Explanipedia

MRI Analysis of Cardiac Fat, Abdominal Adiposity and Cardiac Function After Vertical Sleeve Gastrectomy in Youth With Type 2 Diabetes Open

Laura Gutiérrez, Lorna P. Browne, Melanie Cree‐Green, Laura Pyle, Jonathan L. Hills‐Dunlap , et al. · 2025

Background Adolescents with youth‐onset type 2 diabetes (YO‐T2D) have an increased risk for cardiometabolic complications. The impact of vertical sleeve gastrectomy (VSG) on fat distribution and cardiac morphology/function in YO‐T2D is unk…

MON-184 Androgen Concentrations, Metabolic And Mental Health Among Adolescents With Pcos With And Without Gender Incongruence Open

Limin Chen, Natalie Nokoff, Samantha Bothwell, G. C. R. Carey, Nazeen Morelli , et al. · 2025

Disclosure: L. Chen: None. N. Nokoff: Neurocrine Biosciences, Inc, World Athletics. S. Bothwell: None. G. Carey: None. N. Morelli: None. T. Vigers: None. M.G. Cree: Novo Nordisk, Eli Lilly & Company. Background: The intersection of polycys…

SUN-252 Cardiovascular Disease In Adolescents and Young Women with Polycystic Ovary Syndrome: Atherogenic Dyslipidemia, Atherosclerotic Cardiovascular Disease and Cardiac Function Open

Donna F. Vine, Xiaoying Wu, Mahua Ghosh, Melanie Cree‐Green, Harald Becher , et al. · 2025

Disclosure: D.F. Vine: None. X.F. Wu: None. M. Ghosh: None. M. Cree: None. H. Becher: None. P. Raggi: None. J. Windram: None. K. Nadeau: None. Background: Polycystic ovary syndrome (PCOS) is associated with increased cardiometabolic risk a…

SAT-126 Total Testosterone Before and After Metabolic Bariatric Surgery in Adolescent Females with Obesity Open

Heidi Vanden Brink, Seungyeon Ha, Laura Torchen, Ella Nonni, Justin R. Ryder , et al. · 2025

Disclosure: H. Vanden Brink: None. S. Ha: None. L.C. Torchen: None. E. Nonni: None. J.R. Ryder: None. T. Jenkins: None. S. Sisley: None. T. Burgert: None. M.G. Cree: None. F.F. Bacha: None. T. Inge: None. Introduction. Polycystic Ovary Syn…

MON-176 Impact of Pharmacotherapy on Metabolic Health in Adolescents with PCOS: Findings from the Clinical Adolescent Polycystic Ovary (CALICO) Database Open

Christine M Burt Solorzano, Heidi Vanden Brink, Tim Vigers, G. C. R. Carey, Michele Garant , et al. · 2025

Disclosure: C.M. Burt Solorzano: None. H. Vanden Brink: None. T. Vigers: None. G. Carey: None. M. Garant: None. A.B. Sopher: None. R. Shah: None. C. Branstetter: None. A. Coren: None. L.C. Torchen: None. J. Snell-Bergeon: None. D.H. Geller…

Atherogenic ApoB-dyslipidemia, atherosclerotic cardiovascular disease, cardiac dysfunction and remodeling in high-risk young women with and without polycystic ovary syndrome: A pilot study Open

Xiaoying Wu, Mich Wilke, Julette Marie Batara, Spencer D. Proctor, Melanie Cree‐Green , et al. · 2025

Introduction Polycystic ovary syndrome (PCOS) is associated with increased cardiometabolic risk in young women of reproductive age. There are limited studies on atherogenic dyslipidemia, inclusive of triglycerides (TG), Apolipoprotein (apo…

Evening Chronotype Is Associated With Daytime Impairment and Differential Sleep and Circadian Response to a Sleep Extension Manipulation in Short Sleeping Adolescents Open

Stacey L. Simon, Emily Cooper, Angel Bernard, Anne E. Bowen, Sydney Holtman , et al. · 2025

Adolescents frequently experience insufficient sleep, which can negatively impact physical and mental health. We sought to examine differences in symptoms of insufficient sleep and response to a sleep extension manipulation by chronotype i…

GLP-1R polymorphisms modify the relationship between exposure to gestational diabetes and offspring body mass index growth: The EPOCH study. Open

Kylie K. Harrall, Deborah H. Glueck, Leslie A. Lange, Elizabeth Litkowski, Lauren A. Vanderlinden , et al. · 2025

Objective: Exposure to maternal gestational diabetes (GDM) is associated with childhood body mass index (BMI). Among youth, we explored whether three different glucagon-like-peptide-1 receptor gene (GLP-1R) polymorphisms modified the assoc…

