Maria Knierim
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View article: Prediction of postoperative delirium after cardiac surgery by the interplay between preoperative plasma p-tau181 and IL-6 and heart-brain axis related factors: results from the prospective observational study FINDERI
Prediction of postoperative delirium after cardiac surgery by the interplay between preoperative plasma p-tau181 and IL-6 and heart-brain axis related factors: results from the prospective observational study FINDERI Open
Postoperative delirium (POD) following cardiac surgery is a severe complication. There is evidence of a link between neuroinflammation and neurodegeneration in POD. We investigated the preoperative proinflammatory interleukin-6 (IL-6) and …
View article: Cytosolic calcium handling signature: integration with clinical predictors enhances prediction of post-operative atrial fibrillation
Cytosolic calcium handling signature: integration with clinical predictors enhances prediction of post-operative atrial fibrillation Open
Background and Aims Atrial fibrillation (AF) is a prevalent complication after cardiac surgery, worsening patient outcomes. Considering the established role of Ca2+-handling abnormalities in AF pathogenesis, this study aimed to evaluate if…
Intra- and early postoperative predictors of delirium risk in cardiac surgery: results from the prospective observational FINDERI study Open
Background: Postoperative delirium (POD) is a severe complication following cardiac surgery and is associated with increased morbidity and mortality. The impact of intra- and early postoperative factors on the occurrence of POD following c…
Simulation of cardiac arrhythmias in human induced pluripotent stem cell-derived cardiomyocytes Open
The effects and mechanisms of cardiac arrhythmias are still incompletely understood and an important subject of cardiovascular research. A major difficulty for investigating arrhythmias is the lack of appropriate human models. Here, we pre…
Cellular calcium handling and electrophysiology are modulated by chronic physiological pacing in human induced pluripotent stem cell-derived cardiomyocytes Open
Electric pacing is increasingly used in research with human induced pluripotent stem cell cardiomyocytes (hiPSC-CM), for example to simulate arrhythmias but also to enhance maturity. Therefore, it is mandatory to understand the effects of …
NaV1.8 as Proarrhythmic Target in a Ventricular Cardiac Stem Cell Model Open
The sodium channel NaV1.8, encoded by the SCN10A gene, has recently emerged as a potential regulator of cardiac electrophysiology. We have previously shown that NaV1.8 contributes to arrhythmogenesis by inducing a persistent Na+ current (l…
Molecular and Functional Relevance of NaV1.8-Induced Atrial Arrhythmogenic Triggers in a Human SCN10A Knock-Out Stem Cell Model Open
In heart failure and atrial fibrillation, a persistent Na+ current (INaL) exerts detrimental effects on cellular electrophysiology and can induce arrhythmias. We have recently shown that NaV1.8 contributes to arrhythmogenesis by inducing a…
Electrophysiological remodeling in tachycardia-induced cardiomyopathy Open
Background Tachycardia-induced cardiomyopathy (TCM) is a reversible and likely underrecognized form of heart failure. Thus, a better understanding of the TCM-pathophysiology is warranted as the underlying early mechanisms that mediate the …
Effects of atrial fibrillation on ventricular remodeling in the human heart Open
Atrial fibrillation (AF) is often found in patients with heart failure (HF). Clinical data indicated that the arrhythmic component of AF alone could contribute to left-ventricular (LV) dysfunction. However, the effects of non-tachycardic A…
Atrial fibrillation impairs ventricular function by altering excitation-contraction coupling in the human heart Open
Atrial fibrillation (AF) often co-exists in patients with heart failure (HF). Recent clinical evidence suggests that the arrhythmic component of AF alone may contribute to ventricular dysfunction. However, the pathophysiological effects of…
4967Effects of atrial fibrillation on the human ventricle Open
Background The consequence of normofrequent atrial fibrillation (AF) on the ventricle remains largely unknown. Methods and results To elucidate the effects of arrhythmic excitation on human ventricular myocardium we performed contractility…