Margaret J. Wright
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View article: Classification of major depressive disorder using vertex-wise brain sulcal depth, curvature, and thickness with a deep and a shallow learning model
Classification of major depressive disorder using vertex-wise brain sulcal depth, curvature, and thickness with a deep and a shallow learning model Open
Major depressive disorder (MDD) is a complex psychiatric disorder that affects the lives of hundreds of millions of individuals around the globe. Even today, researchers debate if morphological alterations in the brain are linked to MDD, l…
View article: Queensland Twin Adolescent Brain (QTAB) Non-Imaging Phenotypes
Queensland Twin Adolescent Brain (QTAB) Non-Imaging Phenotypes Open
Non-imaging phenotypes for the Queensland Twin Adolescent Brain (QTAB) project. The non-imaging phenotypes dataset contains restricted demographic data, as well as assessments of puberty, cognition, anxiety and/or depression, emotional and…
View article: Leveraging Spatial Transcriptomics to Decode Craniofacial Development
Leveraging Spatial Transcriptomics to Decode Craniofacial Development Open
Understanding how intricate cellular networks and signaling pathways communicate during the formation of craniofacial tissues like the palate and tooth has been the subject of intense investigation for several decades. Both organ systems u…
View article: Updated Interventions for Radiation-Induced Diarrhea: Putting Evidence Into Practice With the Oncology Nursing Society
Updated Interventions for Radiation-Induced Diarrhea: Putting Evidence Into Practice With the Oncology Nursing Society Open
The team categorized the effectiveness of nutritional supplementation as not established, sulfasalazine as unlikely to be effective, SpaceOAR™ as effective with caution for patients with prostate cancer, and probiotics as recommended for p…
View article: Genetics of environmental sensitivity to psychiatric and neurodevelopmental phenotypes: evidence from GWAS of monozygotic twins
Genetics of environmental sensitivity to psychiatric and neurodevelopmental phenotypes: evidence from GWAS of monozygotic twins Open
Individual sensitivity to environmental exposures may be genetically influenced. This genotype-by-environment interplay implies differences in phenotypic variance across genotypes. However, environmental sensitivity genetic variants have p…
View article: Lifespan reference curves for harmonizing multi-site regional brain white matter metrics from diffusion MRI
Lifespan reference curves for harmonizing multi-site regional brain white matter metrics from diffusion MRI Open
Age-related white matter (WM) microstructure maturation and decline occur throughout the human lifespan with a unique trajectory in the brain, complementing the process of gray matter development and degeneration. Normative modeling can es…
View article: The heritability of subjective cognitive complaints in older Australian twins
The heritability of subjective cognitive complaints in older Australian twins Open
Background Subjective cognitive complaints (SCCs) may be a precursor to mild cognitive impairment (MCI) and dementia. This study aimed to examine the heritability of SCCs, and the influence of personality and mood on the relationship betwe…
View article: Classification of Major Depressive Disorder Using Vertex-Wise Brain Sulcal Depth, Curvature, and Thickness with a Deep and a Shallow Learning Model
Classification of Major Depressive Disorder Using Vertex-Wise Brain Sulcal Depth, Curvature, and Thickness with a Deep and a Shallow Learning Model Open
Major depressive disorder (MDD) is a complex psychiatric disorder that affects the lives of hundreds of millions of individuals around the globe. Even today, researchers debate if morphological alterations in the brain are linked to MDD, l…
View article: The Queensland Twin Adolescent Brain Project, a longitudinal study of adolescent brain development
The Queensland Twin Adolescent Brain Project, a longitudinal study of adolescent brain development Open
We describe the Queensland Twin Adolescent Brain (QTAB) dataset and provide a detailed methodology and technical validation to facilitate data usage. The QTAB dataset comprises multimodal neuroimaging, as well as cognitive and mental healt…
View article: The Heritability of Subjective Cognitive Complaints in Older Australian Twins
The Heritability of Subjective Cognitive Complaints in Older Australian Twins Open
