Michael D. Kleinhenz
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View article: Pharmacokinetic Parameters of Oral Firocoxib, Oral Meloxicam, and Transdermal Flunixin in Meat Type Goats
Pharmacokinetic Parameters of Oral Firocoxib, Oral Meloxicam, and Transdermal Flunixin in Meat Type Goats Open
The objective of this study was to determine and compare the pharmacokinetics of oral firocoxib, oral meloxicam, and transdermal flunixin (TD) in 44 adult, male castrated, crossbred goats. Pharmacokinetic (PK) analysis was performed for ea…
View article: Comparison of multiple drug regimens for reduction of synovitis-induced lameness pain in meat-type goats
Comparison of multiple drug regimens for reduction of synovitis-induced lameness pain in meat-type goats Open
Objective This study evaluated the analgesic effects of firocoxib, meloxicam, and transdermal flunixin in meat-type goats with experimentally induced lameness. Methods 44 crossbred castrated meat-type goats with an average weight of 35 kg …
View article: 178 Cannabinoid transference and retention in tissues of beef steers fed hemp leaves
178 Cannabinoid transference and retention in tissues of beef steers fed hemp leaves Open
Hemp, Cannabis sativa L., is a versatile and environmentally sustainable crop that has recently been approved for production in the U.S. under certain regulations. Hemp production is accompanied by by-products that, if not utilized in huma…
View article: Evaluation of oral meloxicam in beef calves with neonatal calf diarrhea
Evaluation of oral meloxicam in beef calves with neonatal calf diarrhea Open
Objective To examine behavioral and physiologic outcomes associated with the expression of pain in calves with naturally occurring neonatal calf diarrhea (NCD) and determine the impact of meloxicam administration on reducing these pain-rel…
View article: Evaluating the efficacy of maternal bovine appeasing substance (MBAS) (FerAppease®) administration on pain outcomes in calves after cautery dehorning and surgical castration
Evaluating the efficacy of maternal bovine appeasing substance (MBAS) (FerAppease®) administration on pain outcomes in calves after cautery dehorning and surgical castration Open
Castration and disbudding are routine procedures that cause pain and distress in cattle. No FDA analgesic or anesthetic drugs are currently approved in the U.S. to relieve pain in calves. Maternal bovine appeasing substance (MBAS) is natu…
View article: Evaluation of pain and meloxicam use in neonatal calf diarrhea
Evaluation of pain and meloxicam use in neonatal calf diarrhea Open
Scours is one of the most common neonatal diseases affecting beef and dairy calves. Multiple etiologic agents have been implicated. The disease manifests as malabsorptive or secretory diarrhea with inflammation of the intestinal epitheliu…
View article: Determining the Effect of Varied Proportions of Cohort Administered Tulathromycin at Arrival on Nasopharyngeal Microbiota and Performance Characteristics in Yearling Steers in the First 56 Days on Feed
Determining the Effect of Varied Proportions of Cohort Administered Tulathromycin at Arrival on Nasopharyngeal Microbiota and Performance Characteristics in Yearling Steers in the First 56 Days on Feed Open
Metaphylaxis or treating the entire population of cattle at arrival with an antimicrobial has been studied extensively in the cattle industry; however, little information is available on the impacts of treating only a proportion of the pop…
View article: Comparison of firocoxib and meloxicam for pain mitigation in goats undergoing surgical castration
Comparison of firocoxib and meloxicam for pain mitigation in goats undergoing surgical castration Open
Castration is a common husbandry practice in food animal management. Castration reduces aggression, prevents indiscriminate breeding, and improves carcass quality. For male goats intended to be kept as pets, castration is recommended clos…
View article: Evaluation of a needle-free injection system for administration of cloprostenol for luteolysis in lactating dairy cows
Evaluation of a needle-free injection system for administration of cloprostenol for luteolysis in lactating dairy cows Open
Luteolytic drugs are critical for managing reproductive success in dairy cows. Currently prostaglandin analogs are only approved for intramuscular injection. The utilization of a needle and syringe for administration of any drug can resul…
View article: Comparison of firocoxib and meloxicam for pain mitigation in goats undergoing surgical castration
Comparison of firocoxib and meloxicam for pain mitigation in goats undergoing surgical castration Open
OBJECTIVE This study sought to determine whether firocoxib (FIRO) or meloxicam (MEL) was effective at providing analgesia after surgical castration in goats. ANIMALS 18 intact male crossbred goats (6 to 8 months old) were enrolled with a m…
View article: Genetically Modified Live Vaccine Offers Protective Immunity Against Wild-Type Anaplasma Marginale Tick-Transmission Challenge
Genetically Modified Live Vaccine Offers Protective Immunity Against Wild-Type Anaplasma Marginale Tick-Transmission Challenge Open
