M. Illa
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Doppler Assessment of the Fetal Brain Circulation Open
Doppler assessment of fetal cerebral circulation has become a cornerstone of modern fetal medicine. It is used to evaluate cerebral vascular malformations, brain anomalies, fetal growth restriction due to placental insufficiency, fetal ane…
Dual Effect of Melatonin in Fetal Brain: Structural and Cellular Implications in a Rabbit Model of Intrauterine Growth Restriction Open
Intrauterine growth restriction (IUGR) is a condition in which the fetus fails to reach its genetic growth potential, often resulting in neurodevelopmental alterations. This study investigates the neuroprotective potential of gestational m…
Fetal Advanced Neurosonography in the First Trimester of Pregnancy Open
Introduction: Some of the central nervous system malformations (CNSs) can be detected or suspected during the first trimester. Methods: Prospective observational study including singleton pregnancies, CRL between 60 and 82 mm and normal ba…
View article: Ultrasonographic findings in mid-trimester adolescent pregnancy: prevalence and risk of abnormalities
Ultrasonographic findings in mid-trimester adolescent pregnancy: prevalence and risk of abnormalities Open
Background Adolescent pregnancy, defined as pregnancy in females aged 19 or younger, is associated with higher risks for adverse outcomes compared to older women. Ultrasound imaging during the mid-trimester is crucial for prenatal care, pr…
View article: Systematic Ultrasound Evaluation of Olfactory Sulci in Fetuses with Congenital Heart Defects: A Clue for CHARGE Syndrome Diagnosis
Systematic Ultrasound Evaluation of Olfactory Sulci in Fetuses with Congenital Heart Defects: A Clue for CHARGE Syndrome Diagnosis Open
Introduction: Arhinencephaly have been identified as a significant feature in CHARGE syndrome. This study aimed to evaluate the diagnostic role of olfactory sulci (OS) in identifying CHARGE syndrome among fetuses with major congenital hear…
View article: Systematic review and meta-analysis of the association between young maternal age and fetal abnormalities
Systematic review and meta-analysis of the association between young maternal age and fetal abnormalities Open
Fetal anomalies among young women and adolescents pose major public health concerns. This systematic review aims to elucidate the relationship between young maternal age and the incidence of fetal abnormalities. According to the systematic…
Lactoferrin/sialic acid prevents adverse effects of intrauterine growth restriction on neurite length: investigations in an in vitro rabbit neurosphere model Open
Introduction Intrauterine growth restriction (IUGR) is a well-known cause of impaired neurodevelopment during life. In this study, we aimed to characterize alterations in neuronal development underlying IUGR and discover strategies to amel…
Acute fetal cardiovascular adaptation to artificial placenta in sheep model Open
Objective To describe the acute cardiovascular adaptation of the fetus after connection to an artificial placenta (AP) in a sheep model, using ultrasound and invasive and non‐invasive hemodynamic assessment. Methods This was an experimenta…
An Artificial Placenta Experimental System in Sheep: Critical Issues for Successful Transition and Survival up to One Week Open
Objective: To describe the development of an artificial placenta (AP) system in sheep with learning curve and main bottlenecks to allow survival up to one week. Methods: A total of 28 fetal sheep were transferred to an AP system at 110–115…
Neonatal Effects of Maternal Supplementation with Docosahexaenoic Acid and Lactoferrin on the Fetal Brain and Placenta in a Rabbit Model of Intrauterine Growth Restriction Open
The main objective is to evaluate the protective effects of maternal supplementation with docosahexaenoic acid (DHA) and lactoferrin (Lf) on the fetal brain and in the placenta structure in a rabbit model of Intrauterine growth restriction…
Application of the adverse outcome pathway to identify molecular changes in prenatal brain programming induced by IUGR: Discoveries after EGCG exposure Open
Following a multi-disciplinary approach integrating information from several experimental models we have collected new evidence supporting, expanding and redesigning the AOP "Disrupted laminin/int-β1 interaction leading to decreased cognit…
The Role of “Uterine Artery Doppler” at 11 to 13+6 Weeks for Prediction of Preeclampsia: A Systematic Review Open
Objective: This systematic review is aimed to review the role of uterine artery Doppler in first trimester of pregnancy along with use of maternal characteristics as a predictor of early and late on set pre-eclampsia (PE). Selection Criter…
View article: EP09.07: Kallman syndrome: phenotypic variability in the same family
EP09.07: Kallman syndrome: phenotypic variability in the same family Open
Kallman syndrome (KS) is characterised by hypogonadotropic hypogonadism and anosmia and is associated to multiple genetic alterations with different types of inheritance and variable expressivity resulting in a wide clinical spectrum. We p…
Protocols for the Evaluation of Neurodevelopmental Alterations in Rabbit Models In Vitro and In Vivo Open
The rabbit model is gaining importance in the field of neurodevelopmental evaluation due to its higher similarity to humans in terms of brain development and maturation than rodents. In this publication, we detailed 14 protocols covering t…
Docosahexaenoic Acid and Melatonin Prevent Impaired Oligodendrogenesis Induced by Intrauterine Growth Restriction (IUGR) Open
In this study, our aims were to characterize oligodendrogenesis alterations in fetuses with intrauterine growth restriction (IUGR) and to find therapeutic strategies to prevent/treat them using a novel rabbit in vitro neurosphere culture. …
Ultrasonography Knowledge and Practices among Obstetrics/Gynecology Practitioners; A Nationwide Survey in Jordan Open
Background: Ultrasonography is an indispensable tool in obstetric practice. This study aims to assess the ultrasonography-related knowledge, practices, and training aspects of Jordanian Obstetrics/Gynecology (OB/GYN) practitioners. This cr…
View article: Miniaturized Electrochemical Sensors to Monitor Fetal Hypoxia and Acidosis in a Pregnant Sheep Model
Miniaturized Electrochemical Sensors to Monitor Fetal Hypoxia and Acidosis in a Pregnant Sheep Model Open
Perinatal asphyxia is a major cause of severe brain damage and death. For its prenatal identification, Doppler ultrasound has been used as a surrogate marker of fetal hypoxia. However, Doppler evaluation cannot be performed continuously. W…
Strategies for intra-amniotic administration of fetal therapy in a rabbit model of intrauterine growth restriction Open
Intrauterine growth restriction affects up to 10% of all pregnancies, leading to fetal programming with detrimental consequences for lifelong health. However, no therapeutic strategies have so far been effective to ameliorate these consequ…
Docosahexaenoic Acid and Lactoferrin Effects on the Brain and Placenta in a Rabbit Model of Intrauterine Growth Restriction Open
Intrauterine growth restriction (IUGR) is associated with suboptimal perinatal outcomes and neurodevelopment in the offspring. We hypothesize that prenatal supplementation with docosahexaenoic acid (DHA) or lactoferrin (Lf) would ameliorat…
Non-invasive monitoring of pH and oxygen using miniaturized electrochemical sensors in an animal model of acute hypoxia Open
Background One of the most prevalent causes of fetal hypoxia leading to stillbirth is placental insufficiency. Hemodynamic changes evaluated with Doppler ultrasound have been used as a surrogate marker of fetal hypoxia. However, Doppler ev…
Supplementary Material for: Structural Brain Changes during the Neonatal Period in a Rabbit Model of Intrauterine Growth Restriction Open
Background: Intrauterine growth restriction (IUGR) is associated with abnormal neurodevelopment, but the associated structural brain changes are poorly documented. The aim of this study was to describe in an animal model the brain changes …