Michael Sullivan
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View article: PTHP-15. Enhancing Medulloblastoma Classification: Integrating IHC and DNA Methylation Data from the SJMB12 Clinical Trial
PTHP-15. Enhancing Medulloblastoma Classification: Integrating IHC and DNA Methylation Data from the SJMB12 Clinical Trial Open
The SJMB12 trial used immunohistochemistry (IHC)-based molecular grouping to separate medulloblastoma (MB) into WNT, SHH, and non-WNT/non-SHH (NWNS) groups for risk and treatment stratification. IHC was selected due to its rapid turnaround…
View article: P-401 Predicting fertility in young boys after gonadotoxic treatments: recovery of spermatogenesis
P-401 Predicting fertility in young boys after gonadotoxic treatments: recovery of spermatogenesis Open
Study question Can the cyclophosphamide equivalent dose (CED) given to young boys be used to predict future infertility? Summary answer Our data suggests that CED alone is not a good predictor of subsequent infertility. What is known alrea…
View article: Global consensus from the PHITT consortium surrounding an interim chemotherapy guidance for the treatment of children with hepatoblastoma, hepatocellular neoplasm – not otherwise specified (HCN-NOS), hepatocellular carcinoma and fibrolamellar carcinoma after trial closure
Global consensus from the PHITT consortium surrounding an interim chemotherapy guidance for the treatment of children with hepatoblastoma, hepatocellular neoplasm – not otherwise specified (HCN-NOS), hepatocellular carcinoma and fibrolamellar carcinoma after trial closure Open
Malignant liver tumors affecting children and adolescents are rare. In order to adequately study liver tumors occurring in this patient population and establish a more uniform approach to therapy, the three primary liver tumor consortia, S…
View article: Health Effects and Water Quality Following Low Pressure Events in Drinking Water Distribution Systems in the United States
Health Effects and Water Quality Following Low Pressure Events in Drinking Water Distribution Systems in the United States Open
LPEs were associated with 20% higher risk of HCGI in HHs. Planned improvements to water distribution system infrastructure, adherence to industry standard distribution repair practices, and water monitoring following pipe repairs could sup…
View article: Heterozygous germline <scp>TET2</scp> loss‐of‐function variants associated with an <scp>ALPS</scp> ‐like phenotype
Heterozygous germline <span>TET2</span> loss‐of‐function variants associated with an <span>ALPS</span> ‐like phenotype Open
Summary Germline homozygous loss‐of‐function mutations in TET2 result in significant childhood immunodeficiency that resembles autoimmune lymphoproliferative syndrome and predisposes one to lymphoma. The implications of heterozygous varian…
View article: Building capacity to treat childhood cancer in Papua New Guinea: ‘It’s a multidisciplinary village’
Building capacity to treat childhood cancer in Papua New Guinea: ‘It’s a multidisciplinary village’ Open
Childhood cancer outcomes in low- and middle-income countries are impacted by the presentation of advanced disease and limited diagnostic and treatment resources. Papua New Guinea is highly populated with significant health coverage and wo…
View article: Local application of sodium thiosulfate as an otoprotectant for cisplatin-exposed patients – A narrative literature review to explore the potential benefit for children with cancer
Local application of sodium thiosulfate as an otoprotectant for cisplatin-exposed patients – A narrative literature review to explore the potential benefit for children with cancer Open
Background: Ototoxicity is a highly prevalent, serious, and irreversible side effect in cisplatin-treated childhood cancer patients, which can significantly impact speech-language development, psychosocial development, and quality of life.…
View article: MDB-49. OUTCOMES OF SONIC HEDGEHOG (SHH) MEDULLOBLASTOMA (MB) IN CHILDREN AND ADULTS TREATED WITH RISK-ADAPTED THERAPY ON A PROSPECTIVE INTERNATIONAL PROTOCOL (SJMB12)
MDB-49. OUTCOMES OF SONIC HEDGEHOG (SHH) MEDULLOBLASTOMA (MB) IN CHILDREN AND ADULTS TREATED WITH RISK-ADAPTED THERAPY ON A PROSPECTIVE INTERNATIONAL PROTOCOL (SJMB12) Open
BACKGROUND SJMB12 (NCT01878617) was among the first protocols to treat newly diagnosed MB incorporating molecular subgrouping. METHODS Tumors were subtyped and TP53 mutation assessed via immunohistochemistry. SHH patients were grouped into…
View article: MDB-90. PRIMARY LEPTOMENINGEAL MEDULLOBLASTOMA: A SINGLE-SITE RETROSPECTIVE STUDY OF 5 CASES
MDB-90. PRIMARY LEPTOMENINGEAL MEDULLOBLASTOMA: A SINGLE-SITE RETROSPECTIVE STUDY OF 5 CASES Open
BACKGROUND Primary leptomeningeal medulloblastoma without mass is a rare entity with fewer than 10 reported paediatric cases. Establishing an accurate diagnosis is challenging and reported outcomes are very poor. METHODS We conducted a ret…
View article: MDB-92. EFFECT OF REDUCED-DOSE CRANIOSPINAL IRRADIATION AND REDUCED-DOSE ADJUVANT CHEMOTHERAPY ON CHILDREN AND ADOLESCENTS WITH WNT MEDULLOBLASTOMA WITHOUT RESIDUAL OR METASTATIC DISEASE: RESULTS FROM THE SJMB12 CLINICAL TRIAL
MDB-92. EFFECT OF REDUCED-DOSE CRANIOSPINAL IRRADIATION AND REDUCED-DOSE ADJUVANT CHEMOTHERAPY ON CHILDREN AND ADOLESCENTS WITH WNT MEDULLOBLASTOMA WITHOUT RESIDUAL OR METASTATIC DISEASE: RESULTS FROM THE SJMB12 CLINICAL TRIAL Open
BACKGROUND In response to studies showing medulloblastoma (MB) survival is not only contingent on clinical factors (e.g. metastases, residual disease) but also on molecular factors (e.g. molecular group, gene aberrations), we launched the …
View article: The Australian New Zealand Consortium in Children, Adolescents, and Young Adults Oncofertility action plan
