Nigel M. Hooper
YOU?
Author Swipe
View article: Biofabrication and biomanufacturing in Ireland and the UK
Biofabrication and biomanufacturing in Ireland and the UK Open
View article: Proteolysis of tau by granzyme A in tauopathies generates fragments that are aggregation prone
Proteolysis of tau by granzyme A in tauopathies generates fragments that are aggregation prone Open
Tauopathies, including Alzheimer's disease, corticobasal degeneration and progressive supranuclear palsy, are characterised by the aggregation of tau into insoluble neurofibrillary tangles in the brain. Tau is subject to a range of post-tr…
View article: Post-translational regulation of the low-density lipoprotein receptor provides new targets for cholesterol regulation
Post-translational regulation of the low-density lipoprotein receptor provides new targets for cholesterol regulation Open
The amount of the low-density lipoprotein receptor (LDLR) on the surface of hepatocytes is the primary determinant of plasma low-density lipoprotein (LDL)-cholesterol level. Although the synthesis and cellular trafficking of the LDLR have …
View article: UPTAKE AND REPLICATION OF SARS-CoV-2 IN THE CELLS OF THE NEUROVASCULAR UNIT
UPTAKE AND REPLICATION OF SARS-CoV-2 IN THE CELLS OF THE NEUROVASCULAR UNIT Open
View article: MODELLING ALZHEIMER'S DISEASE THROUGH ENVIRONMENTALLY INDUCED NEUROVASCULAR DYSFUNCTION WITHIN AN IN VITRO CELL MODEL
MODELLING ALZHEIMER'S DISEASE THROUGH ENVIRONMENTALLY INDUCED NEUROVASCULAR DYSFUNCTION WITHIN AN IN VITRO CELL MODEL Open
View article: Inhibition of insulin-degrading enzyme in human neurons promotes amyloid-β deposition
Inhibition of insulin-degrading enzyme in human neurons promotes amyloid-β deposition Open
Alzheimer’s disease (AD) is characterised by the aggregation and deposition of amyloid-β (Aβ) peptides in the human brain. In age-related late-onset AD, deficient degradation and clearance, rather than enhanced production, of Aβ contribute…
View article: Induced pluripotent stem cell model revealed impaired neurovascular interaction in genetic small vessel disease Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy
Induced pluripotent stem cell model revealed impaired neurovascular interaction in genetic small vessel disease Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy Open
Introduction Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) is the most common genetic small vessel disease caused by variants in the NOTCH3 gene. Patients with CADASIL experience recur…
View article: Proteolysis of the low‐density lipoprotein receptor in hepatocytes is mediated by <scp>BMP1</scp> but not by other astacin proteases
Proteolysis of the low‐density lipoprotein receptor in hepatocytes is mediated by <span>BMP1</span> but not by other astacin proteases Open
Bone morphogenetic protein 1 (BMP1), a member of the astacin family of zinc‐metalloproteases, proteolytically cleaves the low‐density lipoprotein receptor (LDLR) within its ligand‐binding domain, reducing the binding and cellular uptake of…
View article: Induced pluripotent stem cell model revealed impaired neurovascular interaction in genetic small vessel disease CADASIL
Induced pluripotent stem cell model revealed impaired neurovascular interaction in genetic small vessel disease CADASIL Open
Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) is the most common genetic small vessel disease caused by variants in the NOTCH3 gene. Patients with CADASIL experience recurrent strokes,…
View article: The role of protein aggregation in the pathogenesis of inclusion body myositis.
