Mahesh Jayaraman
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View article: Basilar Artery Occlusion Stroke Managed With Tenecteplase Versus Alteplase Before Endovascular Treatment (BAO‐TNK)
Basilar Artery Occlusion Stroke Managed With Tenecteplase Versus Alteplase Before Endovascular Treatment (BAO‐TNK) Open
Objective To compare the effectiveness and safety of tenecteplase (TNK) versus alteplase (TPA) in patients with basilar artery occlusion prior to endovascular treatment (EVT). Methods In this retrospective multicenter study (BAO‐TNK), we a…
View article: Characterizing Liquid Embolic Distribution and Its Impact on Chronic Subdural Hematoma Outcomes following Middle Meningeal Artery Embolization
Characterizing Liquid Embolic Distribution and Its Impact on Chronic Subdural Hematoma Outcomes following Middle Meningeal Artery Embolization Open
We present a framework for characterizing the appearance of liquid embolic agents after MMAE. Visualized membrane penetration during angiography was associated with greater and faster cSDH resorption and higher odds of complete resolution.…
View article: Improvements in endovascular stroke treatment workflow over 5 years: ESCAPE to ESCAPE-NA1
Improvements in endovascular stroke treatment workflow over 5 years: ESCAPE to ESCAPE-NA1 Open
Background and Purpose Rapid treatment is a major determinant of outcome in acute ischemic stroke patients with large vessel occlusion. We used patient-level data from the ESCAPE and ESCAPE-NA1 trials to evaluate whether and to what extent…
View article: Mechanical thrombectomy for acute ischemic stroke performed without continuous saline flushes and using moderate sedation: The TOOFAST technique
Mechanical thrombectomy for acute ischemic stroke performed without continuous saline flushes and using moderate sedation: The TOOFAST technique Open
Background Rapid reperfusion is an important predictor of neurologic recovery in acute ischemic stroke due to large vessel occlusion (AIS-LVO) treated with mechanical thrombectomy (MT). We present a single-institution retrospective observa…
View article: Statin therapy in ischemic stroke patients with atrial fibrillation: Efficacy and safety outcomes
Statin therapy in ischemic stroke patients with atrial fibrillation: Efficacy and safety outcomes Open
Introduction: The efficacy and safety of statins for secondary prevention in patients who have experienced a cardioembolic stroke are not well-defined. However, previous observational data reported hyperlipidemia as a risk factor for both …
View article: Emergent Endovascular Intervention for Acute Neurological Deficits Post-Carotid Endarterectomy: A Single-Institutional Analysis and Systematic Review of the Literature
Emergent Endovascular Intervention for Acute Neurological Deficits Post-Carotid Endarterectomy: A Single-Institutional Analysis and Systematic Review of the Literature Open
EVT is likely a technically viable alternative treatment for patients with perioperative acute neurologic deficits after CEA. However, most of the literature available comes from case series, thereby limiting the quality of evidence. Impro…
View article: Treatment of Spontaneous Subarachnoid Hemorrhage: A 20‐Year National Inpatient Sample Review
Treatment of Spontaneous Subarachnoid Hemorrhage: A 20‐Year National Inpatient Sample Review Open
Background Aneurysmal subarachnoid hemorrhage (aSAH) is a major source of morbidity and mortality, and its management has undergone foundational changes over thepast 2 decades. We reviewed the National Inpatient Sample to outline the chang…
View article: Abstract 306: Influence of healthcare access on rate of follow‐up after mechanical thrombectomy for large vessel occlusion in a unique mountain west population
Abstract 306: Influence of healthcare access on rate of follow‐up after mechanical thrombectomy for large vessel occlusion in a unique mountain west population Open
Introduction Stroke remains to be a significant cause of morbidity and mortality in the US, with an estimated 800,000 strokes occurring yearly. It is well understood that thorough follow‐up care and rehabilitation has a significant impact …
View article: In‐hospital recurrent stroke in ipsilateral carotid web patients undergoing thrombectomy
In‐hospital recurrent stroke in ipsilateral carotid web patients undergoing thrombectomy Open
Objective Carotid artery web is a possible cause of ischemic stroke, especially in young patients who lack conventional risk factors. The immediate and long‐term outcomes are not well studied. We aimed to determine the association between …
View article: Infarcts Due to Large Vessel Occlusions Continue to Grow Despite Near-Complete Reperfusion After Endovascular Treatment
Infarcts Due to Large Vessel Occlusions Continue to Grow Despite Near-Complete Reperfusion After Endovascular Treatment Open
Background and Purpose Infarcts in acute ischemic stroke (AIS) patients may continue to grow even after reperfusion, due to mechanisms such as microvascular obstruction and reperfusion injury. We investigated whether and how much infarcts …
View article: How Do Quantitative Tissue Imaging Outcomes in Acute Ischemic Stroke Relate to Clinical Outcomes?
