Robert M.W. Hofstra
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View article: Human Enteric Glia Diversity in Health and Disease: New Avenues for the Treatment of Hirschsprung Disease
Human Enteric Glia Diversity in Health and Disease: New Avenues for the Treatment of Hirschsprung Disease Open
Two major enteric glial classes were identified in the pediatric intestine, highlighting the significant postnatal contribution of Schwann-like enteric glia to glial heterogeneity. Crucially, these glial subtypes persist in aganglionic seg…
Impact of Enteric Neuronal Loss on Intestinal Cell Composition Open
Summary Hirschsprung disease (HSCR) is a congenital disorder characterized by the absence of an enteric nervous system (ENS) in the distal gut. While the ENS is critical for normal gut function, its broader role in maintaining intestinal h…
Human enteric glia diversity in health and disease: new avenues for the treatment of Hirschsprung disease Open
Hirschsprung disease (HSCR) is caused by an absence of the enteric nervous system (ENS), which is crucial for intestinal function. The ENS is composed of enteric neurons and glia, and is mostly derived from migrating vagal neural crest cel…
Supplementary Table 4 from Histone Methyltransferase Gene <i>SETD2</i> Is a Novel Tumor Suppressor Gene in Clear Cell Renal Cell Carcinoma Open
Supplementary Table 4 from Histone Methyltransferase Gene SETD2 Is a Novel Tumor Suppressor Gene in Clear Cell Renal Cell Carcinoma
Supplementary Figure 1 from Histone Methyltransferase Gene <i>SETD2</i> Is a Novel Tumor Suppressor Gene in Clear Cell Renal Cell Carcinoma Open
Supplementary Figure 1 from Histone Methyltransferase Gene SETD2 Is a Novel Tumor Suppressor Gene in Clear Cell Renal Cell Carcinoma
Supplementary Figure 2G from Histone Methyltransferase Gene <i>SETD2</i> Is a Novel Tumor Suppressor Gene in Clear Cell Renal Cell Carcinoma Open
Supplementary Figure 2G from Histone Methyltransferase Gene SETD2 Is a Novel Tumor Suppressor Gene in Clear Cell Renal Cell Carcinoma
Supplementary Figure 1 from Histone Methyltransferase Gene <i>SETD2</i> Is a Novel Tumor Suppressor Gene in Clear Cell Renal Cell Carcinoma Open
Supplementary Figure 1 from Histone Methyltransferase Gene SETD2 Is a Novel Tumor Suppressor Gene in Clear Cell Renal Cell Carcinoma
Supplementary Figure 3 from Histone Methyltransferase Gene <i>SETD2</i> Is a Novel Tumor Suppressor Gene in Clear Cell Renal Cell Carcinoma Open
Supplementary Figure 3 from Histone Methyltransferase Gene SETD2 Is a Novel Tumor Suppressor Gene in Clear Cell Renal Cell Carcinoma
Supplementary Figure 2G from Histone Methyltransferase Gene <i>SETD2</i> Is a Novel Tumor Suppressor Gene in Clear Cell Renal Cell Carcinoma Open
Supplementary Figure 2G from Histone Methyltransferase Gene SETD2 Is a Novel Tumor Suppressor Gene in Clear Cell Renal Cell Carcinoma
Supplementary Table 3 from Histone Methyltransferase Gene <i>SETD2</i> Is a Novel Tumor Suppressor Gene in Clear Cell Renal Cell Carcinoma Open
Supplementary Table 3 from Histone Methyltransferase Gene SETD2 Is a Novel Tumor Suppressor Gene in Clear Cell Renal Cell Carcinoma
Supplementary Table 4 from Histone Methyltransferase Gene <i>SETD2</i> Is a Novel Tumor Suppressor Gene in Clear Cell Renal Cell Carcinoma Open
Supplementary Table 4 from Histone Methyltransferase Gene SETD2 Is a Novel Tumor Suppressor Gene in Clear Cell Renal Cell Carcinoma
Data from Histone Methyltransferase Gene <i>SETD2</i> Is a Novel Tumor Suppressor Gene in Clear Cell Renal Cell Carcinoma Open
Sporadic clear cell renal cell carcinoma (cRCC) is genetically characterized by the recurrent loss of the short arm of chromosome 3, with a hotspot for copy number loss in the 3p21 region. We applied a method called “gene identification by…
Supplementary Figure 3 from Histone Methyltransferase Gene <i>SETD2</i> Is a Novel Tumor Suppressor Gene in Clear Cell Renal Cell Carcinoma Open
Supplementary Figure 3 from Histone Methyltransferase Gene SETD2 Is a Novel Tumor Suppressor Gene in Clear Cell Renal Cell Carcinoma
Supplementary Table 2 from Histone Methyltransferase Gene <i>SETD2</i> Is a Novel Tumor Suppressor Gene in Clear Cell Renal Cell Carcinoma Open
Supplementary Table 2 from Histone Methyltransferase Gene SETD2 Is a Novel Tumor Suppressor Gene in Clear Cell Renal Cell Carcinoma