The role of protein aggregation in the pathogenesis of inclusion body myositis. Open
Inclusion body myositis (IBM) is characterised by infiltration of CD8+ T-cells and signs of protein aggregation such as rimmed vacuoles and inclusion bodies. Aggregated proteins include those present in neurodegenerative diseases, and also…
View article: 3D hydrogel models of the neurovascular unit to investigate blood–brain barrier dysfunction
3D hydrogel models of the neurovascular unit to investigate blood–brain barrier dysfunction Open
The neurovascular unit (NVU), consisting of neurons, glial cells, vascular cells (endothelial cells, pericytes and vascular smooth muscle cells (VSMCs)) together with the surrounding extracellular matrix (ECM), is an important interface be…
View article: Severe and Regionally Widespread Increases in Tissue Urea in the Human Brain Represent a Novel Finding of Pathogenic Potential in Parkinson’s Disease Dementia
Severe and Regionally Widespread Increases in Tissue Urea in the Human Brain Represent a Novel Finding of Pathogenic Potential in Parkinson’s Disease Dementia Open
Widespread elevations in brain urea have, in recent years, been reported in certain types of age-related dementia, notably Alzheimer’s disease (AD) and Huntington’s disease (HD). Urea increases in these diseases are substantive, and approx…
View article: Substantively Lowered Levels of Pantothenic Acid (Vitamin B5) in Several Regions of the Human Brain in Parkinson’s Disease Dementia
Substantively Lowered Levels of Pantothenic Acid (Vitamin B5) in Several Regions of the Human Brain in Parkinson’s Disease Dementia Open
Pantothenic acid (vitamin B5) is an essential trace nutrient required for the synthesis of coenzyme A (CoA). It has previously been shown that pantothenic acid is significantly decreased in multiple brain regions in both Alzheimer’s diseas…
View article: Exploiting the neuroprotective effects of α-klotho to tackle ageing- and neurodegeneration-related cognitive dysfunction
Exploiting the neuroprotective effects of α-klotho to tackle ageing- and neurodegeneration-related cognitive dysfunction Open
Cognitive dysfunction is a key symptom of ageing and neurodegenerative disorders, such as Alzheimer’s disease (AD). Strategies to enhance cognition would impact the quality of life for a significant proportion of the ageing population. The…
View article: Severe and regionally-widespread increases in tissue urea in the human brain represent a novel finding of pathogenic potential in Parkinson’s disease dementia
Severe and regionally-widespread increases in tissue urea in the human brain represent a novel finding of pathogenic potential in Parkinson’s disease dementia Open
Background: Widespread elevations in brain urea have, in recent years, been reported in certain types of age-related dementia, notably Alzheimer’s disease (AD) and Huntington’s disease (HD). Urea increases in these diseases are substantive…
View article: Nanoparticle-Enabled Enrichment of Longitudinal Blood Proteomic Fingerprints in Alzheimer’s Disease
Nanoparticle-Enabled Enrichment of Longitudinal Blood Proteomic Fingerprints in Alzheimer’s Disease Open
Blood-circulating biomarkers have the potential to detect Alzheimer's disease (AD) pathology before clinical symptoms emerge and to improve the outcomes of clinical trials for disease-modifying therapies. Despite recent advances in underst…
View article: Widespread Decreases in Cerebral Copper Are Common to Parkinson's Disease Dementia and Alzheimer's Disease Dementia
Widespread Decreases in Cerebral Copper Are Common to Parkinson's Disease Dementia and Alzheimer's Disease Dementia Open
Several studies of Parkinson's disease (PD) have reported dysregulation of cerebral metals, particularly decreases in copper and increases in iron in substantia nigra (SN). However, few studies have investigated regions outside the SN, few…
View article: Impact of type-1 collagen hydrogel density on integrin-linked morphogenic response of SH-SY5Y neuronal cells
Impact of type-1 collagen hydrogel density on integrin-linked morphogenic response of SH-SY5Y neuronal cells Open
Cellular metabolism and behaviour is closely linked to cytoskeletal tension and scaffold mechanics.
