Mark J. Edwards
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View article: Cognition and metacognition in functional motor symptoms and functional seizures: A case-control study
Cognition and metacognition in functional motor symptoms and functional seizures: A case-control study Open
Summary Background Cognitive symptoms are common in functional neurological disorder (FND), yet there is inconsistent evidence of impaired neurocognitive test performance in this population. We aimed to assess core cognitive functions and …
View article: A Case-Control Study of Aetiological Factors in Functional Seizures and Functional Motor Symptoms: Shared and Distinct Features
A Case-Control Study of Aetiological Factors in Functional Seizures and Functional Motor Symptoms: Shared and Distinct Features Open
Background: Functional seizures (FS) and functional motor symptoms (FMS), subtypes of functional neurological disorder, may involve distinct predisposing, precipitating, perpetuating, and triggering (PPPT) factors. This study investigated …
View article: Identifying Poor Responders to STN DBS in Parkinson Disease: The Role of Rapid Disease Progression in the First Year in Optimal Responders to Levodopa
Identifying Poor Responders to STN DBS in Parkinson Disease: The Role of Rapid Disease Progression in the First Year in Optimal Responders to Levodopa Open
Background The factors contributing to a poor response to subthalamic nucleus deep brain stimulation (STN‐DBS) in Parkinson's disease (PD) are not yet fully understood. Accordingly, predicting the outcome might be challenging particularly …
View article: Interoception and dissociation in migraine: a case–control study of chronic and episodic subtypes
Interoception and dissociation in migraine: a case–control study of chronic and episodic subtypes Open
Background Migraine is one of the most common neurological disorders. Despite advances in understanding of episodic migraine, little is understood about the mechanisms underlying the chronification of migraine. Recently, increasing attenti…
View article: Sleep in Functional Motor Disorders: A Case–Control Polysomnographic Study
Sleep in Functional Motor Disorders: A Case–Control Polysomnographic Study Open
Sleep problems are frequent in functional motor disorders (FMDs). Surprisingly, objective correlates of impaired sleep and its relationship to other comorbidities have been understudied, and no polysomnographic study is available. We aimed…
View article: Human Factors: Affect Everyone, Involve Everyone
Human Factors: Affect Everyone, Involve Everyone Open
Background The NHS Patient Safety Syllabus highlights human factors as a core education theme for all healthcare staff. Despite this, no multidisciplinary Human Factors courses in NHS Wales have previously been reported. Approach A multidi…
View article: Randomised feasibility study evaluating eye movement desensitisation and reprocessing therapy for functional neurological disorder (MODIFI)
Randomised feasibility study evaluating eye movement desensitisation and reprocessing therapy for functional neurological disorder (MODIFI) Open
Background Functional neurological disorder (FND) is a common neurological presentation with symptoms such as seizures, walking difficulties, limb weakness and cognitive difficulties. Treatments for FND include physiotherapy and psychologi…
View article: The journey to a diagnosis of Functional Neurological Disorder (FND)
The journey to a diagnosis of Functional Neurological Disorder (FND) Open
Purpose This qualitative study aimed to explore participants’ experiences of being diagnosed with functional neurological disorder (FND), accessing treatment, and navigating life after diagnosis. Participants were drawn from a randomised f…
View article: Outcomes of specialist physiotherapy for functional motor disorder: the Physio4FMD RCT
Outcomes of specialist physiotherapy for functional motor disorder: the Physio4FMD RCT Open
Background Functional motor disorder often causes persistent disabling symptoms that are associated with high healthcare costs. In recent years, specialist physiotherapy, informed by an understanding of functional motor disorder, has emerg…
View article: Public and professional attitudes towards deceptive and open-label placebo in functional neurological disorder and wider neurological practice
Public and professional attitudes towards deceptive and open-label placebo in functional neurological disorder and wider neurological practice Open
Background Placebo effects are powerful and have been suggested to be particularly relevant in certain neurological conditions, including functional neurological disorder (FND). Methods A survey on attitudes towards and current practice of…
View article: Service use, healthcare costs and productivity losses of functional cognitive disorder in a sample of attenders to out-patient cognitive, neurology and memory clinics
Service use, healthcare costs and productivity losses of functional cognitive disorder in a sample of attenders to out-patient cognitive, neurology and memory clinics Open
Background People with functional disorders often receive high levels of healthcare resource use yet have poor outcomes. The health service costs and productivity losses of functional cognitive disorders (FCD) is unknown. Aims This study a…
View article: Long-term (seven-year) follow-up of sensory-motor rehabilitation therapy for task-specific focal hand dystonia
Long-term (seven-year) follow-up of sensory-motor rehabilitation therapy for task-specific focal hand dystonia Open
Benefits of sensory-motor rehabilitation can be sustained. The underlying mechanisms of these changes require investigation.