Supplementary Table 1 from Histone Methyltransferase Gene <i>SETD2</i> Is a Novel Tumor Suppressor Gene in Clear Cell Renal Cell Carcinoma Open
Supplementary Table 1 from Histone Methyltransferase Gene SETD2 Is a Novel Tumor Suppressor Gene in Clear Cell Renal Cell Carcinoma
Supplementary Figure 2A-F from Histone Methyltransferase Gene <i>SETD2</i> Is a Novel Tumor Suppressor Gene in Clear Cell Renal Cell Carcinoma Open
Supplementary Figure 2A-F from Histone Methyltransferase Gene SETD2 Is a Novel Tumor Suppressor Gene in Clear Cell Renal Cell Carcinoma
Supplementary Table 3 from Histone Methyltransferase Gene <i>SETD2</i> Is a Novel Tumor Suppressor Gene in Clear Cell Renal Cell Carcinoma Open
Supplementary Table 3 from Histone Methyltransferase Gene SETD2 Is a Novel Tumor Suppressor Gene in Clear Cell Renal Cell Carcinoma
Supplementary Table 1 from Histone Methyltransferase Gene <i>SETD2</i> Is a Novel Tumor Suppressor Gene in Clear Cell Renal Cell Carcinoma Open
Supplementary Table 1 from Histone Methyltransferase Gene SETD2 Is a Novel Tumor Suppressor Gene in Clear Cell Renal Cell Carcinoma
Supplementary Figure 2A-F from Histone Methyltransferase Gene <i>SETD2</i> Is a Novel Tumor Suppressor Gene in Clear Cell Renal Cell Carcinoma Open
Supplementary Figure 2A-F from Histone Methyltransferase Gene SETD2 Is a Novel Tumor Suppressor Gene in Clear Cell Renal Cell Carcinoma
Supplementary Table 2 from Histone Methyltransferase Gene <i>SETD2</i> Is a Novel Tumor Suppressor Gene in Clear Cell Renal Cell Carcinoma Open
Supplementary Table 2 from Histone Methyltransferase Gene SETD2 Is a Novel Tumor Suppressor Gene in Clear Cell Renal Cell Carcinoma
Data from Histone Methyltransferase Gene <i>SETD2</i> Is a Novel Tumor Suppressor Gene in Clear Cell Renal Cell Carcinoma Open
Sporadic clear cell renal cell carcinoma (cRCC) is genetically characterized by the recurrent loss of the short arm of chromosome 3, with a hotspot for copy number loss in the 3p21 region. We applied a method called “gene identification by…
The long Filamin-A isoform is required for intestinal development and motility: implications for chronic intestinal pseudo-obstruction Open
Filamin A (FLNA) is a cytoplasmic actin binding protein, recently shown to be expressed as a long and short isoform. Mutations in FLNA are associated with a wide spectrum of disorders, including an X-linked form of chronic intestinal pseud…
Unbiased intestinal single cell transcriptomics reveals previously uncharacterized enteric nervous system populations in larval zebrafish Open
The enteric nervous system (ENS) regulates many gastrointestinal functions including peristalsis, immune regulation and uptake of nutrients. Defects in the ENS can lead to severe enteric neuropathies such as Hirschsprung disease (HSCR), wh…
TFAP2B Haploinsufficiency Impacts Gastrointestinal Function and Leads to Pediatric Intestinal Pseudo-obstruction Open
Background: Pediatric Intestinal Pseudo-obstruction (PIPO) is a congenital enteric disorder characterized by severe gastrointestinal (GI) dysmotility, without mechanical obstruction. Although several genes have been described to cause this…
View article: Corrigendum: TALPID3/KIAA0586 Regulates Multiple Aspects of Neuromuscular Patterning During Gastrointestinal Development in Animal Models and Human
Corrigendum: TALPID3/KIAA0586 Regulates Multiple Aspects of Neuromuscular Patterning During Gastrointestinal Development in Animal Models and Human Open
In the original article, there was an error. Figures 2, 3, 4 and 5 were referenced incorrectly. All references to Figure 5 should have been Figure 2, all references to Figure 4 should have been Figure 3, all references to Figure 3 should h…
View article: TALPID3/KIAA0586 Regulates Multiple Aspects of Neuromuscular Patterning During Gastrointestinal Development in Animal Models and Human
TALPID3/KIAA0586 Regulates Multiple Aspects of Neuromuscular Patterning During Gastrointestinal Development in Animal Models and Human Open
TALPID3/KIAA0586 is an evolutionary conserved protein, which plays an essential role in protein trafficking. Its role during gastrointestinal (GI) and enteric nervous system (ENS) development has not been studied previously. Here, we analy…