significantly, c…
View article: Variation in outcomes and practice patterns among patients with localized pancreatic cancer: the impact of the pancreatic cancer multidisciplinary clinic
Variation in outcomes and practice patterns among patients with localized pancreatic cancer: the impact of the pancreatic cancer multidisciplinary clinic Open
Introduction Patients with localized pancreatic adenocarcinoma (PDAC) benefit from multi-modality therapy. Whether care patterns and oncologic outcomes vary if a patient was seen through a pancreatic multi-disciplinary clinic (PMDC) versus…
View article: Discovery of the Optical and Radio Counterpart to the Fast X-Ray Transient EP 240315a
Discovery of the Optical and Radio Counterpart to the Fast X-Ray Transient EP 240315a Open
Fast X-ray Transients (FXTs) are extragalactic bursts of soft X-rays first identified ≳10 yr ago. Since then, nearly 40 events have been discovered, although almost all of these have been recovered from archival Chandra and XMM-Newton data…
View article: The power of personas: Exploring an innovative model for understanding stakeholder perspectives in an oncology learning health network
The power of personas: Exploring an innovative model for understanding stakeholder perspectives in an oncology learning health network Open
Introduction Learning health networks (LHNs) improve clinical outcomes by applying core tenets of continuous quality improvements (QI) to reach community‐defined outcomes, data‐sharing, and empowered interdisciplinary teams including patie…
View article: Minorities Face Delays to Pancreatic Cancer Treatment Regardless of Diagnosis Setting
Minorities Face Delays to Pancreatic Cancer Treatment Regardless of Diagnosis Setting Open
Introduction Our analysis was designed to characterize the demographics and disparities between the diagnosis of pancreas cancer during emergency presentation (EP) and the outpatient setting (OP) and to see the impact of our institutions p…
View article: Discovery of the optical and radio counterpart to the fast X-ray transient EP240315a
Discovery of the optical and radio counterpart to the fast X-ray transient EP240315a Open
Fast X-ray Transients (FXTs) are extragalactic bursts of soft X-rays first identified >10 years ago. Since then, nearly 40 events have been discovered, although almost all of these have been recovered from archival Chandra and XMM-Newton d…
View article: EUS-guided hydrogel injection to separate pancreatic head carcinoma from duodenum for enhanced radiotherapy: Multi-site feasibility study
EUS-guided hydrogel injection to separate pancreatic head carcinoma from duodenum for enhanced radiotherapy: Multi-site feasibility study Open
Background and study aims The proximity of a pancreas head tumor to the duodenum often limits delivery of an ablative dose of radiation therapy. This study evaluated the feasibility and safety of using an injectable polyethylene glycol (PE…
View article: Does the Addition of Radiation to Neoadjuvant Systemic Therapy Improve Outcomes for Patients with Resected Pancreatic Adenocarcinoma? Analysis of the National Cancer Database
Does the Addition of Radiation to Neoadjuvant Systemic Therapy Improve Outcomes for Patients with Resected Pancreatic Adenocarcinoma? Analysis of the National Cancer Database Open
Purpose The incorporation of neoadjuvant radiation therapy into the treatment algorithm for pancreatic cancer is a topic of ongoing debate. This study compares neoadjuvant chemotherapy (NAC) alone to NAC combined with radiation (NAC + RT).…
View article: Optimizing Outpatient Radiation Oncology Consult Workflow by Using Time-Driven Activity-Based Costing: Efficiency and Financial Impacts
Optimizing Outpatient Radiation Oncology Consult Workflow by Using Time-Driven Activity-Based Costing: Efficiency and Financial Impacts Open
PURPOSE Clinical efficiency is a key component of value-based health care. Our objective here was to identify workflow inefficiencies by using time-driven activity-based costing (TDABC) and evaluate the implementation of a new clinical wor…
View article: Neoadjuvant radioimmunotherapy in pancreatic cancer enhances effector T cell infiltration and shortens their distances to tumor cells
Neoadjuvant radioimmunotherapy in pancreatic cancer enhances effector T cell infiltration and shortens their distances to tumor cells Open
