M. Kamran Ikram
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View article: Association between carotid-femoral pulse wave velocity and cardiovascular disease in individuals with moderate blood pressure: a systematic review and individual participant meta-analysis
Association between carotid-femoral pulse wave velocity and cardiovascular disease in individuals with moderate blood pressure: a systematic review and individual participant meta-analysis Open
Objectives The predictive value of carotid-femoral pulse wave velocity (cfPWV) for cardiovascular (CV) events in individuals with blood pressure (BP) 120–159/80–99 mm Hg, where more accurate risk stratification has the greatest clinical ef…
View article: Risk of Cardiovascular Disease With Co‐Occurring Covert Brain Infarction and Unrecognized Myocardial Infarction
Risk of Cardiovascular Disease With Co‐Occurring Covert Brain Infarction and Unrecognized Myocardial Infarction Open
Background Covert brain infarction (CBI) increases the risk of atherosclerotic cardiovascular disease (ASCVD), but optimal clinical management is uncertain. To enable tailored preventive measures, we aimed to determine whether the co‐occur…
View article: Improving reproducibility of data analysis and code in medical research: 5 recommendations to get started
Improving reproducibility of data analysis and code in medical research: 5 recommendations to get started Open
Due to the growing use of high-dimensional data and methodological advances in medical research, reproducibility of research is increasingly dependent on the availability of reproducible code. However, code is rarely made available and too…
View article: Physical activity relates to carotid plaque vulnerability in older persons with subclinical carotid atherosclerosis
Physical activity relates to carotid plaque vulnerability in older persons with subclinical carotid atherosclerosis Open
The Rotterdam Study is supported by the Erasmus Medical Center and Erasmus University Rotterdam; the Netherlands Organisation for Scientific Research (NWO); the Netherlands Organisation for Health Research and Development (ZonMw); the Rese…
View article: Substitutions of Sleep, Physical Activity, and Sedentary Behaviour and the Risk of Dementia and Stroke
Substitutions of Sleep, Physical Activity, and Sedentary Behaviour and the Risk of Dementia and Stroke Open
Sleep, sedentary behaviour, and physical activity (PA) are important for brain health. Spending more time in one behaviour always substitutes time in another, which may affect associations and should be considered in prevention strategies.…
View article: Long-term safety and efficacy of renal sympathetic denervation in comparison to a population-based cohort: a propensity-matching approach
Long-term safety and efficacy of renal sympathetic denervation in comparison to a population-based cohort: a propensity-matching approach Open
Objective: To evaluate the long-term changes in risk of cardiovascular outcomes and blood pressure (BP) in hypertensive patients treated with renal sympathetic denervation (RDN) as compared to hypertensive controls from a population-based …
View article: Prospective versus retrospective: a simple matter of timing?
Prospective versus retrospective: a simple matter of timing? Open
Background The terms “prospective” and “retrospective” are commonly used to describe the timing of a study. However, there is much confusion surrounding the use of these terms. In this paper we describe two common definitions used for thes…
View article: Incidence and Determinants of Nonfocal Transient Neurologic Attacks
Incidence and Determinants of Nonfocal Transient Neurologic Attacks Open
Nonfocal TNAs predominantly affect older adults and those with lower educational attainment, suggesting that these attacks originate from socioeconomic determinants rather than from established cardiovascular risk factors.
View article: Improving Reproducibility of Data Analysis and Code in Medical Research - 5 Recommendations to Get Started
Improving Reproducibility of Data Analysis and Code in Medical Research - 5 Recommendations to Get Started Open
Due to the growing use of high dimensional data and methodological advances in medical research, reproducibility of research is increasingly dependent on the availability of reproducible code. However, code is rarely made available and too…
View article: Improving Reproducibility of Data Analysis and Code in Medical Research - 5 Recommendations to Get Started
Improving Reproducibility of Data Analysis and Code in Medical Research - 5 Recommendations to Get Started Open
Due to the growing use of high dimensional data and methodological advances in medical research, reproducibility of research is increasingly dependent on the availability of reproducible code. However, code is rarely made available and too…
View article: 0338 Self-reported Multidimensional Sleep Health Is Not Associated with Cognitive Decline and the Risk of Dementia in Two Population-Based Cohort Studies
0338 Self-reported Multidimensional Sleep Health Is Not Associated with Cognitive Decline and the Risk of Dementia in Two Population-Based Cohort Studies Open
Introduction The links between sleep disturbances, cognitive decline, and dementia are increasingly recognized, but few studies have considered that sleep health is multidimensional. We evaluated how multidimensional sleep health relates t…
