Manuella P. Kaster
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View article: Impact of Coffee Intake on Measures of Wellbeing in Mice
Impact of Coffee Intake on Measures of Wellbeing in Mice Open
Coffee intake is increasingly recognized as a life-style factor associated with the preservation of health, but there is still a debate on the relative effects of caffeinated and decaffeinated coffee. We now tested how the regular drinking…
View article: Circulating myeloid-derived MMP8 in stress susceptibility and depression
Circulating myeloid-derived MMP8 in stress susceptibility and depression Open
Psychosocial stress has profound effects on the body, including the immune system and the brain 1,2 . Although a large number of pre-clinical and clinical studies have linked peripheral immune system alterations to stress-related disorders…
View article: Stress-activated brain-gut circuits disrupt intestinal barrier integrity and social behaviour
Stress-activated brain-gut circuits disrupt intestinal barrier integrity and social behaviour Open
Chronic stress underlies the etiology of both major depressive disorder (MDD) and irritable bowel syndrome (IBS), two highly prevalent and debilitating conditions with high rates of co-morbidity. However, it is not fully understood how the…
View article: Individual history of winning and hierarchy landscape influence stress susceptibility in mice
Individual history of winning and hierarchy landscape influence stress susceptibility in mice Open
Social hierarchy formation is strongly evolutionarily conserved. Across species, rank within social hierarchy has large effects on health and behavior. To investigate the relationship between social rank and stress susceptibility, we expos…
View article: Individual history of winning and hierarchy landscape influence stress susceptibility in mice
Individual history of winning and hierarchy landscape influence stress susceptibility in mice Open
Social hierarchy formation is strongly evolutionarily conserved. Across species, rank within social hierarchy has large effects on health and behavior. To investigate the relationship between social rank and stress susceptibility, we expos…
View article: CD300f immunoreceptor is associated with major depressive disorder and decreased microglial metabolic fitness
CD300f immunoreceptor is associated with major depressive disorder and decreased microglial metabolic fitness Open
A role for microglia in neuropsychiatric diseases, including major depressive disorder (MDD), has been postulated. Regulation of microglial phenotype by immune receptors has become a central topic in many neurological conditions. We explor…
View article: Cross-cultural adaptation and psychometric evaluation of the Brazilian version of the Temporal Experience of Pleasure Scale (TEPS-Br)
Cross-cultural adaptation and psychometric evaluation of the Brazilian version of the Temporal Experience of Pleasure Scale (TEPS-Br) Open
Introduction: Anhedonia is a critical symptom of major depressive disorder that is defined as the reduced ability to experience pleasure. The Temporal Experience of Pleasure Scale (TEPS) is commonly used to measure anhedonia and has exhibi…
View article: Leptin polymorphism rs3828942: risk for anxiety disorders?
Leptin polymorphism rs3828942: risk for anxiety disorders? Open
Leptin is an anorexigenic hormone well recognized by its role in mediating energy homeostasis. Recently, leptin has been associated with psychiatric disorders and interestingly, leptin treatment has shown antidepressant and anxiolytic effe…
View article: Association of interleukin-10 levels with age of onset and duration of illness in patients with major depressive disorder
Association of interleukin-10 levels with age of onset and duration of illness in patients with major depressive disorder Open
Higher levels of IL-10 are correlated with late onset of MDD symptoms. Moreover, levels of this cytokine might decrease with disease progression, suggesting that an anti-inflammatory balance may be involved in the onset of depressive sympt…
View article: Caffeine acts through neuronal adenosine A <sub>2A</sub> receptors to prevent mood and memory dysfunction triggered by chronic stress
Caffeine acts through neuronal adenosine A <sub>2A</sub> receptors to prevent mood and memory dysfunction triggered by chronic stress Open
Significance Epidemiological studies show that individuals exposed to repeated stress, a major trigger of depression, increase their caffeine intake, which correlates inversely with the incidence of depression. However, the mechanism under…