Morten Høyer
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View article: Patterns of practice of image guided particle therapy for brain tumours: A site specific multi-institutional survey of the European particle therapy network
Patterns of practice of image guided particle therapy for brain tumours: A site specific multi-institutional survey of the European particle therapy network Open
There is generally agreement across European proton centres, but variability remained in key components of treatment planning, verification and workflow optimisation, including the frequency and modality of control imaging, plan robustness…
View article: Clinical implementation of intensity modulated proton therapy for testicular seminoma
Clinical implementation of intensity modulated proton therapy for testicular seminoma Open
Background and purpose: We have previously shown that proton therapy results in considerable reduced doses to abdominal organs at risk (OAR) which likely reduces the patient’s risk of a second malignant tumor, which is vital for this young…
View article: Radiotherapy for Locally Advanced Pancreatic Cancer in the Modern Era: A Systematic Review and Meta-Analysis
Radiotherapy for Locally Advanced Pancreatic Cancer in the Modern Era: A Systematic Review and Meta-Analysis Open
Background: The optimal treatment strategy for locally advanced unresectable pancreatic cancer (LAPC) is still investigated. Therefore, we evaluated the role of radiotherapy (RT) in the management of LAPC in the modern era. Methods: A syst…
View article: Prediction model for the selection of patients with glioma to proton therapy
Prediction model for the selection of patients with glioma to proton therapy Open
Background and purpose: The selection of patients with low-grade gliomas for proton therapy (PT) is often based on the comparison of photon and PT plans and demonstrating meaningful dose reduction to the healthy brain or critical structure…
View article: European practice on neurovascular late effects after pediatric radiotherapy: considerations on dose planning and follow-up – a HARMONIC/SIOPE ROWG survey
European practice on neurovascular late effects after pediatric radiotherapy: considerations on dose planning and follow-up – a HARMONIC/SIOPE ROWG survey Open
Background and purpose: The risk of developing neurovascular late effects after radiotherapy is an area of concern when treating pediatric brain tumor patients. However, knowledge is sparse regarding best practice for clinical management d…
View article: Accuracy of four models and update strategies to estimate liver tumor motion from external respiratory motion
Accuracy of four models and update strategies to estimate liver tumor motion from external respiratory motion Open
Background This study investigates different strategies for estimating internal liver tumor motion during radiotherapy based on continuous monitoring of external respiratory motion combined with sparse internal imaging. Methods Fifteen pat…
View article: Recent update of proton beam therapy for hepatocellular carcinoma: a systematic review and meta-analysis
Recent update of proton beam therapy for hepatocellular carcinoma: a systematic review and meta-analysis Open
Backgrounds/Aims: Although access to proton beam therapy (PBT) is limited worldwide, its use for the treatment of hepatocellular carcinoma (HCC) is gradually increasing with the expansion of new facilities. Therefore, we conducted a system…
View article: Think big–think BiGART. The 21st Acta Oncologica Symposium—BiGART 2023
Think big–think BiGART. The 21st Acta Oncologica Symposium—BiGART 2023 Open
Acta Oncologica has supported Nordic symposia from the start in the late eighties and since 2006 they have supported a biannual Acta Oncologica Symposium hosted by radiotherapy research environment in Aarhus, Denmark.The topics have includ…
View article: Prediction of dose-sparing by protons assessed by a knowledge-based planning tool in radiotherapy of brain tumours
Prediction of dose-sparing by protons assessed by a knowledge-based planning tool in radiotherapy of brain tumours Open
Click to increase image sizeClick to decrease image size Disclosure statementThe authors have nothing to disclose.Data availability statementCorresponding author can be contacted for access to data and will provide data upon reasonable req…
View article: Plan robustness evaluation strategies in whole-pelvic proton therapy for high-risk prostate cancer patients within a randomised clinical trial
Plan robustness evaluation strategies in whole-pelvic proton therapy for high-risk prostate cancer patients within a randomised clinical trial Open
The PRE strategy predicted the DRE scenarios for CTVp and rectum. CTVe, bladder, and bowel showed more complex anatomical variations than simulated by the PRE isocenter shift. Both original and recalculated nominal treatment plans showed r…
View article: Radiation dose to sleep-relevant brain structures linked to impaired sleep quality in primary brain tumor patients
Radiation dose to sleep-relevant brain structures linked to impaired sleep quality in primary brain tumor patients Open
Figure 1.Individual (iDVH) and mean dose volume histograms (DVH) for good (blue) and poor (red) daytime dysfunction across selected brain structures.
View article: Dose comparison of robustly optimized intensity modulated proton therapy (IMPT) vs IMRT and VMAT photon plans for testicular seminoma
Dose comparison of robustly optimized intensity modulated proton therapy (IMPT) vs IMRT and VMAT photon plans for testicular seminoma Open
Patients with stage II seminoma have traditionally been treated with photons to the retroperitoneal and iliac space, which leads to a substantial dose bath to abdominal and pelvic organs at risk (OAR). As these patients are young and with …
View article: Using immunotherapy to enhance the response of a C3H mammary carcinoma to proton radiation
Using immunotherapy to enhance the response of a C3H mammary carcinoma to proton radiation Open
Checkpoint inhibitors enhanced the response of this C3H mammary carcinoma to proton irradiation. However, this enhancement depended on the checkpoint inhibitor and radiation dose.
View article: Proton therapy planning and image-guidance strategies within a randomized controlled trial for high-risk prostate cancer
Proton therapy planning and image-guidance strategies within a randomized controlled trial for high-risk prostate cancer Open
The Danish Prostate Cancer Group is launching the randomized trial, PROstate PROTON Trial 1 (NCT05350475), that compares photons and protons to the prostate and pelvic lymph nodes in treatment of high-risk prostate cancer. The aim of the w…
View article: Intrafraction tumor motion monitoring and dose reconstruction for liver pencil beam scanning proton therapy
Intrafraction tumor motion monitoring and dose reconstruction for liver pencil beam scanning proton therapy Open
Background Pencil beam scanning (PBS) proton therapy can provide highly conformal target dose distributions and healthy tissue sparing. However, proton therapy of hepatocellular carcinoma (HCC) is prone to dosimetrical uncertainties induce…
View article: Plan robustness evaluation strategies in whole-pelvic proton therapy for high-risk prostate cancer patients within a randomised clinical trial
Plan robustness evaluation strategies in whole-pelvic proton therapy for high-risk prostate cancer patients within a randomised clinical trial Open
Inter-fractional anatomical changes challenge robust delivery of whole-pelvic proton therapy for high-risk prostate cancer. Pre-treatment robust evaluation (PRE) takes uncertainties in isocenter shifts and distal beam edge in treatment pla…
View article: Health effects of ionising radiation in paediatrics undergoing either cardiac fluoroscopy or modern radiotherapy (The HARMONIC project)
Health effects of ionising radiation in paediatrics undergoing either cardiac fluoroscopy or modern radiotherapy (The HARMONIC project) Open
The use of ionising radiation (IR) for medical diagnosis and treatment procedures has had a major impact on the survival of paediatric patients. Although the benefits of these techniques lead to efficient health care, evaluation of potenti…