View article: Effects of Alterations of Post-Mortem Delay and Other Tissue-Collection Variables on Metabolite Levels in Human and Rat Brain
Effects of Alterations of Post-Mortem Delay and Other Tissue-Collection Variables on Metabolite Levels in Human and Rat Brain Open
The use of post-mortem human tissue is indispensable in studies investigating alterations in metabolite levels in neurodegenerative conditions such as Alzheimer’s disease (AD). However, variability between samples may have unknown effects …
View article: Mild Cognitive Impairment: the Manchester consensus
Mild Cognitive Impairment: the Manchester consensus Open
Given considerable variation in diagnostic and therapeutic practice, there is a need for national guidance on the use of neuroimaging, fluid biomarkers, cognitive testing, follow-up and diagnostic terminology in mild cognitive impairment (…
View article: A Preliminary Evaluation of the Pro-Chondrogenic Potential of 3D-Bioprinted Poly(ester Urea) Scaffolds
A Preliminary Evaluation of the Pro-Chondrogenic Potential of 3D-Bioprinted Poly(ester Urea) Scaffolds Open
Degeneration of articular cartilage (AC) is a common healthcare issue that can result in significantly impaired function and mobility for affected patients. The avascular nature of the tissue strongly burdens its regenerative capacity cont…
View article: Gene Ontology Curation of Neuroinflammation Biology Improves the Interpretation of Alzheimer’s Disease Gene Expression Data
Gene Ontology Curation of Neuroinflammation Biology Improves the Interpretation of Alzheimer’s Disease Gene Expression Data Open
Background: Gene Ontology (GO) is a major bioinformatic resource used for analysis of large biomedical datasets, for example from genome-wide association studies, applied universally across biological fields, including Alzheimer’s disease …
View article: Extracellular Vesicles Isolated from Human Induced Pluripotent Stem Cell-Derived Neurons Contain a Transcriptional Network
Extracellular Vesicles Isolated from Human Induced Pluripotent Stem Cell-Derived Neurons Contain a Transcriptional Network Open
Healthy brain function is mediated by several complementary signalling pathways, many of which are driven by extracellular vesicles (EVs). EVs are heterogeneous in both size and cargo and are constitutively released from cells into the ext…
View article: Evidence that levels of nine essential metals in post-mortem human-Alzheimer’s-brain and<i>ex vivo</i>rat-brain tissues are unaffected by differences in post-mortem delay, age, disease staging, and brain bank location
Evidence that levels of nine essential metals in post-mortem human-Alzheimer’s-brain and<i>ex vivo</i>rat-brain tissues are unaffected by differences in post-mortem delay, age, disease staging, and brain bank location Open
Studies of neurodegenerative conditions such as Alzheimer’s disease (AD) using post mortem brain tissues have uncovered several perturbations in metals such as copper, iron, and zinc. However, studies of the effects of key, potentially con…
The cellular expression and proteolytic processing of the amyloid precursor protein is independent of TDP-43 Open
View article: Author Correction: Proteolysis of the low density lipoprotein receptor by bone morphogenetic protein-1 regulates cellular cholesterol uptake
Author Correction: Proteolysis of the low density lipoprotein receptor by bone morphogenetic protein-1 regulates cellular cholesterol uptake Open
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
View article: Proteolysis of the low density lipoprotein receptor by bone morphogenetic protein-1 regulates cellular cholesterol uptake
Proteolysis of the low density lipoprotein receptor by bone morphogenetic protein-1 regulates cellular cholesterol uptake Open
The development of cardiovascular disease is intimately linked to elevated levels of low-density lipoprotein (LDL) cholesterol in the blood. Hepatic LDL receptor (LDLR) levels regulate the amount of plasma LDL. We identified the secreted z…
View article: Proteolysis of the low density lipoprotein receptor by bone morphogenetic protein-1 regulates cellular cholesterol uptake
Proteolysis of the low density lipoprotein receptor by bone morphogenetic protein-1 regulates cellular cholesterol uptake Open
The development of cardiovascular disease is intimately linked to elevated levels of low-density lipoprotein (LDL) cholesterol in the blood. Hepatic LDL receptor (LDLR) levels regulate the amount of plasma LDL. We identified the secreted z…
View article: P4‐524: PROTEOLYTIC CLEAVAGE OF TAU IN CORTICOBASAL DEGENERATION AND PROGRESSIVE SUPRANUCLEAR PALSY PATHOGENESIS
P4‐524: PROTEOLYTIC CLEAVAGE OF TAU IN CORTICOBASAL DEGENERATION AND PROGRESSIVE SUPRANUCLEAR PALSY PATHOGENESIS Open
During the pathogenesis of tauopathies, such as corticobasal degeneration (CBD) and progressive supranuclear palsy (PSP), proteases cleave tau into fragments which have an altered propensity to be phosphorylated, to spread, to aggregate an…
View article: Blended alginate/collagen hydrogels promote neurogenesis and neuronal maturation
Blended alginate/collagen hydrogels promote neurogenesis and neuronal maturation Open