View article: Nasopharyngeal Bacterial Prevalence and Microbial Diversity at First Treatment for Bovine Respiratory Disease (BRD) and Its Associations with Health and Mortality Outcomes in Feedyard Cattle
Nasopharyngeal Bacterial Prevalence and Microbial Diversity at First Treatment for Bovine Respiratory Disease (BRD) and Its Associations with Health and Mortality Outcomes in Feedyard Cattle Open
Bovine respiratory disease (BRD) is an economically important disease in feedyards influencing both animal welfare and antimicrobial utilization. Major pathogens associated with BRD have been identified in previous research, but little inf…
View article: A novel needle-free method of lidocaine administration during standing castration of Holstein bulls
A novel needle-free method of lidocaine administration during standing castration of Holstein bulls Open
The American Veterinary Medical Association recognizes castration to be important for both human and animal safety. Lidocaine delivered through-the-needle has been shown to be effective at reducing cortisol response to castration, but this…
View article: Kansas State University is advancing animal welfare with practical analgesic solutions for food animals
Kansas State University is advancing animal welfare with practical analgesic solutions for food animals Open
P ain management in farm animals is a significant animal wel- fare concern, with more than 120 million pigs and 35 million calves raised in the US each year.However, there are no drugs labeled to relieve pain resulting from dehorning and c…
View article: Evaluating the efficacy of two local anesthetics to extend analgesia in Holstein calves after dehorning
Evaluating the efficacy of two local anesthetics to extend analgesia in Holstein calves after dehorning Open
The dehorning of dairy calves is a painful procedure routinely done in commercial production systems, to facilitate handling and increase human and animal safety. The American Association of Bovine Practitioners recommends the use of proc…
View article: Pilot study to investigate the impacts of cannabinoids from industrial hemp and repeated transportation events on cattle health and immune status
Pilot study to investigate the impacts of cannabinoids from industrial hemp and repeated transportation events on cattle health and immune status Open
The segmentation of the cattle industries necessitates regular transportation. Transport alters immune and stress biomarkers in cattle. The passage of the 2018 Farm Bill excluded industrial hemp (IH; Cannabis sativa, ≤ 0.3% tetrahydrocan…
View article: Determination of milk concentrations and pharmacokinetics of salicylic acid following acetylsalicylic acid (aspirin) administration in postpartum dairy cows
Determination of milk concentrations and pharmacokinetics of salicylic acid following acetylsalicylic acid (aspirin) administration in postpartum dairy cows Open
The objectives of this descriptive study were to 1) describe the pharmacokinetics of salicylic acid (SA) in the milk and plasma of postpartum dairy cattle following oral administration of acetylsalicylic acid (ASA) (aspirin); 2) to estima…
View article: Pharmacokinetics, Milk Residues, and Toxicological Evaluation of a Single High Dose of Meloxicam Administered at 30 mg/kg per os to Lactating Dairy Cattle
Pharmacokinetics, Milk Residues, and Toxicological Evaluation of a Single High Dose of Meloxicam Administered at 30 mg/kg per os to Lactating Dairy Cattle Open
Adverse effects associated with overdose of NSAIDs are rarely reported in cattle, and the risk level is unknown. If high doses of NSAIDs can be safely administered to cattle, this may provide a longer duration of analgesia than using curre…
View article: Measurement of Cyclooxygenase Products in Plasma as Markers for Inhibition of Cyclooxygenase Isoforms by Oral Meloxicam in New Zealand White Rabbits (<i>Oryctolagus cuniculus </i>)
Measurement of Cyclooxygenase Products in Plasma as Markers for Inhibition of Cyclooxygenase Isoforms by Oral Meloxicam in New Zealand White Rabbits (<i>Oryctolagus cuniculus </i>) Open
Pain management in rabbits is a challenging task that is complicated by the rabbit's ability to hide signs of distress and the limited pharmacologic data available for this species. Pharmacokinetic data has shown that in rabbits, meloxicam…
View article: Determination of milk concentrations and pharmacokinetics of salicylic acid following acetylsalicylic acid (aspirin) administration in postpartum dairy cows
Determination of milk concentrations and pharmacokinetics of salicylic acid following acetylsalicylic acid (aspirin) administration in postpartum dairy cows Open
The objectives of this descriptive study were to (1) describe the pharmacokinetics of salicylic acid (SA) in the milk and plasma of postpartum dairy cattle following oral administration of acetylsalicylic acid (ASA; aspirin), (2) to estima…
View article: Characterizing the diagnostic sensitivity and specificity of pain biomarkers in cattle using receiver operating characteristic curves
Characterizing the diagnostic sensitivity and specificity of pain biomarkers in cattle using receiver operating characteristic curves Open
Biomarkers are used to assess pain and analgesic drug efficacy in livestock. However, often the diagnostic sensitivity and specificity of these biomarkers for different painful conditions over time have not been described. Receiver operati…
