Michel P. Hermans
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View article: Cardiometabolic insights in cystic fibrosis and highly effective modulator therapies: a narrative review
Cardiometabolic insights in cystic fibrosis and highly effective modulator therapies: a narrative review Open
Graphical Abstract Abstract Alongside pulmonary and nutritional benefits, highly effective modulator therapies (HEMT) can promote an increase in body fat and raise the prevalence of overweight/obesity, dyslipidemia, and hypertension in pat…
View article: Rationale and design of the Renal Lifecycle trial assessing the effect of dapagliflozin on cardiorenal outcomes in severe chronic kidney disease
Rationale and design of the Renal Lifecycle trial assessing the effect of dapagliflozin on cardiorenal outcomes in severe chronic kidney disease Open
Background Several clinical trials have shown beneficial effects of sodium–glucose co-transporter 2 (SGLT2) inhibitors on kidney disease progression and cardiovascular morbidity and mortality in patients with chronic kidney disease (CKD) w…
View article: Trends in socio-economic level and accessibility to healthcare of households in Eastern Democratic Republic of Congo from 2011 to 2023: Documentary review of South Kivu
Trends in socio-economic level and accessibility to healthcare of households in Eastern Democratic Republic of Congo from 2011 to 2023: Documentary review of South Kivu Open
Background In the Democratic Republic of Congo (DRC), the population's standard of living has deteriorated over the years as a result of the country's worsening socio-economic, security and political context. The aim of this study was to a…
View article: Health status of adults exposed to severe acute malnutrition during childhood in the Eastern Democratic Republic of the Congo: the Lwiro cohort study
Health status of adults exposed to severe acute malnutrition during childhood in the Eastern Democratic Republic of the Congo: the Lwiro cohort study Open
Background While most studies of adults with a history of severe acute malnutrition (SAM) focused on survival and long-term non-communicable diseases, few studies have examined community health. The aim of this study was to compare the ove…
View article: Working Conditions and Environment of Maternal and Neonatal Healthcare Providers in the Context of Armed Conflicts and Humanitarian Crises: The Case of Eastern DR Congo
Working Conditions and Environment of Maternal and Neonatal Healthcare Providers in the Context of Armed Conflicts and Humanitarian Crises: The Case of Eastern DR Congo Open
Introduction Healthcare worker (HCW) play a crucial role in reducing maternal and infant mortality. However, in contexts of endemic armed conflicts, such as in the Democratic Republic of Congo (DRC), these professionals must operate under …
View article: Health-Economic Modelling of Improved Behavior in Insulin Injection Technique in Belgium
Health-Economic Modelling of Improved Behavior in Insulin Injection Technique in Belgium Open
Our model shows that even in an era of technological advances and established diabetes care, lack of adherence to correct IIT has an important impact on economic and health outcomes of PwD in Belgium.
View article: Can standard CGM data be used to identify an HNF1B MODY-5 glucotype? Insights from a clinical case
Can standard CGM data be used to identify an HNF1B MODY-5 glucotype? Insights from a clinical case Open
Introduction : Diagnosing and managing maturity-onset diabetes of the young (MODY) is clinically challenging. Hepatocyte nuclear factor-1β (HNF1B) diabetes (MODY-5) is infrequent MODY subtype, characterized by mutations leading to a cluste…
View article: Maternal mortality in Eastern Democratic Republic of Congo: a 10-year multi-zonal institutional death review
Maternal mortality in Eastern Democratic Republic of Congo: a 10-year multi-zonal institutional death review Open
This study imperatively highlights the need for targeted interventions to reduce maternal mortality. By emphasizing the crucial importance of antenatal consultations, intrapartum/immediate post-partum care and quality of care, significant …
View article: Lessons from PROMINENT and prospects for pemafibrate
Lessons from PROMINENT and prospects for pemafibrate Open
The neutral result of the PROMINENT trial has led to questions about the future for pemafibrate. This commentary discusses possible reasons for the lack of benefit observed in the trial. There were, however, indicators suggesting therapeut…
View article: The surge of mpox in Africa: a call for action
The surge of mpox in Africa: a call for action Open
Mpox was previously thought to be a zoonotic disease endemix on parts of central, west and east Africa; however, from 2022 to 2023, a large global outbreak of mpox from clade II monkeypox virus occured, marking the first instance of sustai…
View article: Trends, epidemiology and causes of maternal deaths over a decade (2013-2022) in a context of crisis among 8 health zones in Eastern Democratic Republic of Congo
Trends, epidemiology and causes of maternal deaths over a decade (2013-2022) in a context of crisis among 8 health zones in Eastern Democratic Republic of Congo Open
Background Maternal mortality (MM) remains a real scourge that hits hardest in the poorest regions of the world, particularly those affected by conflict. However, despite this worrying reality, few studies have been conducted about MM in t…
