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View article: NOTCH1 mutation status as a prognostic biomarker in T-cell acute lymphoblastic leukemia: a systematic review and meta-analysis
NOTCH1 mutation status as a prognostic biomarker in T-cell acute lymphoblastic leukemia: a systematic review and meta-analysis Open
Background The prognostic significance of NOTCH1 mutations in T-cell acute lymphoblastic leukemia (T-ALL) remains uncertain. This study evaluates their impact on key clinical outcomes. Methods A systematic search of the Cochrane Library, P…
View article: Surgical versus conservative management of lumbar disc prolapse: A systematic review and meta-analysis
Surgical versus conservative management of lumbar disc prolapse: A systematic review and meta-analysis Open
Lumbar disc prolapse is a common spinal pathology leading to significant pain, disability, and socioeconomic burden. Treatment remains controversial, with both surgical and conservative options widely practiced. This review aimed to system…
View article: Functional genomics and tumor microenvironment analysis reveal prognostic biological subtypes in Mantle cell lymphoma
Functional genomics and tumor microenvironment analysis reveal prognostic biological subtypes in Mantle cell lymphoma Open
Mantle cell lymphoma (MCL) is a genetically and clinically heterogeneous B-cell malignancy. We studied two MCL cohorts with differing treatment patterns: one enriched for immunochemotherapy, the other for chemotherapy alone. TP53 alteratio…
View article: Cooperative role of distinctive TP53 and PTEN combined loss in the peripheral T cell lymphoma–GATA3 molecular subgroup
Cooperative role of distinctive TP53 and PTEN combined loss in the peripheral T cell lymphoma–GATA3 molecular subgroup Open
Peripheral T cell lymphoma (PTCL) is a heterogeneous group of postthymic T cell neoplasms, with ~40% classified as PTCL–not otherwise specified (PTCL-NOS). PTCL-GATA3, a molecularly defined subtype, associated with T helper 2 (T H 2)–like …
View article: High-grade B-cell lymphoma, not otherwise specified: an LLMPP study
High-grade B-cell lymphoma, not otherwise specified: an LLMPP study Open
Molecular characterization of high-grade B-cell lymphoma, not otherwise specified (HGBCL-NOS), is hindered by its rarity, evolving definition, and poor diagnostic reproducibility. To address this challenge, we analyzed 92 HGBCL-NOS tumors …
View article: Functional genomics and tumor microenvironment analysis reveal prognostic biological subtypes in Mantle cell lymphoma
Functional genomics and tumor microenvironment analysis reveal prognostic biological subtypes in Mantle cell lymphoma Open
Mantle cell lymphoma (MCL) is a genetically and clinically heterogeneous B-cell malignancy. We studied two MCL cohorts with differing treatment patterns: one enriched for immunochemotherapy, the other for chemotherapy alone. TP53 alteratio…
View article: Integrative Genomic and Transcriptomic Analysis Reveals Targetable Vulnerabilities in Angioimmunoblastic T‐Cell Lymphoma
Integrative Genomic and Transcriptomic Analysis Reveals Targetable Vulnerabilities in Angioimmunoblastic T‐Cell Lymphoma Open
Nodal follicular helper T‐cell ( T FH ) lymphoma of the angioimmunoblastic (AITL) subtype has a dismal prognosis. Using whole‐exome sequencing ( n = 124), transcriptomic ( n = 78), and methylation ( n = 40) analysis, we identified recurren…
View article: High-grade B-cell lymphoma, not otherwise specified: an LLMPP study
High-grade B-cell lymphoma, not otherwise specified: an LLMPP study Open
Molecular characterization of high-grade B-cell lymphoma, not otherwise specified (HGBCL-NOS), is hindered by its rarity, evolving definition, and poor diagnostic reproducibility. To address this challenge, we analyzed 92 HGBCL-NOS tumors …
View article: Advances in peripheral T cell lymphomas: pathogenesis, genetic landscapes and emerging therapeutic targets
Advances in peripheral T cell lymphomas: pathogenesis, genetic landscapes and emerging therapeutic targets Open
Peripheral T cell lymphomas (PTCLs) are a biologically diverse and aggressive group of non‐Hodgkin lymphomas that originate from mature T cells, often presenting with complex clinical and morphological features. This review explores the ch…
View article: High‐grade B‐cell lymphoma not otherwise specified, with diffuse large B‐cell lymphoma gene expression signatures: Genomic analysis and potential therapeutics