View article: Randomised controlled feasibility trial of online group acceptance and commitment therapy for functional cognitive disorder
Randomised controlled feasibility trial of online group acceptance and commitment therapy for functional cognitive disorder Open
Background Functional cognitive disorder is an increasingly recognised subtype of functional neurological disorder for which treatment options are currently limited. We have developed a brief online group acceptance and commitment therapy …
View article: Probing the functional magnetic resonance imaging response to psilocybin in functional neurological disorder (PsiFUND): study protocol
Probing the functional magnetic resonance imaging response to psilocybin in functional neurological disorder (PsiFUND): study protocol Open
Background Functional neurological disorder (FND) is a common cause of neurological symptoms including seizures and movement disorders. It can be debilitating, is associated with high health and social care costs, and can have a poor progn…
View article: Cost Utility of Specialist Physiotherapy for Functional Motor Disorder (Physio4FMD)
Cost Utility of Specialist Physiotherapy for Functional Motor Disorder (Physio4FMD) Open
International Standard Randomised Controlled Trial registry, ISRCTN56136713.
View article: Development of a diagnostic checklist to identify functional cognitive disorder versus other neurocognitive disorders
Development of a diagnostic checklist to identify functional cognitive disorder versus other neurocognitive disorders Open
Background Functional cognitive disorder (FCD) poses a diagnostic challenge due to its resemblance to other neurocognitive disorders and limited biomarker accuracy. We aimed to develop a new diagnostic checklist to identify FCD versus othe…
View article: Clinical practice guidelines for the treatment of tardive dyskinesia in Europe: A descriptive review
Clinical practice guidelines for the treatment of tardive dyskinesia in Europe: A descriptive review Open
Background While evidence-based clinical practice guidelines promote high-quality care, their absence may create unwarranted variation in disease management, leading to suboptimal outcomes. This study aimed to identify existing clinical pr…
View article: The impact of motor and non-motor symptoms fluctuations on health-related quality of life in people with functional motor disorder
The impact of motor and non-motor symptoms fluctuations on health-related quality of life in people with functional motor disorder Open
Objective: To assess the effect of overall, between- and within-day subjectively rated fluctuations in motor and non-motor symptoms in people with functional motor disorder (FMD) on the health-related quality of life (HRQoL). Background: F…
View article: Functional Neurological Disorder and Autism Spectrum Disorder: A Complex and Potentially Significant Relationship
Functional Neurological Disorder and Autism Spectrum Disorder: A Complex and Potentially Significant Relationship Open
Introduction Functional neurological disorder (FND) and autism spectrum disorder (ASD) are two complex neuropsychiatric conditions that have been historically classified within psychiatric domains, resulting in a lack of extensive research…
View article: Real-time biopsychosocial antecedents and correlates of functional neurological symptoms in daily life: A pilot remote monitoring technology study
Real-time biopsychosocial antecedents and correlates of functional neurological symptoms in daily life: A pilot remote monitoring technology study Open
Functional neurological symptom disorder (FNSD) is a neuropsychiatric diagnosis referring to symptoms resembling those of neurological disorders, occurring without causal neuropathology. FNSD has a complex biopsychosocial aetiology but its…
View article: External Factors Modulating Pain and Pain‐Related Functional Impairment in Cervical Dystonia
External Factors Modulating Pain and Pain‐Related Functional Impairment in Cervical Dystonia Open
Background Little is known about factors modulating pain and pain‐related functional impairment in isolated cervical dystonia (CD). Objective The aim was to assess the prevalence and interrelationship between pain‐modulating factors and pa…
View article: Probing the functional magnetic resonance imaging response to psilocybin in functional neurological disorder (PsiFUND): study protocol
Probing the functional magnetic resonance imaging response to psilocybin in functional neurological disorder (PsiFUND): study protocol Open
Background Functional neurological disorder (FND) is a common cause of neurological symptoms including paralysis, seizures, and movement disorders. It is often debilitating, is associated with high health and social care costs, and can hav…