How Do Quantitative Tissue Imaging Outcomes in Acute Ischemic Stroke Relate to Clinical Outcomes? Open
Background and Purpose Infarct volume and other imaging markers are increasingly used as surrogate measures for clinical outcome in acute ischemic stroke research, but how improvements in these imaging surrogates translate into better clin…
View article: Treatment of Spontaneous Subarachnoid Hemorrhage: A 20-year National Inpatient Sample Review
Treatment of Spontaneous Subarachnoid Hemorrhage: A 20-year National Inpatient Sample Review Open
Background Aneurysmal subarachnoid hemorrhage is a major source of morbidity and mortality, and its management has undergone foundational changes over the last 2 decades. We reviewed the National Inpatient Sample (NIS) to outline the chang…
View article: Statin Therapy in Ischemic Stroke Patients with Atrial Fibrillation: Efficacy and Safety Outcomes
Statin Therapy in Ischemic Stroke Patients with Atrial Fibrillation: Efficacy and Safety Outcomes Open
Background The efficacy and safety of statins for secondary prevention in patients who have experienced a cardioembolic stroke are not well-defined. However, previous observational data reported hyperlipidemia as a risk factor for both isc…
View article: Technique and impact on first pass effect primary results of the ASSIST global registry
Technique and impact on first pass effect primary results of the ASSIST global registry Open
Background Patients treated with mechanical thrombectomy (MT) for acute ischemic strokes from large vessel occlusion (LVO) have better outcomes with effective reperfusion. However, it is unknown which technique leads to better technical an…
View article: The Impact of Atherosclerotic Burden on Vascular Outcomes in Patients with Stroke and Atrial Fibrillation: The ATHENA study
The Impact of Atherosclerotic Burden on Vascular Outcomes in Patients with Stroke and Atrial Fibrillation: The ATHENA study Open
Introduction: Patients with ischemic stroke (IS) and atrial fibrillation (AF) face a higher risk of recurrent vascular events. This study evaluates the impact of atherosclerotic vascular disease burden across different vascular territories…
View article: Minimizing blood loss with direct percutaneous polymethylmethacrylate embolization before corpectomy for vascular spinal tumors
Minimizing blood loss with direct percutaneous polymethylmethacrylate embolization before corpectomy for vascular spinal tumors Open
Background: Standard surgical treatment for vascular spinal tumors, including renal cell carcinomas and hemangiomas, may result in significant blood loss despite preoperative arterial tumor embolization. Methods: This is a retrospective re…
View article: Modeling the Decay in Probability of Receiving Endovascular Thrombectomy on the Basis of Time From Stroke Onset
Modeling the Decay in Probability of Receiving Endovascular Thrombectomy on the Basis of Time From Stroke Onset Open
Background American Heart Association guidelines specify infarct core volume as 1 determinant of eligibility for endovascular thrombectomy. Therefore, it is important to understand how time‐dependent infarct core growth translates to a pat…
View article: Risk of recurrent stroke in patients with atrial fibrillation treated with oral anticoagulants alone or in combination with anti-platelet therapy
Risk of recurrent stroke in patients with atrial fibrillation treated with oral anticoagulants alone or in combination with anti-platelet therapy Open
Introduction: Ischaemic stroke patients with atrial fibrillation (AF) are at high risk of stroke recurrence despite oral anticoagulation therapy. Patients with cardiovascular comorbidities may take both antiplatelet and oral anticoagulatio…
View article: LB-013 Real world performance of the zoom aspiration system: insights from the NVQI-QOD registry
LB-013 Real world performance of the zoom aspiration system: insights from the NVQI-QOD registry Open
Background The real-world performance of the Zoom aspiration system is not well studied as compared with preliminary trials. Objective To compare the real-world performance of the Zoom aspiration system with preliminary trials, using data …
View article: The risk of stroke recurrence in patients with atrial fibrillation and reduced ejection fraction
The risk of stroke recurrence in patients with atrial fibrillation and reduced ejection fraction Open
Background: Atrial fibrillation (AF) and congestive heart failure often coexist due to their shared risk factors leading to potential worse outcome, particularly cerebrovascular events. The aims of this study were to calculate the rates of…
View article: LB002 Long term effect of field triage on times to endovascular treatment for emergent large vessel occlusion
LB002 Long term effect of field triage on times to endovascular treatment for emergent large vessel occlusion Open
Background Delays to endovascular therapy (EVT) for stroke may be mitigated with direct field triage to EVT centers. Objective To compare times to treatment over a five-and-a-half-year span between two adjacent states, one with field triag…
View article: Dual antiplatelet use in the management of COVID-19 associated acute ischemic stroke reocclusion
Dual antiplatelet use in the management of COVID-19 associated acute ischemic stroke reocclusion Open
Intro SARS-CoV-2 (COVID-19) infection is associated with acute ischemic stroke (AIS), which may be due to a prothrombotic state. Early reports have suggested high rates of reocclusion following mechanical thrombectomy (MT) with poor radiog…
View article: Recurrent Ischemic Stroke and Bleeding in Patients With Atrial Fibrillation Who Suffered an Acute Stroke While on Treatment With Nonvitamin K Antagonist Oral Anticoagulants: The RENO-EXTEND Study
Recurrent Ischemic Stroke and Bleeding in Patients With Atrial Fibrillation Who Suffered an Acute Stroke While on Treatment With Nonvitamin K Antagonist Oral Anticoagulants: The RENO-EXTEND Study Open
Background: In patients with atrial fibrillation who suffered an ischemic stroke while on treatment with nonvitamin K antagonist oral anticoagulants, rates and determinants of recurrent ischemic events and major bleedings remain uncertain.…
View article: Abstract 1122‐000140: National Trends in Readmission after Mechanical Thrombectomy in Acute Ischemic Stroke
Abstract 1122‐000140: National Trends in Readmission after Mechanical Thrombectomy in Acute Ischemic Stroke Open
Introduction : Mechanical thrombectomy (MT) has become the standard of care in patients with large vessel occlusion after trials have demonstrated (MT) improved outcomes in acute ischemic stroke (AIS) as compared to medical therapy. Despit…