The Australian New Zealand Consortium in Children, Adolescents, and Young Adults Oncofertility action plan Open
International and national oncofertility networks, including the US‐led Oncofertility Consortium, FertiProtekt, and the Danish Network, have played pivotal roles in advancing the discipline of oncofertility over the last decade. Many other…
View article: Use of Sodium Thiosulfate as an Otoprotectant in Patients With Cancer Treated With Platinum Compounds: A Review of the Literature
Use of Sodium Thiosulfate as an Otoprotectant in Patients With Cancer Treated With Platinum Compounds: A Review of the Literature Open
PURPOSE Hearing loss occurs in 50%-70% of children treated with cisplatin. Scientific efforts have led to the recent approval of a pediatric formula of intravenous sodium thiosulfate (STS) for otoprotection by the US Food and Drug Administ…
View article: The RELIVE consortium for relapsed or refractory pediatric hepatoblastoma and hepatocellular carcinoma: a scoping review of the problem and a proposed solution
The RELIVE consortium for relapsed or refractory pediatric hepatoblastoma and hepatocellular carcinoma: a scoping review of the problem and a proposed solution Open
Liver tumors account for approximately 2% of all pediatric malignancies. Children with advanced stages of hepatoblastoma (HB) are cured only 50-70% of the time while children with advanced hepatocellular carcinoma (HCC) have a <20% 5-year …
View article: Intra-arterial chemotherapy for retinoblastoma in Australia: 11-year experience
Intra-arterial chemotherapy for retinoblastoma in Australia: 11-year experience Open
Background: Intra-arterial chemotherapy (IAC) is increasingly used in managing patients with retinoblastoma. In Australia, IAC is primarily used as a globe-salvage treatment when primary treatment has failed. Methods: A retrospective, sing…
View article: Design status of the Electron-Ion Collider
Design status of the Electron-Ion Collider Open
The Electron-Ion Collider is gearing up for "Critical Decision 2", the project baseline with defined scope, cost and schedule. Lattice designs are being finalized, and preliminary component design is being carried out. Beam dynamics studie…
View article: System and methods for hardware-software cooperative pipeline error detection
System and methods for hardware-software cooperative pipeline error detection Open
An error reporting system utilizes a parity checker to receive data results from execution of an original instruction and a parity bit for the data. A decoder receives an error correcting code (ECC) for data resulting from execution of a s…
View article: Sodium thiosulfate as cisplatin otoprotectant in children: The challenge of when to use it
Sodium thiosulfate as cisplatin otoprotectant in children: The challenge of when to use it Open
Cisplatin is an essential chemotherapeutic agent for children treated with hepatic tumors, neuroblastoma, medulloblastoma, germ cell tumors, and osteosarcoma. Unfortunately, cisplatin-induced hearing loss (CIHL) occurs in about 50% of trea…
View article: Optimizing software-directed instruction replication for GPU error detection
Optimizing software-directed instruction replication for GPU error detection Open
Software-only and software-hardware optimizations to reduce the overhead of intra-thread instruction duplication on a GPU or other instruction processor are disclosed. The optimizations trade off error containment for performance and inclu…
View article: Concentrator-type photovoltaic (CPV) modules, receiver and sub-receivers and methods of forming same
Concentrator-type photovoltaic (CPV) modules, receiver and sub-receivers and methods of forming same Open
CPV modules include a back plate having an array of 1 mm2 or smaller solar cells thereon. A backplane interconnect network is also provided on the back plate. This backplane interconnect network operates to electrically connect the array o…
View article: Cardio-Oncology Recommendations for Pediatric Oncology Patients
Cardio-Oncology Recommendations for Pediatric Oncology Patients Open
Cardio-oncology is a new multidisciplinary area of expertise that seeks to pre-emptively and proactively address cardiac complications that emerge during and following cancer therapy. Modern therapies including molecular targeted therapy a…
View article: Development and Implementation of Ontario Critical Care Clinical Practice Rounds
Development and Implementation of Ontario Critical Care Clinical Practice Rounds Open
Background The COVID-19 pandemic brought unprecedented challenges to health care systems across the world. Health care professionals were burdened with time constraints as they balanced care for a large number of patients while managing cr…
View article: Growth hormone and targeted oncological agents: Are we stopping children with brain tumours from reaching their true height potential?
Growth hormone and targeted oncological agents: Are we stopping children with brain tumours from reaching their true height potential? Open
Children with low‐grade gliomas have excellent long‐term survival outcomes. The development of therapies targeted to the driver mutations along the Mitogen Activated Protein (MAP) kinase signalling pathway are providing long‐term stability…
View article: Understanding decisions to participate in genomic medicine in children's cancer care: A comparison of what influences parents, health care providers, and the general community
Understanding decisions to participate in genomic medicine in children's cancer care: A comparison of what influences parents, health care providers, and the general community Open
Background The emerging role of genomically guided precision medicine in pediatric cancer care presents significant clinical, practical, and ethical challenges. We investigated the factors that influence decision‐making in genomic medicine…