Background: Subjective cognitive complaints (SCCs) may be a precursor to mild cognitive impairment (MCI) and dementia. Objective: This study aimed to examine the heritability of SCCs, correlations between SCCs and memory ability, and the i…
View article: Queensland Twin Adolescent Brain (QTAB) Non-Imaging Phenotypes
Queensland Twin Adolescent Brain (QTAB) Non-Imaging Phenotypes Open
Non-imaging phenotypes for the Queensland Twin Adolescent Brain (QTAB) project. The non-imaging phenotypes dataset contains restricted demographic data, as well as assessments of puberty, cognition, anxiety and/or depression, emotional and…
View article: Queensland Twin Adolescent Brain (QTAB) Non-Imaging Phenotypes
Queensland Twin Adolescent Brain (QTAB) Non-Imaging Phenotypes Open
Non-imaging phenotypes for the Queensland Twin Adolescent Brain (QTAB) project. The non-imaging phenotypes dataset contains restricted demographic data, as well as assessments of puberty, cognition, anxiety and/or depression, emotional and…
View article: Genome-wide analyses of individual differences in quantitatively assessed reading- and language-related skills in up to 34,000 people
Genome-wide analyses of individual differences in quantitatively assessed reading- and language-related skills in up to 34,000 people Open
The use of spoken and written language is a fundamental human capacity. Individual differences in reading- and language-related skills are influenced by genetic variation, with twin-based heritability estimates of 30 to 80% depending on th…
View article: Multi-site benchmark classification of major depressive disorder using machine learning on cortical and subcortical measures
Multi-site benchmark classification of major depressive disorder using machine learning on cortical and subcortical measures Open
Machine learning (ML) techniques have gained popularity in the neuroimaging field due to their potential for classifying neuropsychiatric disorders. However, the diagnostic predictive power of the existing algorithms has been limited by sm…
View article: Genetic Specificity of Hippocampal Subfield Volumes, Relative to Hippocampal Formation, Identified in 2148 Young Adult Twins and Siblings
Genetic Specificity of Hippocampal Subfield Volumes, Relative to Hippocampal Formation, Identified in 2148 Young Adult Twins and Siblings Open
The hippocampus is a complex brain structure with key roles in cognitive and emotional processing and with subregion abnormalities associated with a range of disorders and psychopathologies. Here we combine data from two large independent …
View article: Nature Versus Nurture – Studying the Relationships Between Diet and Depression in Older Adults
Nature Versus Nurture – Studying the Relationships Between Diet and Depression in Older Adults Open
Objectives Prior work suggests that higher fruit and vegetable consumption may protect against depression in older adults. By better understanding the influence of genetic and environmental factors on fruit and vegetable intakes, more effe…
View article: Persistence of Anxiety/Depression Symptoms in Early Adolescence: A Prospective Study of Daily Life Stress, Rumination, and Daytime Sleepiness in a Genetically Informative Cohort
Persistence of Anxiety/Depression Symptoms in Early Adolescence: A Prospective Study of Daily Life Stress, Rumination, and Daytime Sleepiness in a Genetically Informative Cohort Open
In this prospective study of mental health, we examine the influence of three interrelated traits — perceived stress, rumination, and daytime sleepiness — and their association with symptoms of anxiety and depression in early adolescence. …
View article: Dissociable Cellular and Genetic Mechanisms of Cortical Thinning at Different Life Stages
Dissociable Cellular and Genetic Mechanisms of Cortical Thinning at Different Life Stages Open
Mechanisms underpinning neurotypical age-related variations in cortical thickness in the human brain remain insufficiently specified. Here we used cell-specific marker genes, followed by gene ontology and enrichment analyses, to quantify t…
View article: The Queensland Twin Adolescent Brain Project, a longitudinal study of adolescent brain development
The Queensland Twin Adolescent Brain Project, a longitudinal study of adolescent brain development Open
We describe the Queensland Twin Adolescent Brain (QTAB) dataset and provide a detailed methodology and technical validation to facilitate data usage. The QTAB dataset comprises multimodal neuroimaging, as well as cognitive and mental healt…