GLP-1R Polymorphisms Modify the Relationship Between Exposure to Gestational Diabetes Mellitus and Offspring BMI Growth: The EPOCH Study Open

Kylie K. Harrall, Deborah H. Glueck, Leslie A. Lange, Elizabeth Litkowski, Lauren A. Vanderlinden , et al. · 2025

OBJECTIVE Exposure to maternal gestational diabetes mellitus (GDM) is associated with childhood BMI. Among youth, we explored whether three different glucagon-like peptide 1 receptor gene (GLP-1R) polymorphisms modified the associations be…

GLP-1R polymorphisms modify the relationship between exposure to gestational diabetes and offspring body mass index growth: The EPOCH study. Open

Kylie K. Harrall, Deborah H. Glueck, Leslie A. Lange, Elizabeth Litkowski, Lauren A. Vanderlinden , et al. · 2025

Objective: Exposure to maternal gestational diabetes (GDM) is associated with childhood body mass index (BMI). Among youth, we explored whether three different glucagon-like-peptide-1 receptor gene (GLP-1R) polymorphisms modified the assoc…

Impact of Testosterone on Endothelial Function Varies by GnRH Agonist Treatment Open

Natalie Nokoff, Lyndsey E. DuBose, Samantha Bothwell, Melanie Cree‐Green, Megan M. Kelsey , et al. · 2025

Context Transgender adults taking testosterone have impaired endothelial function, a triggering mechanism for cardiovascular disease. The impact of testosterone with and without gonadotropin-releasing hormone agonists (GnRHa) on endothelia…

0990 Effect of Semaglutide on Apnea Hypopnea Index in Female Adolescents with Polycystic Ovary Syndrome and Obesity Open

Karolina Bohdan, Cristina Giles, Allison Shapiro, Yesenia Garcia‐Reyes, Jaclyn Lo , et al. · 2025

Introduction Polycystic ovary syndrome (PCOS) affects approximately 11% of female adolescents globally and is associated with obesity, obstructive sleep apnea (OSA), and long-term negative health consequences. Weight loss medications are e…

A Comparative Study of Evolving Three-Year Trends in Wellness, Inclusiveness, and Sense of Belonging Efforts Among Residency Program Websites Across Six Medical Specialties Open

Catherine A. Little, Lucelen Fontoura Bastos, Albert B. Schultz, Grace E. Dean, Kathryn Self , et al. · 2025

Introduction: Wellness and Belonging are vital factors shaping today’s healthcare landscape. Recognized for fostering a resilient and effective healthcare workforce, these factors are crucial in promoting resident well-being, preventing bu…

P-520. Barriers and facilitators towards HIV Pre-Exposure Prophylaxis (PrEP) prescription among healthcare providers in North Louisiana Open

Patricia Pichilingue Reto, Melanie Cree‐Green, Alexandre Malek, Paulette Pinargote, Deborah J. Smith · 2025

Background The HIV/AIDS epidemic remains a major global health challenge. To end the HIV epidemic, it is crucial to ensure that everyone has fair and equal access to HIV treatment and prevention, including PrEP. Identifying and addressing …

Sex Differences in Circadian Timing and Biological Night in Adolescents Open

Armelle Duston, Sydney Holtman, Anne E. Bowen, Melanie Cree‐Green, Kristen J. Nadeau , et al. · 2025

Circadian rhythms, intrinsic 24-h cycles that drive rhythmic changes in behavior and physiology, are important for normal physiology and health. Previous work in adults has identified sex differences in circadian rhythms of melatonin, temp…

Glycemia, Insulin Sensitivity, and Secretion Improve 3 Months Post-sleeve Gastrectomy in Youth With Type 2 Diabetes Open

Tyler Dobbs, Melanie Cree‐Green, Alex Bailey, Amy Baumgartner, Justin Garrish , et al. · 2025

Context Metabolic bariatric surgery reduces weight in youth with severe obesity; however, its impacts on youth-onset type 2 diabetes (T2D) are unclear. Objective We evaluated short-term outcomes in youth with T2D 3 months after vertical sl…

Weight Loss Via Oral Semaglutide or Diet Intervention in Adolescent Females with Obesity and Polycystic Ovary Syndrome: Treating Pcos with Semaglutide vs Active Lifestyle Intervention (Teal) Study, a Randomized, Open-Label, Phase 3 Trial Open

Nazeen Morelli, Jaclyn S Lo, G. C. R. Carey, Meredith A Ware, Carlos Vivas , et al. · 2025

Double Right Coronary Artery Originating From Separate Ostia in an Older Female Cadaver With Cerebrovascular Disease: A Case Report Open

Paul Daly, Rachel Thomas, Melanie Cree‐Green, Tierra Kindred, Selena Anand , et al. · 2025