Radiotherapy is hypothesized to have an immune-modulating effect on the tumor microenvironment (TME) of pancreatic ductal adenocarcinoma (PDAC) to sensitize it to anti–PD-1 antibody (a–PD-1) treatment. We collected paired pre- and posttrea…
View article: Stereotactic Body Radiotherapy Plus Rucosopasem in Locally Advanced or Borderline Resectable Pancreatic Cancer: GRECO-2 Phase II Study Design
Stereotactic Body Radiotherapy Plus Rucosopasem in Locally Advanced or Borderline Resectable Pancreatic Cancer: GRECO-2 Phase II Study Design Open
Ablative doses of stereotactic body radiotherapy (SBRT) may improve pancreatic cancer outcomes but may carry greater potential for gastrointestinal toxicity. Rucosopasem, an investigational selective dismutase mimetic that converts superox…
View article: Endoscopic Ultrasound-Guided Fiducial Placement for Stereotactic Body Radiation Therapy in Patients with Pancreatic Cancer
Endoscopic Ultrasound-Guided Fiducial Placement for Stereotactic Body Radiation Therapy in Patients with Pancreatic Cancer Open
Accurate delivery of stereotactic body radiotherapy (SBRT) to pancreatic tumors relies on successful EUS-guided placement of fiducial markers. The aim of this study is to report the technical feasibility and safety of EUS-guided fiducial p…
View article: Development of a Neoadjuvant Treatment Pathway to Standardize Pancreatic Cancer Care and Improve Outcomes Across a Large Diverse Health System
Development of a Neoadjuvant Treatment Pathway to Standardize Pancreatic Cancer Care and Improve Outcomes Across a Large Diverse Health System Open
Background Management of localized pancreatic cancer is variable. We describe the development of a neoadjuvant therapy pathway (NATP) to standardize care across a large healthcare system. Methods We conducted an IRB-approved retrospective …
View article: The “other” NIL and SportCrit: Narrative Identity and Liminality of Black Gendered Scholar-Athletes
The “other” NIL and SportCrit: Narrative Identity and Liminality of Black Gendered Scholar-Athletes Open
The purpose of this conceptual manuscript is to advance a new integrated model: the Narrative Identity (NI), and Liminality Model (NILM). The NILM advances narrative as an intervention tool for Black gendered scholar-athletes (BGSAs) by in…
View article: Patient-reported Adverse Events During Neoadjuvant Therapy in a Phase 2 Borderline Resectable Pancreatic Cancer Clinical Trial (Alliance A021501)
Patient-reported Adverse Events During Neoadjuvant Therapy in a Phase 2 Borderline Resectable Pancreatic Cancer Clinical Trial (Alliance A021501) Open
Objective: We sought to evaluate symptomatic adverse event (AE) rates among patients with pancreatic cancer receiving neoadjuvant therapy on clinical trial (A021501) using the Patient-Reported Outcomes Common Terminology Criteria for Adver…
View article: Borderline resectable pancreatic cancer: a review of recent radiation therapy literature and clinical practice
Borderline resectable pancreatic cancer: a review of recent radiation therapy literature and clinical practice Open
: Borderline resectable pancreatic cancer (BRPC) has emerged as a unique entity among the spectrum of pancreatic cancer adenocarcinoma. BRPC is defined as pancreatic cancer having contact with vascular structures, unfavorable tumor biology…
View article: Proton Therapy for Unresectable and Medically Inoperable Locally Advanced Pancreatic Cancer: Results From a Multi-Institutional Prospective Registry
Proton Therapy for Unresectable and Medically Inoperable Locally Advanced Pancreatic Cancer: Results From a Multi-Institutional Prospective Registry Open
Proton beam RT for LAPC offered excellent tolerability while still maintaining disease control and survival rates comparable with dose-escalated photon-based RT. These findings are consistent with the known physical and dosimetric advantag…
View article: Supplementary Tables S1 - S12 from Whole Genome Sequencing Defines the Genetic Heterogeneity of Familial Pancreatic Cancer
Supplementary Tables S1 - S12 from Whole Genome Sequencing Defines the Genetic Heterogeneity of Familial Pancreatic Cancer Open
Supplementary Tables S1 - S12. Supplementary Table S1. Prioritization of candidate FPC susceptibility genes by private heterozygous PTVs. Supplementary Table S2. FPC patients harboring a private PTVs ASXL1, DNMT3A, and TET2. Supplementary …