View article: Dynamics in the Prevalence of Insulin Resistance between 2005 and 2023 in Type 2 Diabetics in South Kivu in the East of the Democratic Republic of Congo: Cross-Sectional Studies
Dynamics in the Prevalence of Insulin Resistance between 2005 and 2023 in Type 2 Diabetics in South Kivu in the East of the Democratic Republic of Congo: Cross-Sectional Studies Open
AIM: Sub-Saharan Africa is undergoing an epidemiological transition responsible for a change in the metabolic profile in favour of insulin resistance. The aim of this study was to assess the dynamics of the prevalence of insulin resistance…
View article: Vitamin D, Parathyroid Hormone, Insulin Sensitivity and Islet <i>β</i>-Cell Secretory Function in Diabetic Patients from South Kivu in the Democratic Republic of Congo: Cross-Sectional Study
Vitamin D, Parathyroid Hormone, Insulin Sensitivity and Islet <i>β</i>-Cell Secretory Function in Diabetic Patients from South Kivu in the Democratic Republic of Congo: Cross-Sectional Study Open
Background: The role of vitamin D and parathyroid hormone in the metabolic profile of type 2 diabetes mellitus in sub-Saharan Africa has not been adequately assessed. The aim of this study was to determine the prevalence of low vitamin D l…
View article: The antihyperlipidemic effect of a combined supplement of standardized dry extracts of amla (Emblica officinalis), walnut (Juglans regia), olive (Olea europaea) and red yeast rice (Monascus purpureus) powder: Reduction in circulatory low-density lipoprotein-cholesterol (LDL-C) and remnant cholesterol (RC) levels in patients with hypercholesterolemia
The antihyperlipidemic effect of a combined supplement of standardized dry extracts of amla (Emblica officinalis), walnut (Juglans regia), olive (Olea europaea) and red yeast rice (Monascus purpureus) powder: Reduction in circulatory low-density lipoprotein-cholesterol (LDL-C) and remnant cholesterol (RC) levels in patients with hypercholesterolemia Open
Background: Hyperlipidemia is associated with a higher rate of cardiovascular, cerebrovascular, and peripheral vascular disease. Conventional drugs such as statins are effective in controlling hyperlipidemia; however, they are associated w…
View article: The Human Mpox Global Outbreak: Available Control Tools and the Opportunity to Break a Cycle of Neglect in Endemic Countries
The Human Mpox Global Outbreak: Available Control Tools and the Opportunity to Break a Cycle of Neglect in Endemic Countries Open
The 2022 global outbreak of human Mpox (formerly monkeypox) virus (MPXV) infection outside of the usual endemic zones in Africa challenged our understanding of the virus’s natural history, transmission dynamics, and risk factors. This outb…
View article: Unsuspected diabetic ketoacidosis after myocardial infarction in a patient treated with SGLT2 inhibitor increased length of stay in the hospital: how can it be prevented? A case report
Unsuspected diabetic ketoacidosis after myocardial infarction in a patient treated with SGLT2 inhibitor increased length of stay in the hospital: how can it be prevented? A case report Open
Background As the use of sodium–glucose co-transporter 2 inhibitors (SGLT2is) has expanded beyond glucose-lowering therapy in type 2 diabetes mellitus (T2DM), including chronic kidney disease and heart failure, there has also been an incre…
View article: A Cross-sectional Real-life Study of the Prevalence, Severity, and Determinants of Metabolic Dysfunction-associated Fatty Liver Disease in Type 2 Diabetes Patients
A Cross-sectional Real-life Study of the Prevalence, Severity, and Determinants of Metabolic Dysfunction-associated Fatty Liver Disease in Type 2 Diabetes Patients Open
Simple bioclinical tools allowed routine triage of T2DM patients for MAFLD severity, with high adherence of high-risk patients to subsequent noninvasive exams.
View article: Combined CFTR modulator therapies are linked with anabolic benefits and insulin-sparing in cystic fibrosis-related diabetes
Combined CFTR modulator therapies are linked with anabolic benefits and insulin-sparing in cystic fibrosis-related diabetes Open
Combined CFTR modulator therapies are correlated with a decrease in insulin doses and positive effects on BMI and FEV1. HOMA indices did not change on tezacaftor + ivacaftor among CF patients without diabetes.
View article: Association between severe acute malnutrition in childhood and hematological disorders in adulthood: the Lwiro follow-up study in the Eastern Democratic Republic of the Congo
Association between severe acute malnutrition in childhood and hematological disorders in adulthood: the Lwiro follow-up study in the Eastern Democratic Republic of the Congo Open
Background: Despite growing evidence on the short-term deleterious effects of severe acute malnutrition (SAM) in childhood on hematopoiesis, little is known about the long-term hematological effects of SAM in low-income countries (LICs). O…
View article: Association between Metabolic Syndrome Components and Serum High-Sensitivity C-Reactive Protein or Interleukin-6 Levels among Congolese Adults
Association between Metabolic Syndrome Components and Serum High-Sensitivity C-Reactive Protein or Interleukin-6 Levels among Congolese Adults Open
Metabolic syndrome (MetS) and its components have been linked to elevated serum levels of inflammatory biomarkers such as C-reactive protein, interleukin-6, interleukin-1β and tumor necrosis factor alpha. The aim of our study was to addres…