Michael J. Owens
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View article: Impacts of mitochondrial dysfunction on axonal microtubule bundles as a potential mechanism of neurodegeneration
Impacts of mitochondrial dysfunction on axonal microtubule bundles as a potential mechanism of neurodegeneration Open
Mitochondrial dysfunction is an important cause for neurodegeneration, often associated with dyshomeostasis of reactive oxygen species, i.e., oxidative stress. However, apart from ATP production, mitochondria have many other functions the …
View article: Microtubule curling as an efficient readout to uncover fundamental concepts of axonal cell biology
Microtubule curling as an efficient readout to uncover fundamental concepts of axonal cell biology Open
In neurodegeneration, axons tend to be prime lesion sites. Axons are the slender, up-to-meter-long processes of nerve cells that essentially wire nervous systems. These delicate structures must survive for an organism’s lifetime. Their lon…
View article: Assessing impacts of mitochondrial dysfunction on axonal microtubule bundles as potential mechanism in neurodegeneration
Assessing impacts of mitochondrial dysfunction on axonal microtubule bundles as potential mechanism in neurodegeneration Open
Mitochondrial dysfunction is an important cause for neurodegeneration, often associated with dyshomeostasis of reactive oxygen species, i.e. oxidative stress. However, apart from ATP production, mitochondria have many other functions the a…
View article: Different mechanisms link gain and loss of kinesin functions to axonal degeneration
Different mechanisms link gain and loss of kinesin functions to axonal degeneration Open
Axons are the slender, often meter-long projections of neurons that form the biological cables wiring our bodies. Most of these delicate structures must survive for an organism’s lifetime, meaning up to a century in humans. Long-term maint…
View article: Different Mechanisms Link Gain and Loss of Kinesin Functions to Axonal Degeneration
Different Mechanisms Link Gain and Loss of Kinesin Functions to Axonal Degeneration Open
View article: IMPROVING COMFORT LEVELS IN PERFORMING AWAKE FIBEROPTIC INTUBATION: A COLLABORATIVE EFFORT BETWEEN OTOLARYNGOLOGY AND ANESTHESIA
IMPROVING COMFORT LEVELS IN PERFORMING AWAKE FIBEROPTIC INTUBATION: A COLLABORATIVE EFFORT BETWEEN OTOLARYNGOLOGY AND ANESTHESIA Open
View article: Locus Coeruleus Noradrenergic Modulation of Diurnal Corticosterone, Stress Reactivity, and Cardiovascular Homeostasis in Male Rats
Locus Coeruleus Noradrenergic Modulation of Diurnal Corticosterone, Stress Reactivity, and Cardiovascular Homeostasis in Male Rats Open
Introduction: Activation of the locus coeruleus-noradrenergic (LC-NA) system during awakening is associated with an increase in plasma corticosterone and cardiovascular tone. These studies evaluate the role of the LC in this corticosterone…
View article: PPS volume 19 issue 3 Cover and Front matter
PPS volume 19 issue 3 Cover and Front matter Open
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View article: Pharmacokinetics of α-Pyrrolidinovalerophenone in Male Rats with and without Vaccination with an α-Pyrrolidinovalerophenone Vaccine
Pharmacokinetics of α-Pyrrolidinovalerophenone in Male Rats with and without Vaccination with an α-Pyrrolidinovalerophenone Vaccine Open
PURPOSE: α-Pyrrolidinovalerophenone (α-PVP) is a second-generation synthetic cathinone which acts as an inhibitor at the dopamine and norepinephrine transporters in the brain. These novel studies determined the pharmacokinetics (PK) of α-P…
View article: Towards Digital Place(s): cultivating a language of digital design in architecture
Towards Digital Place(s): cultivating a language of digital design in architecture Open
The term “place” has been used to identify meaningful locations or buildings in reference to limitless connections, be they sensorial or emotional that develop an embodied memory of space as experienced by the senses. In the contemporary a…
View article: Towards digital place(s): cultivating a language of digital design in architecture
Towards digital place(s): cultivating a language of digital design in architecture Open
The term “place” has been used to identify meaningful locations or buildings in reference to limitless connections, be they sensorial or emotional that develop an embodied memory of space as experienced by the senses. In the contemporary a…
View article: Faculty Opinions recommendation of Extensive impact of non-antibiotic drugs on human gut bacteria.
