John M. Inadomi
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View article: <scp>GLP</scp> ‐1 receptor agonists for treating obesity without diabetes: A systematic review and meta‐analysis of economic evaluations
<span>GLP</span> ‐1 receptor agonists for treating obesity without diabetes: A systematic review and meta‐analysis of economic evaluations Open
Aim To pool the incremental net benefits (INBs) of using glucagon‐like peptide‐1 receptor agonists (GLP‐1RAs) for treating obesity without diabetes. Materials and Methods PubMed, Embase, EconLit, CEA Registry, ProQuest Dissertation and The…
View article: 268. COST-EFFECTIVENESS OF SCREENING FOR BARRETT’S ESOPHAGUS WITH ESOCHECK/ESOGUARD COMPARED TO SCREENING WITH UPPER ENDOSCOPY
268. COST-EFFECTIVENESS OF SCREENING FOR BARRETT’S ESOPHAGUS WITH ESOCHECK/ESOGUARD COMPARED TO SCREENING WITH UPPER ENDOSCOPY Open
Background Barrett’s Esophagus (BE), a precursor to esophageal adenocarcinoma (EAC), is typically screened using endoscopy, an effective but invasive procedure. EsoCheck/EsoGuard (ECEG), a less invasive tool that uses a swallowable balloon…
View article: Feasible and acceptable social drivers of health screening among patients with chronic liver disease
Feasible and acceptable social drivers of health screening among patients with chronic liver disease Open
Background: Social drivers of health (SDoH) contribute to health disparities among patients with chronic liver disease (CLD). Little is known about the feasibility and acceptability of SDoH screening in hepatology clinics. This study aimed…
View article: Benefits of colorectal cancer screening using fecal immunochemical testing with varying positivity thresholds by age and sex
Benefits of colorectal cancer screening using fecal immunochemical testing with varying positivity thresholds by age and sex Open
Background Fecal immunochemical test (FIT) performance for colorectal cancer screening varies by age and sex, yet most FIT-based screening programs use uniform positivity thresholds. This study assessed the potential benefits of stratifyin…
View article: Characteristics of a cost-effective blood test for colorectal cancer screening
Characteristics of a cost-effective blood test for colorectal cancer screening Open
Background Blood-based biomarker tests can potentially change the landscape of colorectal cancer (CRC) screening. We characterize the conditions under which blood test screening would be as effective and cost-effective as annual fecal immu…
View article: Screening for social determinants of health among populations at risk for MASLD: a scoping review
Screening for social determinants of health among populations at risk for MASLD: a scoping review Open
Background Social determinants of health (SDoH) have been associated with disparate outcomes among those with metabolic dysfunction-associated steatotic liver disease (MASLD) and its risk factors. To address SDoH among this population, rea…
View article: Effectiveness and Cost-Effectiveness of Colorectal Cancer Screening With a Blood Test That Meets the Centers for Medicare & Medicaid Services Coverage Decision
Effectiveness and Cost-Effectiveness of Colorectal Cancer Screening With a Blood Test That Meets the Centers for Medicare & Medicaid Services Coverage Decision Open
Even with higher screening uptake, triennial blood-based screening, with the CMS-specified minimum performance sensitivity of 74% and specificity of 90%, was not projected to be cost-effective compared with established strategies for color…
View article: Cost-Effectiveness of Blood-Based Biomarkers for Colorectal Cancer Screening—An Ounce of Prevention Is Worth a Pound of Cure
Cost-Effectiveness of Blood-Based Biomarkers for Colorectal Cancer Screening—An Ounce of Prevention Is Worth a Pound of Cure Open
Zainab Aziz, BS; Sophie Wagner, BS; Alice Agyekum, BS; Yoanna S. Pumpalova, MD; Matthew Prest, MS; Francesca Lim, MS; Sheila Rustgi, MD; Fay Kastrinos, MD, MPH; William M. Grady, MD; Chin Hur, MD, MPH
View article: SI Table S5 from Implications of Epigenetic Drift in Colorectal Neoplasia
SI Table S5 from Implications of Epigenetic Drift in Colorectal Neoplasia Open
This file provides a list of 'static' CGI-gene pairs for which methylation is significantly correlated with gene expression (q-value ) in left colon (including rectum) and right colon
View article: SI Table S4 from Implications of Epigenetic Drift in Colorectal Neoplasia
SI Table S4 from Implications of Epigenetic Drift in Colorectal Neoplasia Open
This file provides a list of drift-related CGI-gene pairs for which methylation is significantly correlated with gene expression (q-value ) in left colon (including rectum) and right colon.
View article: Data from Novel DNA Methylation Biomarker Panel for Detection of Esophageal Adenocarcinoma and High-Grade Dysplasia
Data from Novel DNA Methylation Biomarker Panel for Detection of Esophageal Adenocarcinoma and High-Grade Dysplasia Open
Purpose:Current endoscopy-based screening and surveillance programs have not been proven effective at decreasing esophageal adenocarcinoma (EAC) mortality, creating an unmet need for effective molecular tests for early detection of this hi…
View article: SI Table S2 from Implications of Epigenetic Drift in Colorectal Neoplasia
SI Table S2 from Implications of Epigenetic Drift in Colorectal Neoplasia Open
This file provides a list of the genomic location, associated genes, proximity to transcription start sites (TSS200 or TSS1500), the number of array probes and number of identified drift probes and the island-level drift rate (regression s…