High‐grade B‐cell lymphoma not otherwise specified, with diffuse large B‐cell lymphoma gene expression signatures: Genomic analysis and potential therapeutics Open
High‐grade B‐cell lymphoma not otherwise specified (HGBCL, NOS) has overlapping morphological and genetic features with diffuse large B‐cell lymphoma (DLBCL) and Burkitt lymphoma (BL), leading to uncertainty in its diagnosis and clinical m…
View article: Generating a Model of Human CD8+ T-Cell Lymphoma from Genetically Modified Normal T-Cells
Generating a Model of Human CD8+ T-Cell Lymphoma from Genetically Modified Normal T-Cells Open
Background: JAK2 fusions with multiple partners have been recurrently and frequently detected in the primary cutaneous CD8+ aggressive epidermotropic T-cell lymphoma (PCAETCL), in which CDKN2A mutation/deletion also commonly co-occurred1. …
View article: <i>Tet2</i> Loss and IDH2R172<i>K</i> Mutation Develop TFH-Cell-like Lymphoma with Restricted TH1 Differentiation Program and Cognate Interaction with B Cells
<i>Tet2</i> Loss and IDH2R172<i>K</i> Mutation Develop TFH-Cell-like Lymphoma with Restricted TH1 Differentiation Program and Cognate Interaction with B Cells Open
Introduction: Nodal lymphomas of T-follicular helper cells (n-TFHLs) are considered neoplasms of mature TFH cells and are classified by the World Health Organization (WHO) under one umbrella with three subtypes: angioimmunoblastic-type (n-…
View article: Complementary Roles of DNMT3A and TET2 KO in Sculpting CD4-T Cells for Sustained Proliferation without Exhaustion to Promote Lymphomagenesis
Complementary Roles of DNMT3A and TET2 KO in Sculpting CD4-T Cells for Sustained Proliferation without Exhaustion to Promote Lymphomagenesis Open
Angioimmunoblastic T-cell lymphoma (AITL) is a type of peripheral T-cell lymphoma characterized by frequent genetic mutations affecting TET2 and often together with DNMT3A. We have derived mice with conditional KO of both Tet2 and Dnmt3a m…
View article: An Llmpp Study: Genomic Characterization of Novel PTCL- Biological Subtypes Reveal Distinctive Therapeutic Vulnerabilities
An Llmpp Study: Genomic Characterization of Novel PTCL- Biological Subtypes Reveal Distinctive Therapeutic Vulnerabilities Open
Introduction Peripheral T-cell lymphoma (PTCL) encompasses a heterogeneous group of clinically aggressive entities. ~30% of cases cannot be further classified and are designated as PTCL - not otherwise specified (NOS). We delineated two no…
View article: New insights into the biology of T-cell lymphomas
New insights into the biology of T-cell lymphomas Open
Peripheral T-cell lymphomas (PTCLs) encompass a heterogeneous group of postthymic T-cell lymphomas with >30 distinct subtypes associated with varied clinicopathological features. Unfortunately, the overall survival of the major PTCL sub…
View article: Supplementary Data 1 from KLRG1 Cell Depletion as a Novel Therapeutic Strategy in Patients with Mature T-Cell Lymphoma Subtypes
Supplementary Data 1 from KLRG1 Cell Depletion as a Novel Therapeutic Strategy in Patients with Mature T-Cell Lymphoma Subtypes Open
Supplementary Methods and Figures
View article: Data from KLRG1 Cell Depletion as a Novel Therapeutic Strategy in Patients with Mature T-Cell Lymphoma Subtypes
Data from KLRG1 Cell Depletion as a Novel Therapeutic Strategy in Patients with Mature T-Cell Lymphoma Subtypes Open
Purpose:Develop a novel therapeutic strategy for patients with subtypes of mature T-cell and NK-cell neoplasms.Experimental Design:Primary specimens, cell lines, patient-derived xenograft models, commercially available, and proprietary ant…
View article: Supplementary Data 1 from KLRG1 Cell Depletion as a Novel Therapeutic Strategy in Patients with Mature T-Cell Lymphoma Subtypes
Supplementary Data 1 from KLRG1 Cell Depletion as a Novel Therapeutic Strategy in Patients with Mature T-Cell Lymphoma Subtypes Open
Supplementary Methods and Figures
View article: Data from KLRG1 Cell Depletion as a Novel Therapeutic Strategy in Patients with Mature T-Cell Lymphoma Subtypes
Data from KLRG1 Cell Depletion as a Novel Therapeutic Strategy in Patients with Mature T-Cell Lymphoma Subtypes Open
Purpose:Develop a novel therapeutic strategy for patients with subtypes of mature T-cell and NK-cell neoplasms.Experimental Design:Primary specimens, cell lines, patient-derived xenograft models, commercially available, and proprietary ant…
View article: Successful management of cervical tuberculosis and severe kyphosis using polyetheretherketone expandable cage and titanium plate: A case report