View article: 393 Young Scholar Award Talk: Investigation of Pain and Analgesic Strategies in Cattle Undergoing Painful Husbandry Procedures and Disease Conditions
393 Young Scholar Award Talk: Investigation of Pain and Analgesic Strategies in Cattle Undergoing Painful Husbandry Procedures and Disease Conditions Open
Cattle are stoic by nature and have long been subject to evolutionary pressure to mask pain to avoid becoming prey. Quantifying pain via biomarkers allows researchers to capture changes that are not easily detected by the human eye. Negati…
View article: Evaluating the utility of a CO2 surgical laser for piglet tail docking to reduce behavioral and physiological indicators of pain and to improve wound healing: A pilot study
Evaluating the utility of a CO2 surgical laser for piglet tail docking to reduce behavioral and physiological indicators of pain and to improve wound healing: A pilot study Open
In the U.S. millions of commercially raised piglets are routinely tail docked. Human and veterinary medical patients experienced reduced inflammation, healing time and post-procedural pain using a CO2 surgical laser compared to standard su…
View article: Pharmacokinetics and ex vivo pharmacodynamics of oral firocoxib administration in New Zealand White rabbits (Oryctolagus cuniculus)
Pharmacokinetics and ex vivo pharmacodynamics of oral firocoxib administration in New Zealand White rabbits (Oryctolagus cuniculus) Open
OBJECTIVE To examine the pharmacokinetics and ex vivo pharmacodynamics of oral firocoxib administration in New Zealand White rabbits ( Oryctolagus cuniculus ). ANIMALS 6 healthy New Zealand White rabbits. PROCEDURES Pharmacokinetics were d…
View article: 11 Determination of Milk Concentrations and Pharmacokinetics of Salicylic Acid Following Acetylsalicylic Acid (Aspirin) Administration in Postpartum Dairy Cows
11 Determination of Milk Concentrations and Pharmacokinetics of Salicylic Acid Following Acetylsalicylic Acid (Aspirin) Administration in Postpartum Dairy Cows Open
Administration of non-steroidal anti-inflammatory drugs, such as the widely available drug aspirin, or acetylsalicylic acid (ASA), may improve health and milk production in postpartum dairy cows. However, plasma pharmacokinetic (PK) data f…
View article: Short term feeding of industrial hemp with a high cannabidiolic acid (CBDA) content increases lying behavior and reduces biomarkers of stress and inflammation in Holstein steers
Short term feeding of industrial hemp with a high cannabidiolic acid (CBDA) content increases lying behavior and reduces biomarkers of stress and inflammation in Holstein steers Open
Industrial hemp (IH) is defined as Cannabis sativa containing < 0.3% delta-9 tetrahydrocannabinol (THC) and was legalized in the 2018 Farm Bill. The impact of cannabinoids in IH fed to livestock, especially after repeat exposure, has not b…
View article: Comparison of lidocaine alone or in combination with a local nerve block of ethanol, bupivacaine liposome suspension, or oral meloxicam to extend analgesia after scoop dehorning in Holstein calves
Comparison of lidocaine alone or in combination with a local nerve block of ethanol, bupivacaine liposome suspension, or oral meloxicam to extend analgesia after scoop dehorning in Holstein calves Open
The American Veterinary Medical Association recommends the use of practices that reduce or eliminate pain and discomfort associated with dehorning. Identification of an effective, long-acting local anesthetic that is practical for producer…
View article: Behavioral and performance response associated with administration of intravenous flunixin meglumine or oral meloxicam immediately prior to surgical castration in bull calves
Behavioral and performance response associated with administration of intravenous flunixin meglumine or oral meloxicam immediately prior to surgical castration in bull calves Open
The objective of this study was to determine the effects of flunixin meglumine or meloxicam on behavioral response and performance characteristics associated with surgical castration in crossbred bulls. Intact male Bos taurus calves (n = 2…
View article: The effect of breed, sex, and oral meloxicam administration on pain biomarkers following hot-iron branding in Hereford and Angus calves
The effect of breed, sex, and oral meloxicam administration on pain biomarkers following hot-iron branding in Hereford and Angus calves Open
Hot-iron branding uses thermal injury to permanently identify cattle causing painful tissue damage. The primary objective was to examine the physiological and behavioral effects of oral meloxicam (MEL), compared to a control, administered …
View article: Comparative Pharmacokinetics and Tissue Concentrations of Flunixin Meglumine and Meloxicam in Tilapia (Oreochromis spp.)
Comparative Pharmacokinetics and Tissue Concentrations of Flunixin Meglumine and Meloxicam in Tilapia (Oreochromis spp.) Open
Evidence of pain perception in fish is well established, but analgesic use in aquaculture is limited. The objective was to investigate the comparative pharmacokinetics of flunixin administered intramuscularly (IM) and meloxicam administere…