Faculty Opinions recommendation of Extensive impact of non-antibiotic drugs on human gut bacteria. Open
A few commonly used non-antibiotic drugs have recently been associated with changes in gut microbiome composition, but the extent of this phenomenon is unknown. Here, we screened more than 1,000 marketed drugs against 40 representative gut…
View article: Early Life Stress Associated With Increased Striatal <i>N</i>-Acetyl-Aspartate: Cerebrospinal Fluid Corticotropin-Releasing Factor Concentrations, Hippocampal Volume, Body Mass, and Behavioral Correlates
Early Life Stress Associated With Increased Striatal <i>N</i>-Acetyl-Aspartate: Cerebrospinal Fluid Corticotropin-Releasing Factor Concentrations, Hippocampal Volume, Body Mass, and Behavioral Correlates Open
Introduction Using proton magnetic resonance spectroscopy imaging, the effects of early life stress on nonhuman primate striatal neuronal integrity were examined as reflected by N-acetyl aspartate (NAA) concentrations. NAA measures were in…
View article: The Aerospace Spectral Energy Distribution (ASED) Program - 2018 Update
The Aerospace Spectral Energy Distribution (ASED) Program - 2018 Update Open
The observations-based catalog of stellar spectral energy distributions (SEDs) has been developing for over 20 years, with some look-back to data from over 40 years ago. This presentation will provide examples of the data taken and show so…
View article: Test–Retest Reliability of the SERT Imaging Agent <sup>11</sup>C-HOMADAM in Healthy Humans
Test–Retest Reliability of the SERT Imaging Agent <sup>11</sup>C-HOMADAM in Healthy Humans Open
The aim of this study was to measure the test-retest reliability of 11C-N,N-dimethyl-2-(2'-amino-4'-hydroxymethylphenylthio)benzylamine (11C-HOMADAM) imaging of serotonin transporter (SERT) density in healthy c…
View article: Reduced left ventricular dimension and function following early life stress: A thrifty phenotype hypothesis engendering risk for mood and anxiety disorders
Reduced left ventricular dimension and function following early life stress: A thrifty phenotype hypothesis engendering risk for mood and anxiety disorders Open
ELS is associated with both structural and functional reductions of left ventricular measures, potentially implying a body-wide thrifty phenotype. Parallel "thrift" adaptations may occur in key brain areas following ELS and may play an une…
View article: Prenatal stress-induced increases in hippocampal von Willebrand factor expression are prevented by concurrent prenatal escitalopram
Prenatal stress-induced increases in hippocampal von Willebrand factor expression are prevented by concurrent prenatal escitalopram Open
View article: In vivo investigation of escitalopram's allosteric site on the serotonin transporter
In vivo investigation of escitalopram's allosteric site on the serotonin transporter Open
View article: Synthesis, binding affinity, radiolabeling, and microPET evaluation of 4-(2-substituted-4-substituted)-8-(dialkylamino)-6-methyl-1-substituted-3,4-dihydropyrido[2,3-b]pyrazin-2(1H)-ones as ligands for brain corticotropin-releasing factor type-1 (CRF1) receptors
Synthesis, binding affinity, radiolabeling, and microPET evaluation of 4-(2-substituted-4-substituted)-8-(dialkylamino)-6-methyl-1-substituted-3,4-dihydropyrido[2,3-b]pyrazin-2(1H)-ones as ligands for brain corticotropin-releasing factor type-1 (CRF1) receptors Open
View article: Synthesis, F-18 radiolabeling, and microPET evaluation of 3-(2,4-dichlorophenyl)-N-alkyl-N-fluoroalkyl-2,5-dimethylpyrazolo[1,5-a]pyrimidin-7-amines as ligands of the corticotropin-releasing factor type-1 (CRF1) receptor
Synthesis, F-18 radiolabeling, and microPET evaluation of 3-(2,4-dichlorophenyl)-N-alkyl-N-fluoroalkyl-2,5-dimethylpyrazolo[1,5-a]pyrimidin-7-amines as ligands of the corticotropin-releasing factor type-1 (CRF1) receptor Open