This case report presents an extraordinary finding: a double right coronary artery with each artery originating from separate ostia off the aorta. This case was discovered in the cadaver of a 76-year-old woman whose cause of death was cere…

Fasting intact insulin by mass spectrometry is associated with metabolic dysfunction–associated steatotic liver disease in youth Open

Helaina Huneault, Jaclyn S Lo, Shasha Bai, Zhulin He, Michael J. McPhaul , et al. · 2024

Background: Fasting intact insulin concentrations can predict metabolic dysfunction–associated steatotic liver disease (MASLD) in adults without diabetes; however, research in youth is limited. We sought to determine whether fasting intact…

Differences in cardiorespiratory fitness by gonadotropin-releasing hormone agonist treatment before and after testosterone in transgender adolescents Open

Natalie Nokoff, Travis Nemkov, Samantha Bothwell, Melanie Cree‐Green, Kelly N Z Fullmeyer , et al. · 2024

This study demonstrates differences in exercise capacity and mitochondrial respiration at baseline based on whether or not individuals had feminizing puberty blocked. Individuals who had puberty blocked had greater improvements in cardiopu…

5G Energy FRAME Report on 5G for Grid Use Case (Year 3 Final Report) Open

Xiaoyuan Fan, Yousu Chen, Dexin Wang, Chuan Qin, Yuan Liu , et al. · 2024

This report provides an extensive overview of the interrelationships among energy, communication, and computing—especially in the context of decarbonization goals, challenges, and opportunities. Technical examples enabled by 5G technologie…

A Critical Assessment of Interpretable and Explainable Machine Learning for Intrusion Detection Open

Omer Subasi, Melanie Cree‐Green, Joseph Manzano, Elena Peterson · 2024

There has been a large number of studies in interpretable and explainable ML for cybersecurity, in particular, for intrusion detection. Many of these studies have significant amount of overlapping and repeated evaluations and analysis. At …

Network Analysis Reveals Multi-omic Associations With Hyperandrogenism and Hepatic Fat in Individuals With PCOS Open

Anthony A Wang, Jaclyn Lo, Samantha Bothwell, Laura Pyle, Janet Siebert , et al. · 2024

Muscle mitochondrial function is impaired in adults with type 1 diabetes Open

Daniel J. Gottlieb, Layla A. Abushamat, Kristen J. Nadeau, Judith G. Regensteiner, Jane E.B. Reusch , et al. · 2024

Insulin sensitivity, body composition and bone mineral density after testosterone treatment in transgender youth with and without prior GnRH agonist therapy Open

Natalie Nokoff, Samantha Bothwell, John D. Rice, Melanie Cree‐Green, Megan M. Kelsey , et al. · 2024

Diagnostic Accuracy of Transient Elastography in Hepatosteatosis in Youth With Obesity Open

Emir Tas, Divya Sundararajan, Jaclyn S Lo, Nazeen Morelli, Yesenia Garcia‐Reyes , et al. · 2024

Context Steatotic liver disease is common but overlooked in childhood obesity; diagnostic methods are invasive or expensive. Objective We sought to determine the diagnostic accuracy of vibration-controlled transient elastography (VCTE) com…

Prediction of resting energy expenditure for adolescents with severe obesity: A multi‐centre analysis Open

Amy Rydin, Cameron Severn, Laura Pyle, Nazeen Morelli, Ashley H. Shoemaker , et al. · 2024

Summary Background and Objectives Resting energy expenditure (REE) assessments can help inform clinical treatment decisions in adolescents with elevated body mass index (BMI), but current equations are suboptimal for severe obesity. We dev…

Comprehensive transition of care for polycystic ovary syndrome from adolescence to adulthood Open

Stacey L. Simon, Phoutdavone Phimphasone‐Brady, Kathryn M. McKenney, Lauren D. Gulley, Andrea E. Bonny , et al. · 2024

Metabolic effects of an essential amino acid supplement in adolescents with PCOS and obesity Open

Talyia M. Fordham, Nazeen Morelli, Yesenia Garcia‐Reyes, Meredith A Ware, Haseeb Rahat , et al. · 2024

Objective Polycystic ovary syndrome (PCOS) is characterized by hyperandrogenism, insulin resistance, and hepatic steatosis (HS). Because dietary essential amino acid (EAA) supplementation has been shown to decrease HS in various population…

Distinct Reproductive Phenotypes Segregate With Differences in Body Weight in Adolescent Polycystic Ovary Syndrome Open

Angie Chen-Patterson, Angelina Bernier, Tania S. Burgert, Vanessa Davis, T. Khan , et al. · 2024

Introduction Polycystic ovary syndrome (PCOS) is a heterogenous clinical syndrome defined by hyperandrogenism and irregular menses. In adult women with PCOS, discrete metabolic and reproductive subgroups have been identified. We hypothesiz…

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