View article: Comparison of Negative Suction Subcutaneous Drain versus Simple Closure in Caesarean Section among High-Risk Patients to Prevent Postoperative Wound Complication
Comparison of Negative Suction Subcutaneous Drain versus Simple Closure in Caesarean Section among High-Risk Patients to Prevent Postoperative Wound Complication Open
Background and Aim: High-risk women, particularly those with obesity and diabetes, are prone to wound complications after Caesarean section. This randomized controlled trial aimed to compare negative suction subcutaneous drainage and simpl…
View article: CORRELATION OF HBA1C LEVEL WITH DIABETIC RETINOPATHY
CORRELATION OF HBA1C LEVEL WITH DIABETIC RETINOPATHY Open
Background: Diabetes mellitus (DM) is considered to be a significant universal public health issue. According to the American Society of Retina Specialists, diabetic retinopathy (DR) is a complication of diabetes that damages retinal blood…
View article: Type 2 Diabetes Sub-Phenotypes and Their Association with Cardiovascular Disease Risk: A Multi-Center Study
Type 2 Diabetes Sub-Phenotypes and Their Association with Cardiovascular Disease Risk: A Multi-Center Study Open
Aims/Hypothesis Type 2 diabetes mellitus (T2D) is a heterogeneous condition influenced by lipid metabolism, inflammation, and genetic predisposition, all of which contribute to variable cardiovascular disease (CVD) risk. Identifying robust…
View article: Guideline-Directed Application of Coronary Artery Calcium Scores for Primary Prevention of Atherosclerotic Cardiovascular Disease
Guideline-Directed Application of Coronary Artery Calcium Scores for Primary Prevention of Atherosclerotic Cardiovascular Disease Open
The ACC/AHA and ESC/EAS guidelines differ in the selection and application of the CAC score for primary prevention of ASCVD. Guideline-directed application of CAC score in a middle-aged apparently healthy population improved risk stratific…
View article: Optimizing Electrical Efficiency and Levelized Cost of Energy in Photovoltaic Systems Through Thermal Management Using Microchannel Heat Sinks
Optimizing Electrical Efficiency and Levelized Cost of Energy in Photovoltaic Systems Through Thermal Management Using Microchannel Heat Sinks Open
Solar energy is a ubiquitous renewable resource for photovoltaic (PV) power generation; however, higher operating temperatures significantly reduce the efficiency of PV modules, impacting their electrical output and increasing the levelize…
View article: Hypertension, intracranial arteriosclerosis, and structural brain changes in patients with TIA or ischemic stroke
Hypertension, intracranial arteriosclerosis, and structural brain changes in patients with TIA or ischemic stroke Open
Introduction: Hypertension is a major risk factor of structural brain changes, including atrophy and cerebral small vessel disease. Intracranial arteriosclerosis could be an underlying mechanism between hypertension and structural brain ch…
View article: Association between gut microbiome profiles and host metabolic health across the life course: a population-based study
Association between gut microbiome profiles and host metabolic health across the life course: a population-based study Open
R.L is supported by European UnionHorizon 2020 research and innovation program under Marie Skłodowska-Curie grant agreement No 860898 [FIDELIO].
View article: Risk of Cardiovascular Diseases After Nonfocal Transient Neurologic Attacks in the Elderly
Risk of Cardiovascular Diseases After Nonfocal Transient Neurologic Attacks in the Elderly Open
In this study, participants with nonfocal TNA did not have a subsequently elevated risk of CVD when compared with their matched counterparts, which contrasts with the elevated risk of stroke following a TIA. In the absence of other indicat…
View article: Lessons learned for pandemic preparedness in the neurodegenerative research and clinical fields: an advice report based on Parkinson’s disease as an example
Lessons learned for pandemic preparedness in the neurodegenerative research and clinical fields: an advice report based on Parkinson’s disease as an example Open
Background A sustainable pandemic preparedness strategy is essential to ensure equitable access to healthcare for individuals with neurodegenerative diseases. Moreover, it is vital to provide clinicians and researchers in the neurodegenera…
View article: Author Correction: Subclassification of obesity for precision prediction of cardiometabolic diseases
Author Correction: Subclassification of obesity for precision prediction of cardiometabolic diseases Open
Correction to: Nature Medicinehttps://doi.org/10.1038/s41591-024-03299-7, published online 24 October 2024. In the version of the article initially published, Pierre Bauvin’s surname appeared incorrectly (as Bauvain) and has now been amend…
View article: Extremely rare CNVs contributing to Alzheimer disease risk: a case-control association analysis of exome sequencing data from 22,319 individuals
Extremely rare CNVs contributing to Alzheimer disease risk: a case-control association analysis of exome sequencing data from 22,319 individuals Open
Rare coding single nucleotide variants (SNV) and short insertions or deletions (indels) contribute to Alzheimer disease (AD) genetic risk, from pathogenic variants in autosomal dominant genes to risk factors with diverse effects. In contra…