Successful management of cervical tuberculosis and severe kyphosis using polyetheretherketone expandable cage and titanium plate: A case report Open
Key Clinical Message Successful management of cervical tuberculosis and severe kyphosis was achieved using a PEEK expandable cage and titanium plate, demonstrating favorable outcomes in restoring cervical alignment and stability. This appr…
View article: MYC overexpression in natural killer cell lymphoma: prognostic and therapeutic implications
MYC overexpression in natural killer cell lymphoma: prognostic and therapeutic implications Open
The current clinical management of Extranodal NK/T-cell lymphoma (ENKTL) primarily depends on conventional chemotherapy and radiotherapy, underscoring the need for innovative therapeutic strategies. This study explores the clinical signifi…
View article: KLRG1 Cell Depletion as a Novel Therapeutic Strategy in Patients with Mature T-Cell Lymphoma Subtypes
KLRG1 Cell Depletion as a Novel Therapeutic Strategy in Patients with Mature T-Cell Lymphoma Subtypes Open
Purpose: Develop a novel therapeutic strategy for patients with subtypes of mature T-cell and NK-cell neoplasms. Experimental Design: Primary specimens, cell lines, patient-derived xenograft models, commercially available, and proprietary …
View article: Integrative analysis of clinicopathological features defines novel prognostic models for mantle cell lymphoma in the immunochemotherapy era: a report from The North American Mantle Cell Lymphoma Consortium
Integrative analysis of clinicopathological features defines novel prognostic models for mantle cell lymphoma in the immunochemotherapy era: a report from The North American Mantle Cell Lymphoma Consortium Open
Background Patients with mantle cell lymphoma (MCL) exhibit a wide variation in clinical presentation and outcome. However, the commonly used prognostic models are outdated and inadequate to address the needs of the current multidisciplina…
View article: CLL Cells within the Proliferation Centers of the Patient Lymph Nodes Are Enriched for Notch Signaling, Thus NOTCH a Viable Target for CLL Therapy
CLL Cells within the Proliferation Centers of the Patient Lymph Nodes Are Enriched for Notch Signaling, Thus NOTCH a Viable Target for CLL Therapy Open
CLL cells within the Proliferation Centers of the Patient Lymph Nodes are enriched for Notch signaling, thus a Target for CLL Therapy. Shantaram S. Joshi, Michael Pitner, Matt Kling, Furqan Mehdi, Mamta Shukla, Ashima Shukla, Vipul Shukla,…
View article: The Influence of <i>TET2</i> and/or <i>DNMT3A</i> Knockout on the 5hmC Levels and Growth Characteristics of Modified Human Primary CD4 T Cells after Activation
The Influence of <i>TET2</i> and/or <i>DNMT3A</i> Knockout on the 5hmC Levels and Growth Characteristics of Modified Human Primary CD4 T Cells after Activation Open
Angioimmunoblastic T-cell lymphoma (AITL) has a unique immunohistological profile featuring malignant CD4+ T follicular helper cells (Tfh) inter-mixed with an extensive infiltrate of multiple lineages of immune cells. The AITL tumor microe…
View article: A case study of the pathology on a rare case of scalp lymphangioma in an adult patient
A case study of the pathology on a rare case of scalp lymphangioma in an adult patient Open
Lymphangiomas are congenital malformations of the lymphatic system, mostly well-circumscribed and cystic. Although many theories were proposed to explain etiology, it is still controversial. Most of these lesions are found in the cervicofa…
View article: Inhibition of CDK4 as a potential therapy for natural killer cell lymphoma with MYC overexpression
Inhibition of CDK4 as a potential therapy for natural killer cell lymphoma with MYC overexpression Open
Current clinical management of Extranodal NK/T-cell lymphoma (ENKTL) primarily depends on conventional chemotherapy and radiotherapy, underscoring the need for innovative therapeutic strategies. This study explores the clinical significanc…
View article: SAM-Competitive EZH2-Inhibitors Induce Platinum Resistance by EZH2-Independent Induction of ABC-Transporters
SAM-Competitive EZH2-Inhibitors Induce Platinum Resistance by EZH2-Independent Induction of ABC-Transporters Open
T-cell lymphomas are heterogeneous and rare lymphatic malignancies with unfavorable prognosis. Consequently, new therapeutic strategies are needed. The enhancer of zeste homologue 2 (EZH2) is the catalytic subunit of the polycomb repressiv…